Engenheiros ficaram chocados ao encontrar a mensagem bem no fundo da parede de um farol no sul da Escócia.

Cate Blanchett intepreta Catherine Ravenscroft, uma famosa jornalista investigativa que recebe anonimamente um romance no qual ela é, indiscutivelmente, a personagem central

“Our domestic tomato industry has been harmed by Mexican producers dumping tomatoes in the U.S. market.”

The post Tomato Suspension Agreement Withdrawal Praised by FL Lawmakers appeared first on Shark Tank.

President Trump and the congress are still light years away from coming to agreeing on funding the border wall, but now it appears as if Homeland Security is a little bit closer to finding the money it needs to secure the southern border. During his 2016 presidential campaign, then-candidate Donald Trump spent a whopping $66.1... Read More

The post President Trump pens $100K check to Homeland Security appeared first on Shark Tank.

An anonymous reader quotes a report from 404 Media: Flock is one of the largest vendors of automated license plate readers (ALPRs) in the country. The company markets itself as having the goal to fully "eliminate crime" with the use of ALPRs and other connected surveillance cameras, a target experts say is impossible. [...] Flock and automated license plate reader cameras owned by other companies are now in thousands of neighborhoods around the country. Many of these systems talk to each other and plug into other surveillance systems, making it possible to track people all over the country. "It went from me seeing 10 license plate readers to probably seeing 50 or 60 in a few days of driving around," [said Alabama resident and developer Will Freeman]. "I wanted to make a record of these things. I thought, 'Can I make a database of these license plate readers?'" And so he made a map, and called it DeFlock. DeFlock runs on Open Street Map, an open source, editable mapping software. He began posting signs for DeFlock (PDF) to the posts holding up Huntsville's ALPR cameras, and made a post about the project to the Huntsville subreddit, which got good attention from people who lived there. People have been plotting not just Flock ALPRs, but all sorts of ALPRs, all over the world. [...] When I first talked to Freeman, DeFlock had a few dozen cameras mapped in Huntsville and a handful mapped in Southern California and in the Seattle suburbs. A week later, as I write this, DeFlock has crowdsourced the locations of thousands of cameras in dozens of cities across the United States and the world. He said so far more than 1,700 cameras have been reported in the United States and more than 5,600 have been reported around the world. He has also begun scraping parts of Flock's website to give people a better idea of where to look to map them. For example, Flock says that Colton, California, a city with just over 50,000 people outside of San Bernardino, has 677 cameras. People who submit cameras to DeFlock have the ability to note the direction that they are pointing in, which can help people understand how these cameras are being positioned and the strategies that companies and police departments are using when deploying them. For example, all of the cameras in downtown Huntsville are pointing away from the downtown core, meaning they are primarily focused on detecting cars that are entering downtown Huntsville from other areas.

Read more of this story at Slashdot.

By Robert Schmad The Department of Health and Human Services (HHS) spends tens of millions of dollars annually on diversity-related expenses, according to a new report from the watchdog group Open The Books. American taxpayers foot a bill of roughly $38.7 million every year to employ 297 staffers conducting diversity, equity and inclusion (DEI) work […]

The post Biden-Harris Health Department Spent Tens Of Millions Annually On DEI appeared first on Liberty Unyielding.

The BBC will lose one of its highest-profile presenters when he stops hosting Match of the Day.

Watch the best plays from week ten in the NFL, featuring an amazing catch by Pittsburgh Steelers wide receiver George Pickens.

The panel of 28 felt it was important to give people choice, but only if they were terminally ill.

Opponents say the legislation, which would apply to close family members, is unconstitutional.

At least 20 children are among the dead in attacks north of Beirut and in northern Gaza, officials rescuers and medics say.

House Minority Leader Kevin McCarthy (R-CA) threatened to introduce a motion on the floor to oust House Speaker Nancy Pelosi (D-CA) as speaker if she attempts to impeach President Trump for “following the constitution” to slow down the Supreme Court confirmation process to fill the vacancy for the late Justice Ruth Bader Ginsburg. “I will […]

The post McCarthy Threatens Motion To Oust Pelosi If She Attempts Impeachment appeared first on Hispolitica.

Pro-Palestinian demonstrators gathered following violence against Israeli football fans earlier in the week.

Ukraine's president says the incursion is limiting the forces Moscow can deploy inside his country.

