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11757b programming user guide

11757b programming user guide




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to wire a switch to an outlet diagram

to wire a switch to an outlet diagram




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to wire an outlet in series diagram

to wire an outlet in series diagram




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to wire a garage diagram

to wire a garage diagram




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to wire switched outlets diagram

to wire switched outlets diagram




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3600 parts diagram

3600 parts diagram




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to wire a two gang light switch diagram

to wire a two gang light switch diagram




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Loan No. 2972-PAK: Power Distribution Enhancement Investment Program, Tranche-III [ADB-TRANCHE-III-MEPCO-01]




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Loan No. 2924-IND: Uttarakhand Power Sector Investment Program - Project 4 [ICB No. 3-P/ADB/PTCUL/2012-13]




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Loan No. 3411-AZE: Water Supply and Sanitation Investment Program - Tranche 4 [MFF42408-044-T4-ICB-1.02]




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Loan No. 42486-IND: Madhya Pradesh Urban Services Improvement Program [MPUSIP 6D REBIDDING]




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Loan Nos. 3076/3077-PNG: Highland Region Road Improvement Investment Program [CSTB No. 2946]




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Loan No. 42401-AZE: Power Distribution Enhancement Investment Program - Tranche 1 [AI/ADB-10.1 and AI/ADB-10.2]




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Loan No. 3203-PAK: Power Transmission Enhancement Investment Program Tranche 4 [ADB-79-2015] EXTENDED




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Loan No. 2972-PAK: Power Distribution Enhancement Investment Program - Tranche 3 [LESCO-10-2013]




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Loan No. 2830-IND: Madhya Pradesh Energy Efficiency Improvement Investment Program – Tranche 2 [MD / WZ / 06 / PUR / ADB /993]




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Climate and Disaster Resilience Enhancement Program (Subprogram 1)

The proposed program will support the enhancement of Pakistan's resilience to disasters triggered by natural hazards and the impacts of climate change. Through an integrated approach, the program will support (i) strengthened institutional capacity for strategy, planning, and response; (ii) increased investment in disaster risk reduction (DRR) and climate resilience; and (iii) enhanced disaster risk financing (DRF) using a risk-layered approach.




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Fiscal Sustainability and Financial Markets Development Program (Subprogram 2)




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Health Care Quality Improvement Program

The program aims to improve the quality of health care as stipulated in the Government Program, 2021-2026, Health Sector Strategy 2023-2026, the UHI Concept Paper, and the Quality of Care Strategy 2022-2026.




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Seismic Safety Improvement Program 3

The Republic of Armenia is located at the intersection of major tectonic faults, making it highly prone to seismic activity. The devastation of the 1988 Spitak earthquake claimed about 25,000 lives, including 6,000 school children; left 517,000 people homeless, destroyed 190 schools and many urban infrastructures; and incurred direct economic losses of $15 billion-$20 billion. The recent 7.8-magnitude earthquake in neighboring Trkiye and Syria in 2023 is a wake-up call for Armenia, posing a significant threat to the country. rkiye and Syria in 2023 is a wake-up call for Armenia, posing a significant threat to the country.




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Resilient Amu Darya River Basin Sector Development Program

The proposed project will undertake a long-term and strategic approach to deliver climate adaptive solutions for water resources management in the Amu Darya River Basins in Uzbekistan. Predicted climate change impacts include increased temperatures, increased frequency and severity of extreme events such as floods and droughts, and a reduction of water availability and increased variability of water flows in the major river basins. Decreasing availability and increased water requirements by different sectors are leading to a growing seasonal and absolute supply-demand gap.




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MFF: Green and Resilience Financing Facility Investment Program

The proposed program is a large-scale transformative and integrated initiative addressing the constraints. It aims to bridge the financing, capacity, institutional, and technical gaps in implementing the NAP and adaptation measures mentioned in the NDC and GRID while promoting mitigation, biodiversity, air pollution, and food security as co-benefits.




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Paramotorists collect rare plant species from Peruvian desert oases

Kew scientists use paramotorists to collect rare plant species from Peruvian desert oases




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Richard Dawkins's latest crams gorgeous writing in an ill-fitting box

A new book from the science-writing legend is an Attenborough-esque romp through some of the wonders of the natural world. Just beware the title's misfiring metaphor




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Black holes scramble information – but may not be the best at it

Information contained within quantum objects gets scrambled when they interact. Physicists have now derived a speed limit for this process, challenging the idea that black holes are the fastest data scramblers




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Quantum holograms can send messages that disappear

Entangled particles of light can transmit holographic images that can be selectively erased, allowing for secure communications that can also be deleted




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Dramatic images show the dark side of cobalt mining boom

Pascal Maitre's photos from the Democratic Republic of Congo detail the problems arising as demand for cobalt grows




