Most Americans and Canadians up to age 70 need no more than 600 international units (IUs) of vitamin D per day to maintain health, and those 71 and older may need as much as 800 IUs, says a new report from the Institute of Medicine.

Recipients of the 10th annual Communication Awards were announced today by the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine outlines how to examine whether specific levels of nutrients or other food substances (NOFSs) can ameliorate the risk of chronic disease and recommends ways to develop dietary reference intakes (DRI) based on chronic disease outcomes.

The academic biomedical research community should improve its ability to mitigate and recover from the impacts of disasters, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. Department of Energy should place a higher priority on developing an accurate and actionable inventory of agency-owned or managed properties that can be leased or sold for energy development, says a new report from the National Academies of Sciences, Engineering, and Medicine.

U.S. colleges and universities should respond with urgency to the current surge in undergraduate enrollments in computer science courses and degree programs, which is straining resources at many institutions, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine reviews current evidence and updates intake recommendations known as the Dietary Reference Intakes (DRIs) for sodium and potassium that were established in 2005.

When it comes to water usage, not all car washes are created equal. Most car washes don’t recycle water, but more and more newly built car washes are starting to. Santa Ana Express Car Wash opened three years ago and its million-dollar equipment recycles 70 percent of its water.; Credit: Maya Sugarman/KPCC

Washing your car with a garden hose can use up to 120 gallons of water. Most corner conveyor belt operations use less, but all that water can add up, as we told you in August.

That’s why the group LA Waterkeeper is challenging motorists to drive dirty and pledge to skip car washes for 60 days. 

"Water conservation is the easiest and most affordable way to quickly reduce water demand and also extend supplies into next year," says Liz Crosson, the group's executive director. 

This summer Ventura County’s water agency asked people to skip washing their rides for a month; some people got detailing and car washes as a reward. Crosson’s group is hoping bragging rights will be enough of an incentive. (Though there are some as-yet-undisclosed prizes.)

People who live in LA are really excited and interested by the cars that they drive," Crosson says. "And frankly, you can have a dirty car and you can have a sticker and have an excuse for having a dirty car so it saves your image too."

The campaign’s just kicking off this weekend (at the Abbott-Kinney festival), but Crosson’s already optimistic for success. Early adopters of the pledge are hundreds of people from the online site Reddit and the general manager for the Los Angeles Department of Water and Power.

GO DIRTY FOR THE DROUGHT. Take the #DirtyCarPledge to not wash your car for 60 days. Ready, Set, Go Dirty! http://t.co/TsxdvsgpCv

— LAWaterkeeper (@LAWaterkeeper) September 25, 2014

From the ED, I’m Molly Peterson, 89-point-3. KPCC.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Peter Epstein of Epstein Research discusses the macro picture for precious metals prices and one junior that he believes will benefit from higher prices.

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It was a new day at the Supreme Court, which for the first time ever live-streamed oral arguments.; Credit: Andrew Harnik/AP

The U.S. Supreme Court made history Monday. The coronavirus lockdown forced the typically cautious court to hear arguments for the first time via telephone, and to stream the arguments live for the public to hear.

Chief Justice John Roberts was at the court as the telephone session began, one or two other justices were in their offices at the court, and the rest of the justices dialed in from home.

The first and only case heard Monday involved an arcane trademark question only a lawyer could love. Online travel search engine Booking.com is appealing a U.S. Patent and Trademark Office refusal to grant a trademark to the company.

With the justices asking questions in order of seniority, the first big surprise was that Justice Clarence Thomas, who in the past has gone years without asking a question, did ask one, several in fact, when it came his turn.

"Could Booking acquire an 800 number ... that's a vanity number, 1-800-BOOKING, for example?" Thomas asked Assistant Solicitor General Erica Ross.

Yes, replied Ross, but domain names pose a different problem than phone numbers. Ultimately, she argued "the core problem with Booking.com is that it allows [Booking.com] to monopolize booking on the internet" to the exclusion of other sites like hotelbooking.com.

Justice Stephen Breyer followed up when his turn came: "Same question as Justice Thomas ... good morning, anyway ... You can have a trademark that's an address. You can have a trademark that's a telephone number. So why can't you have a trademark that's a dot-com?"

