At least two people were killed and more were injured in western Afghanistan on May 9 when police clashed with hundreds of protesters angry over what they insisted was unfair distribution of food aid during the COVID-19 pandemic, a local lawmaker said.

Crowd in impoverished Ghor province protests COVID-19-related food shortages during Ramadan

Background The Procuring Authority has engaged the International Finance Corporation, acting through its Public Private Partnerships Transaction Advisory Services division, to act as lead transaction advisor in relation to the Project. The RFQ will ...

Seven people were killed when protesters angry over what they see as unfair food aid distribution during the coronavirus pandemic clashed with police in Afghanistan's western Ghor province on Saturday, according to a local member of parliament. Fourteen more were wounded during the protest - sparked by growing unhappiness at the distribution...

KABUL (Sputnik) - The Afghan government...

The World Bank approved a $400 million grant on Friday to help Afghanistan deal with the coronavirus while maintaining economic and public finance reforms. The grant will support efforts to improve business regulation and encourage private investment, improve taxation capacity and expand social inclusion, among others. It is made up of $160 million from the International Development...

New Delhi: The United States is understood to have reiterated its desire for India to play a key role in the Afghan peace process, given New Delhi’s strong relationship with the Afghan Government. Strengthening its ties with Kabul amid the Coronavirus pandemic, New Delhi meanwhile has dispatched a consignment of 10,000 tonnes of wheat on Thursday to Afghanistan through the Iranian port of Chabahar and this brings...

Phased withdrawal of U.S. troops from Afghanistan sharpens focus on CPEC  Todaynewspaper

Redacted figures, including drone strikes, are the latest military data to be restricted in a conflict that killed or injured 10,000 civilians in 2019.

[This Day] The federal government yesterday raised the alarm that many states in the country may soon run out of bed spaces for COVID-19 patients at their isolation centres due to the increasing number of Nigerians testing positive to Coronavirus.

Fourteen more were wounded during the protest - sparked by growing unhappiness at the distribution allegedly favouring people with political connections, said Gulzaman Nayeb, a local lawmaker.

HERAT: Afghanistan has recovered 18 bodies of migrants who were allegedly beaten and tortured before being forced into a river by Iranian border guards last week, a senior Afghan official said...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

HERAT, Afghanistan: Afghanistan has recovered 18 bodies of migrants who were allegedly beaten and tortured before being forced into a river by Iranian border guards last week, a senior Afghan official said Friday.Afghan authorities are investigating claims the migrants drowned while illegally...

HERAT, Afghanistan: Afghanistan has recovered 18 bodies of migrants who were allegedly beaten and tortured before being forced into a river by Iranian border guards last week, a senior Afghan official said on Friday.Afghan authorities are investigating claims the migrants drowned while illegally...

Two policemen and four other people were killed in Afghanistan Saturday after a deadly clash at a public food donation in central Ghor province, officials said.

RAWALPINDI: US Special Representative for Afghan Reconciliation Zalmay Khalilzad Friday called on Chief of Army Staff General Qamar Javed Bajwa here on Friday. During the meeting, issues of mutual interest and overall regional security situation, including Afghan reconciliation process, came...

RAWALPINDI: US Special Representative for Afghan Reconciliation Zalmay Khalilzad Friday called on Chief of Army Staff General Qamar Javed Bajwa here on Friday.During the meeting, issues of mutual interest and overall regional security situation, including Afghan reconciliation process, came under...

RAWALPINDI: US Special Representative for Afghan Reconciliation Zalmay Khalilzad Friday called on Chief of Army Staff General Qamar Javed Bajwa here on Friday.During the meeting, issues of mutual interest and overall regional security situation, including Afghan reconciliation process, came under...

RAWALPINDI: Chief of Army Staff Gen Qamar Javed Bajwa said Pakistan’s support towards Afghan peace is a manifestation of “our goodwill to the cause” in a meeting with US Special Representative for Afghan Reconciliation Zalmay Khalilzad.According to a press release issued by the...

ISLAMABAD: Chief of the Army Staff Gen Qamar Javed Bajwa has said Pakistan’s support for the Afghan reconciliation process is a proof of its sincerity for peace in Afghanistan.

Talking to US Special Envoy for Afghan Reconciliation Dr Zalmay Khalilzad on Friday, the army chief said: “Our support towards peace process is a manifestation of our goodwill towards the cause.”

Dr Khalilzad was visiting Pakis­tan after a meeting with Taliban leaders in Doha and a stopover in Delhi, where he met Indian Exter­nal Affairs Minister Subrahman­yam Jaishankar and National Security Adviser Ajit Doval.

