Trees, shrubs and woody vines are among the top food sources for honey bees in urban environments, according to an international team of researchers. By using honey bees housed in rooftop apiaries in Philadelphia, the researchers identified the plant species from which the honey bees collected most of their food, and tracked how these food resources changed from spring to fall. The findings may be useful to homeowners, beekeepers and urban land managers who wish to sustain honey bees and other bee and pollinator species.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

With speed and ingenuity, more than 100 researchers across Penn State are shifting their research programs to address the COVID-19 crisis, thanks to funding from a seed grant initiative led by the Huck Institutes of the Life Sciences. In total, the initiative awarded $2.25 million to 47 teams of researchers from three campuses, 10 colleges and more than 25 departments.

Abusive head trauma (AHT) remains a significant cause of morbidity and mortality in the pediatric population, especially in young infants. In the past decade, advancements in research have refined medical understanding of the epidemiological, clinical, biomechanical, and pathologic factors comprising the diagnosis, thereby enhancing clinical detection of a challenging diagnostic entity. Failure to recognize AHT and respond appropriately at any step in the process, from medical diagnosis to child protection and legal decision-making, can place children at risk. The American Academy of Pediatrics revises the 2009 policy statement on AHT to incorporate the growing body of knowledge on the topic. Although this statement incorporates some of that growing body of knowledge, it is not a comprehensive exposition of the science. This statement aims to provide pediatric practitioners with general guidance on a complex subject. The Academy recommends that pediatric practitioners remain vigilant for the signs and symptoms of AHT, conduct thorough medical evaluations, consult with pediatric medical subspecialists when necessary, and embrace the challenges and need for strong advocacy on the subject.

Graham A. Colditz
Jul 1, 1995; 96:29-35
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T. Michael O'Shea
Jul 1, 1999; 104:15-21
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Wolfgang Lindner
May 1, 1999; 103:961-967
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Jeffrey D. Horbar
Jun 1, 2012; 129:1019-1026
ARTICLES

Robert Guthrie
Sep 1, 1963; 32:338-343
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Richard A. Ehrenkranz
Aug 1, 1999; 104:280-289
ARTICLES

G. C. Liggins
Oct 1, 1972; 50:515-525
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Terrie E. Inder
Feb 1, 2005; 115:286-294
ARTICLES

Jeffrey D. Horbar
Jul 1, 2002; 110:143-151
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C. Michael Cotten
Jan 1, 2009; 123:58-66
ARTICLES

Richard A. Ehrenkranz
Apr 1, 2006; 117:1253-1261
ARTICLES

Julie A. Jaskiewicz
Sep 1, 1994; 94:390-396
COMMENTARY

Mary Ellen Avery
Jan 1, 1987; 79:26-30
ARTICLES

Andrew T. Shennan
Oct 1, 1988; 82:527-532
ARTICLES

Kate Costeloe
Oct 1, 2000; 106:659-671
ARTICLES

Betty R. Vohr
Jun 1, 2000; 105:1216-1226
ARTICLES

The IMpact-RSV Study Group
Sep 1, 1998; 102:531-537
ARTICLES

Barbara J. Stoll
Sep 1, 2010; 126:443-456
ARTICLES

Federal education officials have begun announcing a new round of grants from the Teacher Incentive Fund.

Another dozen school districts have landed federal Teacher Incentive Fund grants, including one that will focus on paying principals and assistant principals for their performance.

With plenty of best sellers at $4.99 or less, like Midnight in Chernobyl, you're basically getting a free book or two.

JooYoung Seo, a doctoral candidate in the College of Education’s Learning, Design, and Technology program, has secured a highly competitive internship with RStudio that will allow him to help people just like himself — those with severe visual impairments.

Source: www.youtube.com - Saturday, February 29, 2020

The Institute for Computational and Data Sciences, in conjunction with several Penn State colleges, awarded more than $725,000 in seed grants to fund 32 new computational and data sciences projects. The 57 researchers involved in the awards represent 12 Penn State colleges and 31 academic departments.

The Assessment for Learning Project, a partnership between Center for Innovation in Education and Next Generation Learning Challenges, granted twelve grants totaling $2 million for rethinking assessment.

