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Polysubstituted cyclopentadiene compound wherein at least two different substituents are present from the group consisting of linear, branched and cyclic alkyls, aralkyls and alkenyls, and a process for the preparation of a cyclopentadiene compound substituted with at least two different groups chosen from the group consisting of linear, branched, cyclic and aromatic alkyls and alkenyls, characterized in that it comprises the reacting of a halide of a first substituting group in a mixture of the cyclopentadiene compound and an aqueous solution of a base, in which the quantity of the base relative to the cyclopentadiene compound is between 5 and 30 mol/mol, in the presence of a phase transfer catalyst, followed by the addition of a halide of a second or optionally a third substituting group to the reaction mixture.

A process for the conversion of biomass to hydrocarbon products such as transportation fuels, kerosene, diesel oil, fuel oil, chemical and refinery plant feeds. The instant process uses a hydrocarbon or synthesis gas co-feed and hot pressurized water to convert the biomass in a manner commonly referred to as hydrothermal liquefaction.

A processing apparatus includes an execution unit which performs computation on two operand inputs each being selectable between read data from a register and an immediate value. The processing apparatus also includes another execution unit which performs computation on two operand inputs, one of which is selectable between read data from a register and an immediate value, and the other of which is an immediate value. A control unit determines, based on a received instruction specifying a computation on two operands, whether each of the two operands specifies read data from a register or an immediate value. Depending on the determination result, the control unit causes one of the execution units to execute the computation specified by the received instruction.

Fault Current Limiters (FCL) provide protection for upstream and/or downstream devices in electric power grids. Conventional FCL require the use of expensive conductors and liquid or gas cryogen handling. Disclosed embodiments describe FCL systems and devices that use lower cost superconductors, require no liquid cryogen, and are fast cycling. These improved FCL can sustain many sequential faults and require less time to clear faults while avoiding the use of liquid cryogen. Disclosed embodiments describe a FCL with a superconductor and cladding cooled to cryogenic temperatures; these are connected in parallel with a second resistor across two nodes in a circuit. According to disclosed embodiments, the resistance of the superconducting components and its sheath in the fault mode are sufficiently high to minimize energy deposition within the cryogenic system, minimizing recovery time. A scheme for intermediate heat storage also is described which allows a useful compromise between conductor length enabled energy minimization and allowable number of sequential faults to enable an overall system design which is affordable, and yet allows conduction cooled (cryogen free) systems which have fast recovery and allows for multiple sequential faults.

A CPU executes a communication partner search process for searching for a communication partner (another game machine). The CPU confirms received data content. If identification information included in the received data matches, application identification information saved in a wireless communication module is compared with application identification information included in the received data. When the pieces of application identification information match, a notice that another game machine having exchange data corresponding to the matched application identification information is found is given to a main body. Then, giving/receiving of exchange data is executed to/from another game machine.

The present weed reducing material reduces the necessary weed control work by making joint filling sand a hostile substrate for plant and fungus growth by using an environmentally acceptable slow release mineral additive. The additive, having similar grain size distribution, mechanical and rheological properties, forms an integral part of the joint filling sand. The specific gravity of the additive is lower than quartz sand imparting a tendency for the additive to migrate towards the top part of the joint. The additive leads to pore waters rich in sodium and at high pH, both qualities being maintained over long periods. The mixture of additive and sand is handled and applied using conventional laying techniques and equipment, observing usual precautions for mortar or cement mixes with sand. In the environment, reaction with CO2 in the air or in the soil porosity inactivates the causticity, yielding harmless carbonate salts.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.

A process for the synthesis of methanol, comprising the steps of reforming a hydrocarbon source obtaining a make-up gas feed (101), feeding said make up gas to a synthesis loop (L), converting said make up gas to methanol (108) in a substantially isothermal catalytic environment, wherein said catalytic environment comprises a plurality of isothermal catalytic beds (11, 12, 21) preferably arranged in series, and at least a portion of make-up gas (101) is mixed with recycle gas (112) from the loop (L), obtaining a gaseous mixture of fresh gas and recycle gas, and at least a portion of said gaseous mixture is directed between two consecutive catalytic beds acting as a quench gas. A related plant is also disclosed.

