Paris : G. Steinheil, 1895.

Paris : G. Steinheil, 1891.

Paris : Société d’éditions scientifiques, 1893.

Paris : V.A. Delahaye, 1878.

Edinburgh : Oliver and Boyd, 1884.

London : Longmans, Green, 1902.

The Mississippi education department will be the first to operate a teacher residency program, which aims to increase retention and diversity in the profession.

Berlin (Louisen-Str. 53) : Published by F. Silber, [between 1800 and 1899]

[Dublin] : National Art Union for Ireland, [between 1847 and 1851?]

Liverpool (82, Duke Street) ; And in London (13 St. James's Place, Hampstead Road) : Published ... by the artist, April 10th. 1854.

Rockville, Maryland : National Institute on Drug Abuse, 1976.

Rockville, Maryland : U.S. Dept. of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, 1976.

[Hong Kong] : [Art In Hospitals], [2019]

Chih-Yuan Hsu, Yi-Hau Chen, Ruoh-Rong Yu, Tsung-Wei Hung.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 160--177.

Abstract:
Workers in Taiwan overall have been suffering from long-lasting wage stagnation since the mid-1990s. In particular, there seems to be little mobility for the wages of Taiwanese workers to transit across wage quantile groups. It is of interest to see if certain groups of workers, such as female, lower educated and younger generation workers, suffer from the problem more seriously than the others. This work tries to apply a systematic statistical approach to study this issue, based on the longitudinal data from the Panel Study of Family Dynamics (PSFD) survey conducted in Taiwan since 1999. We propose the quantile transition regression model, generalizing recent methodology for quantile association, to assess the wage status transition with respect to the marginal wage quantiles over time as well as the effects of certain demographic and job factors on the wage status transition. Estimation of the model can be based on the composite likelihoods utilizing the binary, or ordinal-data information regarding the quantile transition, with the associated asymptotic theory established. A goodness-of-fit procedure for the proposed model is developed. The performances of the estimation and the goodness-of-fit procedures for the quantile transition model are illustrated through simulations. The application of the proposed methodology to the PSFD survey data suggests that female, private-sector workers with higher age and education below postgraduate level suffer from more severe wage status stagnation than the others.

South Australia -- Genealogy.

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2018

Oracle and Zoom just entered a deal that for once is more about technological audacity than about dollars -- a partnership to host Zoom on Oracle Cloud Infrastructure. In just a few months -- basically since the beginning of the novel coronavirus pandemic -- Zoom has seen demand for its service grow from about 10 million daily meeting participants to more than 300 million.

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory and inhibitory synaptic constituents in an rTg4510 mouse model of tauopathy, which develops tau pathologies leading to noticeable brain atrophy at 5-6 months of age. Both male and female mice were analyzed in this study. We observed that radiosignals derived from [¹¹C]flumazenil, a tracer for benzodiazepine receptor, in rTg4510 mice were significantly lower than the levels in nontransgenic littermates at 2-3 months of age. In contrast, retentions of (E)-[¹¹C]ABP688, a tracer for mGluR5, were unaltered relative to controls at 2 months of age but then gradually declined with aging in parallel with progressive brain atrophy. Biochemical and immunohistochemical assessment of postmortem brain tissues demonstrated that inhibitory, but not excitatory, synaptic constituents selectively diminished without overt loss of somas of GABAergic interneurons in the neocortex and hippocampus of rTg4510 mice at 2 months of age, which was concurrent with enhanced immunoreactivity of cFos, a well-characterized immediate early gene, suggesting that impaired inhibitory neurotransmission may cause hyperexcitability of cortical circuits. Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.

SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[¹¹C]ABP688 and [¹¹C]flumazenil, respectively. We identified inhibitory synapse as being significantly dysregulated before brain atrophy at 2 months of age, while excitatory synapse stayed relatively intact at this stage. In line with this observation, postmortem assessment of brain tissues demonstrated selective attenuation of inhibitory synaptic constituents accompanied by the upregulation of cFos before the formation of tau pathology in the forebrain at young ages. Our findings indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy.

