Guarantees are one of government’s most powerful financing tools for mobilizing private sector participation in development projects.

Lining up rights-of-way for megaprojects, such as railways and highways, in crowded places is challenging but it can be done with an imaginative and respectful plan.

The Asia and Pacific region is aging rapidly, and that is affecting the region’s workforce, but increased longevity is adding an unexpected element to the picture

Asian cities act as engines of economic growth, providing jobs, expertise, and the sharing of resources. But in some cases, these powerful engines are sputtering due to insufficient infrastructure, inadequate planning, and poor governance.

Two people had the dubious distinction of being the first to wear electronic tags on their wrists for violating quarantine rules. Health authorities said the two were wearing the devices from 6 p.m. Tuesday and will have to keep them on for the rest of their self-quarantine period. One was caught in...

Microchip’s Low-Power Radiation-Tolerant (RT) PolarFire FPGA Enables High-Bandwidth Space Systems with Lower Total System Cost

Microchip Announces Industry’s First Space-Qualified COTS-Based Radiation-Tolerant Ethernet Transceiver and Embedded Microcontroller

Grant agreements outline the terms of an agreement for a grant. This document dated 7 May 2020 is provided for the ADB project 54229-001 in Fiji.

MUMBAI: Fourteen migrant labourers walking back to their villages after being left destitute by India’s strict coronavirus lockdown were killed on Friday after being hit by a train, officials said.

The men were returning home when they were hit by the goods train near Aurangabad, in the western state of Maharashtra, police official S.S. Sutale said.

They were among millions of migrant workers who have been left unemployed, officials said, after Indian Prime Minister Narendra Modi announced a national lockdown in March, sparking an exodus from major cities.

Hours after the incident, the Indian rail ministry tweeted that the train driver applied the brakes after seeing the men, but was unable to stop the train in time.

Three others were injured and taken to hospital, the ministry said, announcing an inquiry.

State police official Vaibhav Kalumbarme said officers were investigating the accident as there were strict guidelines to prevent migrants accessing the railway tracks from stations.

“But it is impossible to monitor every inch of the tracks when they take shortcuts,” Kalumbarme said.

Although states announced special trains to return migrant labourers, many continue to walk long distances to reach their villages.

Local media reported some provinces were charging for the rail tickets, which most can’t afford.

The return home has proved deadly for several workers ever since the lockdown started.

A study conducted by the non-profit SaveLIFE Foundation said 140 were killed in car crashes across the country — with at least 42 of them migrant labourers travelling home.

“We have been running campaigns cautioning people not to walk on tracks and we are doing everything we can urgently to get them back to their families. This is a tragic incident,” Kalumbarme added.

Published in Dawn, May 9th, 2020

Around 500 migrants are arriving at the Colombian border city of Cúcuta every day intending to return to Venezuela. As of April 15, a total of 34,000 people had passed through the city.

ADB today announced the release of a $6 million grant from its Pacific Disaster Resilience Program (Phase 2) to help finance the Government of the Marshall Islands’ response to the novel coronavirus disease (COVID-19) pandemic.

ADB today announced a $400,000 grant to the Government of Fiji to help fund priority recovery activities following Tropical Cyclone Harold, which hit Fiji's western, central, and eastern divisions on 8 and 9 April.

ADB today approved a $200,000 (460,000 pa’anga) grant to the Government of Tonga to help restore life-sustaining services following the damage from Tropical Cyclone Harold.

NEW DELHI: Low-cost housing, which found several mentions in BJP’s 2014 election manifesto, is likely to get infrastructure status, making it easier for real-estate developers to get finance from banks and for longer tenures, and eventually increasing the supply of houses. While developers are in favour of an infrastructure tag to the housing sector as a whole, the government is likely to grant it only to the low-cost segment, said a senior government official, who did not wish to be named. According to government definition, low-cost houses are those with an area of up to 40 sq metres. BJP’s manifesto talks about rolling out a massive low-cost housing programme to […]

A Dutch restaurant has come up with an idea on how to offer classy outdoor dining in the age of coronavirus: small glass cabins built for two or three people, creating intimate cocoons on a public...

Police in India's western Aurangabad district have returned the bodies of 16 migrants killed by a train on Friday, to their home towns. Ciara Lee reports

The dense, bristly hairs on the skins shed by tarantulas when they moult are naturally efficient sponges and could be used to soak up ocean oil spills

U.S. Food and Drug Administration Commissioner Stephen Hahn is in self-quarantine for a couple of weeks after coming into contact with someone who tested positive for COVID-19, an FDA spokesman told Reuters late on Friday.

Even Tim Gunn, the immaculately dressed fashion mentor from "Project Runway" and Amazon's new competition show "Making the Cut," is finding it hard to get out of his pajamas these days.

