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AT#122 - Travel to Barcelona, Spain

By traffic.libsyn.com
Published On :: Sat, 26 Jan 2008 19:25:00 +0000

Barcelona, Spain


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AT#19 - Cruising - Formal or Barefoot?

By traffic.libsyn.com
Published On :: Sun, 16 Nov 2008 08:02:07 +0000

The Amateur Traveler compares two very different cruise options, a Royal Caribbean cruise with formal nights and midnight buffets and the Windjammer Barefoot Cruise. Which cruising option is right for you?


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AT#164 - Travel to Zanzibar in Tanzania

By traffic.libsyn.com
Published On :: Sat, 13 Dec 2008 19:54:38 +0000

The Amateur Traveler talks to Tadzio about his trip to Zanzibar in Tanzania, off the east coast of Africa. Tadzio worked as a ranger on Chumbe then toured Stonetown, the northern beaches, the Jozani forest, and Pemba. Hear about the food, the people, the snorkeling, the swimming, the beaches and the history of this tropical island paradise.


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AT#315 - Cruise Barge Canals in England and Wales

By europe.amateurtraveler.com
Published On :: Sat, 11 Feb 2012 14:00:00 +0000

The Amateur Traveler  talks to Richard Graw about his experiences cruising the canals of England in a canal boat (or narrow boat). The canals traverse through tunnels, up staircases of locks and even up over aqueducts.


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AT#481 - Travel to Santa Barbara, California

By usa.amateurtraveler.com
Published On :: Sat, 29 Aug 2015 16:51:55 +0000

Hear about travel to Santa Barbara, California as the Amateur Traveler talks to Heather Simon from wellplannedtravel.net about the "American Riviera".


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AT#501 - Travel to Barcelona, Spain

By europe.amateurtraveler.com
Published On :: Sat, 06 Feb 2016 15:00:00 +0000

Hear about travel to Barcelona, Spain as the Amateur Traveler talks to Lauren Aloise from devourspain.com about traveling to this capital of the region of Catalan. 


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AT#577 - Travel to Barbados

By caribbean.amateurtraveler.com
Published On :: Sat, 30 Sep 2017 14:00:00 +0000

Hear about travel to Barbados as the Amateur Traveler talks to Jane and Duncan from totraveltoo.com about the time they spent on the island recently.


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Academic Who Infamously Mocked Barron Trump Gets Censorship Gig from Facebook

By www.westernjournal.com
Published On :: Fri, 08 May 2020 23:11:25 +0000

A powerful player on Facebook’s new content oversight board infamously mocked Barron Trump during last year’s impeachment hearings, sowing doubt in the social media platform’s promises of unbiased moderation. The selection of Pamela Karlan, a professor at Stanford Law School, was announced Wednesday by Facebook, according to CNBC. Karlan will sit alongside 19 other experts…

The post Academic Who Infamously Mocked Barron Trump Gets Censorship Gig from Facebook appeared first on The Western Journal.


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After Treating Barely Any Patients for a Massive $7.5 Million Each, 16 Emergency COVID Hospitals Are Standing Down

By www.westernjournal.com
Published On :: Sat, 09 May 2020 13:26:54 +0000

At a cost of $7.5 million a patient, they were 16 very expensive field hospitals. Yet, according to NPR, those hospitals are now “stand[ing] down.” You probably remember them from headlines early in the pandemic: makeshift medical centers being assembled at breakneck speed by companies contracted by the Army Corps of Engineers in anticipation of…

The post After Treating Barely Any Patients for a Massive $7.5 Million Each, 16 Emergency COVID Hospitals Are Standing Down appeared first on The Western Journal.


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Sport24.co.za | Umtiti suffers calf knock in second Barca training session

By www.sport24.co.za
Published On :: Sat, 09 May 2020 17:11:45 +0200

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the cornonavirus quarantine.


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Bells sound across Barrie to mark the 75th anniversary of VE Day

By barrie.ctvnews.ca
Published On :: Fri, 8 May 2020 17:29:51 -0400

Church bells rang out across the city of Barrie on Friday morning to commemorate the anniversary of the Victory in Europe Day on Friday.


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MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out

By 100percentfedup.com
Published On :: Wed, 06 May 2020 01:49:01 +0000

The following article, MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out, was first published on 100PercentFedUp.com.

