This paper presents a new open source Python framework for causal discovery from observational data and domain background knowledge, aimed at causal graph and causal mechanism modeling. The cdt package implements an end-to-end approach, recovering the direct dependencies (the skeleton of the causal graph) and the causal relationships between variables. It includes algorithms from the `Bnlearn' and `Pcalg' packages, together with algorithms for pairwise causal discovery such as ANM.

Jonathan R. Bradley, Noel Cressie, Tao Shi.

Source: Statistics Surveys, Volume 10, 100--131.

Abstract:
In this article, we review and compare a number of methods of spatial prediction, where each method is viewed as an algorithm that processes spatial data. To demonstrate the breadth of available choices, we consider both traditional and more-recently-introduced spatial predictors. Specifically, in our exposition we review: traditional stationary kriging, smoothing splines, negative-exponential distance-weighting, fixed rank kriging, modified predictive processes, a stochastic partial differential equation approach, and lattice kriging. This comparison is meant to provide a service to practitioners wishing to decide between spatial predictors. Hence, we provide technical material for the unfamiliar, which includes the definition and motivation for each (deterministic and stochastic) spatial predictor. We use a benchmark dataset of $mathrm{CO}_{2}$ data from NASA’s AIRS instrument to address computational efficiencies that include CPU time and memory usage. Furthermore, the predictive performance of each spatial predictor is assessed empirically using a hold-out subset of the AIRS data.

Increasing number of sectors which affect human lives, are using Machine Learning (ML) tools. Hence the need for understanding their working mechanism and evaluating their fairness in decision-making, are becoming paramount, ushering in the era of Explainable AI (XAI). In this contribution we introduced a few intrinsically interpretable models which are also capable of dealing with missing values, in addition to extracting knowledge from the dataset and about the problem. These models are also capable of visualisation of the classifier and decision boundaries: they are the angle based variants of Learning Vector Quantization. We have demonstrated the algorithms on a synthetic dataset and a real-world one (heart disease dataset from the UCI repository). The newly developed classifiers helped in investigating the complexities of the UCI dataset as a multiclass problem. The performance of the developed classifiers were comparable to those reported in literature for this dataset, with additional value of interpretability, when the dataset was treated as a binary class problem.

Florentina Bunea, Christophe Giraud, Xi Luo, Martin Royer, Nicolas Verzelen.

Source: The Annals of Statistics, Volume 48, Number 1, 111--137.

Abstract:
The problem of variable clustering is that of estimating groups of similar components of a $p$-dimensional vector $X=(X_{1},ldots ,X_{p})$ from $n$ independent copies of $X$. There exists a large number of algorithms that return data-dependent groups of variables, but their interpretation is limited to the algorithm that produced them. An alternative is model-based clustering, in which one begins by defining population level clusters relative to a model that embeds notions of similarity. Algorithms tailored to such models yield estimated clusters with a clear statistical interpretation. We take this view here and introduce the class of $G$-block covariance models as a background model for variable clustering. In such models, two variables in a cluster are deemed similar if they have similar associations will all other variables. This can arise, for instance, when groups of variables are noise corrupted versions of the same latent factor. We quantify the difficulty of clustering data generated from a $G$-block covariance model in terms of cluster proximity, measured with respect to two related, but different, cluster separation metrics. We derive minimax cluster separation thresholds, which are the metric values below which no algorithm can recover the model-defined clusters exactly, and show that they are different for the two metrics. We therefore develop two algorithms, COD and PECOK, tailored to $G$-block covariance models, and study their minimax-optimality with respect to each metric. Of independent interest is the fact that the analysis of the PECOK algorithm, which is based on a corrected convex relaxation of the popular $K$-means algorithm, provides the first statistical analysis of such algorithms for variable clustering. Additionally, we compare our methods with another popular clustering method, spectral clustering. Extensive simulation studies, as well as our data analyses, confirm the applicability of our approach.

And they're on sale for Black Friday. 

