In this time of social distancing and online learning, athletic departments across the country have scrambled to embrace flexibility.

Cummins is partnering with Minnesota-based 3M to make filters for use in respirators used during the COVID-19 outbreak.

Indiana workers could lose their eligibility for unemployment benefits if they are recalled to work but refuse to return over fears of the coronavirus

An anonymous reader quotes CNN: The U.S. Food and Drug Administration on Friday issued an emergency use authorization for the first at-home Covid-19 test that uses saliva samples, the agency said in a news release. Rutgers University's RUCDR Infinite Biologics lab received an amended emergency authorization late Thursday. With the test, people can collect their own saliva at home and send their saliva samples to a lab for results... "Authorizing additional diagnostic tests with the option of at-home sample collection will continue to increase patient access to testing for COVID-19. This provides an additional option for the easy, safe and convenient collection of samples required for testing without traveling to a doctor's office, hospital or testing site," FDA Commissioner Dr. Stephen M. Hahn said in the FDA's press release on Friday... The test remains prescription only.

Read more of this story at Slashdot.

Oladipo: 'I can look at it like I was just getting my rhythm back or as an opportunity to rest and ... continue building strength in my tendon.'

Chicagoans are racing to make personal protective equipment for frontline workers.

"Onward" and "Soul" deal with the eternal and the ethereal.

• A hospital in India is using robots to screen possible coronavirus patients.
• The humanoid robot, called Mitra, uses a handheld thermal camera to evaluate patients before sending them on to healthcare workers.
• Thermal imaging is being tested in other countries as a way to check for coronavirus symptoms. 
• Visit Business Insider's homepage for more stories.

India is yet another country using robots to take some of the burden off of HealthCare workers, with a humanoid robot named Mitra that takes patients' temperatures using a thermal camera.

India's 1.3 billion residents have been under lockdown since March 24, and last week the orders were extended for at least another two weeks. "To save India and every Indian, there will be a total ban on venturing out of your homes," Prime Minister Narendra Modi said. In late April, some convenience stores were allowed to reopen, but specific rules vary by state.

The Indian government has also developed a controversial contact tracing app which shares residents' location constantly. More than 90 million people have reportedly already downloaded the app, and in at least one city, not having the app is punishable with six months in jail.

Meanwhile, these robots are being used in a hospital in Bangalore as the first screening for some patients who may have coronavirus. A pharmacy in Italy has implemented similar technology to screen customers for signs of infection. Here's how they work.

SEE ALSO: Stores in Italy are using robots to screen customers for mask wearing and high temperatures before they can go inside as the country reopens

The robots are a safer way for doctors to perform initial screenings of patients.

A tablet on one robot's chest allows doctors to video chat with patient without putting their own health at risk.

A thermal camera-equipped robot takes a patient's temperature without needing to touch them.

Using this information, healthcare providers can send patients to the appropriate specialist, and patients who are unlikely to have coronavirus won't be unnecessarily exposed.

After receiving a temperature reading, the robot gives the patient instructions for their next steps.

Some experts have suggested that temperature guns are not always accurate because they must be held at a specific distance, but the tablet mostly avoids that problem by instructing patients on where to stand.

Even the most accurate thermometers aren't a perfect measure to stop the virus, though. Infected people can go up to 14 days without showing symptoms, and some people never develop symptoms.

Source: Business Insider

• The $400 iPhone SE stands out for its fast performance, compact design, and effective camera.
• Still, the iPhone SE is lacking some of the camera features found on similarly priced Android rivals.
• Overall, the phone is best suited for Apple loyalists upgrading from an older device like the iPhone 6S that want something affordable and familiar.
• Visit Business Insider's homepage for more stories.

Apple's iPhone SE is unlike any iPhone Apple has released in the past two years. In fact, it looks a lot more like the the iPhone you probably remember from 2017 and earlier, back when iPhones still had home buttons and smaller-sized screens.

I switched from the $1,000 iPhone 11 Pro to Apple's new iPhone SE recently, and overall I've found it to be a solid option for Apple fans looking for a cheap, portable device. The smaller and lighter size is easy to manage and operate with one hand, and Touch ID brings some convenience that Face ID can lack. 

But of course, since it's significantly cheaper than the iPhone 11 and 11 Pro, it's lacking in some areas. It doesn't have an ultra-wide-angle camera or low-light photography capabilities, for example, even though similarly priced Android devices offer some of those features.

After spending a couple of weeks with Apple's cheapest iPhone, here are my favorite (and least favorite) things about it.  

SEE ALSO: Apple is expected to release a new Apple Watch this fall — here are the features we want to see

The iPhone SE runs on Apple's latest iPhone processor, which makes it feel snappy and fast.

