Imipenem-relebactam (I-R) is a recently developed carbapenem–beta-lactamase inhibitor combination agent that can overcome carbapenem resistance, which has now emerged in Escherichia coli, including sequence type 131 (ST131) and its fluoroquinolone-resistant H30R subclone, the leading cause of extraintestinal E. coli infections globally. To clarify the likely utility of I-R for carbapenem-resistant (CR) E. coli infections in the United States, we characterized 203 recent CR clinical E. coli isolates from across the United States (years 2002 to 2017) for phylogroup, clonal group (including ST131, H30R, and the CTX-M-15-associated H30Rx subset within H30R), relevant beta-lactamase genes, and broth microdilution MICs for I-R and 11 comparator agents. Overall, I-R was highly active (89% susceptible), more so than all comparators except tigecycline and colistin (both 99% susceptible). I-R’s activity varied significantly in relation to phylogroup, clonal background, resistance genotype, and region. It was greatest among phylogroup B2, ST131-H30R, H30Rx, Klebsiella pneumoniae carbapenemase (KPC)-positive, and northeast U.S. isolates and lowest among phylogroup C, New Delhi metallo-β-lactamase (NDM)-positive, and southeast U.S. isolates. Relebactam improved imipenem’s activity against CR isolates within each phylogroup—especially groups A, B1, and B2—and particularly against isolates containing KPC. I-R remained substantially active against isolates coresistant to comparator agents, albeit somewhat less so than against the corresponding susceptible isolates. These findings suggest that I-R should be useful for treating most CR E. coli infections in the United States, largely independent of coresistance, although this likely will vary in relation to the local prevalence of specific E. coli lineages and carbapenem resistance mechanisms.

Businesses, individuals with land, and local governments are competing to host an underground nuclear waste facility in the UK, and receive a yearly £2.5 million incentive

TfL as in Transport for London. Greeeeeaaat.

Don't analyse them too closely, they didn't have HD in the 1970s.

As a very ugly standoff develops between legacy cinemas and legacy studios, Disney appears to be playing its cards close to its chest.

Einstein’s theory of relativity predicts that fast-spinning objects stretch space and time around them, and we’ve watched that effect make a pair of stars wobble

When Earth and Venus formed, they both had global magma oceans deep underground. Earth’s has turned solid by now, but Venus’s may still remain hidden

Your weekly selection of awesome robot videos

As always, our coverage will feature the coolest, weirdest, and most interesting things that we find at this massive robotics conference

Alright folks, it's out so it's time to feel out if the Dexit folks were right or wrong. We also hear about Path of Exile 2 and more RPG news than you'd expect at this time of year. But let's be honest, we just want to go back to leveling up our starters.

From Stay at Home T-shirts to NHS baseball caps, here’s a selection from small labels donating some or all of their profits to charities helping healthcare workers and the Covid-19 response

To avoid arsenic contamination, many Bangladeshi households access water via private wells drilled to 300 feet or less, beneath impermeable clay layers. Such clay layers have been thought to protect groundwater in the underlying aquifers from the downward flow of contaminants. However, a new study suggests that such clay layers do not always protect against arsenic, and could even be a source of contamination in some wells.

The BJP leaders waged a social media war against the Bengal government by accusing the state of hiding Covid-19 figures and also complaining the Centre that TMC-led government in Bengal has completely failed in handling the coronavirus crisis.

The BJP leaders waged a social media war against the Bengal government by accusing the state of hiding Covid-19 figures and also complaining the Centre that TMC-led government in Bengal has completely failed in handling the coronavirus crisis.

If Judy Becker is forced to pick a side in “Feud: Bette and Joan,” the production designer for the FX series says she’s team Bette Davis, but she’d rather live in Joan Crawford’s house. “We designed an amazing closet for her and I can’t deny that I would love to have that,” she says. The […]

The newly launched #SmithsonianEdu campaign highlights 1.7 million online tools geared specifically toward students and teachers

The different hominid species, possibly including the oldest-known Homo erectus, existed in the region's hills and caves

While COVID-19 stymies travel, help conserve those things—from cacti to manta rays—that will beckon you later

The Monte Conca cave system in Sicily is showing signs of being altered by pollution from above.

Read our live coronavirus updates HERE

Follow our live coronavirus updates HERE Coronavirus: the symptoms

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More than a century ago, Einstein predicted how much the star's orbit changes, and now the data collected by scientists exactly matches his theory.

Incredible street art and graffiti has been popping up across the UK and Ireland over the last few weeks as the coronavirus pandemic grips the world.

A UK police force has upped patrols around 5G masts in a bid to stop further attacks linked to coronavirus conspiracy theories.

Muslims around the world have begun the month long fasting period of Ramadan as many countries remain under coronavirus lockdown.

You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

Countdown presenter Rachel Riley has won the first round of a High Court libel case against a former aide to Jeremy Corbyn.

The death toll linked to coronavirus in England is around 40 per cent higher than previously reported, new figures show.

Wetherspoon's is planning for a reopening of its pubs and hotels "in or around June", the company has announced.

People in countries across Europe are gradually regaining some old freedoms as governments start to lift their coronavirus lockdowns after many weeks.

A huge underground car park in the heart of the West End is to be converted into a £150 million subterranean healthcare and entertainment complex.

Schools are installing hand-washing troughs in playgrounds and preparing to mark out two-metre lines to keep parents apart as they drop off their children in anticipation of the coronavirus lockdown ending.

Team owners have long discussed shortening the draft from its usual 40 rounds, and it was expected to be a point of discussion heading into the winter 2021 expiration of the labor agreement between the league and players' union.

In today’s film news roundup, romantic comedy “Tell Me I Love You” finds a home; the Canadian government gives COVID-19 relief funding to the Canada Media Fund and Telefilm Canada; and the cancelled Sun Valley Film Festival gives out awards. ACQUISITION Vision Films has acquired Los Angeles romantic comedy film “Tell Me I Love You,” […]

Major League Baseball will cut its amateur draft from 40 rounds to five this year, a move that figures to save teams about $30 million US, a person familiar with the decision told The Associated Press.

For the second year in a row, the Government of Canada is enacting restrictions to help protect the southern resident killer whale population.

'I'd love to do a millennium one'