Justice Samuel Alito noted that the court's prior decision in this area of the law was more than 100 years old, and the statute dealing with trademarks was similarly enacted decades ago.

"How can a rule that makes sense in the internet age be reconciled with the language" in these "pre-Internet era" laws? asked Alito.

Next up to her lectern from her home was lawyer Lisa Blatt. This was her 40th Supreme Court argument and despite being a veteran, she said later that she was, as usual, sick to her stomach beforehand.

But once at the lectern "it's always a rush of excitement," she said, and this time it was a special rush.

"I loved getting a question from Justice Thomas ... I would go to the phone for the foreseeable future if I could get Justice Thomas to ask questions. That was wonderful," she said.

Indeed, despite the new format Blatt and Ross seemed to have had a good time.

"Your client would not object to the registration of any trademark that simply made a slight variation in Booking.com?" asked Alito.

"There's a million booking registrations already," parried Blatt.

Alito: "Would you just answer the question."

Blatt: "They don't and have not and would not."

Not, she added, unless another company ripped off the trademark with no variation. That would be theft, she said.

So, when when the argument was over, what was her reaction?

"After I hung up, I screamed, 'That was hard!' Because you're saying enough to answer, but not too much. And you don't have any like visual feedback, so it was hard."

In the end, she said, the argument felt more like an oral exam than an oral argument.

Tom Goldstein, publisher of Scotusblog, had a similar reaction. Goldstein, who has argued 43 cases before the court, said he thought the argument was probably more useful to the public than usual.

"But I bet it was less useful for the justices," he said. "Because there was less opportunity to follow up on lines of questions and less opportunity to influence someone ... so there's much less engagement in the oral argument."

Still there were no major hitches on this first day. Justice Sonia Sotomayor briefly forget to unmute her phone at one point, prompting a "Sorry, chief." Justice Breyer's voice broke up in static for a second or two. But as Goldstein observes, this was a big change for the court.

"Culturally a change, technologically a change. And it could have been a big embarrassment if it didn't go well, but it went fine," he said. "I think they're happy."

This content is from Southern California Public Radio. View the original story at SCPR.org.

The L.A. Philharmonic will be the new operator of the John Anson Ford Theatre, the smaller outdoor venue near  the 101 Freeway across from the Hollywood Bowl, under a plan approved by the Los Angeles County Board of Supervisors.  

L.A.  funding sustains the Ford, and the county recently spent $80 million renovating the 1,200  seat amphitheater.  But attendance has been lackluster — and Supervisor Sheila Kuehl hopes the L.A. Philharmonic can change that. 

“The Ford will be able to take advantage of the natural synergies in marketing, capacity-building and program resources that simply haven’t been available to the Ford as an independent institution," she  said.

The move by the L.A. County  blindsided many local artists.  They say the Ford is an important incubator for diverse talent.  They also worry ticket prices will increase.  Prompted by their criticism, the Supervisors will require the Phil to meet with artists and annually review the diversity of the Ford’s shows with county officials.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Populations of otters, grey seals and sea eagles are slowly recovering in Sweden, which is likely to be thanks in part to a ban on organochlorine chemicals, such as PCBs and DDT, in the 1970s, according to a new study. However, the research shows that negative effects of these chemicals on the reproductive health of female animals persisted for more than 15 years after the ban was introduced.

Password recycling or using easy-to-guess passwords are just two common mistakes you may be making when protecting your digital accounts

The post 5 common password mistakes you should avoid appeared first on WeLiveSecurity

Source: Streetwise Reports   05/04/2020

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS^® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
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5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

( Companies Mentioned: STML:NASDAQ, )

Public authorities in EU Member States are encouraged to purchase more environmentally-friendly goods and services through Green Public Procurement (GPP). A recent survey of purchasing managers in Italy has identified some factors that influence their adoption of this strategy, and suggests that a broad knowledge of GPP is key to its implementation.

Local food systems, such as vegetable box schemes or farmers' markets, can encourage sustainable consumption. However, authorities must take care before becoming too involved in such citizen-led initiatives, because these collectives may be wary of government intervention, a new study suggests.