The iPhone SE runs on Apple's A3 Bionic processor, the same chip that powers the iPhone 11 and iPhone 11 Pro. As a result, the iPhone SE feels snappy and fast in daily use.

I found this to be especially true when switching from my old iPhone 8 to the SE. In most cases, it was able to launch apps, render 4K video clips, and find surfaces more quickly in augmented reality than Apple's more-than-two-year-old iPhone 8.

That being said, the iPhone SE is pretty similar to the iPhone 8 in just about every other way, save for a few exceptions. It's best suited for those upgrading from an iPhone 7 or older. 

The A13 Bionic is the major advantage the iPhone SE has over similarly-priced Android phones, many of which may offer more sophisticated cameras but run on less powerful processors. 

It's small and compact, which means it's easier to use with one hand and fit into pockets.

The iPhone SE is the most compact iPhone Apple has released in years. It has a 4.7-inch screen just like the iPhone 8, and weighs noticeably less than the iPhone 11 and 11 Pro.

The iPhone SE weighs 5.22 ounces, while the iPhone 11 weighs 6.84 ounces and the iPhone 11 Pro weighs 6.63 ounces. 

It's also the only iPhone Apple sells that comes with a Touch ID home button.

Although I've grown accustomed to swiping up from the home screen to return home and unlocking my phone just by looking at it, I've really appreciated having Touch ID again.

Apple's fingerprint sensor sometimes works a bit faster than Face ID in my experience when unlocking my phone. And since Face ID works best when held directly in front of your face, I often have to physically pick up my phone to unlock it when using the iPhone 11 Pro. 

With the iPhone SE, by comparison, I can unlock my phone just by resting a finger on the home button without having to move the device. It's a small convenience, but one that I've come to appreciate.

The camera quality is good for the price.

The iPhone SE has a single 12-megapixel camera that supports Portrait Mode and all six lighting effects that go with it. Overall, the camera system is very similar to the one found on Apple's iPhone XR from 2018.

You won't get the more advanced photography features found on Apple's newer iPhone models, but you won't be disappointed by the SE's camera either. During my time with the phone, I've found that it takes sharp, crisp images that may not be as vibrant as the ones taken on the iPhone 11 Pro, but are in some cases an improvement over the iPhone 8.

But the camera is lacking compared to some similarly priced Android phones.

Given its cheap price, it's reasonable to think that the iPhone SE wouldn't come with all of the capabilities of the iPhone 11 or 11 Pro.

But that hasn't stopped some Android phone makers from bringing features like low-light photography, multi-lens camera systems, and ultra-wide-angle lenses to their devices. Google, Samsung, and TCL all offer compelling smartphones with more feature-rich photography capabilities at similar price points as the iPhone SE.  

The iPhone SE's design also feels a bit antiquated compared to modern smartphones.

While I appreciate the portability of the iPhone SE's design, its appearance does feel a bit outdated compared to other modern smartphones. Other affordable Android phones, like the $400 Samsung Galaxy A51 and $400 Google Pixel 3a, still offer screens with much smaller bezels for around the same price.  

And the battery life leaves me wanting more.

I usually get roughly one full work day out of the iPhone SE, which is acceptable given its low price. But when switching from a more expensive phone like the iPhone 11 Pro, I often found myself scrambling to plug in my phone after work hours.

Battery life will always vary depending on how you use your phone. During the workday, I tend to take a lot of phone calls, leave my screen on for long periods of time to avoid missing work notifications, and record audio frequently. All of these tasks will drain your battery faster than usual, which is why I tend to get more battery life out of the SE on the weekends.

The bottom line is: If you're a power user that's frequently recording video or audio, or running graphics-heavy games, you may want to make sure you have a charger handy or opt for a phone with longer battery life.

So is it right for you?

The iPhone SE is a reliable, affordable choice for Apple fans that want something that feels familiar and won't break the bank. 

You shouldn't expect to get all of the benefits you'd find on a much more expensive phone like the iPhone 11 Pro. But the SE's A13 Bionic chip offers fast performance for the price, and should provide some reassurance that you're phone won't quickly feel outdated in terms of speed. 

IPTV operators will now benefit from industry-leading revenue security solutions when using Dune HD media players, thanks to a new partnership between Dune HD and Verimatrix. Verimatrix is the specialist in securing and enhancing revenue for multi-screen digital TV services around the globe, and its Video Content Authority System for IPTV solution and embedded ViewRight security client are now available across Dune HD’s award-winning range of digital media players, enabling operators to better protect content from piracy while enhancing service revenues.

Verimatrix VCAS software-based security solutions are the most widely deployed content protection systems amongst tier-one operators globally, with a growing base of over 600 deployments. These operators and other Verimatrix partners will now be able to install Dune HD’s extensive range of digital media players and set-top boxes, which combine high performance, engineering excellence and customisable features, backed up by the highest levels of content security.

strataconf: Innovative ways journalists are using data to tell stories http://t.co/y8RVUwHO4G Global open data, scholarships, mapping a civil war & more

So it is difficult to imagine who would want to stop the SARB if it would help reduce load shedding and contain further job losses.A similar argument arises in providing social houses to replace our dangerous rusty corrugated iron suburbs.

