rugs Talk Evidence - Z drugs, subclinical hypothyroidism and Drazen's dozen By feeds.bmj.com Published On :: Tue, 25 Jun 2019 16:58:44 +0000 This week on the podcast, (2.02) a listener asks, when we suggest something to stop, should we suggest an alternative instead? (8.24) Helen tells us to stop putting people on treatment for subclinical hypothyroidism, but what does that mean for people who are already receiving thyroxine? (20.55) Carl has a black box warning about z drugs, and... Full Article
rugs Comprehensive Glycomic Analysis Reveals That Human Serum Albumin Glycation Specifically Affects the Pharmacokinetics and Efficacy of Different Anticoagulant Drugs in Diabetes By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:29-07:00 Long-term hyperglycemia in patients with diabetes leads to human serum albumin (HSA) glycation, which may impair HSA function as a transport protein and affect the therapeutic efficacy of anticoagulants in patients with diabetes. In this study, a novel mass spectrometry approach was developed to reveal the differences in the profiles of HSA glycation sites between patients with diabetes and healthy subjects. K199 was the glycation site most significantly changed in patients with diabetes, contributing to different interactions of glycated HSA and normal HSA with two types of anticoagulant drugs, heparin and warfarin. An in vitro experiment showed that the binding affinity to warfarin became stronger when HSA was glycated, while HSA binding to heparin was not significantly influenced by glycation. A pharmacokinetic study showed a decreased level of free warfarin in the plasma of diabetic rats. A preliminary retrospective clinical study also revealed that there was a statistically significant difference in the anticoagulant efficacy between patients with diabetes and patients without diabetes who had been treated with warfarin. Our work suggests that larger studies are needed to provide additional specific guidance for patients with diabetes when they are administered anticoagulant drugs or drugs for treating other chronic diseases. Full Article
rugs Combination of HIV, hepatitis C, MS drugs might resolve COVID-19 infection By www.upi.com Published On :: Fri, 08 May 2020 18:38:48 -0400 Combination therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin appears to improve symptoms and shorten hospital stays for people with mild to moderate COVID-19. Full Article
rugs Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).RESEARCH DESIGN AND METHODSIn this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.RESULTSChange in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.CONCLUSIONSThis phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs. Full Article
rugs Drug eruptions : a clinical study on the irritant effects of drugs upon the skin / by Prince A. Morrow. By feedproxy.google.com Published On :: New York : W. Wood, 1887. Full Article
rugs Elements of materia medica : containing the chemistry and natural history of drugs, their effects, doses, and adulterations : with observations on all the new remedies recently introduced into practice, and on the preparations of the British Pharmacopoeia By feedproxy.google.com Published On :: London : J. Churchill, 1864. Full Article
rugs Fruit on a dish and a tureen, with elaborate vessels, rugs, and a bas-relief of grape-pickers. Colour line block by Leighton Brothers after G. Lance. By feedproxy.google.com Published On :: [London?] : [Illustrated London News?], [between 1850 and 1870?] Full Article
rugs Young men and drugs : a nationwide survey / by John A. O'Donnell, Harwin L. Voss, Richard R. Clayton, Gerald T. Slatin, Robin G. W. Room. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1976. Full Article
rugs Drugs and driving / editor, Robert E. Willette. By search.wellcomelibrary.org Published On :: Rockville, Maryland : The National Institute on Drug Abuse, 1977. Full Article
rugs Women and drugs : a new era for research / editors, Barbara A. Ray, Monique C. Braude. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1986. Full Article
rugs Strategies for research on the interactions of drugs of abuse / editors, Monique C. Braude, Harold M. Ginzburg. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1986. Full Article
rugs Urine testing for drugs of abuse / Richard L. Hawks, C. Nora Chiang. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1986. Full Article
rugs The role of neuroplasticity in the response to drugs / editors, David P. Friedman, Doris H. Clouet. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1987. Full Article
