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[ASAP] Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02092




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[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00227




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[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00547




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[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01392




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[ASAP] Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01937




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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00215




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[ASAP] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via <sup>15</sup>N Direct Detection Nuclear Magnetic Resonance

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00231




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[ASAP] Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00442




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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




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[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00628




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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00431




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[ASAP] Exploration of the Structural Space in 4(3<italic toggle="yes">H</italic>)-Quinazolinone Antibacterials

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00153




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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686




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[ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00641




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[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00029




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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155




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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106




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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115




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[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00066




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[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00009




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[ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00127




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China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude

China’s first domestically designed large solar-powered unmanned plane reached above 20,000 meters in altitude on its test flight in the country’s northwest regions recently. The drone was developed by the China Academy of Aerospace Aerodynamics (CAAA), it’s developers kept the exact size of the drone as a secret, but it is believed to be about 14 …

The post China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude appeared first on LatestSolarNews.




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Filtering (photo) filters

A lot of photo apps allow you to add filters before sharing. The typical UI for picking a filter is a row of little thumbnails that can be horizontally scrolled. I’m sure you’ve used it many times. It looks something like this:

The problem

A filter picker like that is easy to understand and works pretty well. But in my case, there is something that has been bugging me a bit. Here is how I use it:

  1. I start with the first thumbnail and then just keep tapping one after the other.
  2. If there is a filter that I like, I try to remember its name. And somewhat its position, but more like “somewhere at the beginning”.
  3. Then once I reach the end, I start scrolling back trying to find the ones I liked.
  4. Usually there are like 2-3 filters that I would like to quickly compare before making my final choice. But it’s quite hard to scroll between them, especially if they are far apart. Also having to remember their name/position costs some precious brain power.

Now, I don’t really know how most people use these filter pickers. Could be that:

  1. Most people just stop once they found a filter they kinda like and don’t bother trying the rest.
  2. Or some have a few favorites and know their name/position already.
  3. You could also just look at the little thumbnails. But some filters are very similar and I need to see them on the actual photo to judge.

Possible solutions

So I was thinking about some possible improvements:

1. Order by popularity

Automatically order the filters based on how often they get used. This makes filters that you use most appear at the beginning and are easier to get to. You could always keep scrolling in case you’re in the mood for something new. This would of course mess it up for people that have filters remembered by position. But not sure how many actually do that.

2. Manual re-order

Let people manually reorder the position. Could be done similar like the home screen icons on iOS (long press until they wiggle, then drag around). I would probably move my favorites to the front and also sort based on color/style.

3. Narrow down

Let people temporarily toss away the filters they don’t want. This would allow you to narrow down your selection to just a few for easier comparison. Of course, all the filters would be back next time you take a new photo.

Or probably even better (3B): Instead of throwing away the ones you don’t like (could be tedious if there are a lot of filters), you could push up only the ones you like and they would move to the right with a visual separator. It’s similar how you can pin a Chrome browser tab to separate it from the rest. Then once you scrolled to the end, you would have all your previously selected filters next to each other, waiting to be the lucky winner.

Conclusion

I understand that the suggestions might make a photo app more complicated and harder to explain to a new user. But it could be more a “power user” feature that you’re not forced to use if you don’t want to. Anyways, in case I’m not the only one with this (small) problem, I hope some day we will have a better way to filter filters. Ohh.. and let me know if you’re already using an app that tackles this somehow.

Update

Thanks for all the comments. Good to see more people thinking about this. I played around a bit more with the demo, mostly after the conversation with Ignacio in the comments below. So here a 4th option:

4. Select and cycle

Let people select a couple filters and then cycle through them by tapping on the photo. It’s actually similar to 3B, but it keeps the UI simple by using the photo as the secondary navigation control. Here the steps how to use:

  1. You can tab each filter until you find one you like.
  2. If you tab a 2nd time on that filter, it gets selected as a “favorite”. It will move up a little to visualize it.
  3. You can keep trying other filters and mark more as favorites.
  4. Once you reached the end (or think you have enough), you can tap on the photo above the filter picker to quickly cycle through all your previously selected (favorited) filters. Now comparing different filters is really quick and easy.

Try the demo.

The implementation of the demo could still be improved. It is a bit hard to discover that you can tap the photo to cycle through your favorites. Might need some visual clue to help understand it better. Adding swipe gestures instead of tapping would also improve UX. Or to remove a filter from your favorite selection, you could just swipe down on the image. Also note that the filters are CSS based and still a bit glitchy when animating. But you should get the idea.

Update II

Manuel Haring explored a similar concept where you can push up filters to narrow down your selection.

Here a larger video that has even a third selection stage.




