CES 2020, LAS VEGAS – JANUARY 6, 2020 – No wires? No problem. JBL continues to elevate its true wireless headphones portfolio by adding two more options to their existing lineup. Whether it’s window shopping on city streets, commuting into the office, or...

CES 2020 – LAS VEGAS, NV – JANUARY 6, 2020 – When it comes to competitive gaming, sound is survival – and JBL knows great sound. Today at CES, the company unveiled the first-ever JBL headset range and PC speaker designed exclusively for gamers, featuring...

MARCH 28, 2019, NEW DELHI, INDIA – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. today announced its sponsorship of Delhi Capitals, one of the key teams participating in the T20 Cricket Indian Premier League 2019, through its popular...

NORTHRIDGE, Calif.—HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced new JBL Professional One Series 104-BT and 104-BTW desktop reference monitors with Bluetooth will be making their debut at...

BENGALURU, INDIA, FEBRUARY 11, 2020 – Expect fireworks as JBL unveils its new brand film featuring superstar and youth icon Ranveer Singh, urging consumers to ‘Live it real and Live it raw’.  Featuring striking visuals and inspiring rap vocals by the...

Nouvelles lignes de basse percutantes et solos de guitare à tomber : les enceintes JBL Link Portable et Link Music viennent de sortir. Avec leur son signature 360 JBL, le Wi-Fi et le Bluetooth, Chromecast et Google Assistant intégrés, les enceintes sont aussi belles qu’intelligentes.

Le son 360° de JBL, un jeu de lumières bluffant : la Pulse 4 JBL est arrivée. Pour faire la fête, ou décompresser, créez votre propre ambiance. Depuis son salon à une soirée sur la plage (en passant par tout ce qu’il y a entre les deux), la nouvelle Pulse 4 JBL fournit un son incroyable, avec des effets visuels du même calibre.

Satte Bässe oder heiße Gitarrensolos! Die neuen JBL Link Portable und JBL Link Music sind ab sofort verfügbar. Mit 360°-JBL Signature Sound, WLAN und Bluetooth-Konnektivität, integriertem Chromecast und Google Assistant klingen die beiden Lautsprecher genauso gut wie sie aussehen.

Finis les fils avec les tout nouveaux LIVE 300TWS JBL. Dotés de la véritable technologie sans fil, parfaitement connectés et avec un superbe design, les LIVE 300TWS JBL permettent de libérer le son, à tout moment et en tout lieu. Équipés de puissants transducteurs, ils propulsent les graves à un tout autre niveau pour doper les playlists.

Van knallende baslijnen tot vloeiende gitaarsolo’s, JBL introduceert de JBL Link Portable en Link Music. Ze zijn net zo handig als ze mooi zijn, de speakers zijn voorzien van 360 graden JBL’s kenmerkende sound, Wifi- en Bluetooth-connectiviteit en ingebouwde Chromecast en Google assistent.

360° JBL geluid. Een fantastische lichtshow. Met de Pulse 4 van JBL zorg jij voor een goede sfeer, of je nu wilt feesten of chillen. Van woonkamer tot strandfeest (en alles daartussenin), de nieuwe JBL Pulse 4 staat voor je klaar.

Verstrikte snoertjes zijn verleden tijd met de splinternieuwe JBL LIVE 300TWS. De JBL LIVE 300TWS is volledig draadloos, verbindt naadloos en heeft een verfijnde vormgeving. Zo geniet je overal en altijd van je eigen geluid. Dankzij de krachtige drivers is het basgeluid nog beter en popt die muziek echt uit je afspeellijst.

360° JBL sound. Vibrant lightshow. JBL’s Pulse 4 is here; party time or chill, you create the mood. From living room to beach party (and everything in between), the new JBL Pulse 4 provides incredible sound, with visuals to match.

Kabellose Freiheit verspricht der brandneue JBL LIVE 300TWS! Der neue True Wireless-Kopfhörer sorgt für perfekte Verbindung, glänzt mit seinem stylischen Design und garantiert jederzeit entfesselten Sound ohne Einschränkung. Ausgestattet mit leistungsstarken Treibern liefert der Kopfhörer einen verstärkten Bass, der jede Playlist zum Beben bringt.

360°-Sounderlebnis mit dynamischen Lichtshows! Das ist der JBL Pulse, der ab sofort in der vierten Generation verfügbar ist. Ob Party-Modus oder einfach zu m Chillen, der JBL Pulse 4 schafft die perfekte Stimmung. Im Wohnzimmer oder am Strand (und überall dazwischen), der neue Lautsprecher garantiert unglaublichen Sound und die passende Atmosphäre.

From heart-thumping basslines to face-melting guitar solos, the new JBL Link Portable and Link Music have arrived. With 360 JBL Signature Sound, Wi-Fi and Bluetooth connectivity, Chromecast and Google Assistant built-in, they’ve got brains to match their beauty.

360° JBL sound. Vibrant lightshow. JBL’s Pulse 4 is here; party time or chill, you create the mood. From living room to beach party (and everything in between), the new JBL Pulse 4 provides incredible sound, with visuals to match.

