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Galileo’s story is always relevant




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Editorial Expression of Concern: Exploring the quantum speed limit with computer games




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Coronavirus in charts: historical funding for coronavirus research has been tiny




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Don’t be down on stratospheric observatory




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Millennial-scale hydroclimate control of tropical soil carbon storage




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Daily briefing: A dark-matter detector powered by the ‘fifth state of matter’




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Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide




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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications’ door




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Novel sGC stimulator improves outcomes in patients with HFrEF




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Mechanisms by which angiotensin-receptor blockers increase ACE2 levels




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Primate auditory prototype in the evolution of the arcuate fasciculus




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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons




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The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease




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High-level Postdoctoral research fellow recruitment - The international Joint Center for Biomedical Innovation (JCBI), Henan University : Kaifeng, China

The international Joint Center for Biomedical Innovation (JCBI) is comprised of two partner research nodes using nanoparticle technologies to develop solutions for cancer and neurodegenerative diseases diagnostics. Henan University has established a new research laboratory in nano-bio system innovation and theranostics, with start-up funding and new academic positions. Macquarie’s node is built upon its established excellence in neuroscience and cancer research programs. The collaborative succes…




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Recruitment for director and research principal investigators of Shanghai Key Laboratory of Tissue Engineering Research, at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University

Position
Laboratory director and independent principal investigators

Employer
Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine

Location
639 Zhi Zao Ju Rd, Huang Pu District, 200011, Shanghai, China

Discipline
Tissue engineering and regenerative medicine related disciplines including: Stem Cell, Developmental Biology, Biomaterials, Biomedical Engineering

Aim:
Shanghai Tissue Engineering Key Laboratory is among the l…




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Principal Investigator/Professor Positions at Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, GDL

With a generous support from the Guangzhou City Government and the Guangdong Provincial Government, Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL) was launched in 2017. GRMH-GDL aims to bring together multiple leading scientific research units from Guangdong, Hong Kong, Macao and well-known international research institutes to achieve the vital goal of "Healthy China" and to cooperatively tackle the scientific and technical problems and challenges. GRMH-GDL is focused…




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Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection




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Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank




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Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors




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Immune-related adverse events of checkpoint inhibitors




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Immune-related adverse events of checkpoint inhibitors




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A single-centre investigator-blinded randomised parallel-group study protocol to investigate the influence of an acclimatisation appointment on children’s behaviour during N<sub>2</sub>O/O<sub>2</sub> sedation as measured by psycho




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Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer




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PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review




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The motor vertical in the absence of gravicentric cues

npj Microgravity, Published online: 03 March 2020; doi:10.1038/s41526-020-0098-8

The motor vertical in the absence of gravicentric cues




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Growth of microorganisms in an interfacially driven space bioreactor analog

npj Microgravity, Published online: 08 April 2020; doi:10.1038/s41526-020-0101-4

Growth of microorganisms in an interfacially driven space bioreactor analog




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Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Safety and efficacy of chimeric antigen receptor T-cell therapy in relapsed/refractory multiple myeloma with renal impairment




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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VEGF receptor (VEGFR)

Zebrafish studies suggest VEGFR inhibitors could help treat tuberculosis.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




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Transcription factors in ferroptotic cell death




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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Strain creates a trion factory




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Wheelchair propulsion fatigue thresholds in electromyographic and ventilatory testing




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Age influences structural brain restoration during weight gain therapy in anorexia nervosa




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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro