mpe

Sketch artists at the impeachment trial are capturing scenes that the cameras cannot

The scenes they draw include a senator seemingly falling asleep.




mpe

Five things we’d like to see in a revamped Obi-Wan Kenobi series on Disney Plus

The Force was reportedly not with the original scripts of the anticipated show.




mpe

This new Biden cartoon captures the shift in the Democratic race — and is now a bumper sticker

Pulitzer-winning cartoonist Mike Luckovich had a middle-of-the-night inspiration after Super Tuesday.




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News24.com | Misinformation flood hampers fight for virus vaccine in Africa

The task of introducing a vaccine for the coronavirus faces an uphill struggle in Africa, where a flood of online misinformation is feeding on mistrust of Western medical research.




mpe

The world is getting hotter. Can temperature-controlled clothing provide some relief?

Sony has introduced a new product called the Reon Pocket, which operates like a mobile air conditioner that fits inside clothing.




mpe

Brightest Young Things brings the millennials to the revamped International Spy Museum

A mostly millennial crowd explored the upgraded and interactive museum.




mpe

Drag queen Pissi Myles causes a stir with unexpected appearance at the impeachment hearings

Myles stole the show with a towering blonde wig and shiny red mini-dress.




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Alyssa Milano on why she went to Trump’s impeachment trial, and how Schiff’s presentation was like ‘watching a one-man show’

The actress and activist wants to encourage the public to get involved because “showing up is participating in how this all works.”




mpe

Anthony Fauci praises ‘classy’ Brad Pitt after SNL impersonation

Anthony Fauci praised Brad Pitt's performance, saying "Everything he said on SNL is what’s going on.”




mpe

Trump thinks the economy makes him impeachment-proof. It might be the opposite.

Any economic improvements aren’t helped by his actions.




mpe

The more love Always Trumpers show, the more dangerous Trump becomes

Come hell or high crimes, they always truckle to Trump. And they’re the true risk to our democracy.




mpe

On health care, is Trump malicious or just incompetent? Yes.

New cuts are actually expansions, according to Mike Pence.




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Fin24.com | OLX Brazil, which is part-owned by Prosus, buys competitor

OLX Brazil, the 50/50 joint venture between Naspers-owned Prosus and Adevinta, which is owned by Norway’s Schibsted, will buy its competitor Grupo Zap in a deal worth almost R10 billion.




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News24.com | Adjudicating land compensation falls squarely in judicial realm




mpe

Campers must clear out of Oppenheimer Park by noon Saturday

With the eviction date looming for campers to leave Oppenheimer Park, B.C.'s social development minister says everyone is still expected to be out of the park by Saturday.




mpe

OPP release composite drawing of man who allegedly impersonated an officer

Essex County OPP have released a composite drawing of a suspect reported to be impersonating a police officer in Lakeshore.




mpe

{alpha}-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are maȷor seed-competent species [Molecular Bases of Disease]

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.




mpe

The major subunit of widespread competence pili exhibits a novel and conserved type IV pilin fold [Protein Structure and Folding]

Type IV filaments (T4F), which are helical assemblies of type IV pilins, constitute a superfamily of filamentous nanomachines virtually ubiquitous in prokaryotes that mediate a wide variety of functions. The competence (Com) pilus is a widespread T4F, mediating DNA uptake (the first step in natural transformation) in bacteria with one membrane (monoderms), an important mechanism of horizontal gene transfer. Here, we report the results of genomic, phylogenetic, and structural analyses of ComGC, the major pilin subunit of Com pili. By performing a global comparative analysis, we show that Com pili genes are virtually ubiquitous in Bacilli, a major monoderm class of Firmicutes. This also revealed that ComGC displays extensive sequence conservation, defining a monophyletic group among type IV pilins. We further report ComGC solution structures from two naturally competent human pathogens, Streptococcus sanguinis (ComGCSS) and Streptococcus pneumoniae (ComGCSP), revealing that this pilin displays extensive structural conservation. Strikingly, ComGCSS and ComGCSP exhibit a novel type IV pilin fold that is purely helical. Results from homology modeling analyses suggest that the unusual structure of ComGC is compatible with helical filament assembly. Because ComGC displays such a widespread distribution, these results have implications for hundreds of monoderm species.




mpe

Corruption and poor governance impede progress in the fight against illegal logging in Cameroon and Malaysia

21 January 2015

20150120LoggingCameroon.jpg

Pallisco logging company's FSC timber operations in Mindourou, Cameroon. Photo by Getty Images.

