con Connecticut Foundation for Dental Outreach postpones Mission of Mercy dental clinic amid coronavirus concerns By www.ada.org Published On :: Tue, 10 Mar 2020 15:36:00 -0500 The Connecticut Foundation for Dental Outreach has postponed the Connecticut Mission of Mercy Free Dental Clinic scheduled for March 20-21 in Danbury, Connecticut, "out of abundant caution" amid the coronavirus disease outbreak. Full Article
con ADA to Congress: Include dentists, patients in coronavirus legislation By www.ada.org Published On :: Fri, 13 Mar 2020 12:44:00 -0500 The American Dental Association is urging Congress to include oral health care providers and their patients in any legislation proposed to confront the coronavirus disease outbreak. Full Article
con ADA lobbies Congress’ coronavirus legislative package By www.ada.org Published On :: Tue, 17 Mar 2020 15:17:00 -0500 As Congress works on legislation in response to the coronavirus disease outbreak, the ADA is working to ensure that those bills include provisions that are beneficial to dentists — particularly dental practice owners — and their patients. Full Article
con Association provides coronavirus infection control resources for dentists By www.ada.org Published On :: Thu, 19 Mar 2020 09:43:00 -0500 The ADA is sharing with members the CDC guidelines on the use of personal protective equipment on its website dedicated to COVID-19. Full Article
con Infection control webinar from ADA, OSAP available late March 20 By www.ada.org Published On :: Thu, 19 Mar 2020 11:20:00 -0500 On March 20, the ADA will release an on-demand webinar offering answers to frequently asked questions about infection control protocol and procedures related to COVID-19. Full Article
con ADA urges Congress to increase relief for small businesses, dentist owners By www.ada.org Published On :: Thu, 19 Mar 2020 14:51:00 -0500 As Congress works on a third legislation package in response to the coronavirus pandemic, the ADA is asking lawmakers to include provisions on how to assist dental practices and other small businesses facing economic burdens. Full Article
con ADA, other organizations outline economic response needs to survive pandemic By www.ada.org Published On :: Fri, 20 Mar 2020 11:16:00 -0500 The ADA and nearly 100 other organizations are asking Congress and the White House to help businesses survive the coronavirus crisis by reducing their costs and increasing their cash flow as much as possible in the coming weeks. Full Article
con ADA infection control webinar live By www.ada.org Published On :: Fri, 20 Mar 2020 14:59:00 -0500 The ADA posted an on-demand webinar March 20 offering answers to frequently asked questions about infection control in the midst of the COVID-19 pandemic. Full Article
con ADA lobbies Congress on CARES Act By www.ada.org Published On :: Fri, 20 Mar 2020 16:22:00 -0500 The ADA on March 20 sent out a Legislative Issues Alert to dentists, assuring them that the Association continues to lobby on their behalf in response to the Coronavirus Aid, Relief and Economic Security Act. Full Article
con How dentists can keep the lights on during economic downturn By www.ada.org Published On :: Tue, 24 Mar 2020 09:33:00 -0500 The ADA is streaming a free practice management webinar March 25 designed to help dentists predict short- and long-term impacts on their business operations during tough economic times and teach them how taking the right steps now can minimize their risk during the COVID-19 outbreak and its aftermath. Full Article
con April JADA compares zirconia-ceramic fixed dental prostheses with metal-ceramic By www.ada.org Published On :: Wed, 25 Mar 2020 13:08:00 -0500 Posterior multiunit zirconia-ceramic restorations are slightly more susceptible to chipping of the veneering ceramic than metal-ceramic restorations, but they are considered a reliable treatment in the medium term, according to a systematic review and meta-analysis published in the April issue of The Journal of the American Dental Association. Full Article
con FDI World Dental Congress canceled By www.ada.org Published On :: Thu, 26 Mar 2020 15:41:00 -0500 This year’s FDI World Dental Congress, scheduled for September in Shanghai, China, is canceled due to the global COVID-19 outbreak, according to a March 26 news release. Full Article
con Harvard dental student recipient of health literacy essay contest By www.ada.org Published On :: Thu, 02 Apr 2020 10:49:00 -0500 An essay on community water fluoridation yielded a Harvard University dental student a first-place win in the annual American Dental Association’s Health Literacy in Dentistry essay contest. Full Article
con Small Business Administration: Dentists can apply for both economic injury disaster and paycheck protection program loans By www.ada.org Published On :: Mon, 06 Apr 2020 13:28:00 -0500 Dentists can apply for both Economic Injury Disaster Loans and Paycheck Protection Program 7(a) loans, the Small Business Administration told the American Dental Association on April 6. Full Article
con Researcher remembered for contributions to dentistry succumbs to COVID-19 complications By www.ada.org Published On :: Fri, 10 Apr 2020 10:11:00 -0500 Dr. Leo M. Sreebny, Ph.D., who had a long and distinguished career in academia as a professor of dentistry and researcher, particularly in issues related to saliva and dry mouth, died April 5 from complications of COVID-19 at age 98. Full Article
con Second week of HPI polling shows dentists’ response to COVID-19 By www.ada.org Published On :: Fri, 10 Apr 2020 12:32:00 -0500 The second round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices showed significant financial impact, with collections for the vast majority of dentists less than 5% of what is typical in their practice. Full Article
con ADA asks Congress to increase funding, extend dates for Small Business Administration loans By www.ada.org Published On :: Mon, 13 Apr 2020 14:08:00 -0500 The ADA is urging Congress to continue supporting small businesses during the COVID-19 pandemic by increasing funding and streamlining the application process for Small Business Administration loans. Full Article
con ADA asks Congress to ensure appropriate PPE for all health care workers By www.ada.org Published On :: Tue, 14 Apr 2020 12:32:00 -0500 The ADA is calling on Congress to help ensure there is appropriate personal protective equipment available to all health care providers — including dentists — who continue to provide emergency care during the COVID-19 pandemic. Full Article
con SBA changes grant computation for Economic Injury Disaster Loans By www.ada.org Published On :: Wed, 15 Apr 2020 17:34:00 -0500 The ADA has received updated information from the Small Business Administration regarding grant advances on Economic Injury Disaster Loans during the COVID-19 pandemic. Full Article
con SBA announces funding no longer available for Economic Injury Disaster Loans, Paycheck Protection Program By www.ada.org Published On :: Thu, 16 Apr 2020 18:59:00 -0500 The Small Business Administration said that as of April 16, the agency is unable to accept any new applications for the Paycheck Protection Program or the Economic Injury Disaster Loans due to a lack of funding. Full Article
con ADA antibiotics guideline authors to discuss C. diff infections in dentistry during Peggy Lillis Foundation conference By www.ada.org Published On :: Fri, 17 Apr 2020 13:55:00 -0500 Two of the authors of the American Dental Association's antibiotics guideline will discuss C. diff infections and antibiotic stewardship in dentistry April 21 as part of a free, online conference organized by the Peggy Lillis Foundation. Full Article
con Wisconsin dentists donate personal protective equipment amid COVID-19 pandemic By www.ada.org Published On :: Fri, 17 Apr 2020 15:43:00 -0500 Wisconsin dentists have answered the call for personal protective equipment by organizing drives and donating their surplus supplies to hospitals and urgent care facilities treating patients with COVID-19. Full Article
con ADA offers interim guidance as some states consider reopening By www.ada.org Published On :: Sat, 18 Apr 2020 21:30:00 -0500 “To aid dentists who may be reopening their practices when state mandates are lifted,” the ADA issued an updated statement and interim guidance April 18 on the personal protective equipment recommended in order to practice during this pandemic and minimize the risk of virus transmission. Full Article
