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The Weekend Effect - what's (un)knowable, and what next?

We do we know about the weekend effect? As Martin McKee puts it in an editorial on thebmj.com, "almost nothing is clear in this tangled tale" In this roundtable, Navjoyt Ladher, Analysis editor for The BMJ is joined by some of the key academics who have published research and commented on the weekend effect to make sense of what we know and...




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This week’s shutterbugs




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This week’s shutterbugs




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This week’s Shutterbugs




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Covid-19: GPs have a fortnight to start organising weekly care home reviews, says NHS




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Weekend live sports include UFC 249, 14 baseball games in Asia

UFC 249 will be sandwiched between 14 live baseball broadcasts out of South Korea and Taiwan this weekend for American sports fans to watch as they wait for major sports leagues to return.




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Japan offers weekend's only top-level event as horse racing struggles to resume

Coronavirus brings worldwide horse racing almost to a halt, with only one Grade 1 event on the weekend schedule, but rays of hope exist.




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Empagliflozin as Add-On to Metformin in Patients With Type 2 Diabetes: A 24-Week, Randomized, Double-Blind, Placebo-Controlled Trial

Hans-Ulrich Häring
Jun 1, 2014; 37:1650-1659
Emerging Technologies and Therapeutics




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Sodium-Glucose Cotransporter 2 Inhibition and Glycemic Control in Type 1 Diabetes: Results of an 8-Week Open-Label Proof-of-Concept Trial

Bruce A. Perkins
May 1, 2014; 37:1480-1483
Novel Communications in Diabetes




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Dental Assistants Recognition Week set for March 1-7

The ADA Council on Dental Practice is encouraging dentists to acknowledge the dedication and contributions of their dental assistants during Dental Assistants Recognition Week.




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Second week of HPI polling shows dentists’ response to COVID-19

The second round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices showed significant financial impact, with collections for the vast majority of dentists less than 5% of what is typical in their practice.




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U.S. fuel pumps see first weekly price rise since October

Fuel prices in the United States on average were just a penny higher at $2.25 per gallon, ending consecutive price declines that had occurred since October.




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What to stream this weekend: 'SNL' season finale, 'Dead to Me' S2

The "Saturday Night Live" Season 45 finale, the Season 2 premiere of Netflix's "Dead to Me" and a second installment of "Disney Family Singalong" are just some of the entertainment options available this weekend.




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Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial

OBJECTIVE

To evaluate the impact of once-weekly exenatide (EQW) on microvascular and cardiovascular (CV) outcomes by baseline renal function in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

RESEARCH DESIGN AND METHODS

Least squares mean difference (LSMD) in estimated glomerular filtration rate (eGFR) from baseline between the EQW and placebo groups was calculated for 13,844 participants. Cox regression models were used to estimate effects by group on incident macroalbuminuria, retinopathy, and major adverse CV events (MACE). Interval-censored time-to-event models estimated effects on renal composite 1 (40% eGFR decline, renal replacement, or renal death) and renal composite 2 (composite 1 variables plus macroalbuminuria).

RESULTS

EQW did not change eGFR significantly (LSMD 0.21 mL/min/1.73 m2 [95% CI –0.27 to 0.70]). Macroalbuminuria occurred in 2.2% of patients in the EQW group and in 2.5% of those in the placebo group (hazard ratio [HR] 0.87 [95% CI 0.70–1.07]). Neither renal composite was reduced with EQW in unadjusted analyses, but renal composite 2 was reduced after adjustment (HR 0.85 [95% CI 0.74–0.98]). Retinopathy rates did not differ by treatment group or in the HbA1c-lowering or prior retinopathy subgroups. CV outcomes in those with eGFR <60 mL/min/1.73 m2 did not differ by group. Those with eGFR ≥60 mL/min/1.73 m2 had nominal risk reductions for MACE, all-cause mortality, and CV death, but interactions by renal function group were significant for only stroke (HR 0.74 [95% CI 0.58–0.93]; P for interaction = 0.035) and CV death (HR 1.08 [95% CI 0.85–1.38]; P for interaction = 0.031).

CONCLUSIONS

EQW had no impact on unadjusted retinopathy or renal outcomes. CV risk was modestly reduced only in those with eGFR ≥60 mL/min/1.73 m2 in analyses unadjusted for multiplicity.