Neither Cameroon nor Malaysia has made progress in tackling illegal logging since 2010, according to new reports from Chatham House. Corruption, lack of political will and a lack of transparency pose problems in both countries. 

Illegal logging is much more widespread in Cameroon, where entrenched corruption, weak institutions and unclear and inappropriate laws are all impeding reform. Although Malaysia does not have such high levels of illegality, problems remain, particularly in the state of Sarawak.

Alison Hoare, Senior Research Fellow at Chatham House, said: 'Illegal logging has a devastating impact on some of the world’s most valuable remaining forests and on the people who live in them and rely on the resources they provide.'

'It is disappointing how little progress Cameroon and Malaysia have made in tackling illegal logging, which exacerbates deforestation, climate change, and poverty. In both countries corruption is a major issue, and the governments need to do much more to address the problem and its underlying drivers.' 

In Cameroon, the principle of transparency has not been accepted within the government, enforcement is weak and information management systems are inadequate. The misuse of  small permits, often granted to allow clearance of forests for infrastructure projects or agricultural expansion, is particularly problematic and could be increasing.

Meanwhile, a huge amount of illegal production takes place in the informal artisanal sector – accounting for around half of all timber produced in the country. Artisanal loggers mainly supply the domestic market, but their timber is also exported.

In Malaysia, governance varies significantly from region to region but there are high levels of deforestation across the country. Expansion of timber, pulp and agricultural plantations is the primary cause of forest loss, with the area of plantations expected to double by 2020. 

Adequate recognition of indigenous peoples’ land rights is also a serious challenge in Malaysia and has held up the negotiation of a Voluntary Partnership Agreement with the European Union. Recent enhanced efforts to tackle corruption, including in Sarawak, could mark a turning point. 

Alison Hoare: 'In both countries, more concerted efforts are needed to tackle corruption, increase consultation, and improve transparency and availability of information. The Cameroonian government also needs to pay more attention to the informal sector and the domestic market.'

Editor's notes

Read the reports:

Trade in Illegal Timber: The Response in the Cameroon by Alison Hoare

Trade in Illegal Timber: The Response in Malaysia by Alison Hoare

For more information please contact Alison Hoare or visit the Illegal Logging portal.

These findings are part of Chatham House’s 'Indicators of Illegal Logging and Related Trade’ project, which looks at consumer, producer and processing countries. A Synthesis Report will be published in early 2015.




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The Paragon Algorithm, a Next Generation Search Engine That Uses Sequence Temperature Values and Feature Probabilities to Identify Peptides from Tandem Mass Spectra

Ignat V. Shilov
Sep 1, 2007; 6:1638-1655
Technology




mpe

The Belt and Road Initiative: geo-economics and Indo-Pacific security competition

8 January 2020 , Volume 96, Number 1

Mingjiang Li

The Belt and Road Initiative (BRI) has been regarded by international society as a major policy tool in China's geo-economic strategy. Under this policy platform, Beijing has pledged to invest billions of dollars in the infrastructure and industrial sectors across Eurasia and in the Indo-Pacific nations. It is widely believed that such huge amount of investment will inevitably generate significant geostrategic repercussions in these regions. In response to the BRI, the United States and other powers have come up with a ‘free and open Indo-Pacific’ strategy. This article attempts to address the following question: what impact is the BRI likely to have on the security ties between China and the other major players in the Indo-Pacific? The author finds that the BRI may significantly transform China's international security policy and the expansion of Beijing's security influence may further intensify the security competition between China and other major powers in the Indo-Pacific region. The article also proposes a new analytical angle for the study of geo-economics that unpacks the role of economic activities and processes in generating geopolitical intentions and catalysing geopolitical competition.




mpe

Understanding the dynamics of the Indo-Pacific: US–China strategic competition, regional actors, and beyond

6 November 2019 , Volume 96, Number 1

The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region.