rugs The incidence of driving under the influence of drugs, 1985 : an update of the state of knowledge / [Richard P. Compton and Theodore E. Anderson]. By search.wellcomelibrary.org Published On :: Springfield, Virginia : National Technical Information Service, 1985. Full Article
rugs The incidence of drugs in fatally injured drivers : final report / [E. J. Woodhouse]. By search.wellcomelibrary.org Published On :: Springfield, Virginia : National Technical Information Service, 1974. Full Article
rugs Evaluation of treatment programs for abusers of nonopiate drugs : problems and approaches. Volume 3 / Wynne Associates for Division of Research, National Institute on Drug Abuse, Alcohol, Drug Abuse and Mental Health Administration, Department of Health, By search.wellcomelibrary.org Published On :: Washington, D.C. : Wynne Associates, [1974] Full Article
rugs Co-ordinating drugs services : the role of regional and district drug advisory committees : a preliminary study for the Department of Health / by Peter Baker and Dorothy Runnicles. By search.wellcomelibrary.org Published On :: London : London Research Centre, 1991. Full Article
rugs Pediatric injectable drugs : the teddy bear book By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9781585285402 (electronic bk.) Full Article
rugs Hepatitis B virus infection : molecular virology to antiviral drugs By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9789811391514 (electronic bk.) Full Article
rugs Garcia sentenced to 33 months: Charged with importing drugs into Ketchikan By www.ketchikandailynews.com Published On :: Full Article
rugs Fentanyl found in P.E.I. drugs linked to 3 overdoses in 1 day By www.cbc.ca Published On :: Fri, 8 May 2020 13:12:05 EDT P.E.I.'s Chief Public Health Officer Dr. Heather Morrison says the powerful and potentially deadly drug fentanyl has been found in street drugs in the province. Full Article News/Canada/PEI
rugs Woman at centre of deadly drugstore stabbing could be allowed to live in community: review board By www.cbc.ca Published On :: Thu, 7 May 2020 16:37:03 EDT A woman found not criminally responsible for fatally stabbing a stranger in the heart at the makeup counter of a Toronto drugstore five years ago could ultimately be allowed to live in the community if the mental health facility where she is staying decides she can, the Ontario Review Board says. Full Article News/Canada/Toronto
rugs One-Year Outcomes of Prenatal Exposure to MDMA and Other Recreational Drugs By pediatrics.aappublications.org Published On :: 2012-08-20T00:07:44-07:00 3,4-Methylenedioxymetham-phetamine (MDMA, ecstasy) is a widely used recreational drug affecting the serotonergic system. Preclinical studies indicate learning/memory problems with fetal exposure. Human infant prenatal exposure was related to alterations in gender ratio and poorer motor development at 4 months.This is the first study documenting that heavier prenatal 3,4-methylenedioxymethamphetamine exposure predicts poorer infant mental and motor development at 12 months with significant, persistent neurotoxic effects. Language and emotional regulation were unaffected. (Read the full article) Full Article
rugs Nonsteroidal Antiinflammatory Drugs in Late Pregnancy and Persistent Pulmonary Hypertension of the Newborn By pediatrics.aappublications.org Published On :: 2012-12-03T00:07:41-08:00 Knowledge is limited regarding the epidemiology of persistent pulmonary hypertension of the newborn (PPHN). Previous work has implicated a host of perinatal risk factors and a few antenatal antecedents of PPHN, including maternal consumption during pregnancy of nonsteroidal antiinflammatory medications.In contrast to results of previous studies, we found no association between PPHN and maternal consumption during late pregnancy of nonsteroidal antiinflammatory drugs in general or ibuprofen in particular. (Read the full article) Full Article