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A dramatic twist to the Gaia hypothesis

James Lovelock's hypothesis that our planet is a living entity is well known. Ferris Jabr's new book Becoming Earth takes it a step further




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Chilling news adds fresh meaning to 2018 Arctic horror drama

A new study amplifies the horror of an excellent series about the doomed Franklin expedition. The Terror is a worthy tribute to the lost sailors, says Bethan Ackerley




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A lost branch of the river Nile flowed past the pyramids of Egypt

Soil core samples show an ancient riverbed under the desert near many Egyptian pyramids, revealing an ancient waterway that dried up thousands of years ago




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Egyptian pyramid may have been built using a water-powered elevator

Ancient Egyptians may have relied on a vertical shaft that could be filled with water, along with a network of water channels and filtration structures, to build the Step Pyramid of Djoser 4500 years ago




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Chilling news adds fresh meaning to 2018 Arctic horror drama

A new study amplifies the horror of an excellent series about the doomed Franklin expedition. The Terror is a worthy tribute to the lost sailors, says Bethan Ackerley




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Walking School Bus Programs Take Off

Title: Walking School Bus Programs Take Off
Category: Health News
Created: 8/23/2011 11:01:00 AM
Last Editorial Review: 8/23/2011 12:00:00 AM




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Ebola: A Medical Drama Unfolds

Title: Ebola: A Medical Drama Unfolds
Category: Health News
Created: 8/23/2014 11:00:00 AM
Last Editorial Review: 8/25/2014 12:00:00 AM




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False-Positive Mammogram Result Traumatic for Most Women: Study

Title: False-Positive Mammogram Result Traumatic for Most Women: Study
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/26/2015 12:00:00 AM




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'Pretend Mommy' Program Doesn't Deter Teen Pregnancy

Title: 'Pretend Mommy' Program Doesn't Deter Teen Pregnancy
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM




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Looking for a Plastic Surgeon on Instagram? Beware

Title: Looking for a Plastic Surgeon on Instagram? Beware
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM




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Newborns' Immune Systems Ramp Up After Birth

Title: Newborns' Immune Systems Ramp Up After Birth
Category: Health News
Created: 8/24/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM




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'Dramatic Resurgence' of Measles in Europe: WHO

Title: 'Dramatic Resurgence' of Measles in Europe: WHO
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM




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Gabapentin vs. Tramadol

Title: Gabapentin vs. Tramadol
Category: Medications
Created: 3/22/2018 12:00:00 AM
Last Editorial Review: 7/22/2022 12:00:00 AM




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Ondansetron (Zofran) vs. Dramamine

Title: Ondansetron (Zofran) vs. Dramamine
Category: Medications
Created: 7/24/2019 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM




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tobramycin

Title: tobramycin
Category: Medications
Created: 8/2/2022 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM




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tramadol

Title: tramadol
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM




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Tramadol vs. Hydrocodone

Title: Tramadol vs. Hydrocodone
Category: Medications
Created: 4/24/2017 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM




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Theoretical framework for the difference of two negative binomial distributions and its application in comparative analysis of sequencing data [METHODS]

High-throughput sequencing (HTS) technologies have been instrumental in investigating biological questions at the bulk and single-cell levels. Comparative analysis of two HTS data sets often relies on testing the statistical significance for the difference of two negative binomial distributions (DOTNB). Although negative binomial distributions are well studied, the theoretical results for DOTNB remain largely unexplored. Here, we derive basic analytical results for DOTNB and examine its asymptotic properties. As a state-of-the-art application of DOTNB, we introduce DEGage, a computational method for detecting differentially expressed genes (DEGs) in scRNA-seq data. DEGage calculates the mean of the sample-wise differences of gene expression levels as the test statistic and determines significant differential expression by computing the P-value with DOTNB. Extensive validation using simulated and real scRNA-seq data sets demonstrates that DEGage outperforms five popular DEG analysis tools: DEGseq2, DEsingle, edgeR, Monocle3, and scDD. DEGage is robust against high dropout levels and exhibits superior sensitivity when applied to balanced and imbalanced data sets, even with small sample sizes. We utilize DEGage to analyze prostate cancer scRNA-seq data sets and identify marker genes for 17 cell types. Furthermore, we apply DEGage to scRNA-seq data sets of mouse neurons with and without fear memory and reveal eight potential memory-related genes overlooked in previous analyses. The theoretical results and supporting software for DOTNB can be widely applied to comparative analyses of dispersed count data in HTS and broad research questions.