Kai He and Mingjiang Li

As a geographical concept, ‘Indo-Pacific’ has existed for decades. As a political and strategic concept, it has since 2010 gradually become established in the foreign policy lexicon of some countries, especially Australia, India, Japan and the United States. However, China seems to be reluctant to identify itself as part of the Indo-Pacific; Chinese leaders believe that the US-led Indo-Pacific strategy aims to contain China's rise. While the battle between the two geographical concepts ‘Indo-Pacific’ and ‘Asia–Pacific’ may be fairly easily settled in the future, US–China strategic competition has just begun. Will the Indo-Pacific become a battlefield for US–China rivalry? How will China cope with the US ‘free and open Indo-Pacific’ (FOIP) strategy? How will other regional actors respond to the US–China strategic competition in the Indo-Pacific? What are the strategic implications of the ‘Indo-Pacific’ concept for regional order transformation? How will the Indo-Pacific be institutionalized, economically, politically and strategically? This article introduces the January 2020 special issue of International Affairs, which aims to address those questions, using both country-specific and regional perspectives. Seven articles focus on the policy responses of major players (Australia, China, India, Indonesia, Japan and ASEAN) to the US FOIP strategy and related US–China rivalry in the region. A further three articles examine the profound implications of Indo-Pacific dynamics for regional institution-building and for geopolitical and geo-economic architecture.




mpe

US–China Strategic Competition: The Quest for Global Technological Leadership

7 November 2019

The current dispute between the US and China goes far beyond trade tariffs and tit-for-tat reprisals: the underlying driver is a race for global technological supremacy. This paper examines the risks of greater strategic competition as well as potential solutions for mitigating the impacts of the US–China economic confrontation.

Marianne Schneider-Petsinger

Senior Research Fellow, US and the Americas Programme

Dr Jue Wang

Associate Fellow, Asia-Pacific Programme (based in Holland)

Dr Yu Jie

Senior Research Fellow on China, Asia-Pacific Programme

James Crabtree

Associate Fellow, Asia-Pacific Programme

Video: Marianne Schneider-Petsinger and Dr Yu Jie discuss key themes from the research paper

Summary

  • The underlying driver of the ongoing US–China trade war is a race for global technological dominance. President Trump has raised a number of issues regarding trade with China – including the US’s trade deficit with China and the naming of China as a currency manipulator. But at the heart of the ongoing tariff escalation are China’s policies and practices regarding forced technology transfer, intellectual property theft and non-market distortions.
  • As China’s international influence has expanded it has always been unlikely that Beijing would continue to accept existing global standards and institutions established and widely practised by developed countries based on ‘the Washington Consensus’.
  • China’s desire to be an alternative champion of technology standard-setting remains unfulfilled. Its ample innovation talent is a solid foundation in its quest for global technology supremacy but tightening controls over personal freedoms could undermine it and deter potential global partners.
  • It is unclear if Chinese government interventions will achieve the technological self-sufficiency Beijing has long desired. China’s approach to macroeconomic management diverges significantly from that of the US and other real market economies, particularly in its policy towards nurturing innovation.
  • Chinese actors are engaged in the globalization of technological innovation through exports and imports of high-tech goods and services; cross-border investments in technology companies and research and development (R&D) activities; cross-border R&D collaboration; and international techno-scientific research collaboration.
  • While the Chinese state pushes domestic companies and research institutes to engage in the globalization of technological innovation, its interventions in the high-tech sector have caused uneasiness in the West.
  • The current US response to its competition with China for technological supremacy, which leans towards decoupling, is unlikely to prove successful. The US has better chances of success if it focuses on America’s own competitiveness, works on common approaches to technology policy with like-minded partners around the globe and strengthens the international trading system.
  • A technically sound screening mechanism of foreign investment can prevent normal cross-border collaboration in technological innovation from being misused by geopolitical rival superpowers.




mpe

Partisanship Meets Trump’s Impeachment

19 December 2019

Dr Lindsay Newman

Senior Research Fellow, US and the Americas Programme
History shows that if those pushing for impeachment and removal want to succeed, they need to drive up popular support for a senate conviction.

