The government of Indonesia wanted to improve land and water management in the Citarum River Basin, and requested assistance from the Asian Development Bank (ADB) to develop a long-term integrated water resources management (IWRM) investment program as part of its strategic road map. In December 2008, ADB approved a multitranche financing facility (MFF) for the Integrated Citarum Water Resources Management Investment Program to support the implementation of the IWRM road map in the basin. A periodic financing request was formulated to implement priority activities from the road map.

670,000 households in Indonesia are benefitting from improved access to water and sanitation.

Proyek perbaikan kawasan kumuh: 670 ribu keluarga di Indonesia nikmati manfaat dari perbaikan akses air dan sanitasi.

HYDERABAD: The Secunderabad Cantonment area may soon have mixed land use zones for the overall development of its civilian areas. This is being proposed as part of the master plan for the area to be implemented between 2014 and 2021 and it will allow usage of land for all purposes like residential, commercial and recreational. As of now, there is no master plan for the Secunderabad Cantonment area and the civilian areas have been developing in a haphazard manner. With an intention to chalk up a master plan along with a development strategy plan and an investment plan, the Secunderabad Cantonment Board (SCB) had recently approached the Hyderabad Metropolitan Development […]

KOLKATA: The state Public Works department (PWD) have divided all its circles into three zones – North, West and South for better supervision and monitoring of development projects of various government department entrusted to PWD all over the state. The PWD authorities were mulling on the plan to reorganise all its circles with the aim to implement the concept of coming up with three zones – North zone, West zone and South zone – so that the authorities can properly monitor and supervise all development projects that have been entrusted on them by the other departments. The PWD has several circles under the PWD road division, national highway and state […]

CES 2020, LAS VEGAS – JANUARY 6, 2020 – HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is announcing its entry into the gaming...

CES 2020, LAS VEGAS – JANUARY 6, 2020 – HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, announces that the Personi-Fi platform...

BANGALORE, INDIA –  HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced the launch of limited edition JBL® Raaga Synchros S500AR headphones, autographed by academy award winner...

NORTHRIDGE, Calif.—HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced new AKG K361-BT and K371-BT professional studio headphones featuring Bluetooth connectivity at the 2020 NAMM show in...

STAMFORD, CT – May 5, 2016 – Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced it will showcase the industry’s first  developer-ready ...

Berlin, Germany - yurbuds® powered by JBL®, the sport earphones guaranteed never to hurt or fall out, is officially debuting yurbuds products with JBL Signature Sound at IFA in Berlin.

CES 2015, LAS VEGAS – HARMAN, the premium global audio, infotainment and enterprise automation group (NYSE:HAR), proudly introduce yurbuds® powered by JBL®, the number one selling sport earphone in the nation, is officially debuting yurbuds® products with JBL® Signature Sound in the US. JBL® is known industry-wide for its supreme quality, so coupling that with yurbuds® ergonomics, guaranteed never to hurt or fall out, you have a headphone like no other on the market.

June 15 - A community in East Java, Indonesia, is turning methane from the local garbage dump into gas for more than 400 homes. Local authorities have set up a system where methane produced by rotting waste is extracted and pumped to villages nearby, turning greenhouse gas emissions into useful energy. Tara Cleary reports.

A pizza chain in northern Russia begins to deliver pizza by Russian-made drones. Elly Park reports.

Amazon or UPS packages won't be dropped by drones anytime soon, but drones are finally getting a flight plan for business. And it starts in Rwanda.

Five species of songbird and five subspecies have been discovered by scientists for the first time in mountainous areas of Indonesia

Dozens of people have died in Indonesia and Mozambique as a result of storms and flooding, possibly driven by climate change

People living in Russia about 20,000 years ago built a "bonehenge" – a circular structure made of mammoth bones that could have been used to store food

Powerful family clans. Mysterious sex lives. Constant warfare. There is more to these fascinating fungi than their distinctive flavour

The data centres servicing our beloved digital devices gobble huge amounts of electricity. A new way to think about heat and energy could help us meet growing demand without burning through the world's resources

Potbelly Corp said on Friday it is unable to file its quarterly report with the U.S. SEC by the May 8 deadline due to the COVID-19 crisis, adding to the restaurant chain's pandemic-led woes.

