Sachikonye, L. M

Ehrlich, Walter, 1921-

Rotenstreich, Nathan, 1914-1993

Bardin, Hillel

This prespecified secondary analysis of the MOMENTUM 3 randomized clinical trial aims to determine whether clinical outcomes of patients with 2 different left ventricular assist devices differed based on preoperative categories of bridge to transplant/bridge to candidacy vs destination therapy.

This study develops and validates a quantitative method to predict the pulmonary to systemic flow ratio in patients with congenital heart disease from chest radiographs using deep learning.

This cohort study assesses whether long-term variability and rate of change of blood pressure from young adulthood to midlife are associated with cardiovascular disease and all-cause mortality by middle age.

This mixed-methods pilot study examines whether the repeated use of a decision aid by heart teams was associated with greater shared decision-making, along with improved patient-centered outcomes and clinicians’ attitudes about decision aids.

This study developed and validated a prognostic prediction model for patients with heart failure.

In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

To the Editor We read the recent article by Klauser et al with great interest. While the potential implications of the findings are exciting, we have several concerns. First, the authors do not explicitly state whether electrocardiogram gating was used in their study. This is an important detail because cardiac motion artifact is a source of artifactual coloration with dual-energy computed tomography (DECT), particularly with dual-source scanners given the approximately 80-millisecond temporal difference between the 2 radiography beams. Furthermore, beam hardening artifact from calcified atheromas and partial volume effect, known sources of artifacts in the 2-material decomposition algorithm of DECT, may largely explain the findings. While patients with gout had higher prevalence of coronary calcification (55 of 59 patients [93%]) and cardiovascular monosodium urate (MSU) deposition (51 of 59 patients [86%]) than controls, the authors do not report whether the 4 patients with gout without coronary calcifications exhibited MSU deposition nor the number of controls or cadaveric hearts with coronary calcification. The images from the article show areas of green pixelization occurring adjacent to calcified plaques on grayscale computed tomography images (eg, Figure 2A and D, left anterior descending artery [yellow arrowhead]), which would favor this artifact hypothesis without additional data.

In Reply We appreciate the valuable comments of Becce et al on our article. We applied prospective electrocardiography gating using a thin-slice cardiac protocol to ensure highest spatial resolution with minimal motion artifact. A noncontrast electrocardiography-gated computed tomography (CT) examination with standardized scan parameters was performed using a 128-slice dual-source CT (SOMATOM Definition Flash; Siemens) with a detector collimation of 2 × 64 × 0.6 mm, rotation time of 0.28 seconds, and prospective electrocardiography triggering for heart rates less than 65 beats per minute (diastolic padding, 70% of RR interval) and more than 65 beats per minute (systolic padding, 40% of RR interval). Axial images were reconstructed with 0.75-mm slice width, increment of 0.5, and a medium-smooth convolution kernel (B26f). When motion artifact was present, it was distinguished by visual analysis of an experienced observer and colorized pixels related to motion were excluded.

This cohort study assesses cardiovascular functional reserve before and after kidney transplant in patients with end-stage renal disease.

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.

This randomized clinical trial assesses the effectiveness of an implantable loop recorder plus 24-hour Holter electrocardiographic monitoring vs standard 24-hour Holter electrocardiographic monitoring alone for detecting arrhythmias in pregnant women with structural heart disease and/or symptoms suggestive of arrhythmias.

A 58-year-old woman presents with no relevant medical history with syncope, elevated troponin and D-dimer levels, and multiple large bilateral pulmonary emboli. What would you do next?

To the Editor We read with interest the study by Sepehrvand et al, which described secular trends in the conduct of pragmatic or explanatory cardiovascular randomized clinical trials over 2 decades. We believe extension of this thoughtful analysis can provide additional insights into pragmatic vs explanatory trials.

In Reply We thank Fernandes et al for their interest in our study and agree that this field requires further exploration. Explanatory trials are primed to maximize the likelihood of finding efficacy of an intervention by testing it in an ideal setting, whereas pragmatic trials aim to test effectiveness of an intervention in a more generalizable setting. Hence, they are expected to generate more generalizable results, with the risk understood that there may be more variation in less tightly controlled environments, which may result in differing results.

This Special Communication analyzes the conclusions drawn from effective regurgitant orifice area analysis and end-diastolic volume analysis from 2 randomized clinical trials to assess disparities in the different clinical outcomes.

This essay describes a physician’s experience of the sudden, unexplained death of her brother and her family’s discovery of the genetic cause.