Last week, we reported about how Shelley Luther, owner of the Salon Á La Mode in North Dallas, Texas, who opened up her business in defiance of lockdown orders in the city. The salon owner said that she was ignoring a citation and a cease and desist order from the city to shut down. This one […]

Continue reading: MI Barber Shop Owner Defies Gov. Whitmer Shutdown Order…Opens Business…Police Officer Walks In…Says, “I love you!”…Walks Out ...


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77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO]

By 100percentfedup.com
Published On :: Wed, 06 May 2020 18:57:01 +0000

The following article, 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO], was first published on 100PercentFedUp.com.

Emergency orders that “non-essential businesses” remain closed during the Covid-19 crisis have devastated small business owners across America. A wave of business owners across the nation are defying executive orders by their governors and opening their businesses anyhow. Yesterday, we reported about a small business owner in the state of Michigan, where Governor Gretchen Whitmer […]

Continue reading: 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] ...


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Iraq's Reconstruction: In Conversation with Governor of Anbar Ali Farhan Hamid

By feedproxy.google.com
Published On :: Mon, 09 Dec 2019 16:30:01 +0000

Invitation Only Research Event

18 December 2019 - 9:00am to 10:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Ali Farhan Hamid, Governor of Anbar Province
Chair: Dr Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House

In the aftermath of the liberation from ISIS, the government of Iraq was left to count the cost of three years of brutal conflict, only the most recent phase in the ongoing cycle of conflict and stabilization that has plagued Iraq for 16 years. While reconstruction has been a focus of both the Iraqi government and international policymakers since 2003, billions of dollars in pledged funds have continually failed to reach the places they are most needed. 

At this roundtable, Ali Farhan Hamid will discuss the efforts of his provincial government to rebuild the cities and towns worst-hit by the conflict. He will provide insights into the practical and structural impediments to reconstruction efforts in both Anbar and neighbouring provinces such as Ninewah where the worst damage was sustained under ISIS but where little in the way of reconstruction has been achieved thereby leaving the door open to the potential resurgence of conflict.

The roundtable is part of the Chatham House Iraq Initiative.

Event attributes

Chatham House Rule

Department/project

Middle East and North Africa Programme, Iraq Initiative

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624


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Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents

By feedproxy.google.com
Published On :: 2004-12-01

Philip L. Ross
Dec 1, 2004; 3:1154-1169
Research


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DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology]

By feedproxy.google.com
Published On :: 2020-05-01T00:06:09-07:00

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.


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Stifling the Media: Barriers to Press Freedom

By feedproxy.google.com
Published On :: Thu, 10 Apr 2014 16:19:46 +0000

Under 35s Forum

20 May 2014 - 6:30pm to 7:30pm

Chatham House, London

Transcript
pdf | 77.33 KB
Transcript Q&A
pdf | 72.27 KB

Event participants

Yavuz Baydar, Columnist, Today's Zaman; Co-Founder, P24, Platform for Independent Journalism; Recipient, Special Award of the European Press Prize 
James Deane, Director of Policy and Learning, BBC Media Action
Kirsty Hughes, Writer; Chief Executive, Index on Censorship (2012-14)
Chair: John Lloyd, Contributing Editor, Financial Times; Director of Journalism, Reuters Institute for the Study of Journalism

From intimidation to restrictive laws and curbs on information, media outlets and individual journalists face a variety of threats to maintaining their independence and integrity in print and online. The panel will outline key challenges to international media freedoms, and Yavuz Baydar will share his experiences as a journalist in Turkey, a country that has faced growing criticism from the international community following a crackdown on social media sites, an increased pressure on its press and high numbers of detained journalists. 

LIVE STREAM: This event will be live streamed for members only. The live stream will be made available here at 18:30 BST on Tuesday 20 May.

ASK A QUESTION: Send questions for the speakers by email to questions@chathamhouse.org or using #askCH on Twitter. A selection will be put to them during the event.

This event will be followed by a reception.

This is an Under 35s Forum event.