The portable, wearable, proximal Alzheimer's disease treatment invention is based upon creating an RF field of particular frequencies and intensities that are applied to the patient's head. To accomplish the aforementioned disease treatment functionality, a system was invented comprising a network of antennas connected to an RF generator via a feedline connector. The invention also provides methods for using measurements to monitor and manage the effectiveness of an ongoing disease treatment regimen, and databases which contain information about measurements, variables, and their relationships to clinical outcome.

A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure. A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods.

Methods and apparatus for intercepting communications in an Internet Protocol (IP) network involve maintaining dialing profiles for respective subscribers to the IP network, each dialing profile including a username associated with the corresponding subscriber, and associating intercept information with the dialing profile of a subscriber whose communications are to be monitored. Intercept information will include determination information for determining whether to intercept a communication involving the subscriber, and destination information identifying a device to which intercepted communications involving the subscriber are to be sent. When the determination information meets intercept criteria communications are established with a media relay through which communications involving the subscriber will be conducted or are being conducted to cause the media relay to send a copy of the communications involving the subscriber to a mediation device specified by the destination information.

A slotted inverse tap, compressible for insertion past damaged entry threads in blind holes. (FIG. 1 thru FIG. 5) The tool can be made to smaller sizes than that of prior art. An elongate slot (23) proceeds through a first threaded end (21), then well into a reduced diameter cylindrical body (25). After insertion to the hole bottom, a tabbed shim (28) is inserted to the slot from its side, then pressed down until stopped. The shim (28) enforces mating engagement with undamaged internal threads. A second end of hex and/or squared or other configuration facilitates use of a tap wrench or other tool for rotational extraction. Damaged threads are reformed/re-cut upon rotational withdrawal.

Milling cutter and method of operating same, and other machine tools, and an adjustment mechanism therefor. A cutting insert is adjusted by moving a resilient web with an adjusting screw.

The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.

A movable device for injecting oxygen and other technical materials into an electric arc furnace includes a housing situated above a portion of a step of a crucible and equipped with a cooling coil, an injection lance of oxygen and other technical materials, a supporting and moving system of the lance between minimum and maximum range points of the liquid bath level contained therein, positioned in the housing, an opening situated in the housing and facing the inside of the crucible in which the lance is transferably guided, and a scraping member disposed between the opening and the lance.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

A service may be provided that reads sensors, and that communicates information based on the sensor readings to applications. In one example, an operating system provides a sensor interface that allows programs that run on a machine to read the values of sensors (such as an accelerometer, light meter, etc.). A service may use the interface to read the value of sensors, and may receive subscriptions to sensor values from other programs. The service may then generate messages that contain the sensor value, and may provide these messages to programs that have subscribed to the messages. The messages may contain raw sensor data. Or, the messages may contain information that is derived from the sensor data and/or from other data.

A program (e.g., an operating system) is provided a warning that it has a grace period in which to perform a function, such as cleanup (e.g., complete, stop and/or move a dispatchable unit). The program is being warned, in one example, that it is losing access to its shared resources. For instance, in a virtual environment, a guest program is warned that it is about to lose its central processing unit resources, and therefore, it is to perform a function, such as cleanup.

A program (e.g., an operating system) is provided a warning that it has a grace period in which to perform a function, such as cleanup (e.g., complete, stop and/or move a dispatchable unit). The program is being warned, in one example, that it is losing access to its shared resources. For instance, in a virtual environment, a guest program is warned that it is about to lose its central processing unit resources, and therefore, it is to perform a function, such as cleanup.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

Techniques for positioning access points and terminals in WLANs and other wireless networks are described. For access point positioning, measurements are obtained for at least one access point in a WLAN. The measurements may be based on transmission sequences (e.g., beacon frames) transmitted periodically by each access point. The measurements may be made by multiple terminals at different locations or a single mobile terminal at different locations. The location of each access point is determined based on the measurements and known locations of the terminal(s). For terminal positioning, measurements for at least one access point in a WLAN are obtained. The location of the terminal is determined based on the measurements and known location of each access point. The measurements may be round trip time (RTT) measurements, observed time difference (OTD) measurements, time of arrival (TOA) measurements, signal strength measurements, signal quality measurements, etc.