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8 of the Top WP Multipurpose Themes That You Can Use

More than a few multipurpose WordPress themes have become big sellers in recent years, and for a reason. Actually, for several reasons. One reason is they serve as excellent toolkits for web designers who have large and varied clienteles. The best multipurpose themes, like those presented here, are popular for other reasons as well. They […]




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Djordje Ozbolt: regaining memory loss / exhibition curator, Nicoletta Lambertucci

Rotch Library - N6488.I8 V433 2019 Y8




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New design, neoplasticism: Nieuwe beelding / Piet Mondrian ; English translation by Harry Holtzman and Martin S. James

Rotch Library - N6948.5.D42 M6613 2019




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Altered states: Substanzen in der zeitgenössischen Kunst = substances in contemporary art / herausgegeben von = edited by Milena Mercer ; Texte = texts, Max Daly ... [and thirteen others]

Rotch Library - N8251.S555 A48 2018




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Le modèle noir: de Géricault à Matisse: Musée d'Orsay / [éditeur, Claude Pommereau]

Rotch Library - N8232.M6325 2019




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Unfinished conversations on the weight of absence: Belu-Simion Făinaru, Dan Mihălțianu, Miklós Onucsán / curator, Cristian Nae

Rotch Library - N6488.I8 V433 2019 R6




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Altered views: Voluspa Jarpa / curated by Agustín Pérez Rubio

Rotch Library - N6488.I8 V433 2019 C5




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Jakob Mohr / herausgegeben von Doris Noell-Rumpeltes + Thomas Röske

Rotch Library - NC251.M64 J35 2018




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Photography reframed: new visions in contemporary photographic culture / edited by Ben Burbridge and Annebella Pollen

Rotch Library - TR185.P52 2018




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Am I there yet?: the loop-de-loop, zigzagging journey to adulthood / by Mari Andrew

Hayden Library - NC1429.A6325 A2 2018




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The art of return: the sixties & contemporary culture / James Meyer

Rotch Library - N6512.M479 2019




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Comradely objects: design and material culture in Soviet Russia, 1960s-1980s / Yulia Karpova

Rotch Library - N6988.K37 2020




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Bestowing beauty: masterpieces from Persian lands-selections from the Hossein Afshar collection / edited by Aimée Froom ; with essays by Walter B. Denny, Aimée Froom, Melanie Gibson, and David J. Roxburgh; and contributions by Robert Hillenbrand

Rotch Library - N7280.B47 2019




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Caught in a whirlwind: a cultural history of Ottoman Baghdad as reflected in its illustrated manuscripts / by Melis Taner

Rotch Library - ND3239.I72 B338 2020




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Medea muckt auf: Radikale Künstlerinnen hinter dem Eisernen Vorhang = The Medea insurrection: radical women artists behind the Iron Curtain / Herausgeber: Staatliche Kunstsammlungen Dresden, Susanne Altmann, Katarina Lozo, Hilke Wagner

Rotch Library - N8354.M43 2019




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Everyone's a critic: the ultimate cartoon book by the world's greatest cartoonists / Bob Eckstein, editor

Rotch Library - NC1426.E94 2020




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This baby doll will be a junkie / Ulrike Montmann ; Kunst und Forschung: Projektbericht uber Abhangigkeiten und Gewaltraume

Rotch Library - N6498.C66 T45 2018




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Goodbye, my Havana: the life and times of a gringa in revolutionary Cuba / Anna Veltfort

Barker Library - NC975.5.V45 A2 2019




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Affect, emotion, and subjectivity in early modern Muslim Empires: new studies in Ottoman, Safavid, and Mughal art and culture / edited by Kishwar Rizvi

Rotch Library - NX650.E46 A39 2018




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Devastation and laughter: satire, power, and culture in the early Soviet state, 1920s-1930s / Annie Gérin

Hayden Library - NX556.A1 G47 2018




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Where is adaptation?: mapping cultures, texts, and contexts / edited by Casie Hermansson, Janet Zepernick, Pittsburg State University

Hayden Library - NX161.W54 2018




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The album of the world emperor: cross-cultural collecting and the art of album-making in seventeenth-century Istanbul / Emine Fetvaci

Rotch Library - ND2955.F43 2019




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Designs for different futures / Kathryn B. Hiesinger & Michelle Millar Fisher, Emmet Byrne, Maite Borjabad López-Pastor & Zoë Ryan ; with Andrew Blauvelt, Colin Fanning, and Orkan Telhan ; contributions by Juliana Rowen Barton [and 24 o

Rotch Library - NK1397.D483 2019




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From the Backstage of Publishing: Memories of Milton Murayama

Originally this post was a way to mark this month’s Asian/Pacific American Heritage Month by sharing personal memories from an editorial perspective of a pioneering Asian American literary icon, Milton Murayama. It has grown to include other remembrances from a marketing perspective. We are all proud to be the publisher of his bestselling novels. Masako […]




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Museums of language and the display of intangible cultural heritage / edited by Margaret J-M. Sönmez, Maia Wellington Gahtan, and Nadia Cannata.




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Uniting Blacks in a raceless nation: blackness, Afro-Cuban culture, and Mestizaje in the prose and poetry of Nicolás Guillén / Miguel Arnedo-Gómez

Hayden Library - PQ7389.G84 Z536 2016