Event attributes

Livestream


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Leaders Who Lunch: Robert Barrington

By feedproxy.google.com
Published On :: Thu, 10 May 2018 00:00:00 +0100


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Migration and Health: Barriers and Means to Achieving Universal Health Coverage

By feedproxy.google.com
Published On :: Fri, 18 Jan 2019 00:00:00 +0000


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An Improved Boosting to Amplify Signal with Isobaric Labeling (iBASIL) Strategy for Precise Quantitative Single-cell Proteomics [Research]

By feedproxy.google.com
Published On :: 2020-05-01T00:05:26-07:00

Mass spectrometry (MS)-based proteomics has great potential for overcoming the limitations of antibody-based immunoassays for antibody-independent, comprehensive, and quantitative proteomic analysis of single cells. Indeed, recent advances in nanoscale sample preparation have enabled effective processing of single cells. In particular, the concept of using boosting/carrier channels in isobaric labeling to increase the sensitivity in MS detection has also been increasingly used for quantitative proteomic analysis of small-sized samples including single cells. However, the full potential of such boosting/carrier approaches has not been significantly explored, nor has the resulting quantitation quality been carefully evaluated. Herein, we have further evaluated and optimized our recent boosting to amplify signal with isobaric labeling (BASIL) approach, originally developed for quantifying phosphorylation in small number of cells, for highly effective analysis of proteins in single cells. This improved BASIL (iBASIL) approach enables reliable quantitative single-cell proteomics analysis with greater proteome coverage by carefully controlling the boosting-to-sample ratio (e.g. in general <100x) and optimizing MS automatic gain control (AGC) and ion injection time settings in MS/MS analysis (e.g. 5E5 and 300 ms, respectively, which is significantly higher than that used in typical bulk analysis). By coupling with a nanodroplet-based single cell preparation (nanoPOTS) platform, iBASIL enabled identification of ~2500 proteins and precise quantification of ~1500 proteins in the analysis of 104 FACS-isolated single cells, with the resulting protein profiles robustly clustering the cells from three different acute myeloid leukemia cell lines. This study highlights the importance of carefully evaluating and optimizing the boosting ratios and MS data acquisition conditions for achieving robust, comprehensive proteomic analysis of single cells.


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Julia Gillard on Breaking Barriers for Women in Politics

By feedproxy.google.com
Published On :: Wed, 06 Nov 2019 14:46:42 +0000

6 November 2019

Gitika Bhardwaj

Editor, Communications & Publishing, Chatham House

The Hon Julia Gillard AC

Prime Minister of Australia and Leader of the Australian Labor Party (2010-13)
In a series exploring women in international affairs, Julia Gillard speaks to Gitika Bhardwaj about serving in the highest political office in Australia and why she believes things are now changing for women around the world.

Gillard-4388.jpg

Julia Gillard discusses her career as a woman in politics and why things are now changing for women in Australia and around the world. Photo: Chatham House.

Julia Gillard, you became the first female prime minister in Australian history in 2010, what have been the challenges and opportunities for you as a woman working in politics? Have the obstacles women face in positions of power changed over the years, and if so, how? 

I want to start positive and say I’m a huge advocate for people going into politics – particularly women. I believe there’s no better way of putting your values into action than going into politics but I’m not going to pretend that there’s no gender bit.

There still is a gender bit and I experienced that personally. A disproportionate focus on appearance, a disproportionate focus on family structures – for example the fact that I didn’t have kids – and the gendered insults becoming the go-to weapon when politics got turbulent, which inevitably happens, as governments make decisions that not everybody agrees with.

In terms of politics past and politics present, I think a lot has changed for the positive. There are more women in politics now which means more role models for other women. There’s been more of an attempt to have the system offer flexibilities for work and family life too. In Australian politics, famously, the non-members bar was replaced by a childcare centre, so that’s giving you a sense that there has been progress. We’ve also just hit the stage where our Senate is now 50 per cent men and 50 per cent women.

But I do think that there’s a new toxicity for women that’s been introduced through social media – through the fact that it’s anonymous and people can say anything and the kinds of revolting material many women politicians receive. I think that there’s a new coarseness in our traditional media too which means things will be said about people in politics today, especially women, which would not have been put in the pages of respectable newspapers 10 or 20 years ago.

So, it’s a mixed picture, where there has been major steps forward but there are still some huge issues to resolve.

