FIFA's decision to temporarily allow up to five substitutions per match to help cope with potential fixture congestion was met coolly in South America on Friday.

Enterococcus faecium strains are commonly resistant to vancomycin and β-lactams. In addition, E. faecium often causes biofilm-associated infections and these infections are difficult to treat. In this context, we investigated the activity of dosing regimens using daptomycin (DAP) (8, 10, 12, and 14 mg/kg of body weight/day) alone and in combination with ceftaroline (CPT), ampicillin (AMP), ertapenem (ERT), and rifampin (RIF) against 2 clinical strains of biofilm-producing vancomycin-resistant Enterococcus faecium (VREfm), namely, strains S447 and HOU503, in an in vitro biofilm model. HOU503 harbors common LiaS and LiaR substitutions, whereas S447 lacks mutations associated with the LiaFSR pathway. MIC results demonstrated that both strains were susceptible to DAP and resistant to CPT, AMP, ERT, and RIF. The 168-h pharmacokinetic/pharmacodynamic (PK/PD) CDC biofilm reactor models (simulating human antibiotic exposures) were used with titanium and polyurethane coupons to evaluate the efficacy of antibiotic combinations. DAP 12 and 14 achieved bactericidal activity against S447 but lacked such effect against HOU503. Addition of ERT and RIF enhanced DAP activity, allowing DAP 8 and 10 plus ERT or RIF to produce bactericidal activity against both strains at 168 h. While DAP 8 and 10 plus CPT improved killing, they did not reach bactericidal reduction against S447. Combination of AMP, CPT, ERT, or RIF resulted in enhanced and bactericidal activity for DAP against HOU503 at 168 h. Our data provide further support for the use of combinations of DAP with AMP, ERT, CPT, and RIF in infections caused by biofilm producing VREfm. Further research involving DAP combinations against biofilm-producing enterococci is warranted.

In children requiring lopinavir coformulated with ritonavir in a 4:1 ratio (lopinavir-ritonavir-4:1) and rifampin, adding ritonavir to achieve a 4:4 ratio with lopinavir (LPV/r-4:4) overcomes the drug-drug interaction. Possible drug-drug interactions within this regimen may affect abacavir concentrations, but this has never been studied. Children weighing <15 kg needing rifampin and LPV/r-4:4 were enrolled in a pharmacokinetic study and underwent intensive pharmacokinetic sampling on 3 visits: (i) during the intensive and (ii) continuation phases of antituberculosis treatment with LPV/r-4:4 and (iii) 1 month after antituberculosis treatment completion on LPV/r-4:1. Pharmacometric modeling and simulation were used to compare exposures across weight bands with adult target exposures. Eighty-seven children with a median (interquartile range) age and weight of 19 (4 to 64) months and 8.7 (3.9 to 14.9) kg, respectively, were included in the abacavir analysis. Abacavir pharmacokinetics were best described by a two-compartment model with first-order elimination and transit compartment absorption. After allometric scaling adjusted for the effect of body size, maturation could be identified: clearance was predicted to be fully mature at about 2 years of age and to reach half of this mature value at about 2 months of age. Abacavir bioavailability decreased 36% during treatment with rifampin and LPV/r-4:4 but remained within the median adult recommended exposure, except for children in the 3- to 4.9-kg weight band, in which the exposures were higher. The observed predose morning trough concentrations were higher than the evening values. Though abacavir exposure significantly decreased during concomitant administration of rifampin and LPV/r-4:4, it remained within acceptable ranges. (This study is registered in ClinicalTrials.gov under identifier NCT02348177.)

FIFA 20 Team Of The Season So Far continues this week, hopefully with the release of the La Liga FUT Squad. Here some predictions on who might be included, plus when they'll be announced.

FIFA 20 Team Of The Season So Far continues this week, hopefully with the additional release of the Portuguese Liga Nos FUT Squad. Here some predictions on who might be included, plus when they'll be announced.

FIFA 20 Team Of The Season So Far continues this week, hopefully with the release of the Bundesliga FUT Squad. Here some predictions on who might be included, plus when they'll be announced.

FIFA 20 Team of the Season So Far Premier League Squad is now live and features Lionel Messi, Luis Suarez and Antoine Griezmann.

Lendbreen, a pass high in the Norwegian mountains, was an important route from the Roman era until the late Middle Ages

Jadon Sancho got the better of Manchester United striker Marcus Rashford as the two England internationals met in the Football's Staying Home Fifa tournament.

You have loaded up a new Fifa 20 career and are ready to delve into the transfer market... but now what?

