Londres : Paris, 1851.

Detroit, Mich. : G.S. Davis, 1887.

[London] (No 69 St Paul's Churchyard) : Printed for Carington Bowles ; [London] (opposite Fetter Lane, Fleet Street) : Robt. Sayer ; [London] (in Cornhil) : Robert Wilkinson, [between 1700 and 1799]

[London] (in St Pauls Churchyard) : Printed for T. Bowles ; [London] (at the Black Horse in Cornhil) : John Bowles & Son ; [London] (opposite Fetter Lane in Fleet Street) : R. Sayer, [between 1700 and 1799]

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1857.

Bombing ground targets from the air is tricky and not always accurate. But a new type of bomb creates an unimaginable level of destruction

The CPT1A p.P479L variant is common to northern aboriginal populations, leads to reduced enzyme activity, and may be associated with increased infant mortality rates.

The p.P479L variant is common in British Columbia First Nations with a coastal distribution correlated with regions of high infant mortality. Homozygotes display an altered acylcarnitine profile and are overrepresented in cases of sudden unexpected infant death in these areas. (Read the full article)

Penn State and the Palmer Museum of Art mourn the loss of dear friend, generous donor, and loyal champion John P. Driscoll, who died from complications due to COVID-19 on Friday, April 10. Driscoll, owner of Driscoll Babcock Galleries in New York, was a longtime friend and supporter of the Palmer Museum and will be remembered for his role as a leader, gracious mentor and trusted adviser, as well as for the expansive gifts he made to the collection and to his alma mater, Penn State.

State authorities are alerting local businesses and purchasers of tropical nursery stock of the recent detection of fire ants in a shipment of palm trees imported from Florida. The red imported fire ants were detected during a routine check at a Sussex County business by the Delaware Department of Agriculture's Plant Industries nursery inspection team. They were eradicated and do not pose a threat.

Red imported fire ants were detected during a routine check at a Sussex County business by the Delaware Department of Agriculture's Plant Industries nursery inspection team. A Hold and Control Order was promptly issued, and a treatment program to eliminate the fire ants is underway. "Buyers of tropical nursery stock - such as palm trees - should carefully inspect their plants for small, aggressive red stinging ants," said Stephen Hauss, Cooperative Agricultural Pest Survey Coordinator for the Department of Agriculture. "We need these to be reported quickly and promptly to keep them from spreading or staying in Delaware over the winter."

The biggest palm oil producers stepped up lobbying in Brussels to defend its future in the European market.

A bug exists in the PalmOS httpd that causes a crash with a "Fatal Error". Full exploit included.

LG International will expand its palm oil operations in Indonesia for the first time in six years. This is a move for the trading company to focus more on the food resource business. The company recently broke the ground for the palm oil plant. It plans to complete the construction by the end of the first half of next year and start producing 110,000 tons of palm oil a year. This is an increase of 30,000 tons from the current capacity. Back in 2009, LG International jumped into the food re...

An extinct variety of date palm tree has been grown from ancient seeds preserved in the Judean desert for 2000 years, the oldest seeds ever germinated

In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes supporting nsP1 anchoring remains poorly studied. Here, we explore the membrane binding capacity of nsP1 with regard to cholesterol. Using the medically important chikungunya virus (CHIKV) as a model, we report that nsP1 cosegregates with cholesterol-rich detergent-resistant membrane microdomains (DRMs), also called lipid rafts. In search for the critical factor for cholesterol partitioning, we identify nsP1 palmitoylated cysteines as major players in this process. In cells infected with CHIKV or transfected with CHIKV trans-replicase plasmids, nsP1, together with the other nonstructural proteins, are detected in DRMs. While the functional importance of CHIKV nsP1 preference for cholesterol-rich membrane domains remains to be determined, we observed that U18666A- and imipramine-induced sequestration of cholesterol in late endosomes redirected nsP1 to these compartments and simultaneously dramatically decreased CHIKV genome replication. A parallel study of Sindbis virus (SINV) revealed that nsP1 from this divergent alphavirus displays a low affinity for cholesterol and only moderately segregates with DRMs. Behaviors of CHIKV and SINV with regard to cholesterol, therefore, match with the previously reported differences in the requirement for nsP1 palmitoylation, which is dispensable for SINV but strictly required for CHIKV replication. Altogether, this study highlights the functional importance of nsP1 segregation with DRMs and provides new insight into the functional role of nsP1 palmitoylated cysteines during alphavirus replication.

IMPORTANCE Functional alphavirus replication complexes are anchored to the host cell membranes through the interaction of nsP1 with the lipid bilayers. In this work, we investigate the importance of cholesterol for such an association. We show that nsP1 has affinity for cholesterol-rich membrane microdomains formed at the plasma membrane and identify conserved palmitoylated cysteine(s) in nsP1 as the key determinant for cholesterol affinity. We demonstrate that drug-induced cholesterol sequestration in late endosomes not only redirects nsP1 to this compartment but also dramatically decreases genome replication, suggesting the functional importance of nsP1 targeting to cholesterol-rich plasma membrane microdomains. Finally, we show evidence that nsP1 from chikungunya and Sindbis viruses displays different sensitivity to cholesterol sequestering agents that parallel with their difference in the requirement for nsP1 palmitoylation for replication. This research, therefore, gives new insight into the functional role of palmitoylated cysteines in nsP1 for the assembly of functional alphavirus replication complexes in their mammalian host.