Mission Statement: JAMA Cardiology publishes exceptional original research, state-of-the-art reviews, and informative opinions that advance the science and practice of cardiology, enhance cardiovascular health, and inform health care policy. JAMA Cardiology is the definitive journal for clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology focuses on all aspects of cardiovascular medicine, including epidemiology and prevention, diagnostic testing, interventional and pharmacologic therapeutics, translational research, health care policy and outcomes, and global health.

With a date span of 1779 through 1955, the McManus-Young Collection provides a rich survey of the literature of "illusion practices," which includes works on conjuring, ventriloquism, fortune-telling, spiritualism, witchcraft, gambling, hypnotism, automata, and mind reading comprised of a gathering of thousands of pamphlets and offprints. This ephemeral literature is the backbone of modern...

Broadcast journalist and Washington hostess. Correspondence, family papers, scrapbooks, speech material, television scripts, writings, and other material relating to Dickerson's work as a pioneering woman in television journalism and her social activities.

Chiefly correspondence dated 1954-1999 by writer Philip Roth to Robert Maurer and his wife, Charlotte Maurer, regarding Roth’s development as a writer, other professional work, and personal life. Also includes one letter between other Maurer family members dated 1945.

Baptist minister. Correspondence and associated miscellany, photographs, and ephemera primarily addressed to Pyle from American Colony in Jerusalem members Jacob E. Spafford and G. Eric Matson.

Journalist and editor. Correspondence, writings, speeches, articles, clippings, notes, photographs, newspapers, and other papers relating primarily to Yudain's career as the founder and publisher of Roll Call.

Lawyer, assistant attorney general for the United States Department of Justice Civil Division, and acting director of the United States Federal Bureau of Investigation (FBI). Correspondence, memoranda, notes, writings, speeches, testimony, legal records, military records, photographs, printed matter, and other papers relating chiefly to Gray's time as acting director of the FBI during the...

Novelist and author. Correspondence, diaries, drafts and galleys of playscripts, poems, songs, and fiction and nonfiction books, tearsheets, dictation and interview transcripts, notes, research materials, descriptive inventories of personal papers, legal and financial documents, clippings, printed material, scrapbooks, publicity and promotional records, maps, book illustrations, photographs, and...

The Wallace Earl Dryer World War II map collection consists of Army Map Service maps of Italy and Northwest Europe, a Dutch map of the Western Front, and a German map of Holland. Dryer served in the American army and was a painter and photographer after the war.

Collection of papers, photographs, interviews, field recordings and other audiovisual materials comprising the professional archive of folklorist Nancy Sweezy created in the course of her career as a folk arts advocate, author, and administrator of non-profit folk craft and performance organizations. Includes research materials for her books Raised in Clay: The Southern Pottery Tradition,...

Dewey Library - PQ6653.E62 M6613 2020

Hayden Library - PQ7082.P7 C23 2018

Dewey Library - PQ7390.G773 D6613 2018

Dewey Library - PQ7409.2.H355 M8313 2018

Dewey Library - PQ7070.C65 2018

With the arrest of Tehsin Akhtar, thought to be Indian Mujahideen (IM) commander of India operations, security agencies have netted another big fish in the fight against terror.

The Congress manifesto is the polar opposite of policies pursued by UPA-II. It promises to undo measures that clogged the economy and make economic growth the "overriding priority".

Lacking a cohesive national campaign, Kejriwal has yet again taken recourse to insurgent tactics – projecting himself as Modi’s only rival when Congress is yet to declare its nominee for Varanasi.

The disappearance of inflammatory communal slogans from political speeches suggests development is the agenda for 2014.

As polls come closer arrows are flying thicker, faster, sharper. Some are of time-honoured design, others quite modern. Included in the first category is flaming a party leader as communal or dissing her for being in the Italians’ pocket.

By fielding one of its vice-presidents – former television soap star Smriti Irani – against Congress’s Rahul Gandhi in Amethi Lok Sabha constituency, BJP has shown it is inclined to take the electoral battle to one of two Gandhi pocket boroughs in Uttar Pradesh.

Trinamool Congress appears ready to move forward from the ferocious acrimony of Mamata-Modi exchanges during the election campaign.

On the face of it the Fifa World Cup is all about quality football, generally recognised as the greatest sporting showpiece on earth.

Going by a letter written by Nawaz Sharif to Narendra Modi, that he was 'much satisfied' with their meeting in New Delhi, the two prime ministers have succeeded in striking up a working relationship.