In order to help in the fight against COVID-19, the European Commission has adopted a Decision, addressed to the Member States, which allows for tax authorities across Europe to offer import tax reliefs to importers of personal protective equipment ...

Over the past decade various attempts have been made to ensure civil litigation and "access to justice" are affordable to all. Indeed when the Woolf reforms were introduced over ten years ago one fundamental tenet of these reforms was to make the co...

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Final-year medical students across the country are afraid to return to hospitals to complete their in-service training as Covid-19 continues to rapidly spread.

(MENAFN - EIN Presswire) Coronavirus - Africa: Commemorating Smallpox Eradication � a legacy of hope, for COVID-19 and other�diseases [To enable links... ......

(MENAFN - African Press Organization) [To enable links in your articles, contact MENAFN Click here ] [To enable links in your articles, contact MEN... ......

The Groceries Code Adjudicator (the “GCA”) was set up in June 2013 to ensure that large retailers with a turnover of over £1bn comply with the Groceries Supply Code of Practice (the “Code”). This statutory body h...

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(MENAFN - Trend News Agency) Baku, Azerbaijan, May 9 Trend: The Azerbaijani Embassy in France will organize a virtual concert dedicated to the 97th bi... ......

JEFFERSON CITY, Mo. (AP) " Frustrated by scarce supplies and a chaotic...

By DAVID A. LIEB JEFFERSON CITY, Mo. (AP) — Frustrated by scarce supplies and a chaotic marketplace amid the coronavirus outbreak, some U.S. governors are seeking to bolster their home-state production of vital medical and protective equipment to ensure a reliable long-term source for state stockpiles. The efforts come as states have been competing against each other, the federal government, hospitals, emergency responders and even other countries to get items such as N95 masks, gloves, medical gowns and hand sanitizer — often paying higher-than-usual prices because of the high demand. Before the coronavirus pandemic, the U.S. got much of its medical supplies from China. But China limited...

Download logo On 8 May 1980, the 33rd World Health Assembly officially declared: ‘The world and all its peoples have won freedom from smallpox.’ The declaration marked the end of a disease that had plagued humanity for at least 3 000 years, killing 300 million people in the 20th century alone. It was ended, thanks to a 10-year global effort, spearheaded by the World Health Organization, that involved thousands of health workers around the world to administer half a billion vaccinations to stamp out smallpox. The US$ 300m price-tag to eradicate smallpox saves the world well over US$ 1 billion every year since 1980. Speaking at a virtual event hosted at WHO-HQ, involving key...

JEFFERSON CITY, Mo. (AP) — Frustrated by scarce supplies and a chaotic marketplace amid the coronavirus outbreak, some U.S. governors are seeking to bolster their home-state production of vital medical and protective equipment to ensure a reliable long-term source for state stockpiles. The efforts come as states have been competing against each other, the federal government, hospitals, emergency responders and even other countries to get items such as N95 masks, gloves, medical gowns and hand sanitizer — often paying higher-than-usual prices because of the high demand. Before the coronavirus pandemic, the U.S. got much of its medical supplies from China. But China limited exports earlier...

Rev Liberato C. Bautista is assistant general secretary for United Nations and International Affairs of the United Methodist Board of Church and Society. He also serves as president of the Conference of Non-Governmental Organizations in Consultative Relationship with the United Nations.

The post Collaboration Can Help Eradicate COVID-19 appeared first on Inter Press Service.

[WHO] Geneva -On 8 May 1980, the 33rd World Health Assembly officially declared: 'The world and all its peoples have won freedom from smallpox.'

[WHO] Geneva -Good morning, good afternoon and good evening.

[Premium Times] In February, PREMIUM TIMES exclusively spoke with Chris Elias, the President of the Global Development Division of the Bill and Melinda Gates Foundation and Paulin Basinga, the foundation's country director, on the role the foundation played in the eradication of wild polio in Nigeria and a range of other developmental issues.