Live free from wires with the brand new JBL LIVE 300TWS. Truly wireless, seamlessly connected and beautifully designed, the JBL LIVE 300TWS lets you unleash your sound, anytime, everywhere. Equipped with powerful drivers, they deliver enhanced bass to make your playlist pop.

Was wäre, wenn Kopfhörer Stimmungen erkennen und die Musikauswahl ihrer Nutzer automatisch individuell daran anpassen könnten? Wie wäre es mit einer App, die Lieblingsballaden auf Knopfdruck in einen Bass-lastigen EDM-Track für spontane Tanzeinlagen verwandeln kann? HARMAN International, eine hundertprozentige Tochtergesellschaft von Samsung Electronics Co. Ltd., die sich auf vernetzte Technologien für Automobil-, Konsum- und Unternehmensmärkte konzentriert, hat zu diesen Fragen sowie zu aktuellen Hörgewohnheiten und der Zukunft des Hörens eine neue Verbraucherstudie1 veröffentlicht.

Palo Alto, CA – Aha™ by HARMAN today announced that the new 2014 Mazda3 to be launched in Japan, the United States, and a number of additional North American and Asian Countries this fall will offer access to the Aha free service with the ability to select presets from more than 40,000* audio and information stations from Japan and other countries.

Can we write any number as the sum of three cubes? It’s a puzzle that has perplexed mathematicians for centuries. Now we have finally have an answer for 42

The US assassination of Iranian general Qassem Soleimani has raised fears of nuclear conflict, but Iran has been on the road to building nuclear weapons for some time

LOS ANGELES, CA – HARMAN International Industries, Inc. (NYSE:HAR), the premium audio and infotainment group, will have a major presence at the 137th Audio Engineering Society Convention as it returns to the Los Angeles Convention Center Thursday, October 9 through Sunday, October 12 for the first time in twelve years. HARMAN, the premiere sponsor of both the annual AES President’s Reception and the AES Student Zone, will present several research papers, highlight new Professional audio equipment, and demonstrate the company’s latest innovative music restoration technology, Clari-Fi, throughout the week.

IFA 2015, BERLIN – HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced the world’s first aftermarket amplifiers to feature HARMAN’s Clari-Fi...

In September, the 41st Cannes Yachting Festival brought together some of the world’s most dazzling vessels in a luxurious, iconic setting. As the official car of the Cannes Yachting Festival for the second consecutive year, Maserati, together with the...

Berlin, Germany - yurbuds® powered by JBL®, the sport earphones guaranteed never to hurt or fall out, is officially debuting yurbuds products with JBL Signature Sound at IFA in Berlin.

CES 2015, LAS VEGAS – HARMAN, the premium global audio, infotainment and enterprise automation group (NYSE:HAR), proudly introduce yurbuds® powered by JBL®, the number one selling sport earphone in the nation, is officially debuting yurbuds® products with JBL® Signature Sound in the US. JBL® is known industry-wide for its supreme quality, so coupling that with yurbuds® ergonomics, guaranteed never to hurt or fall out, you have a headphone like no other on the market.

A dead whale found in the Philippines with 40 kilograms of plastic inside its body is the latest example of the problem of plastic pollution

A decade ago, Johan Rockström identified the limits to Earth's life support systems. From chemical pollution to climate change, we're veering into the danger zone - so why is he (cautiously) optimistic about the future?

CES 2020 – LAS VEGAS, NV – JANUARY 6, 2020 – Harman Kardon adds to its most iconic speaker series with the SoundSticks 4. In 2000, when the original SoundSticks was introduced, it quickly became one of the most sought-after desktop sound systems. The...

Minister of Economy, Nadia Calviño, only the second woman to hold the position in Spanish history, speaks to Breakingviews Global Editor Rob Cox as Spain prepares to hold parliamentary elections on Nov. 10 for the second time in a year.

* Airports say it could be devastating for aviation industry (Adds details, changes sourcing)

M&A in the pharma sector marches on unabated - AstraZeneca buying a 55 percent stake in biotech Acerta Pharma for $4.0 billion to give it new cancer drugs. Hayley Platt reports.

Title: More Than 4 in 10 Americans Are Now Obese: CDC
Category: Health News
Created: 2/27/2020 12:00:00 AM
Last Editorial Review: 2/27/2020 12:00:00 AM

Title: 1 in 4 Toddlers Improperly Vaccinated
Category: Health News
Created: 4/30/2008 12:00:00 AM
Last Editorial Review: 4/30/2008 12:00:00 AM

Title: Studies Point to Reasons for Mammograms in 40s
Category: Health News
Created: 5/1/2012 11:00:00 AM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: More Than 4,000 U.S. Kids Hurt Each Year on Amusement Rides
Category: Health News
Created: 5/1/2013 10:35:00 AM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: 4 in 10 Americans Breathe Unhealthy Air: Report
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: 1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

Title: 4 in 10 People Will Suffer Arthritic Hands Over Lifetime
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM

Title: Measles Outbreak in Minnesota Grows to 34 Cases
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM

Title: 4 Strategies to Cope With a Food Craving
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: Autism Diagnoses Reliable at 14 Months, Study Finds
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

PMC released a new and improved journal list on March 31, 2009, after a comprehensive redesign for greater clarity and organization.