Title: 'Healthy Bones' Shot Could Cut Women's Fracture Risk
Category: Health News
Created: 5/3/2007 2:00:00 AM
Last Editorial Review: 5/3/2007 12:00:00 AM

Title: Cola May Be Bad to the Bones
Category: Health News
Created: 4/27/2008 2:00:00 AM
Last Editorial Review: 4/28/2008 12:00:00 AM

Title: Some Diet Sodas May Ward Off Kidney Stones
Category: Health News
Created: 4/30/2009 2:00:00 AM
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Title: Scientists Find Way to Heal Broken Bones Faster
Category: Health News
Created: 4/28/2010 2:10:00 PM
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Title: Exercise May Lower Older Women's Risk for Kidney Stones
Category: Health News
Created: 5/3/2013 12:35:00 PM
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Title: With Kids In Car, Parents Still Likely to Use Cellphones
Category: Health News
Created: 5/2/2014 12:36:00 PM
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Title: Very Young Kids Often Use Tablets, Smartphones, Study Finds
Category: Health News
Created: 4/26/2015 12:00:00 AM
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Title: Focus on Healthy Foods, Not Avoiding 'Bad' Ones, for Heart Health: Study
Category: Health News
Created: 4/25/2016 12:00:00 AM
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Title: Most Seniors Use Cellphones While Behind the Wheel
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Created: 4/28/2017 12:00:00 AM
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Title: Are Smartphones Helping or Harming Kids' Mental Health?
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Created: 5/3/2017 12:00:00 AM
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Title: College Kids May Be Learning, Even When Checking Smartphones
Category: Health News
Created: 4/27/2018 12:00:00 AM
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Title: Could Smartphones Be Making Migraines Even Tougher to Treat?
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Created: 3/4/2020 12:00:00 AM
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Title: Drinking Takes Toll on Bones of People With HIV: Study
Category: Health News
Created: 3/6/2020 12:00:00 AM
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Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

An exceptionally well-preserved specimen of the articulated rhodophyte Permocalculus, compared with P. tenellus sensu Elliott, 1955, is described from fine-grained Upper Permian limestones of the Khuff Formation of Saudi Arabia. Longitudinal medullary and sheaf-like cortical filaments extend through the uniserial series of elongate-globular, concave- and convex-terminating, interlocking segments for which they are interpreted to have functioned in articulation. The filaments tend to splay and branch laterally into the cortex where they terminate at the pores. At the terminal aperture, the filaments extend as bifurcating and possibly trifurcating branches and may serve as the origin of a new segment. Numerous elongate-globular chambers, up to five in each row and intimately involved with the filaments, are developed in the outer medulla and are considered to represent reproductive sporangia. The specimen is considered to have occupied predominantly low-energy, normal to slightly elevated salinity, shallow conditions within the subtidal regime of a lagoon.

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc₁ complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimized to produce novel quinolones that are active in vitro and in animal models. While these quinolones exhibit potent ex vivo activity against Plasmodium falciparum and Plasmodium vivax, their activity against the zoonotic agent Plasmodium knowlesi is unknown. We screened several of these novel endochin-like quinolones (ELQs) for their activity against P. knowlesi in vitro and compared this with their activity against P. falciparum tested under identical conditions. We demonstrated that ELQs are potent against P. knowlesi (50% effective concentration, <117 nM) and equally effective against P. falciparum. We then screened selected quinolones and partner drugs using a longer exposure (2.5 life cycles) and found that proguanil is 10-fold less potent against P. knowlesi than P. falciparum, while the quinolones demonstrate similar potency. Finally, we used isobologram analysis to compare combinations of the ELQs with either proguanil or atovaquone. We show that all quinolone combinations with proguanil are synergistic against P. falciparum. However, against P. knowlesi, no evidence of synergy between proguanil and the quinolones was found. Importantly, the combination of the novel quinolone ELQ-300 with atovaquone was synergistic against both species. Our data identify potentially important species differences in proguanil susceptibility and in the interaction of proguanil with quinolones and support the ongoing development of novel quinolones as potent antimalarials that target multiple species.

Background:

Sex steroid hormones and sex hormone–binding globulin (SHBG) have been implicated in the etiology of invasive breast cancer, but their associations with risk of the precursor lesion, ductal carcinoma in situ (DCIS) of the breast, remain unclear.

James Dean is set to be the latest actor to star in a film long after his death, but the rise of true Hollywood immortality raises big ethical questions

The data centres servicing our beloved digital devices gobble huge amounts of electricity. A new way to think about heat and energy could help us meet growing demand without burning through the world's resources

New drone standard for remote ID submitted for approval

Mid-air docking of flying batteries can massively extend the flight time of a drone

Researchers in Brazil are developing a drone that scouts for evidence—and want to use its footage to reconstruct crime scenes

A military exercise in Australia demonstrates how small drones can airdrop critical medical supplies to soldiers in combat

New York City study shows that drones could deliver life-saving medical supplies several minutes before an ambulance arrives

A new contest aims to help first responders leverage computer vision algorithms and drone imagery during a search