The Indian leaders, according to reports in Indian media, blamed a recent spike in violence in Afghanistan to alleged “sanctuaries” on Pakistani soil and emphasised their elimination. The Indian allegations have come in the backdrop of renewed terror accusations against Pakistan in India-held Kashmir.

Pakistan has strongly rejected all Indian allegations and has asked the United Nations to seek proofs from India about the alleged “launch pads” and “infiltration bids” at the Line of Control.

Khalilzad scheduled to return to Doha for resumption of negotiations with Taliban

Dr Khalilzad, according to Inter-Services Public Relations (ISPR), praised continuing Pakistani efforts for peace and stability in the region.

India, despite the special envoy’s recent visits to Delhi, is uneasy because its viewpoint on Afghanistan is getting little weightage in Washington.

Pakistan had facilitated long-drawn US-Taliban talks, which culminated with the signing of a landmark peace deal in Doha in February between the two adversaries that have been at war for 19 years. Under the deal, the Afghan Taliban gave counterterrorism assurances and agreed to engage in dialogue with the Afghan government for ending war. The peace agreement was expected to pave the way for the withdrawal of US troops from Afghanistan.

However, the progress towards start of intra-Afghan peace talks have been sluggish because of trust deficit between the Afghan factions and slow release of prisoners by both sides. Intra-Afghan talks were, according to the original plan, to commence on March 10 after release of 5,000 Taliban prisoners by Kabul, while the militant group was to set free 1,000 government personnel. So far the Afghan government has released 933 of the 5,000 Taliban prisoners, while the Taliban have freed 155 captives.

In recent weeks, the Taliban finally intensified attacks against government forces. On Thursday, Khost police chief Ahmad Babazai was killed in a landmine attack.

Dr Khalilzad said he had in his “lengthy” overnight meeting with the head of Taliban political office in Doha emphasised “reduction in violence, humanitarian ceasefire as demanded by the international community to allow for better cooperation on managing Covid-19 pandemic in Afghanistan, acceleration of prisoner releases by both sides, actions necessary to secure the freedom of US citizen Mark Frerichs, regional and international support for the peace process, and movement to intra-Afghan negotiations ASAP”.

The special envoy will travel back to Doha from Islamabad for continuing his discussions with Taliban leaders.

Published in Dawn, May 9th, 2020

Afghanistan has recovered 18 bodies of migrants who were allegedly beaten and tortured before being forced into a river by Iranian border guards last week, a senior Afghan official said Friday.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex.

Pemigatinib was effective in patients with cholangiocarcinomas with FGFR2 fusions or rearrangements.

The FGFR2b inhibitor bemarituzumab was effective in high-FGFR2b gastroesophageal adenocarcinoma.

8p11 myeloproliferative syndrome (EMS) represents a unique World Health Organization (WHO)-classified hematologic malignancy defined by translocations of the FGFR1 receptor. The syndrome is a myeloproliferative neoplasm characterized by eosinophilia and lymphadenopathy, with risk of progression to either acute myeloid leukemia (AML) or T- or B-lymphoblastic lymphoma/leukemia. Within the EMS subtype, translocations between breakpoint cluster region (BCR) and fibroblast growth factor receptor 1 (FGFR1) have been shown to produce a dominant fusion protein that is notoriously resistant to tyrosine kinase inhibitors (TKIs). Here, we report two cases of BCR–FGFR1⁺ EMS identified via RNA sequencing (RNA-seq) and confirmed by fluorescence in situ hybridization (FISH). Sanger sequencing revealed that both cases harbored the exact same breakpoint. In the first case, the patient presented with AML-like disease, and in the second, the patient progressed to B-cell acute lymphoblastic leukemia (B-ALL). Additionally, we observed that that primary leukemia cells from Case 1 demonstrated sensitivity to the tyrosine kinase inhibitors ponatinib and dovitinib that can target FGFR1 kinase activity, whereas primary cells from Case 2 were resistant to both drugs. Taken together, these results suggest that some but not all BCR–FGFR1 fusion positive leukemias may respond to TKIs that target FGFR1 kinase activity.

At least six were killed when protesters angry over what they see as unfair food aid distribution during the coronavirus pandemic clashed with police in Afghanistan's western Ghor province on Saturday, according to officials.

A new virtual exhibition, What the Traveller Saw, the first of its kind by the Royal Geographical Society, marks the centenary of the birth of the writer and former Observer travel editor

NSW's Law Enforcement Conduct Commission recommends disciplinary action be taken against two police officers who engaged in misconduct by racially abusing two Afghan women at a traffic stop in Western Sydney.