The new design not only combines the full-list and tabbed-list views of the previous version but also includes some new or updated features to provide users with a greater overview of the total PMC archive. Looking at this new list, you will find:

1. An Expanded View of PMC journals that includes NIH Portfolio
2. Special Collections
3. A New “Participation Level” Journal Category
4. Hide/Show Display Option for Predecessor Titles
5. Article and Journal Search Feature

For more information, see the complete article in the May-June issue of the NLM Technical Bulletin: https://www.nlm.nih.gov/pubs/techbull/mj09/mj09_pmc_redesign.html

Title: 4 in 10 Security Guards Suffer PTSD, Study Finds
Category: Health News
Created: 4/14/2020 12:00:00 AM
Last Editorial Review: 4/15/2020 12:00:00 AM

Title: 24 Best Foods for Blood Circulation
Category: Health and Living
Created: 4/9/2020 12:00:00 AM
Last Editorial Review: 4/9/2020 12:00:00 AM

Long noncoding RNAs (lncRNA) have been found to play critical roles in tumorigenesis and the development of various cancers, including hepatocellular carcinoma (HCC). Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) has been identified as an oncogene and prognostic biomarker in HCC. Here, we demonstrated that MALAT1 expression was obviously high in sorafenib-resistant HCC cells. Furthermore, knockdown of MALAT1 increased sorafenib sensitivity in nonresponsive HCC cells, whereas forced expression of MALAT1 conferred sorafenib resistance to responsive HCC cells in vitro. In addition, loss/gain-of-function assays revealed that MALAT1 promoted cell proliferation, migration, and epithelial–mesenchymal transition in HCC cells. Mechanistically, MALAT1 regulated Aurora-A expression by sponging miR-140-5p, thus promoting sorafenib resistance in HCC cells. Moreover, MALAT1 inhibition enhanced the antitumor efficacy of sorafenib in vivo. Clinically, we found that MALAT1 expression was negatively correlated with miR-140-5p expression but positively correlated with Aurora-A expression in patients with HCC and that upregulated MALAT1 was closely correlated with poor survival outcomes in patients with HCC. These findings indicated that MALAT1 may be a novel target for prognosis prediction and therapeutic strategies in patients with HCC treated with sorafenib.

Physical and chemical DNA-damaging agents are used widely in the treatment of cancer. Double-strand break (DSB) lesions in DNA are the most deleterious form of damage and, if left unrepaired, can effectively kill cancer cells. DNA-dependent protein kinase (DNA-PK) is a critical component of nonhomologous end joining (NHEJ), one of the two major pathways for DSB repair. Although DNA-PK has been considered an attractive target for cancer therapy, the development of pharmacologic DNA-PK inhibitors for clinical use has been lagging. Here, we report the discovery and characterization of a potent, selective, and orally bioavailable DNA-PK inhibitor, M3814 (peposertib), and provide in vivo proof of principle for DNA-PK inhibition as a novel approach to combination radiotherapy. M3814 potently inhibits DNA-PK catalytic activity and sensitizes multiple cancer cell lines to ionizing radiation (IR) and DSB-inducing agents. Inhibition of DNA-PK autophosphorylation in cancer cells or xenograft tumors led to an increased number of persistent DSBs. Oral administration of M3814 to two xenograft models of human cancer, using a clinically established 6-week fractionated radiation schedule, strongly potentiated the antitumor activity of IR and led to complete tumor regression at nontoxic doses. Our results strongly support DNA-PK inhibition as a novel approach for the combination radiotherapy of cancer. M3814 is currently under investigation in combination with radiotherapy in clinical trials.

The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K₂ subtype menaquinone-4 (MK-4). SCD is characterized by opacification of the cornea, owing to aberrant build-up of cholesterol in the tissue. We previously discovered that sterols stimulate association of UBIAD1 with ER-localized HMG-CoA reductase, which catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids, including GGpp. Binding to UBIAD1 inhibits sterol-accelerated ER-associated degradation (ERAD) of reductase and permits continued synthesis of GGpp in cholesterol-replete cells. GGpp disrupts UBIAD1-reductase binding and thereby allows for maximal ERAD of reductase as well as ER-to-Golgi translocation of UBIAD1. SCD-associated UBIAD1 is refractory to GGpp-mediated dissociation from reductase and remains sequestered in the ER to inhibit ERAD. Here, we report development of a biochemical assay for UBIAD1-mediated synthesis of MK-4 in isolated membranes and intact cells. Using this assay, we compared enzymatic activity of WT UBIAD1 with that of SCD-associated variants. Our studies revealed that SCD-associated UBIAD1 exhibited reduced MK-4 synthetic activity, which may result from its reduced affinity for GGpp. Sequestration in the ER protects SCD-associated UBIAD1 from autophagy and allows intracellular accumulation of the mutant protein, which amplifies the inhibitory effect on reductase ERAD. These findings have important implications not only for the understanding of SCD etiology but also for the efficacy of cholesterol-lowering statin therapy, which becomes limited, in part, because of UBIAD1-mediated inhibition of reductase ERAD.