Following this year’s elections, there are now a record number of female members of parliament in Australia, yet some argue that women are still underrepresented across the major political parties, and over the past 20 years, the country has fallen from 15th in the world to 50th for gender diversity in its parliament.

Given some of the recent experiences of women in Australian politics, do you think the major political parties are doing enough to address gender diversity in their ranks? 

I certainly think on the Labor side of politics important changes have happened in our political party and the benefit of those changes has showed. I’m of that generation of Labor women that fought for an affirmative action target and we had that adopted as a Labor party rule in the early 1990s. It started at 30 per cent, and it’s gone up over time, and the benefit of that now is that the Labor Party is almost at 50-50 per cent men and women, coming off a very low base in the early 1990s where we were at 14 per cent men and women. 

The Conservative side for politics hasn’t embraced a target or quota as of yet. They have done some things, through mentoring and networking and training, but that hasn’t seen as significant a shift in the gender diversity in their ranks. They’ve moved slowly from when they were 13 per cent women to now where they’re in the mid-20 per cent. 

Of course that doesn’t mean the work within Labor is done: we’ve got to keep delivering to the affirmative action target, having women come through for all of the ministries, the Cabinet and for all of the portfolios and to make sure that we’re embracing the full diversity of women too. Australia is a very multicultural society and there is more to do to make sure that women – and men – in the Australian parliament represents that diversity. 

During your premiership, you delivered a famous speech on misogyny and sexism and described there being 'gender wars' in Australian politics. How far has Australia addressed its problems regarding everything from unconscious bias to gender stereotypes? Do you think social attitudes in Australia to women in leadership are changing?

I don’t think these issues are particularly an Australian problem. When I left politics, people kept asking me about my experiences and it became convenient for them to say ‘That’s Australia and its macho culture and Crocodile Dundee and all of that.’ I was always quick to point out, actually, a number of the insults hurled at me were first hurled at Hillary Clinton when she originally put her name forward to be considered as a candidate for US president. So this is not an Australian problem – it’s a global problem. 

I can see progress in Australia though. When I was prime minister, the sort of fashionable analysis by the press was that nothing, in my experience, had anything to do with gender – I was just being treated like every prime minister had always been treated.

Today, there is a very lively debate about sexism in Australian politics and about how women can feel excluded from these structures with various conservative women making complaints about bullying within their political party. So the preparedness to report issues due to the understanding of gender is now much higher and I’m a big believer that you never solve a problem unless you start talking about it so I’m glad we’re talking about it now.

From the implementation of ‘womenomics’ in Japan, to gender-responsive budgeting in Indonesia, countries around the world are making progress towards addressing gender issues, yet, structural and cultural barriers that prevent women’s economic, political and social participation remain.

What are the biggest barriers that women face around the world and do you think enough is being done to address these barriers?

I think so much is context-specific that it’s hard to say, but I would say, in some parts of the world, unequal access to education is the fundamental barrier.

Now that’s not true in the UK or in Australia, where the statistics tell you that disproportionately graduates today are women and not men, but if we look at many of the poorer parts of the world, like in sub-Saharan Africa and other places, there are 260 million children out of school – and the face of a child most likely to miss out is a female face. So there still needs to be a lot more progress on things such as equal access to education around the world. 

In many parts of the developed world, there is actually an assault now on long-held rights around women’s reproduction so I think that is another foundation stone – and then really it comes to a set of issues and barriers around the world of work and full access to every level of work.

Much of this is what we research at the Global Institute for Women’s Leadership because we continue to see workplaces and organizations that have a very traditional view of what merit looks like. It’s a sort of male-defined view of the world and it is one that is not inclusive of women. We are still seeing the unequal sharing of domestic labour which has ramifications for women’s engagement in the world of work and their ability to achieve leadership within it too. 

With a broad brush, I would point to all of this, but the most pressing problems that women continue to face varies from place to place.

Julia Gillard speaking at the House of Representatives on 5 February 2013 in Canberra, Australia. Photo: Getty Images.

Globally, increasing numbers of women are being elected to political office, from the first female president of Slovakia to the first female mayor of Tunis. This comes at a time of record numbers of female ministers in Egypt and Jordan as well as gender-balanced cabinets in 10 countries worldwide – six of which were achieved in 2018 alone.