con ADA advocates that third-party payers modify fee schedules as dentists consider going back to work By www.ada.org Published On :: Thu, 23 Apr 2020 14:19:00 -0500 The ADA is urging third-party payers to alter their fees to account for the increasing cost of personal protective equipment that dentists are using to protect themselves, their staff and patients. Full Article
con Arizona Dental Association hosts one of the largest virtual dental conferences to date By www.ada.org Published On :: Fri, 24 Apr 2020 14:23:00 -0500 Scottsdale, Ariz. — In February, the Arizona Dental Association was fully prepared to host the Western Regional Dental Experience April 2-4 at the Renaissance Phoenix Glendale Hotel and Spa. Full Article
con Dental materials research 'icon' who developed Bis-GMA resin dies By www.ada.org Published On :: Thu, 30 Apr 2020 22:59:00 -0500 Dr. Rafael "Ray" Bowen, who made significant contributions to dental materials research and retired in 2018 after 62 years at the American Dental Association, has died. Full Article
con ADA asks Congress to help dental community in next COVID-19 legislation By www.ada.org Published On :: Tue, 05 May 2020 12:37:00 -0500 As Congress works on the next COVID-19 relief package, the ADA is asking lawmakers to include a number of provisions to assist the dental profession in recovery efforts. Full Article
con Organized dentistry asks Congress for flexibility in Paycheck Protection Program loans By www.ada.org Published On :: Wed, 06 May 2020 15:46:00 -0500 The Organized Dentistry Coalition is asking Congress for flexibility in the Paycheck Protection Program to allow dentists to purchase personal protective equipment as states begin the reopening phase of the COVID-19 pandemic. Full Article
con HPI releases webinar on economic impact of COVID-19 By www.ada.org Published On :: Thu, 07 May 2020 11:59:00 -0500 The ADA Health Policy Institute held a webinar April 29 with leading experts from across the dental industry to discuss how COVID-19 has affected the dental economy and what they think the future will bring. Full Article
con Oil prices ease on renewed concern about a weaker economy By www.upi.com Published On :: Mon, 14 Jan 2019 09:09:34 -0500 Crude oil prices fell Monday amid renewed concerns about potentially declining crude oil demand resulting from weaker economic outlook. Full Article
con Venezuelan crude production continued to decline in December By www.upi.com Published On :: Thu, 17 Jan 2019 10:55:05 -0500 Venezuelan crude oil production continued its steady decline and hit a new low in December with just 1.15 million barrels per day produced. Full Article
con Oil rises after report on possible China talks concessions By www.upi.com Published On :: Fri, 18 Jan 2019 09:11:06 -0500 Oil prices rose early Friday trailing equity gains late Thursday that followed a report about possible concessions ahead in U.S. trade talks with China. Full Article
con Crude oil prices rise amid renewed Venezuela concerns By www.upi.com Published On :: Tue, 29 Jan 2019 09:39:09 -0500 Oil prices were higher early Tuesday amid renewed concern about Venezuelan supplies but market worries about China-U.S. trade issues prevented higher gains. Full Article
con Oil prices rise amid ongoing concern about Venezuela By www.upi.com Published On :: Wed, 30 Jan 2019 09:12:39 -0500 Oil prices rose Wednesday amid expectations that Venezuelan oil shipments would see some disruption following U.S. sanctions. Full Article
con Crude oil prices rise early Friday amid supply concerns By www.upi.com Published On :: Fri, 01 Feb 2019 10:59:28 -0500 Oil prices rose early Friday amid supply concerns following reports of smaller-than-expected stocks, and amid reduced expectation of interest rate hikes. Full Article
con BP to be more transparent about climate efforts amid investor concerns By www.upi.com Published On :: Fri, 01 Feb 2019 12:04:14 -0500 BP on Friday announced plans to increase disclosure on its efforts to fight climate change after requests from two groups of investors. Full Article
con Arctic bird turns down immune system to conserve energy in winter By www.upi.com Published On :: Tue, 28 Apr 2020 16:32:40 -0400 To survive the Arctic's frigid temperatures, animals must use their energy efficiently. According to a new study, one Arctic bird species, the Svalbard rock ptarmigan, utilizes a previously unknown energy-saving method. Full Article