rugs Advanced quantification methods to improve the 18b dormancy model for assessing the activity of tuberculosis drugs in vitro. [Clinical Therapeutics] By aac.asm.org Published On :: 2020-04-27T08:14:57-07:00 One of the reasons for the lengthy tuberculosis (TB) treatment is the difficult to treat non-multiplying mycobacterial subpopulation. In order to assess the ability of (new) TB drugs to target this subpopulation, we need to incorporate dormancy models in our pre-clinical drug development pipeline. In most available dormancy models it takes a long time to create a dormant state and it is difficult to identify and quantify this non-multiplying condition.The Mycobacterium tuberculosis 18b strain might overcome some of these problems, because it is dependent on streptomycin for growth and becomes non-multiplying after 10 days of streptomycin starvation, but still can be cultured on streptomycin-supplemented culture plates. We developed our 18b dormancy time-kill kinetic model to assess the difference in the activity of isoniazid, rifampicin, moxifloxacin and bedaquiline against log-phase growth compared to the non-multiplying M. tuberculosis subpopulation by CFU counting including a novel AUC-based approach as well as time-to-positivity (TTP) measurements.We observed that isoniazid and moxifloxacin were relatively more potent against replicating bacteria, while rifampicin and high dose bedaquiline were equally effective against both subpopulations. Moreover, the TTP data suggest that including a liquid culture-based method could be of additional value as it identifies a specific mycobacterial subpopulation that is non-culturable on solid media.In conclusion, the results of our study underline that the time-kill kinetics 18b dormancy model in its current form is a useful tool to assess TB drug potency and thus has its place in the TB drug development pipeline. Full Article
rugs Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs [Antiviral Agents] By aac.asm.org Published On :: 2020-05-04T08:49:24-07:00 Drug repositioning is the only feasible option to address the COVID-19 global challenge immediately. We screened a panel of 48 FDA-approved drugs against SARS-CoV-2 which were pre-selected by an assay of SARS-CoV and identified 24 potential antiviral drug candidates against SARS-CoV-2 infection. Some drug candidates showed very low micromolar IC50s and in particular, two FDA-approved drugs - niclosamide and ciclesonide – were notable in some respects. Full Article
rugs NovaLead identifies 42 approved drugs with potential to treat coronavirus By www.financialexpress.com Published On :: 2020-04-01T03:10:00+05:30 Novalead’s technology has a track record of successfully discovering repurposed drug candidates with its lead drug candidate currently being in Phase 3 trials in India, for diabetic foot ulcers. Full Article Health Lifestyle
rugs Namibia: 143 Nabbed for Drugs in April By allafrica.com Published On :: Sat, 09 May 2020 10:04:03 GMT [Namibian] POLICE arrested 143 suspects for drug-related crimes in April, the latest police report on drug busts and arrests says. Full Article
rugs Security man on drugs charge allowed to keep working at site By www.herald.ie Published On :: Sat, 09 May 2020 01:30:00 +0000 A security man accused of having drugs at a building site is to be allowed to continue working there after a court was told he had a "constitutional right" to employment. Full Article Courts
rugs Two Hong Kong police officers arrested for possessing HK$12 million in drugs, which the force believes were stolen from record crystal meth haul a week earlier By www.scmp.com Published On :: Thu, 07 May 2020 14:55:22 +0800 Two police officers have been arrested for possessing more than HK$12 million (US$1.9 million) worth of drugs, which the force believes were stolen from the record haul of crystal meth seized last week.One of the two policemen detained, a 41-year-old station sergeant, who is attached to the Kowloon West anti-triad squad, was caught with 2kg of Ice in the Royal Garden Hotel in Tsim Sha Tsui East on Thursday, police said, just days after being part of a team that seized 296kg of the drug in a… Full Article
rugs Navy, ANF seize 100kg drugs off Pasni By feedproxy.google.com Published On :: Sat, 09 May 2020 06:00:00 +0500 ISLAMABAD: In an intelligence-based joint operation, the Pakistan Navy along with Anti-Narcotics Force seized 100kg crystal off Pasni, Balochistan.The drug was valued at approximately Rs3 billion.... [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article
rugs Drugs import from India: Shahbaz Sharif demands probe into billion-rupee scandal By feedproxy.google.com Published On :: Sat, 09 May 2020 06:00:00 +0500 LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary... [[ This is a content summary only. Visit my website for full links, other content, and more! ]] Full Article
rugs Drugs import from India: Shahbaz demands probe into scandal of billions By feedproxy.google.com Published On :: Sat, 09 May 2020 06:00:00 +0500 LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee.“Coming on the heels of sugar, wheat and IPPs scandals, the latest drug scandal indicates how... Full Article