International football may not be able to return until 2021 as priority is given to club fixtures, a Fifa vice-president has warned.

So you're cooped up indoors and much of the professional football across the globe has been suspended for the foreseeable future.

While global sport remains at a standstill due to the coronavirus pandemic, 20 players from some of European football's biggest clubs will substitute their boots for controllers as they compete in the EA Sports's Fifa 20 Stay and Play Cup.

Liverpool star Trent Alexander-Arnold dominated Real Madrid's Vinicius Junior to reach the quarter-finals on an enthralling second day of the virtual Stay and Play Cup.

Football has been suspended for the foreseeable future due to the coronavirus pandemic.

Football has been suspended for the foreseeable future due to the coronavirus pandemic.

So you're cooped up indoors and much of the professional football across the globe has been suspended for the time being.

So you're cooped up indoors and much of the professional football across the globe has been suspended for the time being.

So you're cooped up indoors and much of the professional football across the glob has been suspended for the foreseeable future.

So you're cooped up indoors and professional football has been suspended for the foreseeable future.

Former England captain David Beckham was joined by some of the greatest players of all-time, including Pele and Diego Maradona, in a Fifa campaign to show appreciation for key workers leading the global fight against the coronavirus pandemic.

Fifa has promised to fulfil its planned investment in women's football despite the financial impact of the coronavirus pandemic.

Besiktas board member Erdal Torunogullari has confirmed that on-loan Liverpool goalkeeper Loris Karius has made a complaint to Fifa over unpaid wages.

With football across the globe on hold, it seems the perfect time to load up a new​ FIFA 20 career mode save.

With football across the globe on pause, it seems the perfect time to load up a new​ FIFA 20 career mode save.

With football across the globe on hold, now seems the perfect time to load up a new​ FIFA 20 career mode save.

So you're cooped up indoors and most of the professional football fixtures across the globe have been suspended for the forseeable future.

So you're cooped up indoors and most of the professional football fixtures across the globe have been suspended for the forseeable future.

So you're cooped up indoors and most of the professional football fixtures across the globe have been suspended for the time being.

It's the season of the leaked kits, and while we've seen a number of shirt designs across the Internet, Bleacher Report have now brought them to life... well, to Fifa 20.

It seems football is as much about looking the part is it is playing the part these days, and as such there is always plenty of excitement and speculation around kits at this time of year.

Manchester United are among the clubs to have their possible new shirt designs for the 2020-21 season leaked online.

Wolves' Diogo Jota snatched victory in the final of the Fifa 20 ePremier League Invitational with a dramatic 2-1 victory against Liverpool's Trent Alexander-Arnold.

Players should be given yellow cards should they spit on the field when football resumes, says Fifa's medical committee chairman Michel D'Hooghe.

Fifa medical chief Michel D'Hooghe has warned against a return to football before September.

With football across the globe on hold, it seems the perfect moment to load up a new​ FIFA 20 career mode save.

With football across the globe on hold, it seems the perfect moment to load up a new​ FIFA 20 career mode save.

With football across the globe on hold, it seems the perfect moment to load up a new​ FIFA 20 career mode save.

With football across the globe on pause, it seems the ideal moment to load up a new​ FIFA 20 career mode save.

Football across the globe on hold, so it seems the perfect moment to load up a new​ FIFA 20 career mode save.

Bruno Fernandes' move to Manchester United is part of a Fifa investigation after Sampdoria lodged a complaint against Sporting Lisbon for unpaid sell-on fees.

Teams could be allowed to make up to five substitutions when football resumes after the game's law-making body approved the Fifa proposal.

What better time to start a FIFA 20 career mode save and lead a generation of young footballers along the road to glory?

Has there been a better time to start a FIFA 20 career mode and lead a generation of young footballers along the road to glory?

What better time to start a FIFA 20 career mode and lead a generation of young footballers along the road to glory?

Football across the globe is on hold, so it seems the perfect moment to load up a new​ FIFA 20 career mode save.

More than 147 million people's credit data were exposed during Equifax's 2017 breach. Wednesday is the deadline to file a claim.

Equifax, like most large U.S. companies, failed to encrypt the databases that store some of the most sensitive details of people's lives.

Canada-based Bausch Health Companies, along with its wholly-owned subsidiary, Salix Pharmaceuticals and…

The Department announced that a federal district court judge in Louisville, Ky., approved a settlement of the Department’s lawsuit alleging that those involved in the design and construction of 12 multifamily housing complexes discriminated on the basis of disability. The complexes contain more than 800 units covered by the Fair Housing Act’s accessibility provisions.