1. Sensex, Nifty50 decline for 5th straight session; now down over 9% from peak | Stock Market News  Mint
2. Stock Market LIVE Updates: Nifty at 23,700, Sensex tanks 520 pts; auto, metal, realty major drag  Moneycontrol
3. Markets fall, Nifty, Sensex slip nearly 1 per cent: What’s worrying investors at the moment?  The Financial Express
4. Sensex Today | Stock Market LIVE Updates: Sensex off day's low, trades 500 pts lower; Nifty below 23,750;...  The Economic Times
5. Stock market today: Trade setup for Nifty 50 to Q2 results today; five stocks to buy or sell on Wednesday — Nov 13  Mint

Joe Biden’s stupid, corrupt regime can’t even get a simple Veterans Day message right. As the nation came together to celebrate those who served out country, Biden’s Department of Defense pushed out a social media message telling Americans “Veterans Day, honoring all who served.” While, that is a perfectly fine message, the DoD added a […]

The post Biden’s Nitwit Dept. of Defense Uses Photo of Chinese Jet in Veterans Day Message appeared first on The Lid.

Arab and Muslim leaders demanded that Israel withdraw from occupied Palestinian territories as a precondition for regional peace, while denouncing "shocking" Israeli crimes in war-ravaged Gaza.

Teachers can use evidence-based strategies for delivering vocabulary instruction to improve reading comprehension and vice versa by integrating literacy across content areas. These should engage students in active processing, which is essential to student learning and retention.

Morgan Stanley analysts say Tesla will surge if it can expand to be an AI giant, which may be more likely if Elon Musk exerts influence in a second Trump term.

Mauritians are set to find out who will govern their Indian Ocean island nation for the next five years after a hotly disputed election race.

Teacher question: One of my colleagues told us that we should not be teaching guided reading lessons or comprehension skills or strategies. We’re using a core reading program that includes those kinds of things. He says that the science of reading proves that we would get higher reading achievement by teaching more social studies and science (he’s our science teacher) and dropping the comprehension instruction that we are providing. He’s really vocal about this. Can you help us shut him up? Shanahan’s response

Google DeepMind’s AlphaFold 3 is available to access by researchers around the world via open-source. Google DeepMind, the tech giant’s… Continue reading Google DeepMind opens AlphaFold 3 up to researchers worldwide

The post Google DeepMind opens AlphaFold 3 up to researchers worldwide appeared first on ReadWrite.

Google is investing in the development of the next generation of nuclear power, backing a company that’s building small modular reactors and agreeing to purchase energy once the sites start supplying US grids.

A formal disciplinary process, or lack thereof, around the suspensions of two high-ranking officials at the National Student Financial Aid Scheme (NSFAS) has pitted Higher Education and Training Minister Nobuhle Pamela Nkabane against NSFAS administrator Freeman Nomvalo.

I recently switched over to using a vinegar-based spray cleaner (just vinegar, water, and rubbing alcohol), to clean my kitchen. It works wonderfully for me, and I love that by using it I'm saving money and reducing my exposure to harsh chemicals. — Read the rest

The post The science of vinegar: what happens to bacteria under a microscope appeared first on Boing Boing.

The usual talking heads in the media are freaking out and making all kinds of wild claims. Those are the rage-y emotional reactions. What's a more sensible take on all of this?

The post Why Did Trump Win And What Happens Now? appeared first on Clash Daily.

With some of its infrastructure decaying and no premier division club using it, the somewhat abandoned Dobsonville Stadium offered the perfect setting for Sage Stephens to take his first steps as a Bafana Bafana player at the ripe age of 33.

Alexander Kupers and Oscar Randal-Williams
J. Amer. Math. Soc. 38 (), 63-178.
Abstract, references and article information

Junyi Xie
J. Amer. Math. Soc. 38 (), 1-62.
Abstract, references and article information

Network Power in the Asia-Pacific: Making Sense of the New Regionalism and Opportunities for Cooperation 7 February 2020 — 9:45AM TO 5:30PM Anonymous (not verified) 17 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

The Asia-Pacific region continues to increase in geopolitical and geoeconomic importance. The rise of China and tensions with the US are affecting bilateral relationships and traditional alliances in the region. Whether seen from the perspective of the Quad – Australia, India, Japan and the US – or the Indo-Pacific concept embraced by a wide range of countries but with no shared consensus on scope and objectives or with ASEAN who insists on the importance of its own centrality, the region is redefining and reconceptualising itself.

With a diverse range of initiatives – including the Regional Comprehensive Economic Partnership (RCEP) and Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) – there are a plethora of regional agreements and institutional groupings that add further complexity.

As the Bretton Woods architecture continues to be dominated by Western powers, China is also spearheading parallel governance initiatives such as the Asian Infrastructure Investment Bank (AIIB), the Belt and Road Initiative and the Shanghai Cooperation Organization (SCO) as a means of enhancing its geopolitical and geoeconomic influence.

This one-day conference will focus on how such networks and alliances have been built, and sustained, in the Asia-Pacific region. In order to understand how new regional initiatives might open up opportunities for new forms of international cooperation, the conference will focus on the themes of cyber-technology and innovation, sustainable development and mitigating the impacts of climate change and new infrastructure initiatives. It will assess whether there is a zero-sum conflict between competing networks and agendas or whether a common approach can be developed.

Digital politics threatens democracy and must change Expert comment NCapeling 13 January 2023

Violence in Brazil has again brought into focus the need for technology platforms to prioritize social responsibility to help prevent anti-democratic action.

Immediately following the violent storming of Brazil’s congressional building, supreme court, and presidential palace, comparisons to the infamous events of 6 January 2021 in the US came quickly and easily – and with good reason.

Both Donald Trump and Jair Bolsonaro built a fervent – albeit inchoate – political base of grievance which included Christian evangelicals, gun enthusiasts, and the disenfranchised. Both cynically spread doubts about the election victories of their successors without evidence. And it has been claimed both incited their supporters to overturn these results.

But this list of similarities extend beyond mere politics. The attack on democracy in Brazil was recorded, amplified, coordinated, and funded by exactly the same technologies used by the protesters in the US on 6 January.

In Brazil, the main engines of misinformation and insurrection planning were Telegram, Facebook, and WhatsApp, although some election-denying diehards also shifted to Twitter.

Tactical use of social media to mobilize and fundraise

When Bolsonaro was originally elected in 2018, these platforms were already a medium for promoting disinformation, conspiracy, and fear. But in the lead-up to the violence of 8 January, they became a means by which ‘Bolsonaristas’ raised funding for an attack and mobilized supporters to come to Brasilia – advertising the availability of buses and even free food for marchers – using the Festa da Selma hashtag.

To avoid detection by authorities, organizers used a simple switch of the letter ‘v’ to ‘m’ so that Selva, meaning ‘jungle’, became Selma – which means ‘party in the jungle’ to those in the know. But the authorities in the Brasilia state of Distrito Federal appeared to care little about preventing the attack anyway.

Civil society organizations have warned for decades that policies made in a Silicon Valley boardroom fit poorly to the realities of countries such as Brazil, Somalia, or Myanmar. Content moderation is a near-impossible task at the scale demanded by platforms as vast as those operated by big tech, and automated solutions are far from being a silver bullet as they create as many problems as they solve.

Extremism has found an unfettered enabler on mainstream platforms, and an increasingly sprawling network of alternative tech has made such voices resilient to challenge. Platforms such as Gettr, Gab, and Telegram have become go-to platforms for extremist networks when fringe voices find themselves blocked by mainstream platforms.

Telegram has come under significant scrutiny for the role it played in the storming of Congress in Brasilia but any number of tools and platforms – each with millions of users – could have achieved similar results.

The sordid events in Brasilia are just the latest chapter in digital extremism and conspiracy- mongering which often erupts into anti-democratic violence, and should serve as a reminder of the urgent risks of disinformation and the role digital technology plays in inciting, coordinating, fundraising, and amplifying such events.

But the checks on the power of private social media companies are still few and splintered. In Brazil, Supreme Court Justice Alexandre de Moraes, head of the elections tribunal, attempted to crack down on social media, banning users for spreading misinformation in a move which sparked complaints of censorship from Bolsonaro supporters.

Following the elections, Moraes has advocated for greater judicial authority to regulate social media – but the justice is only one person and his impartiality is already being challenged given his aggressive pursuit of Bolsonaro supporters posting inflammatory messages.

And one justice doing it alone only inflames an already volatile situation. Effective regulation of social media requires an independent body vested with multiparty support and operating under clearly-defined rules and authority.