CTVNews.ca asked Canadians to share how they were using their CERB payments and got a flood of responses. Most said they were covering the basics -- housing, groceries, transportation and medicine.

TL;DR: Have a hot meal wherever you go with the Go portable solar oven for $119, a 14% savings as of May 9.

As we look toward upcoming summer festivities, our calendars are looking pretty bleak. Nearly every event has been postponed. Festival season was straight-up canceled. And gatherings in public places are basically extinct. With fewer options on the table, you're probably going to be spending a lot of time enjoying the great outdoors in small groups or on your own as the weather warms up. By then, you'll be sick of staying home, so it's a good thing nature isn't canceled.

As you head outside for your camping, hiking, biking, and beach excursions, you'll probably need a way to cook your own food, especially if restaurants are still closed or operating on abbreviated hours. We've got just thing, and it's on sale: the Go Portable Solar Oven. All you need is a little bit of sun and this lightweight grill can cook just about anything. Read more...

Every successful business expecting high returns should have investment projects. Just like any other advertisement plan, a business card is crucial. It links up your company and the potential customers easily. It’s cheaper to design and distribute the cards. However, for a startup business which is low on budget and high on initial expenses, designing […]

The post Expand Your Brand Using Business Cards appeared first on Dumb Little Man.

The province is investing $1.5 million to support a housing project in Muskoka to help people with no place to call home.

T.J. Lovell had just 30 minutes to pack up his belongings from the tent city in Oppenheimer Park if he wanted access to a hotel room that he could share with his father.

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology

Philip L. Ross
Dec 1, 2004; 3:1154-1169
Research

M el-Saadani
Apr 1, 1989; 30:627-630
Articles

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

Digital technology was not invented to tackle inequality, and there is even a risk that it could widen existing economic and social disparities. But, as the case of China illustrates, new platforms also offer many possible ways to narrow the opportunity gap.

Esther McVey said the government will release local data on properties and land to help the proptech sector thrive

Yu. V. Kozachenko and I. V. Rozora
Theor. Probability and Math. Statist. 99 (2020), 113-124.
Abstract, references and article information

(Arizona State University) Cun-Zheng Ning, a professor of electrical engineering in the Ira A. Fulton Schools of Engineering at Arizona State University, and collaborators from Tsinghua University in China discovered a process of physics that enables low-power nanolasers to be produced in 2D semiconductor materials. Understanding the physics behind lasers at nanoscale and how they interact with semiconductors can have major implications for high-speed communication channels for supercomputers and data centers.

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

(American Marketing Association) Nonprofits may better meet their missions by learning to effectively employ the entirety of the marketing mix to attract individuals to available donation opportunities.

(Kobe University) Hydrogen is a possible next generation energy solution, and it can be produced from sunlight and water using photocatalysts. A research group from Kobe University has developed a strategy that greatly increases the amount of hydrogen produced using hematite photocatalysts. In addition to boosting the high efficiency of what is thought to be the world's highest performing photoanode, this strategy will be applied to artificial photosynthesis and solar water-splitting technologies via university-industry collaborations.

(University of Bath) Researchers at the University of Bath have developed an AI model that can automatically classify underwater environments directly from sonar measurements.

