Children with Lyme and septic arthritis of the knee may present similarly, although septic arthritis requires prompt treatment initiation to avoid joint destruction. Clinicians must make initial management decisions without Lyme serology and bacterial culture results.

Our clinical prediction rule accurately identified patients at low risk for septic arthritis in a Lyme disease–endemic area. In the appropriate clinical context, low-risk patients may be spared invasive testing such as diagnostic arthrocentesis. (Read the full article)

There is wide variation in testing and treatment of children hospitalized with pneumonia. Limited data are available on diagnostic testing patterns and the association of test utilization with disposition outcomes for children with pneumonia evaluated in the emergency department (ED).

Significant variation exists in testing for pediatric pneumonia. EDs that use more testing have higher hospitalization rates. However, ED revisit rates were not significantly different between high- and low-utilizing EDs, suggesting an opportunity to reduce testing without negatively affecting outcomes. (Read the full article)

The diagnosis of urinary tract infection (UTI) is confirmed by urine testing with urinalysis and culture. No study has characterized the use of urine testing in the setting of empirical antibiotic prescription for outpatient UTI in children.

Urine tests are not performed in a substantial percentage of antibiotic-treated pediatric UTIs. Additional research is necessary to determine whether empirical antibiotic prescription for UTI in children without urine testing is safe and effective. (Read the full article)

Herpes encephalitis outside the neonatal period is typically severe and recognizable to clinicians. Excessive testing for herpes encephalitis is associated with increased medical costs and hospital length of stay, and risks patient harm.

Herpes testing and empirical acyclovir treatment in older and less unwell patients has been increasing in US pediatric hospitals over the past decade, which may reflect a more fundamental problem in current approaches to clinical decision-making. (Read the full article)

Several injuries have been suggested to be disproportionately associated with abuse in young children, but rates of abuse among children with these injuries are not currently known.

Abuse is diagnosed commonly in children with sentinel injuries, including the majority of children <24 months with rib fractures. (Read the full article)

National guidelines recommend testing and prophylaxis for chlamydia, gonorrhea, and pregnancy for adolescent sexual assault victims. Little is known about rates of testing and prophylaxis in adolescent victims of sexual assault evaluated in pediatric emergency departments.

There is significant variation in testing and prophylaxis practices in the pediatric emergency department evaluation of adolescent victims of sexual assault. Adolescents cared for in emergency departments with clinical pathways are more likely to receive recommended prophylaxis. (Read the full article)

Teachers must reject the idea that math is like eating vegetables, says former offensive lineman and current mathematician John Urschel.

A Fin24 reader heading into retirement seeks the opinion of an expert on investing during the uncertainty of Covid-19.

Handyman Vincenzo Perugia walked out of the Louvre with a rolled-up painting under his smock. What ensured should be a lesson to us all, says Hannes Viljoen.

David Figlio and Eduwonkette discuss if today's testing and accountability policies accurately depict student performance and the size of the achievement

A 10-year study by a blue-ribbon panel of scientists concludes that high-stakes testing and other accountability measures have largely failed to translate to real improvements in student achievement.

Brain infections with Cryptococcus neoformans are associated with significant morbidity and mortality. Cryptococcosis typically presents as meningoencephalitis or fungal mass lesions called cryptococcomas. Despite frequent in vitro discoveries of promising novel antifungals, the clinical need for drugs that can more efficiently treat these brain infections remains. A crucial step in drug development is the evaluation of in vivo drug efficacy in animal models. This mainly relies on survival studies or post-mortem analyses in large groups of animals, but these techniques only provide information on specific organs of interest at predefined time points. In this proof-of-concept study, we validated the use of non-invasive preclinical imaging to obtain longitudinal information on the therapeutic efficacy of amphotericin B or fluconazole monotherapy in meningoencephalitis and cryptococcoma mouse models. Bioluminescence imaging (BLI) enabled the rapid in vitro and in vivo evaluation of drug efficacy while complementary high-resolution anatomical information obtained by magnetic resonance imaging (MRI) of the brain allowed a precise assessment of the extent of infection and lesion growth rates. We demonstrated a good correlation between both imaging readouts and the fungal burden in various organs. Moreover, we identified potential pitfalls associated with the interpretation of therapeutic efficacy based solely on post-mortem studies, demonstrating the added value of this non-invasive dual imaging approach compared to standard mortality curves or fungal load endpoints. This novel preclinical imaging platform provides insights in the dynamic aspects of the therapeutic response and facilitates a more efficient and accurate translation of promising antifungal compounds from bench to bedside.