GettyImages-1189454843.jpg

Opposing protests during the House of Representatives debate on whether to charge President Donald Trump with two articles of impeachment. Photo by Sarah Silbiger/Getty Images.

The vote to impeach Donald Trump holds almost no surprises - on both the abuse of power and obstruction of congress articles, the votes were split entirely on party lines with nearly all the majority-led House Democrats but not a single Republican voting to impeach Trump.

However, this ‘pre-ordained’ outcome of the House impeachment inquiry does serve to highlight that the US is in the midst of a hyper-partisan political moment. Policy gridlock has led to two government shutdowns during Donald Trump’s presidency, with one further budgetary fight narrowly avoided.

With a few notable exceptions (such as USMCA), policy areas that lend themselves to bipartisanship - including infrastructure and drug pricing - have seen very little progress under divided congressional chambers. Party identification can now be overlaid with the cable news channel one watches or the newspaper one reads.

Impeachment now moves to the Senate for a trial, requiring a two-thirds majority of the Republican-led senate (or 67 senators) for a conviction. Given the congressional partisanship we are seeing, the baseline scenario continues to be that the senate will not vote to convict Trump and remove him from office - despite much being made of how many senators are likely to vote for a Senate conviction.

Why public opinion could be crucial

There is another story to keep a close eye on. The number to track is 47.2 – the current polling average of public support for Trump’s impeachment. Polling averages from the end of September 2019 (before the hearings began, but after House Speaker Nancy Pelosi announced a formal inquiry) had 49.4% supporting impeachment versus 47.2% this week.

Here’s why this number matters. If those pushing for impeachment and removal are unable to drive popular support across a critical threshold level, then those against impeachment and removal are not going to abandon the president and vote for a senate conviction. With Trump consistently polling in the low 40s on job approval, but in the high 80s/low 90s within the Republican party, this means Republican congress members concerned about re-election are extremely hesitant to distance themselves from him without a clear mandate from the domestic public. 

A tale of the two most recent presidents to face impeachment underscores this point. Gallup polling claimed 58% of adults supported impeaching and removing President Richard Nixon from office in August 1974, whereas only 35% of the public supported impeaching President Bill Clinton in December 1998, the month he was impeached.

Given the respective outcomes of those two impeachments, it suggests public support for impeachment and removal needs to increase well beyond the current 47.2%, to avoid the foregone conclusion of acquittal in the Senate (even if there are signs of the tide moving in the opposite direction with those against impeachment overtaking support for the first time in December).   

What does this mean for Democrats?

In the short term, if the Democrats want to make inroads into the hearts and minds of those across the partisan gulf, it will be critical to secure senate testimony from those in Trump’s inner circle at the time of the Ukrainian affair.

After Trump ordered individuals with first-hand knowledge of the administration’s efforts vis-à-vis Ukraine not to testify, House investigators were unable to call many witnesses with direct evidence (which in fact left the House testimony exposed to Republican claims of hearsay). With Trump impeached, more of the public is likely to tune in to the senate proceedings, and direct evidence by inner circle administration officials required to testify presents an opportunity to move public opinion.

House speaker Nancy Pelosi recognizes how crucial the procedures and participants for the senate trial will be, and has said she could delay sending the articles of impeachment to the senate as leverage for a 'fair trial'.

Democrats also have to consider how an impeachment inquiry that - at least from this vantage point - does not end in a conviction of the president plays out for the 2020 election campaign, especially if this also likely means that public opinion - and certainly Republican-party views - of Trump have not shifted.




mpe

{alpha}-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are maȷor seed-competent species [Molecular Bases of Disease]

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.




mpe

Nanodomains can persist at physiologic temperature in plasma membrane vesicles and be modulated by altering cell lipids [Research Articles]