A positive response notification to provide information regarding locate and/or marking operations for underground facilities may include time-stamp information to provide proof of a time at which the locate and/or marking operation was completed by a locate technician, and/or place-stamp information to provide proof of a presence of the locate technician at or near a work site. An electronic manifest image and/or a virtual white line image similarly may be included in a positive response notification. In one example, such images may be bundled together based on respective descriptor files (or descriptor metadata) that associates the corresponding images with a locate request ticket for the operation. In another example, a positive response notification may include environmental information regarding one or more environmental conditions present at or near the work site during the locate and/or marking operation.

The present disclosure is related to illustrative embodiments of an apparatus and method for maintaining carbonation of sparkling beverages, such as sparkling wines, cocktails, and non-alcoholic beverages such as sodas and coffee. A transparent, shatter-resistant, height-adjustable carbonation enclosure is used to contain an opened bottle of a sparkling beverage. An air-tight carbonation cap with a built-in one-way valve is used to re-carbonate the beverage inside the bottle using a pressurized gas source. The base of the carbonation enclosure includes a platform that may be used to adjust the effective height of the enclosure to fit the height of the bottle and provide an air-tight interface between an opening of the bottle and the carbonation cap. The carbonation enclosure further includes a number of openings to open air to prevent pressurization of the carbonation enclosure. Another illustrative embodiment includes a safety enclosure for multiple bottles pressurized directly by conical nozzles.

The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6'-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

A connecting arrangement is provided between a plastic component with at least two mutually adjacent and at least approximately parallel walls and another structural element, having at least one force-transmission element which is adhesively bonded to the plastic component via an adhesive bond on the plastic component in frusto-conical or spherical-segment-shaped depressions in the mutually adjacent walls of the plastic component. The force-transmission element has a carrying structure for the other structural element. With the exception of a possibly provided coating, the force-transmission element is composed only of metallic material and has a plate which is adapted to the depression in the outer wall of the plastic component, which outer wall is adjacent to the other structural element. The edge of the plate rests with interposition on the outer wall in the surrounding region of the depression, wherein the plate is connected via a web to an end section of the force-transmission element, which end section is adapted to the depression in the other inner wall of the plastic component. The depression is configured in the outer wall without a bottom to such an extent that the end section of the force-transmission element can be inserted through the outer wall into the recess of the inner wall.

A wearable device has a carrier having an aperture. A device has a USB connection and a protrusion wherein the protrusion is received in the aperture to connect the device to a wristband. The device is a USB type device having athletic functionality. The device may further be configured to receive calibration data such that a measured distance may be converted to a known distance based on athletic activity performed by a user.

A communication module is provided in which its characteristic of separation between its first and second tuner units is improved. The module is equipped with a circuit board having a first main surface, and a second main surface opposite to the first main surface; a first amplifier arranged on the first main surface, for amplifying a first signal; a first mixer arranged on the first main surface, for converting a signal supplied from the first amplifier to an intermediate-frequency signal; a second amplifier for amplifying a second signal; and a mixer for converting a signal supplied from the second amplifier to an intermediate-frequency signal, both arranged on the second main surface of the circuit board.

A mobile device utilizes an embedded near field communication (NFC) capability to interact with a contactless transaction card to automatically obtain information from the card, e.g. reducing or eliminating the burden of manual user entry of the account information or the like into the mobile device. The mobile device, for a financial account transaction example, may read the information from the card at the time of a transaction, e.g. to facilitate an on-line purchase, an in-store purchase, ATM transaction or the like. The mobile device may store the information from one or more contactless transaction cards, for use in future transactions of various types. The mobile device and/or a server in communication with the mobile device may track various user activities on the mobile device that also utilize information obtained from the contactless transaction card.