Aspergillus niger, the third species responsible for invasive aspergillosis has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However little is yet known among the section Nigri about the species distribution and the antifungal susceptibility pattern of each cryptic species. A total of 112 clinical isolates collected from 5 teaching hospitals in France and phenotypically identified as A. niger were analyzed. Identification to the species level was carried out by nucleotide sequence analysis. The Minimum Inhibitory Concentrations (MICs) of itraconazole, voriconazole, posaconazole, isavuconazole and amphotericin B were determined by both the EUCAST and gradient concentration strips methods. Aspergillus tubingensis (n=51, 45.5%) and A. welwitschiae (n=50, 44.6%) were the most common species while A. niger accounted for only 6.3% (n=7). The MICs of azoles drugs were higher for A. tubingensis than for A. welwitschiae. The MIC of amphotericin B was 2 mg/L or less for all isolates. Importantly, MICs determined by EUCAST showed no correlation with those determined by gradient concentration strips methods, these latter being lower than the former (Spearman's rank correlation tests ranging - depending on the antifungal agent - from 0.01 to 0.25; p>0.4). In conclusion, A. niger should be considered as a minority species in the section Nigri. The differences in MICs between species for different azoles underline the importance of accurate identification. Significant divergences in the determination of MIC between EUCAST and gradient concentration strips methods require further investigation.

On Tuesday, Avast responded to a PCMag-Motherboard investigation into the company's browser history collection practices, saying it was entirely legal. Avast users should expect to see a prompt from the antivirus products, asking them to consent to the data harvesting.

'As CEO of Avast, I feel personally responsible and I would like to apologize to all concerned,' wrote Ondrej Vlcek following a PCMag-Motherboard investigation into the privacy risks around the data harvesting.

Malware on an air-gapped computer can transmit data like Morse code by changing screen brightness in a way that's invisible to the naked eye but easily recorded with a camera.

BACKGROUND AND OBJECTIVES:

Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Our objective was to determine the prevalence of completed HIV testing among adolescents with incident STIs and identify patient and health care factors associated with HIV testing.

Web Hosting Hub offers excellent customer support and strong shared and WordPress hosting, but it lacks the advanced hosting options that many growing businesses will eventually need.

HostGator is an excellent web hosting service that's simple to use and offers an array of useful plans for consumers and small businesses. It's our top pick for shared web hosting and for novice webmasters in general.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

Africa can be a challenging place to do business and property investment is not exempt from some, often unique, challenges, says a Nedbank expert.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

When the novel coronavirus pandemic prompted the transition to remote learning at Penn State, faculty and administrators in the Department of Mechanical Engineering were prepared for the challenge.

While we wait for Apple Arcade to launch for iOS devices, Google is preparing its own app/game subscription service for Android called Play Pass.

Online learning holds great potential to transform rural education by ensuring that every student has access to great instruction.

Web hosting doesn't need to be expensive. In fact, it can be extremely low cost. If you want solid hosting that won't drain your bank account, these are the 10 best cheap web hosting services that we've reviewed.

Penn State Behrend faculty member Michael Campbell has been named distinguished professor of biology. Campbell, who joined the college in 1994, also directs the Lake Erie Regional Grape Research and Extension Center.

Since learning is so nuanced, so too should be the means in which we assess it. Let's offer students the opportunity to be seen as whole people who can demonstrate different skills and knowledge in a plethora of ways over a period of time.

The PARCC and Smarter Balanced assessments have evolved since they were launched in 2015. Here's a guide to understanding them now.

As civic education undergoes a renaissance in schools, educators are looking beyond standardized tests to determine whether the lessons empower students to embrace civic behaviors, like voting or volunteering.

The collection and use of data about just how prepared individual children are to enter kindergarten can be a ticklish proposition.

Within three weeks, a pandemic has completely changed the national landscape on testing. The U.S. Department of Education has now excused all 50 states and the District of Columbia from the requirement that they test all their students in math and English/language arts.

For their longstanding support of the Center for the Performing Arts and the Penn State community, Deb and Stan Latta have been named the center’s 2020 Distinguished Service Award recipients.

Westinghouse's 32-Inch Ultra HD Home/Office Monitor has some color-accuracy shortfalls and a limited feature set, but it does get you a large-screen 4K display at an affordable price.

Cloudways leverages powerful servers to deliver affordable, powerful, and easy-to-set-up web hosting. It doesn't offer domain registration or email, however.

Web hosting service Domain.com gives you many tools for setting up an entry-level online destination, but it lacks the advanced tiers of hosting growing sites will likely want.

The Scottish Government’s testing strategy during the coronavirus pandemic is to be investigated by the Health and Sport Committee.

UEFA has received declarations of interest from nine associations to host the UEFA Super Cup in 2020.

The UEFA Executive Committee will select the hosts of the 2021 club competition finals in 2019

For Roberto Ramirez, serving God in missions has been one step of faith after another.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

In a sprawling but nuanced examination, comedian John Oliver explained why the U.S. standardized testing system exists and the harms it creates.

Both the House and Senate ESEA bills keep annual tests, but they go very different ways on a lot of other assessment issues.

The Democratic presidential candidate likes to highlight his vote against the No Child Left Behind Act in 2001, although his record on the issue of high-stakes standardized testing isn't black and white.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

We've done the testing, and if you need to build an SMB-focused website, these are the best small business web hosting services for helping you get the job done.