APL Limited has agreed to pay the government $26.3 million to resolve allegations that it submitted false claims to the United States in connection with contracts to transport cargo in shipping containers to support U.S. troops in Iraq and Afghanistan.

Two Department of Defense (DOD) contractors were charged with conspiracy and bribery relating to their roles involving DOD contracts in Afghanistan. A Lebanese contracting company is also charged with participating in the same conspiracy.

Raschad L. "Sean" Lewis, a former fuel section employee of Kellogg Brown and Root Inc. (KBR), assigned to Bagram Airfield in Afghanistan, was found guilty yesterday by a federal jury of conspiracy, false writing, bribery of a public official, and false claims stemming from a bribery and a fuel diversion scheme.

Two U.S. military officials pleaded guilty to various bribery, fraud and conspiracy charges relating to Department of Defense (DOD) contracts in Afghanistan.

Haji Bagcho, aka Haji Bagh Chagul, an Afghan national, was ordered detained today by Magistrate Judge John M. Facciola in U.S. District Court for the District of Columbia while he awaits trial on U.S. narcotics charges.

A retired U.S. military official pleaded guilty to bribery and conspiracy charges relating to Department of Defense (DOD) contracts in Afghanistan. According to the plea agreement, which was filed in U.S. District Court in Chicago today, First Lieutenant Robert Moore (Ret.) pleaded guilty to conspiracy and bribery charges.

Two dual Afghan/U.S. citizens today pleaded guilty for their roles in a scheme to offer $1 million in bribes to a U.S. Army contracting official in Afghanistan.

Raschad L. “Sean” Lewis, a former fuel section employee of Kellogg Brown and Root Inc. (KBR) assigned to Bagram Airfield in Afghanistan, was sentenced today to 84 months in prison for his role in a bribery and a fuel diversion scheme. U.S. District Court Judge Leonie M. Brinkema also ordered Lewis to pay $891,000 in restitution and serve three years of supervised release.

The Department of Justice today announced that Mohammed Jawad, a native of Afghanistan, has been transferred from the detention facility at Guantanamo Bay to Afghanistan.

An Oklahoma man pleaded guilty today for his role in a scheme to solicit kickbacks in connection with the award of a private security services subcontract to protect U.S. government personnel and contractors in Afghanistan. Bryan Lee Burrows, 42, of Wagoner, Okla., pleaded guilty today before U.S. District Court Judge Leonie M. Brinkema in the Eastern District of Virginia to one count of conspiracy to solicit a kickback.

Delmar Dwayne Spier, the chief executive officer and managing director of United States Protection and Investigations, LLC (USPI), today pleaded guilty in U.S. District Court for the District of Columbia to conspiracy, major fraud and wire fraud arising from an alleged scheme to defraud the United States; and his wife, Barbara Edens Spier, the president and owner of USPI, pleaded guilty to conspiracy to defraud the United States in connection with U.S.-sponsored rebuilding efforts in Afghanistan.

Ryan Scott McMonigle, 37, of Ponca City, Okla., was indicted today for his alleged role in a scheme to solicit kickbacks in connection with the award of a security services subcontract to protect U.S. government personnel and contractors in Afghanistan.

The Army Sergeant has agreed to pay $90,000 in restitution to the U.S. Department of Defense (DOD) and to cooperate with the Department of Justice’s ongoing investigation.

While no words can lessen the sorrow being felt today by these families, I hope their loved ones know they have the unending respect and gratitude of this nation. They certainly have mine.

Rohullah Farooqi Lodin and Hashmatullah Farooqi were each sentenced today in Alexandria, Va., to four years in prison for their roles in a scheme to offer $1 million in bribes to a U.S. Army contracting official in Afghanistan.

Scott Anthony Walker, 36, of Australia, pleaded guilty in the Eastern District of Virginia to one count of conspiracy to solicit a kickback.

Bryan Lee Burrows admitted that he conspired with others to solicit kickbacks from private security vendors in return for favorable treatment for those potential bidders in connection with the award of a subcontract.

These transfers were carried out under individual arrangements between the United States and relevant foreign authorities to ensure the transfers took place under appropriate security measures.

Justin Cannon, 27, of Corpus Christi, Texas, and Christopher Drotleff, 29, of Virginia Beach, Va., have been charged with crimes including second-degree murder, attempted murder and firearms offenses while working as contractors for the U.S. Department of Defense in Afghanistan. Cannon and Drotleff were charged under the Military Extraterritorial Jurisdiction Act (MEJA).

Ryan Scott McMonigle, of Ponca City, Okla., pleaded guilty for his role in a scheme to solicit a kickback in connection with the award of a private security services subcontract to protect U.S. government personnel and contractors in Afghanistan.