The action potential (AP) waveform controls the opening of voltage-gated calcium channels and contributes to the driving force for calcium ion flux that triggers neurotransmission at presynaptic nerve terminals. Although the frog neuromuscular junction (NMJ) has long been a model synapse for the study of neurotransmission, its presynaptic AP waveform has never been directly studied, and thus the AP waveform shape and propagation through this long presynaptic nerve terminal are unknown. Using a fast voltage-sensitive dye, we have imaged the AP waveform from the presynaptic terminal of male and female frog NMJs and shown that the AP is very brief in duration and actively propagated along the entire length of the terminal. Furthermore, based on measured AP waveforms at different regions along the length of the nerve terminal, we show that the terminal is divided into three distinct electrical regions: A beginning region immediately after the last node of Ranvier where the AP is broadest, a middle region with a relatively consistent AP duration, and an end region near the tip of nerve terminal branches where the AP is briefer. We hypothesize that these measured changes in the AP waveform along the length of the motor nerve terminal may explain the proximal-distal gradient in transmitter release previously reported at the frog NMJ.

SIGNIFICANCE STATEMENT The AP waveform plays an essential role in determining the behavior of neurotransmission at the presynaptic terminal. Although the frog NMJ is a model synapse for the study of synaptic transmission, there are many unknowns centered around the shape and propagation of its presynaptic AP waveform. Here, we demonstrate that the presynaptic terminal of the frog NMJ has a very brief AP waveform and that the motor nerve terminal contains three distinct electrical regions. We propose that the changes in the AP waveform as it propagates along the terminal can explain the proximal-distal gradient in transmitter release seen in electrophysiological studies.

Biodiversity for food and agriculture is among the earth’s most important resources. Biodiversity is indispensable: be it the insects that pollinate plants, the microscopic bacteria used for making cheese, the diverse livestock breeds used to make a living in harsh environments, the thousands species of fish, and other aquatic species in our lakes, rivers and oceans, or the thousands of [...]

Aquaponics has become all the trend. The combination of aquaculture, the practice of fish farming, and hydroponics, the cultivation of plants in water without soil, aquaponics is one example of recirculating systems generally called Integrated Aquaculture Agriculture (IAA). Some integrated farms can reduce water consumption by 90% compared to traditional agriculture. This is very good news for the agriculture sector, [...]

Select Andrew Lloyd Webber productions will stream on YouTube for 48 hours at a time

The National Book Award winner's new book delves into matters of family grief and loss

While COVID-19 has us homebound, it’s a good time to reflect on the peculiar histories of housewares we take for granted

In 1799, Alexander von Humboldt set foot in the jungles of Cumana, in present-day Venezuela. What ensued was a detailed scientific mission to learn more about the natural world.

Public Health has recorded no new cases of COVID-19 on Saturday, said a news release from the government. 

Parents-to-be who will have their new child delivered at the Thunder Bay Regional Health Sciences Centre have to follow a different set of guidelines than found at many other hospitals across Ontario.

Buenos Aires, Argentina :: Maintenance crew share Christ's love with local welders helping repair Logos Hope.

In this protocol, DNA fragments are separated according to size by electrophoresis through low-melting-temperature agarose, and then recovered by melting the agarose and extracting with phenol:chloroform. The protocol works best for DNA fragments ranging in size from 0.5 to 5.0 kb. Yields of DNA fragments outside this range are usually lower, but often are sufficient for many purposes.

Open for visitors, these houses model upcycling at its finest

People in Truro, N.S., are reeling after the disappearance of three-year-old Dylan Ehler as the community tries to come to grips with another potential tragedy in the area.

A woman who lost her sister to COVID-19 at the start of the month is thanking the staff at Northwood who took "excellent" care of her in her final days. Jean Harrigan, 90, is being remembered for her caring and lively nature.