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The chromatin tapestry as a framework for neurodevelopment [MINI-REVIEW]

The neuronal nucleus houses a meticulously organized genome. Within this structure, genetic material is not simply compacted but arranged into a precise and functional 3D chromatin landscape essential for cellular regulation. This mini-review highlights the importance of this chromatin landscape in healthy neurodevelopment, as well as the diseases that occur with aberrant chromatin architecture. We discuss insights into the fundamental mechanistic relationship between histone modifications, DNA methylation, and genome organization. We then discuss findings that reveal how these epigenetic features change throughout normal neurodevelopment. Finally, we highlight single-gene neurodevelopmental disorders that illustrate the interdependence of epigenetic features, showing how disruptions in DNA methylation or genome architecture can ripple across the entire epigenome. As such, we emphasize the importance of measuring multiple chromatin architectural aspects, as the disruption of one mechanism can likely impact others in the intricate epigenetic network. This mini-review underscores the vast gaps in our understanding of chromatin structure in neurodevelopmental diseases and the substantial research needed to understand the interplay between chromatin features and neurodevelopment.




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Implementation of an Opt-Out Outpatient HIV Screening Program

Background:

Screening rates for Human Immunodeficiency Virus (HIV) remain low despite guidelines by both the CDC and USPSTF recommending that all adolescents and adults be screened at least once. The aim of this quality improvement study was to increase HIV screening among eligible patients.

Methods:

This quality improvement study assessed the impact of interventions to increase HIV screening in an outpatient population at a large urban safety-net hospital. Outcomes were compared from the preintervention (December 2020 to November 2021) to postintervention years (December 2021 to November 2022). Stepwise electronic alerts to prompt HIV screening paired with provider financial incentives were implemented. The proportion of eligible individuals screened for HIV were compared after intervention implementation.

Results:

Average monthly HIV screening increased from 506 ± 97 to 2484 ± 663 between the pre- and postintervention periods, correlating to a 5.1-fold increase in screening (7.8% to 39.8%, P < .01). Increases were seen across all ages, and those aged 55 to 64 and 65+ had the highest relative increase in screening at 7.5 and 9.3-fold, respectively (P < .01). Screening rates increased for Hispanics (7.9% preintervention vs 43.6% postintervention, P < .01). In the pre- and postintervention periods, 41 patients with new HIV diagnoses were identified (13 preintervention and 28 postintervention) and 85.4% were linked to care within 30 days.

Conclusions:

Stepwise interventions targeted at primary care clinicians are an effective way to increase HIV screening rates, particularly in older demographics. Earlier HIV diagnosis coupled with linkage to care is an important strategy in ending the HIV epidemic.




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Perspectives on Using Race in Pulmonary Function Testing: A National Survey of Fellows and Program Directors

BACKGROUND:Pulmonary function tests (PFTs) have historically used race-specific prediction equations. The recent American Thoracic Society guidelines recommend the use of a race-neutral approach in prediction equations. There are limited studies centering the opinions of practicing pulmonologists on the use of race in spirometry. Provider opinion will impact adoption of the new guideline. The aim of this study was to ascertain the beliefs of academic pulmonary and critical care providers regarding the use of race as a variable in spirometry prediction equations.METHODS:We report data from 151 open-ended responses from a voluntary, nationwide survey (distributed by the Association of Pulmonary Critical Care Medicine Program Directors) of academic pulmonary and critical care providers regarding the use of race in PFT prediction equations. Responses were coded using inductive and deductive methods, and a thematic content analysis was conducted.RESULTS:There was a balanced distribution of opinions among respondents supporting, opposing, or being unsure about the incorporation of race in spirometry prediction equations. Responses demonstrated a wide array of understanding related to the concept and definition of race and its relationship to physiology.CONCLUSIONS:There was no consensus among providers regarding the use of race in spirometry prediction equations. Concepts of race having biologic implications persist among pulmonary providers and will likely affect the uptake of the Global Lung Function Initiative per the American Thoracic Society guidelines.




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A Strategic Guide to Improve and De-Risk Vaccine Development: CEPIs CMC Framework

The Coalition for Epidemic Preparedness Innovations (CEPI) has developed a robust CMC (Chemistry, Manufacturing, and Controls) Framework to enhance the likelihood of successful vaccine development. This Framework serves as a comprehensive guide, aiding developers in building effective strategies to overcome the challenges posed by the different phases of vaccine development, including the ones often referred to as the "valleys of death". The Framework lists stage-appropriate deliverables, categorized and refined, spanning five key areas: manufacturing process, formulation and stability, analytics, supply chain, and compliance. By emphasizing the critical aspects of CMC development, CEPI's objective is to expedite the progression of vaccine candidates from research to deployment, reducing delays, mitigating risks, and optimizing the overall development process, all while upholding uncompromising quality standards, ultimately increasing the probability of success.




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Abolished frameshifting for predicted structure-stabilizing SARS-CoV-2 mutants: implications to alternative conformations and their statistical structural analyses [ARTICLE]

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.