The 64 entrants are confirmed, 32 in the UEFA Champions League path and 32 in the domestic champions path to be drawn on Tuesday.

Minister of Public Enterprises Pravin Gordhan briefed a joint meeting of Parliament's Portfolio and Standing Committees on Public Enterprises on Wednesday evening.

OM’s Xenos team in Heilbronn ministers to immigrants in a holistic way by proclaiming the gospel and supporting them in their physical and emotional needs.

A member of OM Germany's Xenos team experiences the joy of seeing immigrants reach other immigrants.

OM workers Elsbeth and Josef* are seeing vibrant communities of Jesus followers among least reached immigrants in Germany.

By manipulating the expression of one gene, geneticists can induce a form of “stress memory” in plants that is inherited by some progeny, giving them the potential for more vigorous, hardy and productive growth, according to Penn State researchers, who suggest the discovery has significant implications for plant breeding.

The Arthur W. Page Center for Integrity in Public Communication announced the recipients of its 2020 Page/Johnson Legacy Scholar Grants. This year’s call will fund 12 projects that examine “organizational listening,” its role in successful corporate communications and the consequences of when companies don’t listen.

The Department of Education has denied 99 percent of applications for public service loan forgiveness under a temporary expanded program funded by Congress, a report finds.

Using a matched cohort design, in this study, we define the adverse clinical and financial implications of UEs in the NICU.

Through propensity score analysis, we examine the effect of living in a segregated area on the development of neonatal IVH, stratified by maternal race.

A Maryland woman who caused a fatal crash while driving under the influence of drugs has been sentenced to prison. Deputy Attorneys General Barzilai Axelrod and William Leonard secured the sentence for Michelle Park, 35, of Earlville. In March 2018, with her 2-year-old child in the car, Park failed to negotiate a curve while driving […]

Applications are being accepted from community organizations for $1.3 million in funds to support crime reduction, neighborhood revitalization, and economic development programs statewide, with special emphasis on programs in and around downtown areas and neighborhoods, Attorney General Matt Denn and Delaware Division of Small Business, Development and Tourism Director Cerron Cade announced Tuesday. Applications are […]

THE NATIONAL ENDOWMENT FOR THE ARTS ANNOUNCES FY 2018 GRANTS TO SUPPORT THE ARTS Two Delaware organizations will receive $20,000 in federal grants Wilmington, Del. (February 7, 2018) – Each year, more than 4,500 communities large and small throughout the United States benefit from National Endowment for the Arts (NEA) grants to nonprofits. For the […]

Delaware’s Public Advocate today issued a letter to the White House asking the Trump administration to deny a request for emergency bailouts for aging coal and nuclear power plants owned by a large regional energy supplier.

Three Delaware organizations will receive $729,100 in federal grants Wilmington, Del. (May 15, 2018) – As the only funder in the country to support arts activities in all 50 states and five U.S. jurisdictions, the National Endowment for the Arts (NEA) announced that three Delaware organizations, including the Division of the Arts, will receive $729,100 in […]

This year the Division will invest nearly $3 million in more than 100 arts and community organizations Wilmington, Del. (August 8, 2018) – The Delaware Division of the Arts is investing nearly $3 million in more than 100 arts and community organizations that will serve Delawareans statewide with arts programming and services, arts education, and […]

Three Delaware organizations will receive $54,000 in federal grants Wilmington, Del. (February 15, 2019) — As the only funder in the country to support arts activities in all 50 states and five U.S. jurisdictions, the National Endowment for the Arts (NEA) announced that three Delaware organizations will receive $54,000 in federal grants. This is the […]

This year the Division will invest nearly $3 million in more than 100 arts and community organizations Wilmington, Del. (July 30, 2019) – The Delaware Division of the Arts is investing nearly $3 million in more than 100 arts and community organizations that will serve Delawareans statewide with arts programming and services, arts education, and […]

Deadline for Spring 2020 EDGE Grants is February 28, 2020 WILMINGTON, Del. – A bio-based materials company, a maker of wearable medical sensors, and a bakery-café were among the 10 Delaware small businesses recognized Thursday as awardees of the second round of EDGE Grants from the state Division of Small Business. Governor John Carney, Secretary […]