Rockville, Maryland : National Institute on Drug Abuse, 1986.

Rockville, Maryland : National Institute on Drug Abuse, 1988.

Rockville, Maryland : National Institute on Drug Abuse, 1986.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Rockville, Maryland : National Institute on Drug Abuse, 1979.

Over four years in Eugene, Ruthy Hebard has made a name for herself with reliability and dynamic play. She's had many memorable moments in a Duck uniform. But her career day against Washington State (34 points), her moment reaching 2,000 career points and her NCAA record for consecutive made FGs (2018) tops the list. Against the Trojans, she set the record (30) and later extended it to 33.

Pac-12 Networks' Ashley Adamson speaks with Oregon stars Sabrina Ionescu, Ruthy Hebard and Satou Sabally to hear how special their recent Naismith Starting 5 honor was, as the Ducks comprise three of the nation's top five players. Ionescu (point guard), Sabally (small forward) and Hebard (power forward) led the Ducks to a 31-2 record in the 2019-20 season before it was cut short.

Pac-12 Networks' Ashley Adamson catches up with Oregon's "Big 3" of Sabrina Ionescu, Ruthy Hebard and Satou Sabally to hear how they're adjusting to the new world without sports while still preparing for the WNBA Draft on April 17. They also share how they're staying hungry for basketball during the hiatus.

Ruthy Hebard, who ranks 2nd in Oregon history in points (2,368) and 3rd in rebounds (1,299), prepares to play in the WNBA following four years in Eugene. Hebard is the Oregon and Pac-12 all-time leader in career field-goal percentage (65.1) and averaged 17.3 points per game and a career-high 9.6 rebounds per game as a senior.

Arizona's Aari McDonald and Pac-12 Networks' Ashley Adamson discuss the guard's decision to return for her senior season in Tucson and how she now has the opportunity to be the face of the league. McDonald, the Pac-12 Defensive Player of the Year, was one of the nation's top scorers in 2019-20, averaging 20.6 points per game.

Learn how Oregon stars Sabrina Ionescu and Ruthy Hebard developed a lasting bond as college freshmen and carried that through storied four-year careers for the Ducks. Watch "Our Stories Unfinished Business: Sabrina Ionescu and Ruthy Hebard" debuting Wednesday, April 15 at 7 p.m. PT/ 8 p.m. MT on Pac-12 Network.

Ruthy Hebard and Sabrina Ionescu have had a remarkable four years together in Eugene, rewriting the history books and pushing the Ducks into the national spotlight. Catch the debut of "Our Stories Unfinished Business: Sabrina Ionescu and Ruthy Hebard" at Wednesday, April 15 at 7 p.m. PT/ 8 p.m. MT on Pac-12 Network.

Jennifer E. Starling, Jared S. Murray, Carlos M. Carvalho, Radek K. Bukowski, James G. Scott.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 28--50.

Abstract:
This article introduces BART with Targeted Smoothing, or tsBART, a new Bayesian tree-based model for nonparametric regression. The goal of tsBART is to introduce smoothness over a single target covariate $t$ while not necessarily requiring smoothness over other covariates $x$. tsBART is based on the Bayesian Additive Regression Trees (BART) model, an ensemble of regression trees. tsBART extends BART by parameterizing each tree’s terminal nodes with smooth functions of $t$ rather than independent scalars. Like BART, tsBART captures complex nonlinear relationships and interactions among the predictors. But unlike BART, tsBART guarantees that the response surface will be smooth in the target covariate. This improves interpretability and helps to regularize the estimate. After introducing and benchmarking the tsBART model, we apply it to our motivating example—pregnancy outcomes data from the National Center for Health Statistics. Our aim is to provide patient-specific estimates of stillbirth risk across gestational age $(t)$ and based on maternal and fetal risk factors $(x)$. Obstetricians expect stillbirth risk to vary smoothly over gestational age but not necessarily over other covariates, and tsBART has been designed precisely to reflect this structural knowledge. The results of our analysis show the clear superiority of the tsBART model for quantifying stillbirth risk, thereby providing patients and doctors with better information for managing the risk of fetal mortality. All methods described here are implemented in the R package tsbart .

Moore, Amy, 1908-2005 -- Family.

King's Orphan Schools (New Town, Tas.)

Cheesman, John -- Family.

Three weeks before he was shot dead, Miguel Calderon, an inmate in the lawless Los Llanos jail on Venezuela's central plains, sent a voice message to his father. Like many of the prisoners in Venezuela's overcrowded and violent penitentiaries, Los Llanos's 4,000 inmates normally subsist on food relatives bring them. The guards, desperate themselves amid national shortages, began stealing the little food getting behind bars, inmates said, forcing some prisoners to turn to eating stray animals.

Barack Obama said the “rule of law is at risk” following the justice department’s decision to drop charges against former Trump advisor Mike Flynn, as he issued a stark warning about the long-term impact on the American way of life by his successor.