Do you think women’s rights and gender equality are benefitting from more female representation in politics and how are female voters responding, if at all, to this increase in the number of women holding political office?

I think, even if women didn’t bring new policy perspectives to the world of politics, I would still be an advocate of gender equality in politics because I believe merit is equally distributed between the sexes.

If you see women being represented at less than 50 per cent then that’s got to mean that there are women of merit who didn’t get there – who should’ve gotten there. I think it’s important to make that point otherwise we’re saying ‘Women should only be there if, when they are there, they do this, this and this’. We don’t tend to put that ‘if’ in sentences about men.

But I do think the evidence shows that more women, being involved in politics, does diversify the public policy agenda. That doesn’t mean that a male politician couldn’t focus his career and advocacy on childcare or domestic violence or combating sexual assault or furthering women’s reproductive rights. But I think the evidence shows that there is a lived experience that women bring to politics that enables them to mobilize around a set of issues that are of particular concern to women.

On the role model effect, I think the evidence shows that, if women and girls do see role models, they are more likely to think that that is a pathway open to them. One of the things that does slightly concern me is whether that evidence is now retrospective evidence and whether the prospective evidence is going to be – because of the toxicity of social media – more women thinking about the real-world threats that being in politics presents for them. And so the role modelling effect will work in reverse because it will show how women are treated in politics is more of a negative than a positive.

I certainly hope this doesn’t happen and young women are encouraged to go into politics. That’s where we still have to shine a light on the positive aspects of what working in politics has to offer.

Despite all of the progress we are seeing, women are still faced with gender-based discrimination and gender-based violence, virtually and physically, with 40 per cent of women and girls living in countries which fail to guarantee basic standards of gender equality. What do you think needs to happen to ultimately realize women’s rights and gender equality globally? Are you hopeful this will be achieved in the future?

Yes I’m an optimist overall. People like to quote the great Martin Luther King quote ‘The moral arc of the universe bends towards justice.’ I believe that but I think sometimes the imagery of the arc as if it’s always in a forward movement hides the nitty-gritty struggle that is there beneath. 

Inevitably, at some points, it feels like there’s more of a backlash against women than a forward movement. But, over time, I’m an optimist that the forward movement wins through. 

I do believe we can reach a stage where societies are generating societies where women can live their lives free from the threat of sexual violence or discriminatory treatment based on gender.


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Barnes no longer Jamaica's coach - Last-minute goal brings sweet victory over Panama

By sportsjamaica.com
Published On ::

THERE'S nothing like the sweet taste of victory, especially when it's long in coming.


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Barnes saw it coming... but coach 'disappointed' he was cut ahead of Gold Cup

By sportsjamaica.com
Published On ::

GIVEN the financial position of the Jamaica Football Federation (JFF), John Barnes had resigned


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CBD News: Statement from Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the IUCN World Conservation Congress, Barcelona, 6 October 2008.

By www.cbd.int
Published On :: Mon, 06 Oct 2008 00:00:00 GMT


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CBD News: Intervention du Secrétaire exécutif M. Ahmed Djoghlaf à l'occasion de la Soirée francophone de l'Organisation internationale de la francophonieau Congrès mondial de la nature, 6 octobre 2008, Barcelone, Espagne.

By www.cbd.int
Published On :: Mon, 06 Oct 2008 00:00:00 GMT


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CBD News: Statement from Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity on the occasion of the High Level Roundtable on Local and Regional Authorities, IUCN World Conservation Congress, Barcelona, 7 October 2008.

By www.cbd.int
Published On :: Tue, 07 Oct 2008 00:00:00 GMT


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CBD News: Message by Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the World Migratory Bird Day 2009: "Barriers to Migration", 9 - 10 May 2009.