1. Salman Khan shoots song titled 'Tere Bina' with Jacqueline Fernandez at his Panvel farmhouse; reveals det  NewsEverything
2. Salman Khan and Jacqueline Fernandez get candid about upcoming song Tere Bina; Watch VIDEO  PINKVILLA
3. Salman Khan’s ladylove Iulia Vantur feels he looks like a “Supermodel” in his latest picture with Niketan  Times of India
4. Iulia Vantur asked when she is marrying Salman Khan, says ‘spending your life with someone’ more important...  Hindustan Times
5. Salman Khan's caravan Being Haangryy provides essentials to needy people of Mumbai  Bollywood Life
6. View Full coverage on Google News

The Last Dance: Ranking every Michael Jordan playoff opponent  NBA IN

Taking mom out for Mother's Day brunch is a tradition for many. But with people staying home and restaurants closed except for delivery or pick-up, this year's Mother's Day will be a little bit different. Food columnist Andrew Coppolino looks at options.

In the middle of a pandemic, who wants to see politicians engage in traditional games of partisan finger pointing and over-the-top attacks?

As British Columbians maintain physical distancing recommendations during the COVID-19 pandemic, this year’s Easter celebrations will have to change. In Kamloops, B.C., organizations are working to make sure Easter is as fun and social as it can be. 

Buenos Aires, Argentina :: Maintenance crew share Christ's love with local welders helping repair Logos Hope.

Blocking federal aid is vile, but it’s also hypocritical.

Apple's Jeff Williams says that supply chains are running well and that the company is optimistic about the future for the economy both for itself and for America as a whole.

AppleInsider has rounded up the best 16-inch MacBook Pro deals going on right now, with coupon savings knocking up to $450 off every single model. Whether you're in the market for a standard config or looking for a loaded Core i9 model, it pays to check out the cash discounts.

Apple's upcoming reopening of some U.S.-based retail locations will be based around guidelines that the company developed for and refined at its open South Korea Apple Store.

Amid one of the worst economic downturns in years, Apple has outperformed most expectations that analysts have placed on it. Just shy of two months into the COVID-19 pandemic, its share price has returned to levels not seen since before the crisis.

An outreach to the north of Madagascar was a new experience not only for those being reached, but for the participants and church as well.

Minister of Employment and Labour Thulas Nxesi said on Thursday afternoon that the Unemployment Insurance Fund was going to be under "very serious strain" and that he foresaw a period where there would be heavy dependence on the state.

Forty-five women from around the world begin their trek on 9 April to Mt. Everest Base Camp and summit of Kala Patthar Peak in Nepal.

London, England, May 5, 2020 / 09:00 am (CNA).- A parish in London’s West End is offering the homeless adoration, access to sacraments, and the rosary -- along with food provided by a five-star restaurant. 

St. Patrick’s Church in Soho, an area known for its nightlife and red-light district, is offering a remarkable ministry to the homeless as the capital struggles to cope with the coronavirus pandemic. 

Pastor Fr. Alexander Sherbrooke said he had “a strong sense that the Holy Spirit is literally building a church on the streets” in response to the crisis. 

When the city began to shut down in mid-March, Westminster City Council turned to Sherbrooke, who has overseen daily outreach to the homeless since he arrived in the parish in 2001.

He told CNA that the council had asked St. Patrick’s to increase its provision of food to the homeless significantly while it tried to house those living on the streets. 

The parish, founded in 1792, had previously fed the homeless in its parish center. But after Catholic churches across the country were ordered to close because of the virus, St. Patrick’s was forced to improvise. It began serving the homeless food on its doorstep twice a day, Monday through Sunday.

“On most days we are providing up to 320 meals,” Sherbrooke explained. “On average, we probably see 220 people a day, some of whom come for both breakfast and dinner.”

Hot food is supplied by the Connaught Hotel, a five-star restaurant in London’s affluent Mayfair district, as well as by Wiltons Restaurant in Jermyn Street. The Pret a Manger chain provides sandwiches. 

“It’s a very sophisticated operation and we fully intend to be diligent in preserving social distancing, personal hygiene, food hygiene, etc,” the priest said. “We have a good number of volunteers. We also continue to provide a shower and lavatory facility.” 

Sherbrooke explained that the homeless in the West End live off the footfall generated by local businesses, restaurants and theaters. 

