The European Court of Justice (ECJ) has this morning given a ruling that represents a significant victory for the charity Age Concern in their fight to have certain parts of UK age discrimination legislation ruled unlawful. As expected, the ECJ has...

The Government has today implemented new regulations (The Employment Relations Act 1999 (Blacklists) Regulations 2010) to outlaw the compiling and use of trade union blacklists. The regulations also aim to stop trade union...

The officer's diagnosis follows that of another one from the Disaster Operations Centre in Pretoria who tested positive on Wednesday.

The Stock Exchange of Hong Kong (“SEHK”), wholly owned subsidiary of Hong Kong Exchanges and Clearing, has published a consultation paper last Friday 22 September 2017 which proposed changes to the Main Board Listing Rules (“MB Rules”) and the Rules...

The Securities and Futures Commission (the “SFC”) and The Stock Exchange of Hong Kong Limited (the “Stock Exchange”) issued a joint consultation paper on proposed enhancements to the Stock Exchange’s decision-making and...

The Stock Exchange of Hong Kong Limited (the “Stock Exchange”) is conducting further public consultation on the listing of companies from emerging and innovative sectors.  The consultation paper published on 23 February 2018 (the &l...

On a dusty plaza in a Native American village that dates back nearly a millennium, a steady trickle of vehicles inched through a pop-up coronavirus testing site.

In recent years, there have been growing concerns over backdoor listings and shell activities in Hong Kong as a result of which new businesses have been able to be listed without going through the listing requirements contained in the Rules Gover...

The Belt and Road Initiative (BRI) is a multi-trillion Chinese led initiative to strengthen trade routes and related infrastructure across over 150 countries worldwide. The initiative covers over 60% of the world’s population in terms of ...

PICURIS PUEBLO, N.M. (AP) — On a dusty plaza in a Native American village that dates back nearly a millennium, a steady trickle of vehicles inched through a pop-up coronavirus testing site. From the bed of a pickup truck...

MOSCOW (AP) " Russian President Vladimir Putin marked Victory Day, the...

As the globe contends with the coronavirus pandemic, still looming large now more than ever is the threat posed by Communist China, which is something Rep. Robert Aderholt (R-AL) warns should not be taken lightly. ......

Stars and Stripes is making stories on the coronavirus pandemic available free of charge. See other free reports here. Sign up for our daily coronavirus newsletter here. Please support our journalism with a subscription. MOSCOW — Russian President Vladimir Putin marked Victory Day, the anniversary of the defeat of Nazi Germany in World War II, in a ceremony shorn of its usual military parade and pomp by the coronavirus pandemic. In neighboring Belarus, however, the ceremonies went ahead in full, with tens of thousands of people in the sort of proximity that has been almost unseen in the world for months....

Photo from Fredy Builes/VIEWpress via Getty Images) Colombian delivery app Rappi is testing pilot robot deliveries in Colombia. Rappi operates in several Latin American countries, and last year SoftBank invested one billion dollars into the startup. Deliveries are made using Kiwibot, a delivery robot from a Colombian owned company in California. Visit Business...

A weekly read to keep you in the loop on humanitarian issues.

The release, which marks a significant shift in disclosure policy, details the capital's testing totals, daily infection counts and infection rates.

Anyone with four days of mild cold symptoms is now being encouraged to consult a public health center about getting tested.

[Premium Times] The Lagos State Commissioner for Health, Akin Abayomi, said on Friday that many people who tested positive for coronavirus were running away from being taken to isolation centres for treatment.

Katie Taylor has Amanda Serrano, Delfine Persoon and Cecilia Braekhus on her radar as the Irish fighter looks to leave behind a legacy that will stand the test of time.

It is almost ten weeks since the coronavirus emergency erupted here, following confirmation of the first case of Covid-19 in Ireland. Our world has changed in the most unexpected ways.

A prideful heart cannot find rest in God’s sovereignty. A person who values his or her own plans, opinions, and desires above all else has nowhere to turn when worry creeps in. In fact, pride paves the way for an anxious heart.

FAISALABAD: Federal Secretary for Education and Professional Training Dr Sajid Yoosufani on Friday visited the National Textile University here. NTU Rector Prof Dr Tanveer Hussain gave briefing to him about the institution. The secretary also visited various departments of the varsity and showed...