con Analysis suggests states need to plan for second wave of COVID-19 By www.upi.com Published On :: Fri, 01 May 2020 18:17:11 -0400 Leaders across the United States should plan for a worst-case scenario, second wave to the COVID-19 pandemic, including no vaccine availability or herd immunity, say experts at the University of Minnesota. Full Article
con Researchers discover microbe that could control spread of malaria By www.upi.com Published On :: Mon, 04 May 2020 12:16:19 -0400 A microbe found in mosquitoes that appears to block malaria could be used to control spread of the disease in humans, according to researchers in Kenya and Britain. Full Article
con 15-minute COVID-19 test proves accurate at confirming infection By www.upi.com Published On :: Fri, 08 May 2020 17:19:00 -0400 A new, point-of-care testing kit for COVID-19 that can deliver results in 15 minutes accurately diagnoses people more than 80 percent of time, an analysis has found. Full Article
con The Association of Lipoprotein(a) Plasma Levels With Prevalence of Cardiovascular Disease and Metabolic Control Status in Patients With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-02-04T06:30:22-08:00 OBJECTIVETo investigate the association of the cardiovascular risk factor lipoprotein (Lp)(a) and vascular complications in patients with type 1 diabetes.RESEARCH DESIGN AND METHODSPatients with type 1 diabetes receiving regular care were recruited in this observational cross-sectional study and divided into four groups according to their Lp(a) levels in nmol/L (very low <10, low 10–30, intermediate 30–120, high >120). Prevalence of vascular complications was compared between the groups. In addition, the association between metabolic control, measured as HbA1c, and Lp(a) was studied.RESULTSThe patients (n = 1,860) had a median age of 48 years, diabetes duration of 25 years, and HbA1c of 7.8% (61 mmol/mol). The median Lp(a) was 19 (interquartile range 10–71) nmol/L. No significant differences between men and women were observed, but Lp(a) levels increased with increasing age. Patients in the high Lp(a) group had higher prevalence of complications than patients in the very low Lp(a) group. The age- and smoking-status–adjusted relative risk ratio of having any macrovascular disease was 1.51 (95% CI 1.01–2.28, P = 0.048); coronary heart disease, 1.70 (95% CI 0.97–3.00, P = 0.063); albuminuria, 1.68 (95% CI 1.12–2.50, P = 0.01); and calcified aortic valve disease, 2.03 (95% CI 1.03–4.03; P = 0.042). Patients with good metabolic control, HbA1c <6.9% (<52 mmol/mol), had significantly lower Lp(a) levels than patients with poorer metabolic control, HbA1c >6.9% (>52 mmol/mol).CONCLUSIONSLp(a) is a significant risk factor for macrovascular disease, albuminuria, and calcified aortic valve disease in patients with type 1 diabetes. Poor metabolic control in patients with type 1 diabetes is associated with increased Lp(a) levels. Full Article
con The Effects of Intensive Glycemic Control on Clinical Outcomes Among Patients With Type 2 Diabetes With Different Levels of Cardiovascular Risk and Hemoglobin A1c in the ADVANCE Trial By care.diabetesjournals.org Published On :: 2020-03-19T15:14:52-07:00 OBJECTIVETo study whether the effects of intensive glycemic control on major vascular outcomes (a composite of major macrovascular and major microvascular events), all-cause mortality, and severe hypoglycemia events differ among participants with different levels of 10-year risk of atherosclerotic cardiovascular disease (ASCVD) and hemoglobin A1c (HbA1c) at baseline.RESEARCH DESIGN AND METHODSWe studied the effects of more intensive glycemic control in 11,071 patients with type 2 diabetes (T2D), without missing values, in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, using Cox models.RESULTSDuring 5 years’ follow-up, intensive glycemic control reduced major vascular events (hazard ratio [HR] 0.90 [95% CI 0.83–0.98]), with the major driver being a reduction in the development of macroalbuminuria. There was no evidence of differences in the effect, regardless of baseline ASCVD risk or HbA1c level (P for interaction = 0.29 and 0.94, respectively). Similarly, the beneficial effects of intensive glycemic control on all-cause mortality were not significantly different across baseline ASCVD risk (P = 0.15) or HbA1c levels (P = 0.87). The risks of severe hypoglycemic events were higher in the intensive glycemic control group compared with the standard glycemic control group (HR 1.85 [1.41–2.42]), with no significant heterogeneity across subgroups defined by ASCVD risk or HbA1c at baseline (P = 0.09 and 0.18, respectively).CONCLUSIONSThe major benefits for patients with T2D in ADVANCE did not substantially differ across levels of baseline ASCVD risk and HbA1c. Full Article