The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting Lo and liquid-disordered lipid domains. However, large-scale phase separation in GPMVs detected by light microscopy is observed only at low temperatures. Comparing Förster resonance energy transfer-detected versus light microscopy-detected domain formation, we found that nanodomains, domains of nanometer size, persist at temperatures up to 20°C higher than large-scale phases, up to physiologic temperature. The persistence of nanodomains at higher temperatures is consistent with previously reported theoretical calculations. To investigate the sensitivity of nanodomains to lipid composition, GPMVs were prepared from mammalian cells in which sterol, phospholipid, or sphingolipid composition in the plasma membrane outer leaflet had been altered by cyclodextrin-catalyzed lipid exchange. Lipid substitutions that stabilize or destabilize ordered domain formation in artificial lipid vesicles had a similar effect on the thermal stability of nanodomains and large-scale phase separation in GPMVs, with nanodomains persisting at higher temperatures than large-scale phases for a wide range of lipid compositions. This indicates that it is likely that plasma membrane nanodomains can form under physiologic conditions more readily than large-scale phase separation. We also conclude that membrane lipid substitutions carried out in intact cells are able to modulate the propensity of plasma membranes to form ordered domains. This implies lipid substitutions can be used to alter biological processes dependent upon ordered domains.







mpe

US–China Strategic Competition: The Quest for Global Technological Leadership

7 November 2019

The current dispute between the US and China goes far beyond trade tariffs and tit-for-tat reprisals: the underlying driver is a race for global technological supremacy. This paper examines the risks of greater strategic competition as well as potential solutions for mitigating the impacts of the US–China economic confrontation.

Marianne Schneider-Petsinger

Senior Research Fellow, US and the Americas Programme

Dr Jue Wang

Associate Fellow, Asia-Pacific Programme (based in Holland)

Dr Yu Jie

Senior Research Fellow on China, Asia-Pacific Programme

James Crabtree

Associate Fellow, Asia-Pacific Programme

Video: Marianne Schneider-Petsinger and Dr Yu Jie discuss key themes from the research paper

Summary

  • The underlying driver of the ongoing US–China trade war is a race for global technological dominance. President Trump has raised a number of issues regarding trade with China – including the US’s trade deficit with China and the naming of China as a currency manipulator. But at the heart of the ongoing tariff escalation are China’s policies and practices regarding forced technology transfer, intellectual property theft and non-market distortions.
  • As China’s international influence has expanded it has always been unlikely that Beijing would continue to accept existing global standards and institutions established and widely practised by developed countries based on ‘the Washington Consensus’.
  • China’s desire to be an alternative champion of technology standard-setting remains unfulfilled. Its ample innovation talent is a solid foundation in its quest for global technology supremacy but tightening controls over personal freedoms could undermine it and deter potential global partners.
  • It is unclear if Chinese government interventions will achieve the technological self-sufficiency Beijing has long desired. China’s approach to macroeconomic management diverges significantly from that of the US and other real market economies, particularly in its policy towards nurturing innovation.
  • Chinese actors are engaged in the globalization of technological innovation through exports and imports of high-tech goods and services; cross-border investments in technology companies and research and development (R&D) activities; cross-border R&D collaboration; and international techno-scientific research collaboration.
  • While the Chinese state pushes domestic companies and research institutes to engage in the globalization of technological innovation, its interventions in the high-tech sector have caused uneasiness in the West.
  • The current US response to its competition with China for technological supremacy, which leans towards decoupling, is unlikely to prove successful. The US has better chances of success if it focuses on America’s own competitiveness, works on common approaches to technology policy with like-minded partners around the globe and strengthens the international trading system.
  • A technically sound screening mechanism of foreign investment can prevent normal cross-border collaboration in technological innovation from being misused by geopolitical rival superpowers.




mpe

The Belt and Road Initiative: geo-economics and Indo-Pacific security competition

8 January 2020 , Volume 96, Number 1

Mingjiang Li

The Belt and Road Initiative (BRI) has been regarded by international society as a major policy tool in China's geo-economic strategy. Under this policy platform, Beijing has pledged to invest billions of dollars in the infrastructure and industrial sectors across Eurasia and in the Indo-Pacific nations. It is widely believed that such huge amount of investment will inevitably generate significant geostrategic repercussions in these regions. In response to the BRI, the United States and other powers have come up with a ‘free and open Indo-Pacific’ strategy. This article attempts to address the following question: what impact is the BRI likely to have on the security ties between China and the other major players in the Indo-Pacific? The author finds that the BRI may significantly transform China's international security policy and the expansion of Beijing's security influence may further intensify the security competition between China and other major powers in the Indo-Pacific region. The article also proposes a new analytical angle for the study of geo-economics that unpacks the role of economic activities and processes in generating geopolitical intentions and catalysing geopolitical competition.




mpe

Understanding the dynamics of the Indo-Pacific: US–China strategic competition, regional actors, and beyond

6 November 2019 , Volume 96, Number 1

The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region.