To determine whether Cav1.2 voltage-gated Ca²⁺ channels contribute to astrocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 α subunit was deleted in GFAP-positive astrocytes. This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of myelin injury and repair which causes astrocyte and microglia activation in the absence of a lymphocytic response. Deletion of Cav1.2 channels in GFAP-positive astrocytes during cuprizone-induced demyelination leads to a significant reduction in the degree of astrocyte and microglia activation and proliferation in mice of either sex. Concomitantly, the production of proinflammatory factors such as TNFα, IL1β and TGFβ1 was significantly decreased in the corpus callosum and cortex of Cav1.2 knock-out mice through demyelination. Furthermore, this mild inflammatory environment promotes oligodendrocyte progenitor cells maturation and myelin regeneration across the remyelination phase of the cuprizone model. Similar results were found in animals treated with nimodipine, a Cav1.2 Ca²⁺ channel inhibitor with high affinity to the CNS. Mice of either sex injected with nimodipine during the demyelination stage of the cuprizone treatment displayed a reduced number of reactive astrocytes and showed a faster and more efficient brain remyelination. Together, these results indicate that Cav1.2 Ca²⁺ channels play a crucial role in the induction and proliferation of reactive astrocytes during demyelination; and that attenuation of astrocytic voltage-gated Ca²⁺ influx may be an effective therapy to reduce brain inflammation and promote myelin recovery in demyelinating diseases.

SIGNIFICANCE STATEMENT Reducing voltage-gated Ca²⁺ influx in astrocytes during brain demyelination significantly attenuates brain inflammation and astrocyte reactivity. Furthermore, these changes promote myelin restoration and oligodendrocyte maturation throughout remyelination.

The sites include the 5,000-year-old tomb of Meresankh III, the Red Monastery and the Mosque-Madrassa of Sultan Barquq

Research suggests bronze blades, thought by some to be too fragile for combat, were deadly weapons across ancient Europe

The dominant bear in the swamp is fending off another challenge to his authority by an intruder. It's a clash of titans with mating rights on the line.

Baltimore Orioles outfielder and first baseman Trey Mancini revealed Tuesday he is in the midst of six months of chemotherapy as he fights Stage III colon cancer.

Oracle and Zoom just entered a deal that for once is more about technological audacity than about dollars -- a partnership to host Zoom on Oracle Cloud Infrastructure. In just a few months -- basically since the beginning of the novel coronavirus pandemic -- Zoom has seen demand for its service grow from about 10 million daily meeting participants to more than 300 million.

Tag: music therapy  Houston Public Media

Visions 2020: Nydia Han and 6abc celebrates Asian Pacific American Heritage Month - 6abc  WPVI-TV

From stage to sofa: NAC brings local arts to homes in new livestream initiative  Connected to India

The COVID-19 pandemic has meant a spike in demand for puppies and an opportunity for scammers who are charging inflated prices for dogs not ready to be adopted out or with missing or bogus papers.

Mary Ellen Dalgleish, a poultry expert at Purity Feeds in Kamloops, B.C., believes the increased interest in backyard chickens follows concerns about food security when consumers saw grocery store shelves cleared out early in the COVID-19 pandemic in B.C.

Bank of Spain Working Papers by Henrique S. Basso and Juan F. Jimeno

Apple has been hit with a class-action lawsuit claiming that the company concealed the so-called "stage lighting" issue experienced by some 2016 MacBook Pro owners.

Is Angola about to become a global player? Luanda’s recent diplomatic charm offensive means the country is running unopposed for one of three African nonpermanent seats on the United Nations Security Council for 2015 and 2016. Angola is no stranger to projecting power and influence. It has expanded its financial interests well beyond the African continent into Asia, Latin America and Europe. It is intent on developing regional and international influence and is poised to become a key interlocutor on a range of African issues. But this will bring with it potentially heavy responsibilities.

Tampico, Mexico :: Logos Hope's international crewmembers perform their onboard theatre show entirely in Spanish for the first time.