The European Commission will tell countries in the European Union to provide state guarantees for travel vouchers during the coronavirus pandemic, if they prefer people to accept the vouchers instead of cash refunds, according to a strategy document seen by Reuters.

* Airports say it could be devastating for aviation industry (Adds details, changes sourcing)

The U.S. Food and Drug Administration (FDA) on Saturday approved emergency use authorization (EUA) to Quidel Corp for the first COVID-19 antigen test.

Even Tim Gunn, the immaculately dressed fashion mentor from "Project Runway" and Amazon's new competition show "Making the Cut," is finding it hard to get out of his pajamas these days.

Police in India's western Aurangabad district have returned the bodies of 16 migrants killed by a train on Friday, to their home towns. Ciara Lee reports

Title: Noncardiac Chest Pain May Warrant More Management: Study
Category: Health News
Created: 4/24/2010 12:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Longer Wait for Mammogram After Benign Breast Biopsy May Be Warranted
Category: Health News
Created: 5/2/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM

Title: Nearly 700 at LA Universities Remain Under Measles Quarantine
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Title: Measles Case Leads to Quarantine of Cruise Ship in St. Lucia
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM

Title: AHA News: Coronavirus Intensifies Existing Issues for Older Immigrants
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM

If it feels like all your internal clocks are melting as your stay-at-home days drone on, you are not alone. Researchers say that people in various levels of COVID-19 quarantine around the world are reporting a distorted sense of time.

The nuclear factor kappa B (NF-B) is a potent transcription factor, activation of which typically results in robust proinflammatory signaling and triggering of fast negative feedback modulators to avoid excessive inflammatory responses. Here, we report that infection of epithelial cells, including primary porcine respiratory epithelial cells, with the porcine alphaherpesvirus pseudorabies virus (PRV) results in the gradual and persistent activation of NF-B, illustrated by proteasome-dependent degradation of the inhibitory NF-B regulator IB and nuclear translocation and phosphorylation of the NF-B subunit p65. PRV-induced persistent activation of NF-B does not result in expression of negative feedback loop genes, like the gene for IBα or A20, and does not trigger expression of prototypical proinflammatory genes, like the gene for tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). In addition, PRV infection inhibits TNF-α-induced canonical NF-B activation. Hence, PRV infection triggers persistent NF-B activation in an unorthodox way and dramatically modulates the NF-B signaling axis, preventing typical proinflammatory gene expression and the responsiveness of cells to canonical NF-B signaling, which may aid the virus in modulating early proinflammatory responses in the infected host.

IMPORTANCE The NF-B transcription factor is activated via different key inflammatory pathways and typically results in the fast expression of several proinflammatory genes as well as negative feedback loop genes to prevent excessive inflammation. In the current report, we describe that infection of cells with the porcine alphaherpesvirus pseudorabies virus (PRV) triggers a gradual and persistent aberrant activation of NF-B, which does not result in expression of hallmark proinflammatory or negative feedback loop genes. In addition, although PRV-induced NF-B activation shares some mechanistic features with canonical NF-B activation, it also shows remarkable differences; e.g., it is largely independent of the canonical IB kinase (IKK) and even renders infected cells resistant to canonical NF-B activation by the inflammatory cytokine TNF-α. Aberrant PRV-induced NF-B activation may therefore paradoxically serve as a viral immune evasion strategy and may represent an important tool to unravel currently unknown mechanisms and consequences of NF-B activation.

Voltage-gated potassium 11.1 (K_v11.1) channels play a critical role in repolarization of cardiomyocytes during the cardiac action potential (AP). Drug-mediated K_v11.1 blockade results in AP prolongation, which poses an increased risk of sudden cardiac death. Many drugs, like pentamidine, interfere with normal K_v11.1 forward trafficking and thus reduce functional K_v11.1 channel densities. Although class III antiarrhythmics, e.g., dofetilide, rescue congenital and acquired forward trafficking defects, this is of little use because of their simultaneous acute channel blocking effect. We aimed to test the ability of a combination of dofetilide plus LUF7244, a K_v11.1 allosteric modulator/activator, to rescue K_v11.1 trafficking and produce functional K_v11.1 current. LUF7244 treatment by itself did not disturb or rescue wild type (WT) or G601S-K_v11.1 trafficking, as shown by Western blot and immunofluorescence microcopy analysis. Pentamidine-decreased maturation of WT K_v11.1 levels was rescued by 10 μM dofetilide or 10 μM dofetilide + 5 μM LUF7244. In trafficking defective G601S-K_v11.1 cells, dofetilide (10 μM) or dofetilide + LUF7244 (10 + 5 μM) also restored K_v11.1 trafficking, as demonstrated by Western blot and immunofluorescence microscopy. LUF7244 (10 μM) increased I_Kv11.1 despite the presence of dofetilide (1 μM) in WT K_v11.1 cells. In G601S-expressing cells, long-term treatment (24–48 hour) with LUF7244 (10 μM) and dofetilide (1 μM) increased I_Kv11.1 compared with nontreated or acutely treated cells. We conclude that dofetilide plus LUF7244 rescues K_v11.1 trafficking and produces functional I_Kv11.1. Thus, combined administration of LUF7244 and an I_Kv11.1 trafficking corrector could serve as a new pharmacological therapy of both congenital and drug-induced K_v11.1 trafficking defects.