The Justice Department announced Thursday that it is dropping its criminal case against President Trump's first national security adviser Michael Flynn. Flynn twice admitted in court he lied to the FBI about his conversations with Russia's U.S. ambassador, and then cooperated in Special Counsel Robert Mueller's investigation. It was an unusual move by the Justice Department, and CNN's legal and political analysts smelled a rat."Attorney General [William] Barr is already being accused of creating a special justice system just for President Trump's friends," and this will only feed that perception, CNN's Jake Tapper suggested. Political correspondent Sara Murray agreed, noting that the prosecutor in the case, Brandon Van Grack, withdrew right before the Justice Department submitted its filing, just like when Barr intervened to request a reduced sentence for Roger Stone.National security correspondent Jim Sciutto laid out several reason why the substance of Flynn's admitted lie was a big deal, and chief legal analyst Jeffrey Toobin was appalled. "It is one of the most incredible legal documents I have read, and certainly something that I never expected to see from the United States Department of Justice," Toobin said. "The idea that the Justice Department would invent an argument -- an argument that the judge in this case has already rejected -- and say that's a basis for dropping a case where a defendant admitted his guilt shows that this is a case where the fix was in."Barr told CBS News' Cathrine Herridge on Thursday that dropping Flynn's case actually "sends the message that there is one standard of justice in this country." Herridge told Barr he would take flak for this, asking: "When history looks back on this decision, how do you think it will be written?" Barr laughed: "Well, history's written by the winners. So it largely depends on who's writing the history." Watch below. More stories from theweek.com Outed CIA agent Valerie Plame is running for Congress, and her launch video looks like a spy movie trailer 7 scathing cartoons about America's rush to reopen Trump says he couldn't have exposed WWII vets to COVID-19 because the wind was blowing the wrong way

Nicole Bohme Carnegie.

Source: Statistical Science, Volume 34, Number 1, 90--93.

Abstract:
With a thorough exposition of the methods and results of the 2016 Atlantic Causal Inference Competition, Dorie et al. have set a new standard for reproducibility and comparability of evaluations of causal inference methods. In particular, the open-source R package aciccomp2016, which permits reproduction of all datasets used in the competition, will be an invaluable resource for evaluation of future methodological developments. Building upon results from Dorie et al., we examine whether a set of potential modifications to Bayesian Additive Regression Trees (BART)—multiple chains in model fitting, using the propensity score as a covariate, targeted maximum likelihood estimation (TMLE), and computing symmetric confidence intervals—have a stronger impact on bias, RMSE, and confidence interval coverage in combination than they do alone. We find that bias in the estimate of SATT is minimal, regardless of the BART formulation. For purposes of CI coverage, however, all proposed modifications are beneficial—alone and in combination—but use of TMLE is least beneficial for coverage and results in considerably wider confidence intervals.

London : Cleanair (33 Stillness Rd, London, SE23 1NG), [198-?]

Svetlana Mastitskaya
Apr 8, 2020; 40:3052-3062
Systems/Circuits

Masaki Yamamoto
May 22, 2019; 39:4179-4192
Neurobiology of Disease

Spanish translation of press release - the Basel Committee on Banking Supervision is finalising stress-testing principles, reviews ways to stop regulatory arbitrage behaviour, agrees on annual G-SIB list, discusses leverage ratio, crypto-assets, market risk framework and implementation, 20 September 2018.

Maintenance of cardiorespiratory homeostasis depends on autonomic reflexes controlled by neuronal circuits of the brainstem. The neurophysiology and neuroanatomy of these reflex pathways are well understood, however, the mechanisms and functional significance of autonomic circuit modulation by glial cells remain largely unknown. In the experiments conducted in male laboratory rats we show that astrocytes of the nucleus of the solitary tract (NTS), the brain area that receives and integrates sensory information from the heart and blood vessels, respond to incoming afferent inputs with [Ca²⁺]_i elevations. Astroglial [Ca²⁺]_i responses are triggered by transmitters released by vagal afferents, glutamate acting at AMPA receptors and 5-HT acting at 5-HT_2A receptors. In conscious freely behaving animals blockade of Ca²⁺-dependent vesicular release mechanisms in NTS astrocytes by virally driven expression of a dominant-negative SNARE protein (dnSNARE) increased baroreflex sensitivity by 70% (p < 0.001). This effect of compromised astroglial function was specific to the NTS as expression of dnSNARE in astrocytes of the ventrolateral brainstem had no effect. ATP is considered the principle gliotransmitter and is released by vesicular mechanisms blocked by dnSNARE expression. Consistent with this hypothesis, in anesthetized rats, pharmacological activation of P2Y₁ purinoceptors in the NTS decreased baroreflex gain by 40% (p = 0.031), whereas blockade of P2Y₁ receptors increased baroreflex gain by 57% (p = 0.018). These results suggest that glutamate and 5-HT, released by NTS afferent terminals, trigger Ca²⁺-dependent astroglial release of ATP to modulate baroreflex sensitivity via P2Y₁ receptors. These data add to the growing body of evidence supporting an active role of astrocytes in brain information processing.