con Continuous Glucose Monitoring in Pregnancy: Importance of Analysing Temporal Profiles to Understand Clinical Outcomes By care.diabetesjournals.org Published On :: 2020-03-24T15:44:44-07:00 OBJECTIVETo determine if temporal glucose profiles differed between 1) women who were randomized to real-time continuous glucose monitoring (RT-CGM) or self-monitored blood glucose (SMBG), 2) women who used insulin pumps or multiple daily insulin injections (MDIs), and 3) women whose infants were born large for gestational age (LGA) or not, by assessing CGM data obtained from the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT).RESEARCH DESIGN AND METHODSStandard summary metrics and functional data analysis (FDA) were applied to CGM data from the CONCEPTT trial (RT-CGM, n = 100; SMBG, n = 100) taken at baseline and at 24- and 34-weeks gestation. Multivariable regression analysis determined if temporal differences in 24-h glucose profiles occurred between comparators in each of the three groups.RESULTSFDA revealed that women using RT-CGM had significantly lower glucose (0.4–0.8 mmol/L [7–14 mg/dL]) for 7 h/day (0800 h–1200 h and 1600 h–1900 h) compared with those with SMBG. Women using pumps had significantly higher glucose (0.4–0.9 mmol/L [7–16 mg/dL]) for 12 h/day (0300 h to 0600 h, 1300 h to 1800 h, and 2030 h to 0030 h) at 24 weeks with no difference at 34 weeks compared with MDI. Women who had an LGA infant ran a significantly higher glucose by 0.4–0.7 mmol/L (7–13 mg/dL) for 4.5 h/day at baseline; by 0.4–0.9 mmol/L (7–16 mg/dL) for 16 h/day at 24 weeks; and by 0.4–0.7 mmol/L (7–13 mg/dL) for 14 h/day at 34 weeks.CONCLUSIONSFDA of temporal glucose profiles gives important information about differences in glucose control and its timing, which are undetectable by standard summary metrics. Women using RT-CGM were able to achieve better daytime glucose control, reducing fetal exposure to maternal glucose. Full Article
con Erratum. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care 2020;43:607-615 By care.diabetesjournals.org Published On :: 2020-04-03T07:56:03-07:00 Full Article
con Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).RESEARCH DESIGN AND METHODSIn this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.RESULTSChange in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.CONCLUSIONSThis phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs. Full Article
con microRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia By care.diabetesjournals.org Published On :: 2020-05-01T07:23:01-07:00 OBJECTIVEIn patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.RESEARCH DESIGN AND METHODSThe association between CD34+ cell migration and cardiovascular mortality was reassessed at 6 years after revascularization. In a new series of T2D-CLI and control subjects, immuno-sorted bone marrow CD34+ cells were profiled for miRNA expression and assessed for apoptosis and angiogenesis activity. The differentially regulated miRNA-21 and its proapoptotic target, PDCD4, were titrated to verify their contribution in transferring damaging signals from CD34+ cells to endothelial cells.RESULTSMultivariable regression analysis confirmed that CD34+ cell migration forecasts long-term cardiovascular mortality. CD34+ cells from T2D-CLI patients were more apoptotic and less proangiogenic than control subjects and featured miRNA-21 downregulation, modulation of several long noncoding RNAs acting as miRNA-21 sponges, and upregulation of the miRNA-21 proapoptotic target PDCD4. Silencing miR-21 in control subject CD34+ cells phenocopied the T2D-CLI cell behavior. In coculture, T2D-CLI CD34+ cells imprinted naïve endothelial cells, increasing apoptosis, reducing network formation, and modulating the TUG1 sponge/miRNA-21/PDCD4 axis. Silencing PDCD4 or scavenging reactive oxygen species protected endothelial cells from the negative influence of T2D-CLI CD34+ cells.CONCLUSIONSMigration of CD34+ cells predicts long-term cardiovascular mortality in T2D-CLI patients. An altered paracrine signaling conveys antiangiogenic and proapoptotic features from CD34+ cells to the endothelium. This damaging interaction may increase the risk for life-threatening complications. Full Article
con Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease By care.diabetesjournals.org Published On :: 2020-05-07T07:52:43-07:00 OBJECTIVEDespite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA.RESEARCH DESIGN AND METHODSBlood, medical history, and personal data were collected in a substudy of 888 participants in the Sleep Apnea Cardiovascular End Points (SAVE) trial in which patients with OSA and stable CVD were randomized to receive CPAP plus usual care, or usual care alone. Serum glucose and glycated hemoglobin A1c (HbA1c) were measured at baseline, 6 months, and 2 and 4 years and incident diabetes diagnoses recorded.RESULTSMedian follow-up was 4.3 years. In those with preexisting diabetes (n = 274), there was no significant difference between the CPAP and usual care groups in serum glucose, HbA1c, or antidiabetic medications during follow-up. There were also no significant between-group differences in participants with prediabetes (n = 452) or in new diagnoses of diabetes. Interaction testing suggested that women with diabetes did poorly in the usual care group, while their counterparts on CPAP therapy remained stable.CONCLUSIONSAmong patients with established CVD and OSA, we found no evidence that CPAP therapy over several years affects glycemic control in those with diabetes or prediabetes or diabetes risk over standard-of-care treatment. The potential differential effect according to sex deserves further investigation. Full Article
con A Randomized Controlled Trial Comparing Glargine U300 and Glargine U100 for the Inpatient Management of Medicine and Surgery Patients With Type 2 Diabetes: Glargine U300 Hospital Trial By care.diabetesjournals.org Published On :: 2020-05-07T08:41:18-07:00 OBJECTIVEThe role of U300 glargine insulin for the inpatient management of type 2 diabetes (T2D) has not been determined. We compared the safety and efficacy of glargine U300 versus glargine U100 in noncritically ill patients with T2D.RESEARCH DESIGN AND METHODSThis prospective, open-label, randomized clinical trial included 176 patients with poorly controlled T2D (admission blood glucose [BG] 228 ± 82 mg/dL and HbA1c 9.5 ± 2.2%), treated with oral agents or insulin before admission. Patients were treated with a basal-bolus regimen with glargine U300 (n = 92) or glargine U100 (n = 84) and glulisine before meals. We adjusted insulin daily to a target BG of 70–180 mg/dL. The primary end point was noninferiority in the mean difference in daily BG between groups. The major safety outcome was the occurrence of hypoglycemia.RESULTSThere were no differences between glargine U300 and U100 in mean daily BG (186 ± 40 vs. 184 ± 46 mg/dL, P = 0.62), percentage of readings within target BG of 70–180 mg/dL (50 ± 27% vs. 55 ± 29%, P = 0.3), length of stay (median [IQR] 6.0 [4.0, 8.0] vs. 4.0 [3.0, 7.0] days, P = 0.06), hospital complications (6.5% vs. 11%, P = 0.42), or insulin total daily dose (0.43 ± 0.21 vs. 0.42 ± 0.20 units/kg/day, P = 0.74). There were no differences in the proportion of patients with BG <70 mg/dL (8.7% vs. 9.5%, P > 0.99), but glargine U300 resulted in significantly lower rates of clinically significant hypoglycemia (<54 mg/dL) compared with glargine U100 (0% vs. 6.0%, P = 0.023).CONCLUSIONSHospital treatment with glargine U300 resulted in similar glycemic control compared with glargine U100 and may be associated with a lower incidence of clinically significant hypoglycemia. Full Article
con Labor Dept.: U.S. economy lost 20.5M jobs in April, unemployment near 15% By www.upi.com Published On :: Fri, 08 May 2020 08:33:06 -0400 The United States economy shed more than 20 million jobs last month, the greatest month-to-month decline in history, the Labor Department said Friday in its monthly employment analysis. Full Article
con Gujarat university, second MBBS examination, forensic medicine question papers, January 2015 By resources.medipacademy.com Published On :: 11 March 2015 11:02:28 Gujarat university, second MBBS examination, forensic medicine question papers, January 2015 Full Article