ABSTRACT

Academics in non-tenure-track positions encounter a unique set of challenges on the road toward tenure. Institutionalized policies and lack of mentors are additional burdens for foreign scientists, resulting in representation differences. Becoming a scientist has been a personal and moving journey in which my multiple selves intersect and clash every now and again. My identity as a scientist is a life project and has intersected with my other identities: a young Latina immigrant in Western Europe. This crossroad has molded, and at times, challenged my participation in science.

An aberrant bi-apical Follicucullus specimen (Albaillellaria, Radiolaria) has been discovered from an upper Guadalupian (Middle Permian) chert block of the Kamiaso Unit of the Mino terrane, central Japan. If this specimen was formed with double malformation, it would be the oldest record of this phenomenon in radiolarians and the first record of its kind in Albaillellaria.

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open cavities connecting with an airway. Several commonly accepted characteristics of caseum were established during the preantibiotic era, when autopsies of deceased tuberculosis (TB) patients were common but methodologies were limited. These pioneering studies generated concepts such as acidic pH, low oxygen tension, and paucity of nutrients being the drivers of nonreplication and persistence in caseum. Here we review widely accepted beliefs about the caseum-specific stress factors thought to trigger the shift of Mycobacterium tuberculosis to drug tolerance. Our current state of knowledge reveals that M. tuberculosis is faced with a lipid-rich diet rather than nutrient deprivation in caseum. Variable caseum pH is seen across lesions, possibly transiently acidic in young lesions but overall near neutral in most mature lesions. Oxygen tension is low in the avascular caseum of closed nodules and high at the cavity surface, and a gradient of decreasing oxygen tension likely forms toward the cavity wall. Since caseum is largely made of infected and necrotized macrophages filled with lipid droplets, the microenvironmental conditions encountered by M. tuberculosis in foamy macrophages and in caseum bear many similarities. While there remain a few knowledge gaps, these findings constitute a solid starting point to develop high-throughput drug discovery assays that combine the right balance of oxygen tension, pH, lipid abundance, and lipid species to model the profound drug tolerance of M. tuberculosis in caseum.

Marissa Guale is like all too many Americans right now. Her husband and father of her two children, Raul, is on a ventilator in a hospital on Long Island, fighting for his life while sick with COVID-19. Raul, a 34-year-old nurse, likely caught the disease while working in a nursing home. When the National Institutes of Health announced an emergency use authorization for the experimental antiviral drug remdesivir, Marissa scrambled friends and family on Facebook to figure out how to get access for Raul, emailing hospital administrators, senators, and doctors. They pressed the Guale family’s case for a potentially lifesaving treatment on social media to anyone who would listen.

Her confusion about where and how to get access to the drug isn’t unique. All over the country, families, doctors, and hospitals are wondering how to get the drug and on what basis it’s being distributed. The Trump administration, which is in charge of allocation, hasn’t published any guidance on how it’s making decisions about the scarce supplies of the drug.

So who decides which hospitals get remdesivir? And what’s the most ethical way to prioritize access?

Read more at The Daily Beast.

Watford chairman Scott Duxbury has questioned whether the Premier League should return amid the coronavirus pandemic.

The Quadrantid meteor shower has a short peak period that lasts only a few hours, so midnight on 3 January is the best time to view in the UK

As novel coronavirus spreads throughout the United States, millions of Americans are spending more time at home.MORE: Here's everything coming to Disney+ in AprilBut whether you're doing so because of a job loss, working from home situation or otherwise taking part in the mass effort to stay safe, chances are you've been bored once or twice while living under quarantine.Thankfully, some very talented people have been creating extra-special performances and experiences that you can enjoy to help you cope with the new normal and that don't break any social distancing rules. ...

The service, which protects political leaders including the president, said in March there was only one case, but new documents show that the disease is more widespread than believed.

Restaurants and drive-in movie theatres are allowed to reopen in Las Vegas today, with casinos hoping to reopen by Memorial Day.

Video games can fill the productivity and social void in this unusual time

U.S. Food and Drug Administration Commissioner Stephen Hahn is in self-quarantine for a couple of weeks after coming into contact with someone who tested positive for COVID-19, an FDA spokesman told Reuters late on Friday.