Writers have been ransacking the Brainy Quotes website looking for inspiration for their coronavirus think pieces. But there is really only one that matters: “We have nothing to fear but fear itself”. Franklin D Roosevelt’s epigram is appropriate because it is as disingenuous as it is paradoxical.

While state school-finance systems have not changed much over time, they are devoting more targeted help to English language learners and student from low-income backgrounds than in the past, a new study finds.

Marc Tucker discusses a new report on teacher shortages from Linda Darling-Hammond's Learning Policy Institute and gives insights into how the U.S. can produce the high-quality educators it needs.

Preterm children born between 29 and 36 gestational weeks are at higher risk of developmental delay. The Ages and Stages Questionnaires (ASQ) have been recommended as a developmental screening tool.

At 12 months’ corrected age (CA), the ASQ was insufficient in identifying delays on both mental and psychomotor scales of the Bayley Scales of Infant Development but was accurate in detecting mental delay at CA of 24 months. (Read the full article)

There are no studies to support the clinical awareness of persistent Tanner stage (TS) 4 breast development in adulthood, and forensic experts continue to use TS 4 as evidence of age <18 years in cases of alleged child pornography.

One-fourth of nonclinical images of women over 18 years of age could be considered by a single forensic expert to represent TS 4. This observation, and substantial discordance in interpretation by pediatric endocrinologists, renders testimony based on this distinction invalid. (Read the full article)

Part C early intervention serves ~2.8% of US children who are younger than 3 years old; however, there is evidence that substantial numbers of infants and toddlers with developmental delays receive no early intervention services.

Broad eligibility criteria can classify children who have no delays or minimal delays as candidates for Part C services. Despite this, no jurisdiction provides Part C services to all children who have substantial delays. (Read the full article)

The Ages and Stages Questionnaires (ASQ) has been validated in many countries and translated into numerous languages. In most publications, it has been reported that the ASQ is accurate in detecting true problems in apparently healthy children and even in children with biological risk factors.

This report compares the third version of the ASQ and the Bayley Scales of Infant and Toddler Development, Third Edition, assessments. Psychometric properties showed a tendency to improve with testing age and when comparing term versus extremely preterm children. (Read the full article)

End-stage kidney disease (ESKD) causes significant morbidity and mortality after solid organ transplantation. Adults commonly develop advanced kidney disease, particularly after liver and intestinal transplantation. Previous pediatric studies have not compared the relative incidence of ESKD by organ type.

This national cohort study shows the highest risk of ESKD among pediatric lung and intestinal transplant recipients, reflecting unique organ-specific causes of kidney injury. Our findings have implications for screening for and treating early kidney disease in transplant recipients. (Read the full article)

Caffeine has predictable effects on cardiovascular function in both adults and children. Our previous work has shown that there are gender differences in this cardiovascular response, with boys having a greater change in heart rate and blood pressure than girls.

This study shows that the gender differences in cardiovascular response to caffeine emerge after puberty and there are some differences in postpubertal girls across the menstrual cycle. (Read the full article)

In HIV-infected children, decisions to start antiretroviral therapy must weigh immunologic benefits against potential risks. Current guidelines recommend using CD4 percentage and age when deciding to start treatment. Population-level effects of these factors on immunologic recovery are unknown.

Starting antiretroviral therapy at higher CD4 percentages and younger ages maximizes potential for immunologic recovery. However, not all benefits are sustained, and viral failure may occur. Our results help clinicians better weigh immunologic benefits against viral failure risks. (Read the full article)

Two-time winners Germany will take on Iceland, the Czech Republic, Slovenia and the Faroe Islands in Group 5 following the qualifying group stage draw in Nyon.

Gamla Ullevi, Gothenburg will stage the 2021 UEFA Women's Champions League final

16 May 2013The Regulatory Reform (Scotland) Bill was introduced in the Scottish Parliament on 27 March 2013. This briefing provides background information on existing regulatory regimes, and the introduction of the Bill.