“There is none of that now,” he said. “It’s amazingly empty and can be quite intimidating, particularly at nighttime.”

”The West End has many who are alcohol and drug dependent and without their normal source of income, this can create a volatile situation. Police are very present, but the West End is very inhospitable, at times threatening and not very pleasant.”

“I’ve been in the parish for some 17 years, throughout which  much of my time has been spent in pastoral care for those who are needy. But nothing has really prepared me for where we are at the moment.”

Volunteers at St. Patrick’s are determined to relieve spiritual as well as physical deprivation. As food is distributed, they pray before the Blessed Sacrament in a nearby adoration tent, while observing social distancing. Sherbrooke is available for visitors seeking a sacramental encounter, sitting at a safe distance and behind a white sheet. There is also a tent offering lectio divina. 

“This enhanced feeding facility has come very much as a response to the request of the local authority,” Sherbrooke said. “We have a long tradition of feeding people happily and well. But in a very strange sort of way, the Church, from being a physical reality behind four walls, is now a reality in the street.”

Sherbrooke, who cites St Damien of Molokai and Mother Teresa as inspirations, continued: “It’s imparting a spiritual, pastoral care, where I have a strong sense that the Holy Spirit is literally building a church on the streets. There’s lectio divina. There’s adoration -- in other words, a prolongation of the Holy Mass -- confession, rosary, etc.”

“We are ministering to the people. We are going to them, speaking to them, giving rosaries and sharing the Gospel. So there is a real work of evangelization going on.”

Volunteers also distribute a sheet each week with reflections, Scripture readings, and advice on how to pray.

“So there’s a kind of catechesis of the poor which is going on,” Sherbrooke said.

“There is a very real sense that in this terrible virus situation that God is creating a very different kind of Church, much more evangelical, and perhaps simpler. All this has happened not through management but I believe through God's providence.”

He noted that despite the present dangers volunteers felt a strong sense of supernatural protection. 

“Personally, I would say that the way that I haven’t caught [the virus] -- given the reality of the situation here -- is that every day I pray that the Precious Blood of Jesus will come into my heart, my veins, my lungs, and protect me from the virus so that I can do this work,” he said. 

In 2011, St. Patrick’s reopened after a £4 million restoration project, which included the excavation of the basement and the creation of the parish center, located beneath the church. Food for the homeless is now prepared there every day.

“It’s almost as though God has crafted this parish for this work at this time,” Sherbrooke said.  

Veracruz, Mexico :: Logos Hope's bookfair receives its seven millionth visitor and celebrates the important milestone.

A long-termer shares how she, as a childless woman, has been given opportunity to speak into local women’s lives in North Africa.

After a week of tensions between government and the indigenous inhabitants, Panamá is on the road to recovery.

Participants from around the world learnt to speak the language of love and laughter during an outreach to the indigenous tribes in Panama.

It’s been a nerve-wracking few years for the traditional auto industry. One Silicon Valley VC firm speculates on its future in an interview with Bloomberg.

Dandelion Cafe

MY mother was known for her pizza but they were never round, not when we were growing up anyway. She would pull them from the ancient coal-fired cast iron range in the living room on long blackened oblong trays, the dough she had spent the day making puffed and undulating but always thin and super chewy.

Calabash African Restaurant

There was a time when I would sit up late in bed, reading novels. As a reviewer, this was often for work, but that didn’t diminish the pleasure of ending the day in another world. Of late, however, I’ve hurried through ordinary books the way you rush the main course in expectation of pudding. The reason? I’ve discovered the joy of gardening catalogues, and of roses in particular. As a result, my evening ritual is extended to include a last look at roses that ramble over walls, or join hand

When Mom, from Cambodia, reassures a sexually-abused girl that God cares, her words are like a healing salve applied to an open wound.

THE SRU would be “very happy” to host the Scottish Cup semi-final between Heart of Midlothian and Hibernian at BT Murrayfield, the governing body’s Chief Operating Officer revealed yesterday.

A SCOTTISH clean energy company has secured a key part in a six-figure contract for a hydrogen fuel project in Northern Ireland.