The present invention relates to an organotemplate-free synthetic process for the production of a zeolitic material comprising YO2 and X2O3, wherein said process comprises the steps of (1) preparing a mixture comprising seed crystals, one or more sources for YO2, one or more sources for X2O3, and one or more solvents;(2) crystallizing the mixture obtained in step (1) to obtain a zeolitic material comprising YO2 and X2O3 as a crystallization product; wherein Y is a tetravalent element, and X is a trivalent element, and wherein at least a portion of the mother liquor obtained in step (2) is recycled to step (1) as a source for YO2, optionally after concentration of the mother liquor.

A cutting machine for gear shaping or the like is provided. The cutting machine includes a gear shaping head. The gear shaping head has a ram that is guided by and reciprocates along a linear guide mounted between a saddle of the gear shaping head and the ram. At least one linear motor reciprocates the ram along a stroke axis relative to the saddle. The ram also carries a rotary drive and a spindle that reciprocate in unison with the ram. The rotary drive directly drives the spindle to journal the spindle through incremental angular positions during gear shaping.

A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan.

The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

High pressure pump systems with reduced pressure ripple for use with waterjet systems and other systems are described herein. A pump system configured in accordance with a particular embodiment includes four reciprocating members operably coupled to a crankshaft at 90 degree phase angles. The reciprocating members can include plungers operably disposed in corresponding cylinders and configured to compress fluid (e.g., water) in the cylinders to pressures suitable for waterjet processing, such as pressures exceeding 30,000 psi.

Embodiments pertain to a scalp care device. The scalp care device includes a handle extended along a longitudinal axis and a set of curved teeth that extend along the longitudinal axis. The teeth are curved so as to facilitate sliding the teeth underneath a user's hair so that the tips of the teeth reach the user's scalp and can manipulate the scalp so as to provide care for it. The curved teeth are joined to the handle by a bridge region. In one embodiment, the teeth are hollow and the handle includes a bottle for holding liquid, such that the liquid may flow through the teeth to be deposited upon the scalp.

Interfaces for electrical (e.g., lighting) devices involve use of electrically conductive edge contacts arranged on or protruding from edges of printed circuit boards (PCBs) that provide or facilitate electrical connections to first and second externally accessible electrical contacts, such as may include threaded and foot contacts of a lighting device including a screw-shaped male base. First and/or second edge contacts of a PCB may protrude through first and second openings in a housing to form first and second externally accessible contact, or directly engage first and second externally accessible contact elements associated with (e.g., retained by) the housing. A contact element retained by a housing may define a slot in the interior of the housing to directly engage an edge contact of the PCB. Electric power is supplied to the PCB via edge contacts without need for intervening wires or soldered connections.

A mammalian quadruped walking system for providing visibility in dimly lit conditions features a body harness having a first side top shoulder strap, a second side top shoulder strap, a bottom strap, an upper body strap, a lower body strap, and a breast shield. The breast shield features a powerful bicycle's strength planar reflector that is only red or blue. The system features a harness extension having an extension first end located at an intersection of a first side top shoulder strap second end, a second side top shoulder strap second end and an upper body strap midpoint. A powerful bicycle's strength spherical red bead reflector is located adjacent to a spherical blue bead reflector close to a harness extension second end. The system features an external light source emitting light in a horizontal beam between 22 inches and 54 inches from a ground surface.

In a computing environment having a multiple input detection system including a detector that detects and transmits multiple simultaneous user inputs from different users at a same time, a method for processing inputs from different users across multiple application windows of one or more applications displayed on a single display of a user interface, resulting in a multi-user graphical user interface (GUI), the computing environment running an operating system (OS) designed to run with a single user GUI, the method including determining, in a primary application, separate from the OS, that a first user input corresponds to a first window and a second user input corresponds to a second window, the primary application sending the first and second user inputs to first and second secondary applications that run in parallel with the primary application, the first and second secondary applications being designed to run with the OS.