A global movement to find solutions

Brazil is not alone in an increasingly frantic search for checks on digital power as dozens of regulatory regimes are springing up around the world. All are premised on platforms being responsible for their own fiefdoms, but few tackle the threat posed to democracy by unchecked corporate power over digital commons.

Well-intentioned regulation will fall short so long as it is narrowly focused on a never-ending game of ‘content whack-a-mole’ and is hamstrung by powerful voices who see any rules as an attack on freedoms of expression or corporate decision-making.

Democracies are traditionally cautious in managing speech, in separating good information from bad information, or in defining acceptable politics. The steady watering down of the UK’s Online Safety Bill, now so thin on disinformation as to be essentially homeopathic, shows that democratic regulation is willing to go only so far in tackling challenges posed by digital politics.

Dongmei Cheng
Jun 1, 2006; 5:1158-1170
Datasets

Qin Liu
Aug 1, 2007; 6:1299-1317
Research

Sean R. Collins
Mar 1, 2007; 6:439-450
Research

Roland Bruderer
May 1, 2015; 14:1400-1410
Research

Claudio P. Albuquerque
Jul 1, 2008; 7:1389-1396
Research

Mohamad Navab
Sep 1, 2000; 41:1495-1508
Articles

Mohamad Navab
Sep 1, 2000; 41:1481-1494
Articles

S Eisenberg
Oct 1, 1984; 25:1017-1058
Reviews

JM Dietschy
Oct 1, 1993; 34:1637-1659
Reviews

Ronald M. Krauss
Jan 1, 1982; 23:97-104
Articles

Expert

In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on non HIF substrates. To gain insight into the factors underlying different PHD substrates and properties, we carried out biochemical and biophysical studies on PHD homologues from the cellular slime mold, Dictyostelium discoideum, and the protozoan parasite, Toxoplasma gondii, both lacking HIF. The respective prolyl-hydroxylases (DdPhyA and TgPhyA) catalyze prolyl-hydroxylation of S-phase kinase-associated protein 1 (Skp1), a reaction enabling adaptation to different dioxygen availability. Assays with full-length Skp1 substrates reveal substantial differences in the kinetic properties of DdPhyA and TgPhyA, both with respect to each other and compared with human PHD2; consistent with cellular studies, TgPhyA is more active at low dioxygen concentrations than DdPhyA. TgSkp1 is a DdPhyA substrate and DdSkp1 is a TgPhyA substrate. No cross-reactivity was detected between DdPhyA/TgPhyA substrates and human PHD2. The human Skp1 E147P variant is a DdPhyA and TgPhyA substrate, suggesting some retention of ancestral interactions. Crystallographic analysis of DdPhyA enables comparisons with homologues from humans, Trichoplax adhaerens, and prokaryotes, informing on differences in mobile elements involved in substrate binding and catalysis. In DdPhyA, two mobile loops that enclose substrates in the PHDs are conserved, but the C-terminal helix of the PHDs is strikingly absent. The combined results support the proposal that PHD homologues have evolved kinetic and structural features suited to their specific sensing roles.

Rhodopsin is a canonical class A photosensitive G protein–coupled receptor (GPCR), yet relatively few pharmaceutical agents targeting this visual receptor have been identified, in part due to the unique characteristics of its light-sensitive, covalently bound retinal ligands. Rhodopsin becomes activated when light isomerizes 11-cis-retinal into an agonist, all-trans-retinal (ATR), which enables the receptor to activate its G protein. We have previously demonstrated that, despite being covalently bound, ATR can display properties of equilibrium binding, yet how this is accomplished is unknown. Here, we describe a new approach for both identifying compounds that can activate and attenuate rhodopsin and testing the hypothesis that opsin binds retinal in equilibrium. Our method uses opsin-based fluorescent sensors, which directly report the formation of active receptor conformations by detecting the binding of G protein or arrestin fragments that have been fused onto the receptor's C terminus. We show that these biosensors can be used to monitor equilibrium binding of the agonist, ATR, as well as the noncovalent binding of β-ionone, an antagonist for G protein activation. Finally, we use these novel biosensors to observe ATR release from an activated, unlabeled receptor and its subsequent transfer to the sensor in real time. Taken together, these data support the retinal equilibrium binding hypothesis. The approach we describe should prove directly translatable to other GPCRs, providing a new tool for ligand discovery and mutant characterization.

L. Oeding
Trans. Moscow Math. Soc. 83 (), 227-250.
Abstract, references and article information