Comprehensive flood risk management should include household measures, such as improving a home’s stability and relocating heating systems to safe places within the house. According to new research, better communication with householders by authorities on the effectiveness of such measures, and how to implement them, could increase their uptake.

Effective flood-risk management requires accurate risk-analysis models. Conventional analysis approaches, however, are based on the evaluation of spatially homogenous scenarios, which do not account for variation in flooding across a river reach/ region. Since flood events are often spatially heterogeneous (i.e. unevenly distributed), this paves the way for error. Now, scientists have developed a novel framework for risk analysis that accounts for their heterogeneity, and successfully demonstrated the accuracy of the approach by applying it in a proof-of-concept exercise in Vorarlberg, Austria. By facilitating improved prediction and quantification of flood events, this model is likely to inform future flood-risk management and related decision-making.

Scientists have identified several wild insects that could undertake the crop pollination function of honeybees. By comparing a range of pollinating insects they found three wild species that appear to be as efficient as the honeybee in pollination but may need management to increase their numbers.

New research in southern Spain has studied what influences participation in agri-environmental schemes (AES). It indicated that the uptake of schemes that involve a major change in farm practices depends on the farm structure, whereas for schemes with minor changes, individual farmer characteristics play a greater role.

Does scientific evidence always help conflicting stakeholders to reach agreement on how to deal with environmental risks? Scientists have now developed a mathematical framework to help answer this question. They show that stakeholder perceptions of the costs and benefits of regulations, as well as their perceptions of the quality of new research, will determine whether they change their standpoint.

Managing landscapes effectively requires the involvement of a wide variety of stakeholders. The views and interests of these different groups can be effectively integrated by agri-environment 'collaboratives' — a type of bridging organisation which can be found in varying forms in Europe. Using data from Germany and the Netherlands, a study concludes that these groups make important contributions to landscape management, ranging from implementing policy to generating income.

A recent survey of Dutch mobile phone owners has identified why some consumers buy refurbished mobile phones while others buy new ones. Some consumers perceived refurbished phones to be inferior, which was a major barrier to their purchase. The study’s authors make a number of recommendations to increase consumer uptake of refurbished mobile phones, including promoting the financial and environmental benefits and offering warranties.

With the latest deal, Jio Platforms is set to net a combined Rs 60,596 crore for the unit of Reliance Industries which comprises mainly its telecom business under Reliance Jio Infocomm

‘Climate-smart agriculture’ aims to sustainably increase agricultural production and increase resilience to climate change. One aspect focuses on climate-smart technologies. This study interviewed users and producers of these technologies, highlighting barriers to adoption and possible means of overcoming them, including increasing awareness, user-focused design and changes to policy.

A new study highlights the economic importance of coastal and marine areas and the urgent need to develop concrete methods for assessing their value. Researchers say the need is especially strong now as climate change's impacts could reduce the economic value of coastal and marine environments.

A framework to value marine and coastal zone ecosystem services, which acknowledges but transcends monetary value, has been proposed by researchers. Using this approach, coastal managers can integrate the different values placed on ecosystem goods and services by various stakeholders to assess how these values affect planning decisions.

You just received the promotion you have worked so hard for, but you overhear a co-worker say that you got it because the boss only gives the easy projects to you while the hard ones are dumped on everyone else. Some of your envious co-workers come to congratulate you with the aim of being seen with you for reputational benefits, but some others may be less kind in their response.

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To tackle the Covid-19 situation, Kotak General Insurance is trying to prepare rapidly, test critical paths and scale up

A ‘feebate’ can be an effective policy option to aid the transition to a more environmentally-friendly transport system, a UK study suggests. This combination of fees and rebates can increase the take-up of low-carbon cars, the researchers argue, which leads to reduced life cycle greenhouse gas (GHG) emissions.

New research on sustainable forest management (SFM) initiatives in Russia and Sweden has indicated that the main challenges to SFM are combining top-down and bottom up approaches to management, coordinating the different sectors involved and including all actors and stakeholders.

A lack of trust between stakeholders, planners and decision makers in coastal Portugal is obstructing adaptation to climate change plans, finds a new study. The researchers suggest that building trust between stakeholders and coastal managers could lead to improved participation and dialogue for future planning, financing and implementation of coastal adaptation.