A personal security apparatus to house weapons, valuables, and/or items requiring concealment includes a lockable insert mechanism to securely house items and at least one receiving apparatus adapted to mount the insert mechanism into or onto various structures and a lockable access door that provides convenient, rapid access to the items contained in the personal security apparatus and further prevents access by unauthorized persons.

A wastewater geothermal heat system is supplied with processed wastewater through a drip field in proximity to a thermal array part of a geothermal heat pump system. The wastewater treatment system portion provides a periodic source of treated wastewater. Several sensors and a control system regulate a pump that discharges wastewater from the treatment system and enters a drip field where it is released into the surrounding soil. The dampened soil provides an efficient vehicle to transfer heat into or out of a thermal array which is positioned adjacent to the drip field such that it is in contact with the soil that is dampened by the discharged wastewater.

In one aspect, a first device includes a housing, at least one system component housed by the housing, a connector coupled to the housing that engages with a second device for exchange, between the first device and the second device, of at least one of data and power, and a first magnet coupled to the housing. The first magnet is coupled to the housing so that a first pole of the first magnet faces away from the first device to repel a first pole of a second magnet coupled to the second device when the first device is juxtaposed next to the second device in a first orientation relative to the second device.

A semiconductor device includes a plurality of circuits, a general bus configured to be connected to each of the plurality of circuits and to provide a general channel among the plurality of circuits, and a designated bus configured to be connected to a subgroup of circuits from among the plurality of circuits and to provide a designated channel among the subgroup of circuits.

A radial-flow plate heat exchanger (5) embedded in the catalytic bed of an isothermal chemical reactor (1) has heat exchange plates (10) comprising fluid passages (13) between a first metal sheet (20) and a second metal sheet (21) joined by perimeter weld seams (23) on a first surface (A) of the plate, a feeding channel (14) and a collecting channel (15) for the heat exchange fluid are formed with suitable metal sheets which are seam welded (25) directly to the opposite surface (B) of the plate, this structure allows the manufacturing of the plate (10) with an automated seam welding process, such as laser beam welding.

A low alloy steel ingot contains from 0.15 to 0.30% of C, from 0.03 to 0.2% of Si, from 0.5 to 2.0% of Mn, from 0.1 to 1.3% of Ni, from 1.5 to 3.5% of Cr, from 0.1 to 1.0% of Mo, and more than 0.15 to 0.35% of V, and optionally Ni, with a balance being Fe and unavoidable impurities. Performing quality heat treatment including a quenching step and a tempering step to the low alloy steel ingot to obtain a material, which has a grain size number of from 3 to 7 and is free from pro-eutectoid ferrite in a metallographic structure thereof, and which has a tensile strength of from 760 to 860 MPa and a fracture appearance transition temperature of not higher than 40° C.

An apparatus to support a device includes a first base; a first support; a first base-support hinge adapted to rotatably couple the first base and the first support along a first axis of rotation; a first swivel slidably connected to the first support and having a first cut-out adapted to receive a first portion of the device; a second base; a second support; a second base-support hinge adapted to rotatably couple the second base and the second support along a second axis of rotation; and a second swivel slidably connected to the second support and having a second cut-out adapted to receive a second portion of the device spaced apart from the first portion of the device.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

Earth-boring tools include a body, one or more blades projecting outwardly from the body, and cutting elements carried by the blade. The cutting elements include at least one shearing cutting element and at least one gouging cutting element. Methods of forming an earth-boring tool include mounting a shearing cutting element comprising an at least substantially planar cutting face to a body of an earth-boring tool, and mounting a gouging cutting element comprising a non-planar cutting face to the body of the earth-boring tool. The gouging cutting element may be positioned on the body of the earth-boring tool such that the gouging cutting element will gouge formation material within a kerf cut in the formation material by the shearing cutting element, or between kerfs cut in the formation material by a plurality of shearing cutting elements.