Decreased release of palmitic acid methyl ester (PAME), a vasodilator, from perivascular adipose tissue (PVAT) might contribute to hypertension pathogenesis. However, the PAME biosynthetic pathway remains unclear. In this study, we hypothesized that PAME is biosynthesized from palmitic acid (PA) via human catechol-O-methyltransferase (COMT) catalysis and that decreased PAME biosynthesis plays a role in hypertension pathogenesis. We compared PAME biosynthesis between age-matched normotensive Wistar Kyoto (WKY) rats and hypertensive spontaneously hypertensive rats (SHRs) and investigated the effects of losartan treatment on PAME biosynthesis. Computational molecular modeling indicated that PA binds well at the active site of COMT. Furthermore, in in vitro enzymatic assays in the presence of COMT and S-5'-adenosyl-L-methionine (AdoMet), the stable isotope [¹³C₁₆]-PA was methylated to form [¹³C₁₆]-PAME in incubation medium or the Krebs–Henseleit solution containing 3T3-L1 adipocytes or rat PVAT. The adipocytes and PVATs expressed membrane-bound (MB)-COMT and soluble (S)-COMT proteins. [¹³C₁₆]-PA methylation to form [¹³C₁₆]-PAME in 3T3-L1 adipocytes and rat PVAT was blocked by various COMT inhibitors, such as S-(5'-adenosyl)-L-homocysteine, adenosine-2',3'-dialdehyde, and tolcapone. MB- and S-COMT levels in PVATs of established SHRs were significantly lower than those in PVATs of age-matched normotensive WKY rats, with decreased [¹³C₁₆]-PA methylation to form [¹³C₁₆]-PAME. This decrease was reversed by losartan, an angiotensin II (Ang II) type 1 receptor antagonist. Therefore, PAME biosynthesis in rat PVAT is dependent on AdoMet, catalyzed by COMT, and decreased in SHRs, further supporting the role of PVAT/PAME in hypertension pathogenesis. Moreover, the antihypertensive effect of losartan might be due partly to its increased PAME biosynthesis.

Your weekly selection of awesome robot videos

Couple bought the property months before the former Beatle's 1980 assassination.

The Met Police is facing legal action in regards to the murder of PC Keith Palmer in the Westminster terror attack.

We could all do with a strong dose of escapism right now, so each week we'll be highlighting a banging boutique to bookmark for when the world presses play again

Reigning league MVP Jasmine Perezchica will go from one desert to another to chase her college dream: 'I really live and breathe softball.'

Deputy Attorney General David W. Ogden today announced plans by the Department of Justice to significantly expand its training and education operations at the National Advocacy Center (NAC), the core training facility for local, state and federal attorneys, law enforcement agents and support personnel.

"The Palmetto Project – as it is known – will allow the Department of Justice to expand the capabilities of the National Advocacy Center. As the core training center for prosecutors, law enforcement agents and other personnel from across the nation, the NAC is crucial to the continued success of the Justice Department’s mission."

"We cannot ignore the fact that protecting our economy is an essential component of our larger security goals," said Attorney General Holder.

Willoughby Farr, 46, of West Palm Beach, Fla., has been charged with perpetrating what is known as a cramming scheme, which was designed to place charges on consumers’ telephone bills for collect calls that were not made, the Justice Department and the U.S. Postal Inspector’s Miami Field Office announced today.

A former Guatemalan special forces soldier was arrested today in Palm Beach County, Fla., for lying on his naturalization application about his participation in a 1982 massacre at a Guatemalan village known as Dos Erres.

The Justice Department announced that it has reached a comprehensive settlement agreement with the School District of Palm Beach County, Fla., the nation’s eleventh-largest school district, to prevent and address discrimination in school enrollment and student discipline.

Several years ago, this established cooperative in Honduras decided to pursue Rainforest Alliance certification for its palm oil. Find out what it looks like today.

Ramón Cruz has been growing oil palms for 37 years. He is a supporter of Rainforest Alliance's sustainable certification process.

Palm oil is found in nearly everything, yet have you ever wondered who makes it? how it's processed? what palm fruit looks like? Take a tour through a Honduran palm oil plantation to learn more.

From cookies and cake mix to hair care and toothpaste, here's where to look for sneaky, eco-catastrophic palm oil.

From palm oil invaders to adorable Sumatran rhinos, this story about a recent environmental victory will inspire you.

Can we just all put palm oil biodiesel produced on deforested peatlands to rest already: A new report from the United Nations Environment Programme shows that biodiesel production under these

The palm oil situation is bad, but some people argue that it would be worse if replaced by other vegetable oils.

We all know the palm oil industry has a horrible reputation for deforestation. The Rainforest Alliance, however, believes that change can happen from within and that sustainable palm oil production is attainable.

The fires used to clear land for new palm oil plantations are out of control this year, and much of Asia is cloaked in a sickening haze. It's time to realize the cost of our global addiction to palm oil.

Done in collaboration with local companies, residents and other organizations, the project's aim is to bring awareness to how palm oil production is negatively affecting humans and animals alike.

Confirming what previous studies have shown, new research from the Union of Concerned Scientists shows that the main threats to tropical forests are no longer from

Since both require the same habitat, scientists are worried how primates will survive the expansion of industrial oil palm plantations.

It resents the world for criticizing the industry, yet understands that some things need to change.

Hershey's, Nestle and Mars have not kept their promises when it comes to sourcing conflict-free palm oil.

Our photo of the day comes from Los Angeles, California.

Campen Auktioner A/S - Specialbilauktion #482 Palmesøndag