SIGNIFICANCE STATEMENT Cardiorespiratory reflexes maintain autonomic balance and ensure cardiovascular health. Impaired baroreflex may contribute to the development of cardiovascular disease and serves as a robust predictor of cardiovascular and all-cause mortality. The data obtained in this study suggest that astrocytes are integral components of the brainstem mechanisms that process afferent information and modulate baroreflex sensitivity via the release of ATP. Any condition associated with higher levels of "ambient" ATP in the NTS would be expected to decrease baroreflex gain by the mechanism described here. As ATP is the primary signaling molecule of glial cells (astrocytes, microglia), responding to metabolic stress and inflammatory stimuli, our study suggests a plausible mechanism of how the central component of the baroreflex is affected in pathological conditions.

Nitric oxide (NO) is an important signaling molecule that fulfills diverse functional roles as a neurotransmitter or diffusible second messenger in the developing and adult CNS. Although the impact of NO on different behaviors such as movement, sleep, learning, and memory has been well documented, the identity of its molecular and cellular targets is still an area of ongoing investigation. Here, we identify a novel role for NO in strengthening inhibitory GABA_A receptor-mediated transmission in molecular layer interneurons of the mouse cerebellum. NO levels are elevated by the activity of neuronal NO synthase (nNOS) following Ca²⁺ entry through extrasynaptic NMDA-type ionotropic glutamate receptors (NMDARs). NO activates protein kinase G with the subsequent production of cGMP, which prompts the stimulation of NADPH oxidase and protein kinase C (PKC). The activation of PKC promotes the selective strengthening of α3-containing GABA_ARs synapses through a GABA receptor-associated protein-dependent mechanism. Given the widespread but cell type-specific expression of the NMDAR/nNOS complex in the mammalian brain, our data suggest that NMDARs may uniquely strengthen inhibitory GABAergic transmission in these cells through a novel NO-mediated pathway.

SIGNIFICANCE STATEMENT Long-term changes in the efficacy of GABAergic transmission is mediated by multiple presynaptic and postsynaptic mechanisms. A prominent pathway involves crosstalk between excitatory and inhibitory synapses whereby Ca²⁺-entering through postsynaptic NMDARs promotes the recruitment and strengthening of GABA_A receptor synapses via Ca²⁺/calmodulin-dependent protein kinase II. Although Ca²⁺ transport by NMDARs is also tightly coupled to nNOS activity and NO production, it has yet to be determined whether this pathway affects inhibitory synapses. Here, we show that activation of NMDARs trigger a NO-dependent pathway that strengthens inhibitory GABAergic synapses of cerebellar molecular layer interneurons. Given the widespread expression of NMDARs and nNOS in the mammalian brain, we speculate that NO control of GABAergic synapse efficacy may be more widespread than has been appreciated.

The severity of this year's bleaching is second only to 2016, during which a third of the reef’s corals died

Hubbard's Sportive Lemurs are nocturnal. This one curiously peeked out of its hollow tree trunk bedroom when we made a bit of noise. We spotted it from a distance at Zombitse National Park in Madagascar.

Alexander von Humboldt was intrigued by deadly electric eels. He was so determined to learn more about them, that in Los Llanos, he’d hold them in his hands to test the strength of their shock.

Police used their conductive energy weapons four times during the arrest of a 31-year-old man who they say was smashing windows with a piece of rebar.

Our ongoing celebration of the Library of Congress National Book Festival continues with young adult and fantasy author Leigh Bardugo discussing "Crooked Kingdom" on the Genre Fiction stage at the 2018 Festival. This post includes prompts for writing and thinking that young readers, families and teachers can use to explore the author and the author’s work—recommended for ages 13+.

The Mississauga Food Bank says a $100,000 donation made earlier this week by New York Knicks rookie RJ Barrett will provide 200,000 meals as part of the community's fight against the COVID-19 pandemic.

Fears that COVID-19 would spread at the Hamilton-Wentworth Detention Centre appear not to have materialized — at least not yet.

No public playground exists in Bar, Montenegro. This year, OM Montenegro plans to build one with the help of an outreach team.

Four volunteers from Switzerland. One empty park. Ten days to build a playground. Could it be done?

170 volunteers from various countries in Central America shared the gospel and saw many lives changed during Easter in Chimaltenango, Guatemala.

Forty-five women from around the world begin their trek on 9 April to Mt. Everest Base Camp and summit of Kala Patthar Peak in Nepal.

IN THE winding lanes of Barcelona’s historic Barri Gòtic it’s no surprise to find a little cheese shop tucked amongst the boutiques and antique shops. What is unexpected though is that this shop, Formageria La Seu, the only one on the Iberian peninsula to feature artisanal cheese from all over Catalonia and Spain, is owned and run by a Scots woman – Katherine McLaughlin.

A Thousand Moons