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Application of Adult-Learning Principles to Patient Instructions: A Usability Study for an Exenatide Once-Weekly Injection Device

Gayle Lorenzi
Sep 1, 2010; 28:157-162
Bridges to Excellence




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Talking Across Divides And Quashing Conspiracy Theories: The Week’s Best Psychology Links

Our weekly round-up of the best psychology coverage from elsewhere on the web




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Publication Bias And Lockdown Memories: The Week’s Best Psychology Links

Our weekly round-up of the best psychology coverage from elsewhere on the web




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Some Montana schools reopen; gyms, theaters can next week




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North Dakota Districts to Switch to Four-Day Week

Two rural North Dakota school districts will switch to a four-day school week to save costs and improve student and teacher morale.




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Some Montana schools reopen; gyms, theaters can next week




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Some Montana schools reopen; gyms, theaters can next week




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The weekend / Charlotte Wood.

Domestic fiction.





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Word of the Week - Mung-goo

Each week, the Indigenous Services Branch of the State Library of NSW will be posting an Indigenous ‘word of the wee




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Our word of the week is Wercan

Each week, the Indigenous Services Branch of the State Library of NSW will be posting an Indigenous ‘word of the wee




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Our word of the week is Noo-roi-mum

Each week, the Indigenous Services Branch of the State Library of NSW will be posting an Indigenous ‘word of the wee




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Screaming awareness week: it's way past time to talk. it's time to scream.




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Rx: 3 x/week LAAM : alternative to methadone / editors, Jack D. Blaine, Pierre F. Renault.

Rockville, Maryland : The National Institute on Drug Abuse, 1976.




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Law Week goes digital in 2020

Get involved online in Law Week 2020.




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Our Lady of Grace family page of history : a bookweek bicentennial project / edited by Janeen Brian.

Our Lady of Grace School (Glengowrie, S.A.)




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This Week in The Journal




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This Week in The Journal




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This Week in The Journal




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This Week in The Journal




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This Week in The Journal




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Notre-Dame Restoration Pauses Amid France's Two-Week Lockdown

Lead decontamination policies enacted in August are now in conflict with measures to prevent spread of COVID-19




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Indonesian Volcano 'Anak Krakatau' Fired Lava and Ash Into the Sky Last Weekend

This eruption is the longest since 2018 when the volcano caused a deadly tsunami




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This Week's Best Livestream Learning Opportunities

From doodle sessions to zoo tours, here's a week of online activities to keep your kids learning during the school shutdown




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Check Out These Educational Livestreams This Week

Authors, scientists and others are offering fun livestream lessons and performances to keep kids engaged during isolation




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LeVar Burton Reads Stories on Twitter and Other Livestream Learning Opportunities This Week

Learn hip-hop dance or do citizen science without leaving home this week, thanks to the internet's many intrepid artists and educators




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Play the Smithsonian Magazine Weekly Crossword: May 4, 2020

Test your mettle with this puzzle created exclusively for our readers




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Play the Smithsonian Magazine Weekly Word Search: State Capitals

Find the capital cities, working from a list of state names




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No new COVID-19 cases in N.L. for 6th time in a week

There are 14 active cases of COVID-19 remaining in the province.



  • News/Canada/Nfld. & Labrador

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Setup Week, TeenStreet 2019

Service Team members share why they enjoy being onsite during Setup Week, when the vision of TeenStreet becomes a reality for them, and what part of the upcoming conference they are most excited for.




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MLB owners to discuss draft length next week: report

Major League Baseball owners will discuss a length for the amateur draft next week and are likely to start the selections on the original date of June 10, a person familiar with the deliberations told The Associated Press.



  • Sports/Baseball/MLB

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Biden’s Best Bleeping Week

OK, you’re gonna hear a lot about Joementum.





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OpenMarkets Weekly: FX Volatility

The volatility experienced this spring in the 7 trillion-dollar foreign exchange market was unprecedented. The JP Morgan G7 FX Volatility...

The post OpenMarkets Weekly: FX Volatility appeared first on OpenMarkets.




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The Helpers | This week's stories of people stepping up in a pandemic

This week on CBC Kitchener-Waterloo's The Morning Edition, we heard about a bagpipe duo performing outside of long-term care homes, a retreat welcoming foreign workers and ducklings saved from a storm drain.



  • News/Canada/Kitchener-Waterloo

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Kate's 5 fun things to do this weekend at home (May 8 to 10)

There's trivia, concerts, virtual nature hikes and improv all online this weekend.



  • News/Canada/Kitchener-Waterloo