Frederick J. Bloom
Jul 1, 2010; 23:165-169
From Research to Practice

Stephen F. Quevedo
Oct 1, 2001; 14:
Feature Articles

Russell E. Glasgow
Apr 1, 2001; 14:
Feature Articles

James A. Wilkins
Apr 13, 2020; 0:RA120.001944v1-mcp.RA120.001944
Research

Samvel K Gularyan
Apr 6, 2020; 0:RA120.001986v1-mcp.RA120.001986
Research

Qingbo Shu
Apr 1, 2020; 19:672-689
Research

Karl A. T. Makepeace
Apr 1, 2020; 19:624-639
Research

Calculation of radiation dosimetry in targeted nuclear medicine therapies is traditionally resource-intensive requiring multiple post-therapy SPECT acquisitions. An alternative approach is to take advantage of existing pharmacokinetic data from these smaller cohorts to enable dose computation from a single post-treatment scan in a manner that may be applied to a much broader patient population. Methods: In this work, a technical description for simplified dose estimation is presented and applied to assessment of ¹⁷⁷Lu-PSMA-617 therapy (Prostate-Specific Membrane Antigen) for metastatic prostate cancer. By normalizing existing time-activity curves to a single measurement time, it is possible to calculate a mean and range of time-integrated activity values which relate to radiation absorbed dose. To assist with accurate pharmacokinetic modelling of the training cohort, a method for contour-guided image registration was developed. Results: Tissue-specific dose conversion factors for common post-treatment imaging times are reported along with a characterization of added uncertainty in comparison to a traditional serial imaging protocol. Single time point dose factors for tumor were determined to be 11.0, 12.1, 13.6, and 15.2 Gy per MBq/mL at image times of 24, 48, 72, and 96 hours, respectively. For normal tissues, parotid gland factors were 6.7, 9.4, 13.3, and 19.3 Gy per MBq/mL and kidneys were 7.1, 10.3, 15.0, and 22.0 Gy per MBq/mL at those times. Tumor dose estimates were most accurate using delayed scanning at times beyond 72 hours. Dose to healthy tissues is best characterized by scanning patients in the first two days of treatment owing to the larger degree of tracer clearance in this early phase. Conclusion: The work demonstrates a means for efficient dose estimation in ¹⁷⁷Lu-PSMA-617 therapy. By providing methods to simplify and potentially automate radiation dosimetry we hope to accelerate the understanding of radiobiology and development of dose-response models in this unique therapeutic context.

Introduction: The aim of this study was to analyze patterns of persistent versus recurrent or new PET lesions in a selected patient cohort with PSA persistence following salvage lymph node dissection (SLND) and pre/post procedure prostate-specific membrane antigen ligand positron emission tomography (PSMA-PET). Material and Methods: 16 patients were included in this multicenter study. Inclusion criteria were: a) PSMA-PET performed for biochemical recurrence before SLND (pre-SLND PET) and b) repeat PSMA-PET performed for persistently elevated PSA level (≥0.1 ng/mL) ≥6 weeks after SLND (post-SLND PET). Image analysis was performed by three independent nuclear medicine physicians applying the molecular imaging TNM system PROMISE. Lesions were confirmed by histopathology, presence on correlative CT/MRI/bone scan or PSA response after focal therapy. Results: post-SLND PET identified PCa-lesions in 88% (14/16) of patients with PSA persistence after SLND. Median PSA was 1.2 ng/mL (IQR, 0.6-2.8 ng/mL). Disease was confined to the pelvis in 56% of patients (9/16) and most of these men had common iliac (6/16, 38%) and internal iliac lymph node metastases (6/16, 38%). Extrapelvic disease was detected in 31% of patients (5/16). In pre- and post-SLND PET comparison, 10/16 had at least one lesion already detected at baseline (63% PET persistence); 4/16 had new lesions only (25% PET recurrence); 2 had no disease on post-SLND PET. All validated regions (11 regions in 9 patients) were true positive. 9/14 (64%) patients underwent repeat local therapies after SLND (7/14 radiotherapy, 2/14 surgery). Conclusion: SLND of pelvic nodal metastases was often not complete according to PSMA-PET. About two thirds of patients had PET positive nodal disease after SLND already seen on pre-SLND PSMA-PET. Notably, about one quarter of patients had new lesions, not detected by pre-surgical PSMA-PET.

Rationale: The treatment of choice for insulinomas and focal lesions in congenital hyperinsulinism (CHI) is surgery. However, intra-operative detection can be challenging. This could be overcome with intra-operative fluorescence imaging, which provides real-time lesion detection with a high spatial resolution. Here, a novel method for targeted near-infrared (NIR) fluorescence imaging of glucagon-like peptide 1 receptor (GLP-1R) positive lesions, using the GLP-1 agonist exendin-4, labeled with IRDye800CW, was examined in vitro and in vivo. Methods: A competitive binding assay was performed using Chinese hamster lung (CHL) cells transfected with the GLP-1R. Tracer biodistribution was determined in BALB/c nude mice bearing subcutaneous CHL-GLP-1R xenografts. In vivo NIR fluorescence imaging of CHL-GLP-1R xenografts was performed. Localization of the tracer in the pancreatic islets of BALB/c nude mice was examined using fluorescence microscopy. Laparoscopic imaging was performed to detect the fluorescent signal of the tracer in the pancreas of mini pigs. Results: Exendin-4-IRDye800CW binds the GLP-1R with an IC50 value of 3.96 nM. The tracer accumulates in CHL-GLP-1R xenografts. Subcutaneous CHL-GLP-1R xenografts were visualized using in vivo NIR fluorescence imaging. The tracer accumulates specifically in the pancreatic islets of mice and a clear fluorescent signal was detected in the pancreas of mini pigs. Conclusion: These date provide the first in vivo evidence of the feasibility of targeted fluorescence imaging of GLP-1R positive lesions. Intra-operative lesion delineation using exendin-4-IRDye800CW could benefit open as well as laparoscopic surgical procedures for removal of insulinomas and focal lesions in CHI.