You know about Beto O'Rourke on the guitar, of course, but what about Bernie Sanders's spoken-word album?

One of the most effective ways you can protect your computer at home is to make sure both the operating system and your applications are patched and updated. Enable automatic updating whenever possible.

‘The idea that what’s happening with searcher behavior is not causing these shifts means that Google is in there writing that code for every intent, every day, and I can’t believe that’s what’s happening,’ said Dr. Pete Meyers on Live with Search Engine Land.

Please visit Search Engine Land for the full article.

This update was an “absolute monster” said Mordy Oberstein from RankRanger.

Please visit Search Engine Land for the full article.

All the latest Covid-19 news from around the world.

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

News24 answers some of the most frequently asked questions on coronavirus and level 4 of the lockdown in South Africa.

On 4 May, 2020 Minister Nathi Mthethwa hosted a briefing, updating the public on the Department of Sports, Arts and Cultures Corona relief funds, and the received applications.

Invitation Only Research Event

Event participants

Nikolay Kozhanov, Research Associate Professor, Gulf Studies Center, Qatar University; Consulting Fellow, Russia and Eurasia Programme, Chatham House 
Chair: Sanam Vakil, Senior Research Fellow, Project Director, Future Dynamics of the Gulf, Middle East & North Africa Programme, Chatham House

Firefox's latest version is out, with new password management features and a raft of security fixes.

Growth at any cost is, well, costing us — and we can’t rely on the marketplace to solve the earth’s problems.

We are now in the peak of job season. Depending upon your branch, applications may have been due as early as October 1. Big deadlines are November 1, November 15, and December 1.  Still, you should basically be done applying now—see … Continue reading →

At 1 a.m. at the Hong Kong Observatory :
Air temperature : 29 degrees Celsius
Relative Humidity : 82 per cent

Pasquale Passarella
Aug 1, 2018; 31:218-224
From Research to Practice

updated April 1, 2020

In response to current challenges that colleges and universities face as a result of the spread of COVID-19, the American Mathematical Society is offering libraries and institutions additional support, in line with recommendations in the ICOLC Statement on the Global COVID-19 Pandemic and Its Impact on Library Services and Resources.

The AMS is also participating in the Copyright Clearance Center Education Continuity License program, providing access to our content for distance learning and other educational uses at no cost to the user.

We are extending grace access for content hosted on our platforms (including MathSciNet) through the end of May for our existing customers. We will re-evaluate this timing as needed.

As courses transition to online, we can provide instructors with complimentary electronic “reserve” copies of our textbooks for cases in which students do not have access to their print copies.

E-books purchased through the perpetual access model on the AMS platform are always available DRM-free with unlimited simultaneous use. In addition, we are partnering with ProQuest to allow multi-user access through mid-June to all e-books purchased on their platforms. Read ProQuest’s statement.

We are providing remote access to all our content, including MathSciNet. In normal circumstances, this remote access can be set up while on campus or while connected via institution VPN (in order to validate IP-based access). We realize many students, faculty, and researchers did not have an opportunity to initiate this access before leaving campus, so we have given instructions to our library partners on how patrons can connect to our content. Please contact your librarian for assistance.

Libraries: if you have not received instructions to share with your patrons, please email us at cust-serv@ams.org or be in touch about any other of your library’s needs.

Review all AMS Resources & Updates.

(To watch the full press conference with sign language interpretation, click here.)

Secretary for Education Kevin Yeung today said the Government is confident that classes can resume on May 27.

Mr Yeung made the statement at a press conference this afternoon.

He said: “We are not announcing class resumption right away. We are giving advance notice of about three weeks for all the stakeholders to get prepared for the school resumption.”

The Government will continue to monitor the situation during this period and adjust the school resumption plan if necessary, he added.

"At this stage we are still pretty confident that we should be able to resume classes on May 27."

(King Abdullah University of Science & Technology (KAUST)) Optical fibers wrapped around date palm trunks could help detect this tree's most destructive pest early enough to save it.

There is no warning in force.

General Situation:
A trough of low pressure will edge towards the coast of Guangdong today and linger over the region in the following couple of days. There will be thundery showers over Guangdong. With the anticyclone aloft strengthening in the middle and latter parts of this week, the weather over southern China will improve and it will be hot.

Date/Month: 10/05 (Sunday)
Wind: South force 3.
Weather: Sunny intervals and a few showers. Isolated thunderstorms later.
Temp range: 28 - 32 C
R.H. range: 65 - 95 per Cent

Date/Month: 11/05 (Monday)
Wind: South force 2 to 3.
Weather: Mainly cloudy with occasional showers and a few squally thunderstorms.
Temp range: 26 - 30 C
R.H. range: 70 - 95 per Cent

Date/Month: 12/05 (Tuesday)
Wind: Light winds force 2.
Weather: Mainly cloudy with a few showers and thunderstorms.
Temp range: 25 - 29 C
R.H. range: 70 - 95 per Cent

Date/Month: 13/05 (Wednesday)
Wind: Southeast force 3.
Weather: Sunny intervals and one or two showers.
Temp range: 26 - 30 C
R.H. range: 65 - 90 per Cent