rugs Drugs import from India: Shahbaz demands probe into billion-rupee scandal By feedproxy.google.com Published On :: Sat, 09 May 2020 06:00:00 +0500 LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee.“Coming on the heels of sugar, wheat and IPPs scandals, the latest drug scandal indicates how... Full Article
rugs Drugs import from India: Shahbaz Sharif demands probe into billion-rupee scandal By feedproxy.google.com Published On :: Sat, 09 May 2020 06:00:00 +0500 LAHORE: Pakistan Muslim League-N President and National Assembly opposition leader Shahbaz Sharif has demanded an in-depth investigation into the medicine scandal through a parliamentary committee. Sugar, wheat and IPPs scandals, the latest drug scandal indicates how powerful mafias within the... Full Article
rugs Drugs may be able to fix our romantic lives when things go wrong By www.newscientist.com Published On :: Wed, 12 Feb 2020 18:00:00 +0000 Are we ready for real-life love potions? Book Love is the Drug explains how pills may affect everything from falling deeper in love to breaking up Full Article
rugs Coronavirus treatment: What drugs could work and when can we get them? By www.newscientist.com Published On :: Wed, 01 Apr 2020 18:00:00 +0000 To fight the new coronavirus, researchers are investigating more than 60 drugs, including remdesivir and hydroxychloroquine and brand new ones. Here’s a breakdown of progress so far Full Article
rugs Red light could be used to precisely target rheumatoid arthritis drugs By www.newscientist.com Published On :: Mon, 04 May 2020 14:57:21 +0000 People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help Full Article
rugs Do ADHD Drugs Stunt Kids' Growth? By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Do ADHD Drugs Stunt Kids' Growth?Category: Health NewsCreated: 5/2/2006 12:00:00 AMLast Editorial Review: 5/2/2006 12:00:00 AM Full Article
rugs More Kids Get Antipsychotic Drugs By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: More Kids Get Antipsychotic DrugsCategory: Health NewsCreated: 5/4/2006 12:00:00 AMLast Editorial Review: 5/4/2006 12:00:00 AM Full Article
rugs OTC Drugs May Work Differently in Obese Kids By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: OTC Drugs May Work Differently in Obese KidsCategory: Health NewsCreated: 4/27/2010 6:10:00 PMLast Editorial Review: 4/28/2010 12:00:00 AM Full Article
rugs FDA Panel Backs 2 Hepatitis C Drugs By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: FDA Panel Backs 2 Hepatitis C DrugsCategory: Health NewsCreated: 4/29/2011 11:01:00 AMLast Editorial Review: 4/29/2011 12:00:00 AM Full Article
rugs Drugs Can Sometimes Prevent Migraines, but at a Cost By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Drugs Can Sometimes Prevent Migraines, but at a CostCategory: Health NewsCreated: 4/29/2013 10:35:00 AMLast Editorial Review: 4/29/2013 12:00:00 AM Full Article
rugs Keep Prescription Drugs Secure From Teens: Expert By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Keep Prescription Drugs Secure From Teens: ExpertCategory: Health NewsCreated: 4/25/2014 2:35:00 PMLast Editorial Review: 4/28/2014 12:00:00 AM Full Article
rugs Slightly Higher Risk of Birth Defects Seen in Pregnant Women on HIV Drugs By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Slightly Higher Risk of Birth Defects Seen in Pregnant Women on HIV DrugsCategory: Health NewsCreated: 4/29/2014 5:35:00 PMLast Editorial Review: 4/30/2014 12:00:00 AM Full Article
rugs Many Ivy League Students Admit Using ADHD Drugs for Better Grades: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Many Ivy League Students Admit Using ADHD Drugs for Better Grades: StudyCategory: Health NewsCreated: 5/2/2014 12:36:00 PMLast Editorial Review: 5/2/2014 12:00:00 AM Full Article
rugs Prices of MS Drugs Soaring, Study Finds By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Prices of MS Drugs Soaring, Study FindsCategory: Health NewsCreated: 4/24/2015 12:00:00 AMLast Editorial Review: 4/27/2015 12:00:00 AM Full Article
rugs Drugs Show Promise for Some Advanced Lung Cancers By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Drugs Show Promise for Some Advanced Lung CancersCategory: Health NewsCreated: 4/29/2015 12:00:00 AMLast Editorial Review: 4/30/2015 12:00:00 AM Full Article
rugs No Link Between Anti-Smoking Drugs, Mental Health Issues: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: No Link Between Anti-Smoking Drugs, Mental Health Issues: StudyCategory: Health NewsCreated: 4/22/2016 12:00:00 AMLast Editorial Review: 4/25/2016 12:00:00 AM Full Article