‘Product-service systems’ are innovative business models designed to satisfy societal needs in an environmentally sustainable manner. This study explores how government policies could increase the uptake of these systems, outlining five key recommendations to achieve this, including schemes to raise awareness and involve local authorities.

A pilot cloud-based learning platform that brings together multiple datasets, models and visualisation tools has been developed with the engagement of numerous stakeholders throughout the design process. This tool could lead to informed decisions about flood risk at the local level. These types of tools and frameworks are effective ways of facilitating better decision making.

After years of working almost exclusively on long-term projects and pushing day-to-day management to his deputies, Bezos, 56, has turned back to the here-and-now problems facing Amazon, the company said, as the giant retailer grapples with a surge of demand, labor unrest and supply chain challenges brought on by the coronavirus.

Facebook on Friday unveiled a new video chat service with virtual "rooms" where people can pop in to visit friends, aiming at users turning to the popular Zoom platform during the pandemic.

Xiaomi India Managing Director said that the company does not collect any user data that the user has not explicitly given permission or consent to. He added that in the browser's incognito mode, all user data is completely encrypted and anonymised. He also pointed out that all Mi Browser and Mi Cloud data of Indian users is stored locally in AWS servers in India.

Jobs are also expected to nosedive in the remaining quarters of the year unless demand picks up by the festive season later this year, experts tracking the sector said. Travel, hospitality, tourism, aviation, retail, outdoor entertainment, food and beverages and real estate sectors have been hit the most, staffing agency TeamLease said.

While the coronavirus lockdown is set to be lifted to May 3, you can now buy mobile phones on Flipkart.

Chinese smartphone maker Oppo expects the Covid-19 supply chain disruption to end in a week or two. It is also planning to open a 5G lab in Hyderabad.

With the latest deal, Jio Platforms is set to net a combined Rs 60,596 crore for the unit of Reliance Industries which comprises mainly its telecom business under Reliance Jio Infocomm

Sharad Agarwal, Head-IT at JK Tyre looks at technology as an enabler which will drive productivity and efficiency within the firm.

Using commercial seed mixtures to replant European grasslands tends to produce a smaller range of species than originally grew on the land. New research has identified several methods that successfully reproduce the original range of species, such as transferring of fresh hay or soil that contains seeds.

A recent analysis highlights the difference between the academic concept and the practical concept of ecosystem services. It suggests that academic science aims to discover and apply general and timeless concepts to measure ecosystem services, whereas in practice, stakeholders' valuations of ecosystem services vary with place and time.

Ecosystems are complex and managing them effectively can mean balancing conflicting conservation goals. In a recent US study in the San Francisco Bay area researchers examine the best strategies to eradicate an invasive plant while protecting an endangered bird that uses it for nesting habitat. They find that with a clear management plan both goals can be achieved, albeit over a longer timeframe.

Increased soil biodiversity can reduce nitrogen pollution, improve nutrient uptake by plants and even increase crop yields, new research suggests. The two-year study found that levels of nitrogen leaching from soil with an abundant soil life were nearly 25% lower than for soil with a reduced level of soil life. Practices which enhance soil biodiversity such as reduced tilling, crop rotation and organic farming may therefore help reduce the environmental impacts of fertilisers and improve agricultural sustainability, the researchers say.

Land and soil are limited natural resources essential to all human life. One of the major environmental challenges facing Europe is an increasing demand for development, which threatens ecosystem services. This Future Brief focuses on how land and soil could be used efficiently to continue to provide these functions and services for generations to come.

Stakeholder support is essential to the success of environmental policies. A recent study has identified stakeholders that can promote biodiversity in European agricultural landscapes. The researchers found farmers were the most influential group of stakeholders, as they make the final decisions on land use. In turn, farmers are influenced in their decisions by a number of actors whose influence is perceived differently on a local and regional level.

The growing human population and a shift to more resource-intensive habits and behaviours are increasing the demands on global ecosystems. Natural capital is a way to describe Earth’s natural assets, including soil, air, water, and living things, existing as complex ecosystems, which provide a range of services to humans. Depleting and degrading these reserves may irreversibly reduce the availability of benefits to future generations. This In-Depth Report presents an overview of ideas, debates and progress so far in natural capital accounting, in particular in accounting for ecosystems and their services.