[DW] Kenya has demanded an investigation into a fatal crash of a humanitarian aircraft which killed all people on board.

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province and provision of automated coronavirus testing machines to medical staff. The demand was made...

PESHAWAR: The Bacha Khan Medical College in Mardan has launched online classes for its students in order to enable them to pursue their studies without any hindrance.It was the first medical college that took the initiative after the government closed all educational institutions in the country...

A surprise jump in Chinese exports in April will be short-lived, analysts said, with the world’s second largest economy unable to stay sheltered from the demand shock to come from the global economic downturn.A 3.5 per cent rise in shipments last month caught economists by surprise and left them scrambling for explanations as the consensus forecast was for an 11 per cent contraction.The rise was, in part, due to factories coming back online in China in March and April to fulfil orders that had…

LATIN AMERICAN MEDICINE DAY Medical professionals honored This December 3, celebrated in Cuba as Latin American Medicine Day, provided an opportunity to recognize those who, with disinterested humility, “struggle every day for the lives of our people and in other sister countries,”

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province...

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French police have dismantled smuggling networks trying to take advantage of a rush to buy medical supplies including face masks to tackle the coronavirus epidemic, the interior minister said Friday.

Medical waste disposal is a key part of pandemic planning and recovery that we must get right during the COVID-19 outbreak.

The Asian Development Bank (ADB) has provided a guarantee for a $25 million trade loan to the State Pharmaceuticals Corporation of Sri Lanka (SPC) to purchase medical supplies as part of the country’s response to the novel ....

Microchip Joins Responsible Business Alliance (RBA) – the Global Industry Coalition Dedicated to Corporate Social Responsibility

In the midst of the Covid-19 pandemic and the drastic changes in social interaction that it has caused, who among us has not felt the desire to reach out, to engage, to reconnect? At HARMAN, one of our most dearly-held beliefs is that music empowers...

In what now seems like a galaxy far, far away, Republican lawmakers routinely talked up the idea of raising the Medicare eligibility age from 65 to 67. In fact, we were in that galaxy just three...

The story of how gin and tonic came together fizzes with adventure, discovery, imperial ambition, biopiracy and a generous splash of fake news

The discovery of a link between anxiety, depression, OCD and more is set to revolutionise how we think about these conditions – and offer new treatments

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This article describes the development of medical competencies for oral medicine specialty training in the UK and Ireland by a collaborative working group using a modified Delphi technique. The current specialty training curriculum for oral medicine (OM) in the UK was developed by a working group including members of the British Society for Oral Medicine (BSOM) and members of the Specialty Advisory Committee for Additional Dental Specialties (SACADS) and adopted by the UK General Dental Council (GDC) in 2010. When the curriculum was developed, the entry requirements for specialty training in OM included undergraduate degrees in both dentistry and medicine. At the time of adoption, the requirement for a medical degree was removed. Medical competencies were assumed to have been delivered in medical undergraduate and postgraduate training. Accordingly, there was a need to define the medical competencies for OM specialty training to benefit trainees, trainers, and assessors. In 2018, a group comprising specialty trainers, recent former specialty trainees, and current specialty trainees in OM held face-to-face meetings in addition to email discussions and developed an updated curriculum document to better reflect the medical competencies required in specialty training. A collaborative modified Delphi approach was used to evaluate medical foundation competencies and to include only those that were considered relevant to OM specialty training. A list of relevant and achievable medical competencies was determined that has been approved by SACADS and will be incorporated into a revised OM curriculum from the UK GDC. The newly agreed-upon document for medical competencies in OM specialty training will serve as a reference for trainees, trainers, and assessors and reflects a successful use of a modified Delphi approach.