As Asia’s rich contemplate where to place their nest eggs, most have overwhelmingly chosen Singapore over rival international financial centre Hong Kong so far this year, according to the region’s largest wealth manager.High-net-worth individuals have mainly instructed their private bankers at UBS to place new money in Singapore rather than Hong Kong, said Edmund Koh, the Swiss bank’s president in the Asia-Pacific region. Last year, the region’s high-net-worth individuals opened more new…

It is about 7pm when Muslim community leader Raheel Ahmed, 57, gathers with his wife, two sons and daughter for a home-made meal of dates, rice and spicy curried chicken, salad, fresh fruit and juice.For this Hong Kong family of Pakistani origin, it is their first meal after fasting for more than 12 hours, as this is the Islamic holy month of Ramadan.The world’s 1.8 billion Muslims mark the month by abstaining from food or drink from sunrise to sunset, and gathering as a community in mosques to…

Jennifer Aniston shares an interesting picture with fans

If you're a fitness junkie with a cool $14 million to spend on a home in Denver, it's hard to beat 460 Saint Paul Street.

The Philippines’ Department of Health (DOH), with support from ADB, has set up a new laboratory in Pampanga province, north of the capital Manila. It will significantly increase the government’s testing capacity for COVID-19...

The Philippines’ Department of Health (DOH), with support from ADB, has set up a new laboratory in Pampanga province, north of the capital Manila. It will significantly increase the government’s testing capacity for COVID-19...

ADB pilot project with the Philippines’ Cantilan Bank tests cloud-based banking.

Drawing on the Philippines as a case study, this brief explores how effective the graduation approach is in reducing poverty and assesses opportunities to apply it in other developing member countries.

When lead is quickly brought to extremely high pressures using 160 laser beams, it suddenly becomes 250 times stronger – and then it explodes

Upside-down jellyfish release tiny balls of stinging cells that can move through water on their own and survive for days – leaving a network of mucus that can sting you

Brazil’s yellow cururu toads eat scorpions, and they can survive five times the dose of scorpion venom that would kill a mouse – the same as 10 stings

A handful of NBA teams are in the process of receiving permission from local government officials to test players and staff for coronavirus, even if they are asymptomatic, ESPN reported Friday.

We need to be very cautious about preliminary studies estimating how many people have already been infected by the coronavirus

Telling Lies is a game where you sift through video calls to solve a mystery. Half the time you don't know what you should be doing, but that's part of the fun, says Jacob Aron

Many countries are focusing coronavirus testing on people who have covid-19 symptoms. But regularly testing all essential workers would have more of an impact

The BCG tuberculosis vaccine boosts the production of immune cells and this may explain how it protects newborns from dying of sepsis

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ABSTRACT

Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host factors that modulate interferon-stimulated gene (ISG) expression, we identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1), a previously described inhibitor of retrovirus integration, as a modulator of basal cell-intrinsic immunity. Ablation of Banf1 by gene editing resulted in chromatin activation near host defense genes with associated increased expression of ISGs, including Oas2, Rsad2 (viperin), Ifit1, and ISG15. The phenotype in Banf1-deficient cells occurred through a cGAS-, STING-, and IRF3-dependent signaling axis, was associated with reduced infection of RNA and DNA viruses, and was reversed in Banf1 complemented cells. Confocal microscopy and biochemical studies revealed that a loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline. Our study identifies an undescribed role for Banf1 in regulating the levels of cytoplasmic DNA and cGAS-dependent ISG homeostasis and suggests possible therapeutic directions for promoting or inhibiting cell-intrinsic innate immune responses.

IMPORTANCE Although the interferon (IFN) signaling pathway is a key host mechanism to restrict infection of a diverse range of viral pathogens, its unrestrained activity either at baseline or in the context of an immune response can result in host cell damage and injury. Here, we used a genome-wide CRISPR-Cas9 screen and identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1) as a modulator of basal cell-intrinsic immunity. A loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline, which triggered IFN-stimulated gene expression via a cGAS-STING-IRF3 axis that did not require type I IFN or STAT1 signaling. Our experiments define a regulatory network in which Banf1 limits basal inflammation by preventing self DNA accumulation in the cytosol.