v Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:42:03 +0530 Full Article
v All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:46:46 +0530 Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore Full Article Kerala
v HC quashes magistrate court’s directive to register FIR against police officers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:36:51 +0530 Magistrate court’s order to file FIR against police officers, including IPS officer and former Malappuram Superintendent of Police Sujith Das, in connection with an alleged sexual assault case quashed Full Article Kerala
v French lower house rejects massively amended 2025 budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:53:03 +0530 Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house Full Article World
v Xi leaves China for APEC meeting in Peru: state media By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:55:46 +0530 Chinese leader Xi Jinping travels to Peru for APEC summit amid trade tensions with U.S., inaugurates Chinese-funded port Full Article News
v COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article Environment
v Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
v France’s bullfighters see red over bill to ban under-16s By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:10:52 +0530 Although public opinion favours outlawing bullfighting in France, a bid to ban the practice failed in 2022 Full Article World
v IndiGo, Air India cancel flights to Bali following volcanic eruption By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:06 +0530 The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds Full Article India
v Sri Lanka to hold key parliamentary vote on November 14 By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:35:59 +0530 President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament Full Article World
v Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
v In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3704-3710DOI: 10.1039/D4MD00552J, Research ArticleJaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul PyunFv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
v Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
v T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
v IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
v Leaders of various parties condemn attack on govt. doctor By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:08:06 +0530 Full Article Tamil Nadu
v Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:14:04 +0530 Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m. Full Article Delhi
v Delhi airport sees seven flight diversions owing to bad weather By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:37 +0530 The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi Full Article Delhi
v DUSU election results to be announced on November 21 By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:18:26 +0530 The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre Full Article Delhi
v Delhi’s air quality turns ‘severe’ for first time this season: CPCB By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:52:21 +0530 According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418 Full Article Delhi
v Rival Zomato's CEO congratulates Swiggy on stock market listing By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:25:51 +0530 Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE Full Article India
v Arvinder Singh Sahney is new chairman of Indian Oil By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:29 +0530 Full Article Business
v Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
v Vodafone Idea narrows Q2 loss to ₹7,176 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:55 +0530 Full Article Business
v Sensex, Nifty hit a five-month low By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:11:22 +0530 Fifth straight losing session at the bourses; shares in the midcap, small cap segments plunged harder than large companies’ stocks in what some called ‘correction mode’ Full Article Business
v Godrej Industries Q2 net profit surges over three fold to ₹288 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:47:28 +0530 Full Article Business
v Greaves Cotton Q2 net loss narrows to ₹14 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:59:39 +0530 Full Article Business
v SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
v Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
v Fervour marks ‘Kaisika Dwadasi’ at Tirumala By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:22:52 +0530 Full Article Andhra Pradesh
v New counters opened at Tirumala for issuing Srivani darshan tickets By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:45:53 +0530 Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO Full Article Andhra Pradesh
v Sakhi centre inaugurated at Vizianagaram Collectorate By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:11:36 +0530 Full Article Andhra Pradesh
v Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
v SEIL Energy bags seven awards from QCFI By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:35:31 +0530 Full Article Andhra Pradesh
v All set for Urus festival at Pedda Dargah in Kadapa By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:11 +0530 Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16 Full Article Andhra Pradesh