ABSTRACT

Staphylococcus aureus is a major concern in human health care, mostly due to the increasing prevalence of antibiotic resistance. Intracellular localization of S. aureus plays a key role in recurrent infections by protecting the pathogens from antibiotics and immune responses. Peptidoglycan hydrolases (PGHs) are highly specific bactericidal enzymes active against both drug-sensitive and -resistant bacteria. However, PGHs able to effectively target intracellular S. aureus are not yet available. To overcome this limitation, we first screened 322 recombineered PGHs for staphylolytic activity under conditions found inside eukaryotic intracellular compartments. The most active constructs were modified by fusion to different cell-penetrating peptides (CPPs), resulting in increased uptake and enhanced intracellular killing (reduction by up to 4.5 log units) of various S. aureus strains (including methicillin-resistant S. aureus [MRSA]) in different tissue culture infection models. The combined application of synergistic PGH-CPP constructs further enhanced their intracellular efficacy. Finally, synergistically active PGH-CPP cocktails reduced the total S. aureus by more than 2.2 log units in a murine abscess model after peripheral injection. Significantly more intracellular bacteria were killed by the PGH-CPPs than by the PGHs alone. Collectively, our findings show that CPP-fused PGHs are effective novel protein therapeutics against both intracellular and drug-resistant S. aureus.

IMPORTANCE The increasing prevalence of antibiotic-resistant bacteria is one of the most urgent problems of our time. Staphylococcus aureus is an important human pathogen that has acquired several mechanisms to evade antibiotic treatment. In addition, S. aureus is able to invade and persist within human cells, hiding from the immune response and antibiotic therapies. For these reasons, novel antibacterial strategies against these pathogens are needed. Here, we developed lytic enzymes which are able to effectively target drug-resistant and intracellular S. aureus. Fusion of these so-called enzybiotics to cell-penetrating peptides enhanced their uptake and intracellular bactericidal activity in cell culture and in an abscess mouse model. Our results suggest that cell-penetrating enzybiotics are a promising new class of therapeutics against staphylococcal infections.

Addressing social drivers of health in medical education—through community engagement experiences—is essential for health equity and the development of future physicians. While this was written before the COVID-19 pandemic, these practices will gain even more importance as we come together to better understand its health and community implications in North Carolina and the United States.

A growing number of small secreted peptides (SSPs) in plants are recognized as important regulatory molecules with roles in processes such as growth, development, reproduction, stress tolerance, and pathogen defense. Recent discoveries further implicate SSPs in regulating root nodule development, which is of particular significance for legumes. SSP-coding genes are frequently overlooked, because genome annotation pipelines generally ignore small open reading frames, which are those most likely to encode SSPs. Also, SSP-coding small open reading frames are often expressed at low levels or only under specific conditions, and thus are underrepresented in non-tissue-targeted or non-condition-optimized RNA-sequencing projects. We previously identified 4,439 SSP-encoding genes in the model legume Medicago truncatula. To support systematic characterization and annotation of these putative SSP-encoding genes, we developed the M. truncatula Small Secreted Peptide Database (MtSSPdb; https://mtsspdb.noble.org/). MtSSPdb currently hosts (1) a compendium of M. truncatula SSP candidates with putative function and family annotations; (2) a large-scale M. truncatula RNA-sequencing-based gene expression atlas integrated with various analytical tools, including differential expression, coexpression, and pathway enrichment analyses; (3) an online plant SSP prediction tool capable of analyzing protein sequences at the genome scale using the same protocol as for the identification of SSP genes; and (4) information about a library of synthetic peptides and root and nodule phenotyping data from synthetic peptide screens in planta. These datasets and analytical tools make MtSSPdb a unique and valuable resource for the plant research community. MtSSPdb also has the potential to become the most complete database of SSPs in plants.

BACKGROUND:

Medicaid plays a critical role during the perinatal period, but pregnancy-related Medicaid eligibility only extends for 60 days post partum. In 2014, the Affordable Care Act’s (ACA’s) Medicaid expansions increased adult Medicaid eligibility to 138% of the federal poverty level in participating states, allowing eligible new mothers to remain covered after pregnancy-related coverage expires. We investigate the impact of ACA Medicaid expansions on insurance coverage among new mothers living in poverty.