By www.cbd.int
Published On :: Fri, 08 May 2009 00:00:00 GMT


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CBD Communiqué: Antigua and Barbuda becomes the first Caribbean island country to sign the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from Their Utilization

By www.cbd.int
Published On :: Mon, 01 Aug 2011 00:00:00 GMT


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CBD Communiqué: Antigua and Barbuda becomes twenty-sixth signatory to the Nagoya - Kuala Lumpur Supplementary Protocol

By www.cbd.int
Published On :: Wed, 10 Aug 2011 00:00:00 GMT


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CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of the Sub-Regional Workshop for the Caribbean on Capacity-Building for Implementation of the CBD Programme of Work on Protected Areas, Christ Church, Barb

By www.cbd.int
Published On :: Mon, 02 Apr 2012 00:00:00 GMT


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CBD Press Release: New insights in biodiversity and sustainability awareness around the world: UEBT launches 2012 edition of its Biodiversity Barometer

By www.cbd.int
Published On :: Thu, 12 Apr 2012 00:00:00 GMT


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CBD Press Release: New report highlights growing biodiversity awareness worldwide - UEBT launches 2013 Biodiversity Barometer

By www.cbd.int
Published On :: Fri, 19 Apr 2013 00:00:00 GMT


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CBD News: The 2015 UEBT Biodiversity Barometer shows that an average of 69% of respondents in nine countries say they have heard of biodiversity, but additional outreach efforts are needed for the world to reach global targets on biodiversity awareness se

By www.cbd.int
Published On :: Thu, 25 Jun 2015 00:00:00 GMT


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CBD News: The Executive Secretary of the Convention on Biological Diversity, Mr. Braulio Ferreira de Souza Dias, applauds the Arctic Partnership announced Thursday by United States President Barack Obama and Canadian Prime Minister Justin Trudeau in Washi

By www.cbd.int
Published On :: Mon, 14 Mar 2016 00:00:00 GMT


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CBD News: Every year, we use some 500 billion plastic bags. Every year, as much as 13 million tons of plastic finds its way into the ocean. Every year, 17 million barrels of oil are used to produce plastic.

By www.cbd.int
Published On :: Mon, 04 Jun 2018 00:00:00 GMT


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Restrictions on bars gazetted

By www.news.gov.hk
Published On :: Thu, 02 Apr 2020 00:00:00 +0800

The Government issued directions in the Gazette today to close bars and premises selling liquor for 14 days from 6pm on April 3.

 

The Secretary for Food & Health issued the directions in accordance with the Prevention & Control of Disease (Requirements & Directions) (Business & Premises) Regulation.

 

The directions include the closure of bars and pubs, as well as any part of a catering business premise or a clubhouse mainly used for the sale or supply of intoxicating liquors for consumption.

 

The new measures were introduced due to the emergence of 62 confirmed COVID-19 cases related to the bar and band cluster with further spread to an additional 14 cases who had not visited bars.

 

The Government on April 1 introduced directions on the closure of karaoke, mahjong-tin kau and nightclub establishments as well as the suspension of karaoke and mahjong-tin kau activities in catering premises and clubhouses.

 

It has also been reviewing the feasibility of relevant measures and will make timely adjustments according to the latest developments of the disease.


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Cultural Barriers to Care: Inverting the Problem

By spectrum.diabetesjournals.org
Published On :: 2001-01-01

Toni Tripp-Reimer
Jan 1, 2001; 14:
Articles


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DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology]

By www.jbc.org
Published On :: 2020-05-01T00:06:09-07:00

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.


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NIH clinical trial tests remdesivir plus anti-inflammatory drug baricitinib for COVID-19

By www.eurekalert.org
Published On :: Fri, 08 May 2020 00:00:00 EDT

(NIH/National Institute of Allergy and Infectious Diseases) A randomized, controlled clinical trial evaluating the safety and efficacy of a treatment regimen of the investigational antiviral remdesivir plus the anti-inflammatory drug baricitinib for COVID-19 has begun. The trial is now enrolling hospitalized adults with COVID-19 in the United States. The trial is expected to open at approximately 100 US and international sites. Investigators currently anticipate enrolling more than 1,000 participants. The National Institute of Allergy and Infectious Diseases is sponsoring the trial.