Date/Month: 14/05 (Thursday)
Wind: Southeast force 3.
Weather: Sunny periods.
Temp range: 26 - 31 C
R.H. range: 60 - 85 per Cent

Date/Month: 15/05 (Friday)
Wind: South to southeast force 3.
Weather: Sunny periods.
Temp range: 27 - 32 C
R.H. range: 60 - 85 per Cent

Date/Month: 16/05 (Saturday)
Wind: South force 3.
Weather: Sunny periods.
Temp range: 27 - 32 C
R.H. range: 60 - 85 per Cent

Date/Month: 17/05 (Sunday)
Wind: South force 3 to 4.
Weather: Sunny periods.
Temp range: 28 - 32 C
R.H. range: 70 - 90 per Cent

Date/Month: 18/05 (Monday)
Wind: South force 3 to 4.
Weather: Sunny periods and isolated showers.
Temp range: 28 - 32 C
R.H. range: 70 - 90 per Cent

Sea surface temperature at 2 P.M. 09/05/2020 at North Point was 25 degrees C.
Soil temperatures at 7 A.M. 09/05/2020 at Hong Kong Observatory :
0.5 M below surface was 27.6 degrees C
1.0 M below surface was 26.4 degrees C

An anticyclone aloft brought hot weather to southern China yesterday. Locally, it was hot with sunny periods and isolated showers. A trough of low pressure will edge towards the coast of Guangdong today and linger over the region in the following couple of days. There will be thundery showers over Guangdong.

Weather forecast for Hong Kong:
Mainly cloudy with a few showers. Sunny intervals during the day. There will be isolated thunderstorms later. Hot with temperatures ranging between 28 and 32 degrees. Moderate southerly winds.

Outlook: There will be showers and thunderstorms on Monday and Tuesday. The weather will improve gradually in the following couple of days.

WYSIWYG Web Builder 9.1 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 9.2 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 9.3 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 9.4 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 10.1 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 10.2 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 10.3 fixes known problems, adds new features and includes other improvements.

WYSIWYG Web Builder 10.4 fixes known problems, adds new features and includes other improvements.

Xien Yu Chua
Apr 1, 2020; 19:730-743
Technological Innovation and Resources

Invitation Only Research Event

Event participants

Nikolay Kozhanov, Research Associate Professor, Gulf Studies Center, Qatar University; Consulting Fellow, Russia and Eurasia Programme, Chatham House 
Chair: Sanam Vakil, Senior Research Fellow, Project Director, Future Dynamics of the Gulf, Middle East & North Africa Programme, Chatham House

Objective: To develop a novel approach to generate individual maps of white matter (WM) innate immune cell activation using ¹⁸F-DPA-714 translocator protein (TSPO) positron emission tomography (PET), and to explore the relationship between these maps and individual trajectories of disability worsening in patients with multiple sclerosis (MS). Methods: Patients with MS (n = 37), whose trajectories of disability worsening over the 2 years preceding study entry were calculated, and healthy controls (n = 19) underwent magnetic resonance magnetic and ¹⁸F-DPA-714 PET. A threshold of significant activation of ¹⁸F-DPA-714 binding was calculated with a voxel-wise randomized permutation-based comparison between patients and controls, and used to classify each WM voxel in patients as characterized by a significant activation of innate immune cells (DPA+) or not. Individual maps of innate immune cell activation in the WM were employed to calculate the extent of activation in WM regions-of-interests and to classify each WM lesion as "DPA-active", "DPA-inactive" or "unclassified". Results: Compared with the WM of healthy controls, patients with MS had a significantly higher percentage of DPA+ voxels in the normal-appearing WM, (NAWM in patients=24.9±9.7%; WM in controls=14.0±7.8%, p<0.001). In patients with MS, the percentage of DPA+ voxels showed a significant increase from NAWM, to perilesional areas, T2 hyperintense lesions and T1 hypointense lesions (38.1±13.5%, 45.0±17.9%, and 51.9±22.9%, respectively, p<0.001). Among the 1379 T2 lesions identified, 512 were defined as DPA-active and 258 as DPA-inactive. A higher number of lesions classified as DPA-active (OR=1.13, P = 0.009), a higher percentage of DPA+ voxels in the NAWM (OR=1.16, P = 0.009) and in T1-spin-echo lesions (OR=1.06, P = 0.036), were significantly associated with a retrospective more severe clinical trajectory in patients with MS. Conclusion: A more severe trajectory of disability worsening in MS is associated with an innate immune cells activation inside and around WM lesions. ¹⁸F-DPA-714 PET may provide a promising biomarker to identify patients at risk of severe clinical trajectory.

Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led to poor pTyr peptide identification and quantitation, critically hindering researchers' ability to elucidate signaling pathways regulated by tyrosine phosphorylation in systems where cellular material is limited. The most popular approaches to wide-scale characterization of the tyrosine phosphoproteome use pTyr enrichment with pan-specific, anti-pTyr antibodies from a large amount of starting material. Methods that decrease the amount of starting material and increase the characterization depth of the tyrosine phosphoproteome while maintaining quantitative accuracy and precision would enable the discovery of tyrosine phosphorylation networks in rarer cell populations. To achieve these goals, the BOOST (Broad-spectrum Optimization Of Selective Triggering) method leveraging the multiplexing capability of tandem mass tags (TMT) and the use of pervanadate (PV) boost channels (cells treated with the broad-spectrum tyrosine phosphatase inhibitor PV) selectively increased the relative abundance of pTyr-containing peptides. After PV boost channels facilitated selective fragmentation of pTyr-containing peptides, TMT reporter ions delivered accurate quantitation of each peptide for the experimental samples while the quantitation from PV boost channels was ignored. This method yielded up to 6.3-fold boost in pTyr quantification depth of statistically significant data derived from contrived ratios, compared with TMT without PV boost channels or intensity-based label-free (LF) quantitation while maintaining quantitative accuracy and precision, allowing quantitation of over 2300 unique pTyr peptides from only 1 mg of T cell receptor-stimulated Jurkat T cells. The BOOST strategy can potentially be applied in analyses of other post-translational modifications where treatments that broadly elevate the levels of those modifications across the proteome are available.

Archaic technology wasting time for Canberrans is in the target of new federal agency.

The presentation of post-translationally modified (PTM) peptides by cell surface HLA molecules has the potential to increase the diversity of targets for surveilling T cells. Whilst immunopeptidomics studies routinely identify thousands of HLA-bound peptides from cell lines and tissue samples, in-depth analyses of the proportion and nature of peptides bearing one or more PTMs remains challenging. Here we have analyzed HLA-bound peptides from a variety of allotypes and assessed the distribution of mass spectrometry-detected PTMs, finding deamidation of asparagine or glutamine to be highly prevalent. Given that asparagine deamidation may arise either spontaneously or through enzymatic reaction, we assessed allele-specific and global motifs flanking the modified residues. Notably, we found that the N-linked glycosylation motif NX(S/T) was highly abundant across asparagine-deamidated HLA-bound peptides. This finding, demonstrated previously for a handful of deamidated T cell epitopes, implicates a more global role for the retrograde transport of nascently N-glycosylated polypeptides from the ER and their subsequent degradation within the cytosol to form HLA-ligand precursors. Chemical inhibition of Peptide:N-Glycanase (PNGase), the endoglycosidase responsible for the removal of glycans from misfolded and retrotranslocated glycoproteins, greatly reduced presentation of this subset of deamidated HLA-bound peptides. Importantly, there was no impact of PNGase inhibition on peptides not containing a consensus NX(S/T) motif. This indicates that a large proportion of HLA-I bound asparagine deamidated peptides are generated from formerly glycosylated proteins that have undergone deglycosylation via the ER-associated protein degradation (ERAD) pathway. The information herein will help train deamidation prediction models for HLA-peptide repertoires and aid in the design of novel T cell therapeutic targets derived from glycoprotein antigens.

When you run SAS Deployment Wizard to install or update SAS 9.4 software, the file system is examined. If any files that the wizard needs to delete are found to be locked, they are reported as unwritable f

The increasing prevalence of type 2 diabetes poses a major challenge to societies worldwide. Blood-based factors like serum proteins are in contact with every organ in the body to mediate global homeostasis and may thus directly regulate complex processes such as aging and the development of common chronic diseases. We applied a data-driven proteomics approach, measuring serum levels of 4,137 proteins in 5,438 elderly Icelanders and identified 536 proteins associated with prevalent and/or incident type 2 diabetes. We validated a subset of the observed associations in an independent case-control study of type 2 diabetes. These protein associations provide novel biological insights into the molecular mechanisms that are dysregulated prior to and following the onset of type 2 diabetes and can be detected in serum. A bi-directional two-sample Mendelian randomization analysis indicated that serum changes of at least 23 proteins are downstream of the disease or its genetic liability, while 15 proteins were supported as having a causal role in type 2 diabetes.

The world is responding to the global coronavirus and COVID-19 epidemic in many ways.  One of the most important is by socially distancing ourselves from one another.   While this helps slow the spread of the epidemic, it also cuts … Continue reading →

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

This month we review articles on:

1. Prognostic Significance of Unrecognized MI in Patients with Diabetes
2. Driving and Glucose Variability
3. Fournier Gangrene Associated with SGLT-2 Inhibitors
4. Faster Acting Insulin Aspart vs. Insulin Aspart
5. Sleep and Glycemia
6. Flash Glucose Monitoring and Effect on Glycemic Control

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

This month we review articles on:

1. Dapagliflozin Plus Saxagliptin Add-on Therapy Compared with Insulin
2. Dulaglutide and Cardiovascular Outcomes in Type 2 Diabetes (REWIND)
3. Mediterranean Diet and the Need for Glucose- Lowering Medications
4. Oral Semaglutide versus Subcutaneous Liraglutide and Placebo
5. Vitamin E and Pioglitazone for Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes
6. Durability of Insulin Degludec plus Liraglutide versus Insulin Glargine U100

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health