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Negotiating the Barrier of Hypoglycemia in Diabetes

By spectrum.diabetesjournals.org
Published On :: 2002-01-01

Philip E. Cryer
Jan 1, 2002; 15:
Articles


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Psychosocial Barriers to Diabetes Self-Management and Quality of Life

By spectrum.diabetesjournals.org
Published On :: 2001-01-01

Russell E. Glasgow
Jan 1, 2001; 14:
Articles


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Cultural Barriers to Care: Inverting the Problem

By spectrum.diabetesjournals.org
Published On :: 2001-01-01

Toni Tripp-Reimer
Jan 1, 2001; 14:
Articles


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Bars may have to remove stools and tables - Holness hints at measures that could accompany reopening of pubs

By jamaica-star.com
Published On :: Thu, 07 May 2020 05:01:26 -0500

It is possible that the next time you walk into a bar you may find that there is only standing room, and you are among a handful of persons allowed inside. Prime Minister Andrew Holness said that in addition to having a specific gathering rule,...


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Bartender finds the going very tough

By jamaica-star.com
Published On :: Thu, 07 May 2020 05:01:24 -0500

Having to witness your child go off to bed without a meal is not the most pleasing experience for a parent. However, this is the reality of Viviene Francis, who was laid off from her job as a bartender. Francis, who is a single mother, told THE...


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Quick Earthquake Messages M6.7 [7.0S, 130.0E] in Tanimbar Islands Region, Indonesia (21:54 HKT 06/05/2020)

By openstreetmap.org
Published On :: Wed, 06 May 2020 22:01:16 +0800

Earthquake: 2020-05-06 21:54HKT M6.7 [7.0S, 130.0E] in Tanimbar Islands Region, Indonesia http://openstreetmap.org/?mlat=-7&mlon=130.


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Beyond CARES: Economist Glenn Hubbard on Government Response to COVID-19

By www8.gsb.columbia.edu
Published On :: Fri, 08 May 2020 00:00:00 -0400

Hubbard asks: Can we design a more effective plan, in case of a next time?


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An Improved Boosting to Amplify Signal with Isobaric Labeling (iBASIL) Strategy for Precise Quantitative Single-cell Proteomics

By feedproxy.google.com
Published On :: 2020-05-01

Chia-Feng Tsai
May 1, 2020; 19:828-838
Research


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Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with 11C-Metoclopramide PET

By jnm.snmjournals.org
Published On :: 2019-12-05T10:37:41-08:00

P-glycoprotein (ABCB1) plays an important role at the blood-brain barrier (BBB) in promoting the clearance of neurotoxic beta-amyloid (Aß) peptides from the brain into the blood. ABCB1 expression and activity were found to be decreased in the brains of Alzheimer disease (AD) patients. Treatment with drugs which induce cerebral ABCB1 activity may be a promising approach to delay the build-up of Aß deposits in the brain by enhancing the clearance of Aß peptides from the brain. The aim of this study was to investigate whether PET with the weak ABCB1 substrate radiotracer 11C-metoclopramide can measure ABCB1 induction at the BBB in a beta-amyloidosis mouse model (APP/PS1-21 mice) and in wild-type mice. Methods: Groups of wild-type and APP/PS1-21 mice aged 50 or 170 days underwent 11C-metoclopramide baseline PET scans or scans after intraperitoneal treatment with the rodent pregnane X receptor (PXR) activator 5-pregnen-3β-ol-20-one-16α-carbonitrile (PCN, 25 mg/kg) or its vehicle over 7 days. At the end of the PET scans, brains were harvested for immunohistochemical analysis of ABCB1 and Aß levels. In separate groups of mice, radiolabeled metabolites of 11C-metoclopramide were determined in plasma and brain at 15 min after radiotracer injection. As an outcome parameter of cerebral ABCB1 activity, the elimination slope of radioactivity washout from the brain (kE,brain) was calculated. Results: PCN treatment resulted in an increased clearance of radioactivity from the brain as reflected by significant increases in kE,brain (from +26% to +54% relative to baseline). Immunohistochemical analysis confirmed ABCB1 induction in the brains of PCN-treated APP/PS1-21 mice with a concomitant decrease in Aß levels. There was a significant positive correlation between kE,brain values and ABCB1 levels in the brain. In wild-type mice, a significant age-related decrease in kE,brain values was found. Metabolite analysis showed that the majority of radioactivity in the brain was composed of unmetabolized 11C-metoclopramide in all animal groups. Conclusion: 11C-metoclopramide can measure ABCB1 induction in the mouse brain without the need to consider an arterial input function and may find potential application in AD patients to non-invasively evaluate strategies to enhance the clearance properties of the BBB.


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