Kai He and Mingjiang Li

As a geographical concept, ‘Indo-Pacific’ has existed for decades. As a political and strategic concept, it has since 2010 gradually become established in the foreign policy lexicon of some countries, especially Australia, India, Japan and the United States. However, China seems to be reluctant to identify itself as part of the Indo-Pacific; Chinese leaders believe that the US-led Indo-Pacific strategy aims to contain China's rise. While the battle between the two geographical concepts ‘Indo-Pacific’ and ‘Asia–Pacific’ may be fairly easily settled in the future, US–China strategic competition has just begun. Will the Indo-Pacific become a battlefield for US–China rivalry? How will China cope with the US ‘free and open Indo-Pacific’ (FOIP) strategy? How will other regional actors respond to the US–China strategic competition in the Indo-Pacific? What are the strategic implications of the ‘Indo-Pacific’ concept for regional order transformation? How will the Indo-Pacific be institutionalized, economically, politically and strategically? This article introduces the January 2020 special issue of International Affairs, which aims to address those questions, using both country-specific and regional perspectives. Seven articles focus on the policy responses of major players (Australia, China, India, Indonesia, Japan and ASEAN) to the US FOIP strategy and related US–China rivalry in the region. A further three articles examine the profound implications of Indo-Pacific dynamics for regional institution-building and for geopolitical and geo-economic architecture.




mpe

euromicron AG bundles digital competencies and forms Digital Hub

euromicron AG, a medium-sized technology group and specialist for the digital support of business processes through secure infrastructures, is pooling its digital expertise at KORAMIS GmbH, the group subsidiary that specializes in cyber security and automation. With focus on digital platforms and services KORAMIS’ portfolio will also cover the areas Smart IoT, Smart Building as well as Data Management in the future. For this step the management of KORAMIS GmbH was extended by Andreas Schmidt.




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CBD News: Message from the Executive Secretary Ahmed Djoghlaf to the participants of the Conference of the Competence Network Urban Ecology "Urban Biodiversity & Design - Implementing the Convention on Biological Diversity in towns and Cities&quo




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CBD Communiqué: Young Talent Recognised in Global Photography Competition.




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CBD Communiqué: Winners announced: Young Hands Together for Diversity International Biodiversity Art Competition.




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CBD News: A new compendium providing the latest and best professional information needed for protected area practitioner capacity development was released this week in the margins of the 6th IUCN World Parks Congress.




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CBD News: The GBIF Secretariat has launched the inaugural GBIF Ebbe Nielsen Challenge, hoping to inspire innovative applications of open-access biodiversity data by scientists, informaticians, data modelers, cartographers and other experts competing for a




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CBD News: Young people from around the world are encouraged to submit videos for the 2019 Global Youth Video Competition showcasing positive solutions on three themes: Nature-based Solutions for Food and Human Health; Cities and Local Action to Combat Cli




mpe

Management of Competitive Athletes With Diabetes

W. Guyton Hornsby
Apr 1, 2005; 18:102-107
Articles




mpe

How small chromosomes compete with big ones for a cell's attention

(Memorial Sloan Kettering Cancer Center) Scientists at the Sloan Kettering Institute have solved the puzzle of how small chromosomes ensure that they aren't skipped over during meiosis, the process that makes sperm and egg.




mpe

Winter warm spells see an increase in duration and frequency in UK temperature records

(University of Warwick) Warm winter spells have increased in frequency and duration two- to three times over since 1878, according to scientists led by the University of Warwick.




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Frontier Airlines becomes first U.S. airline to announce passenger temperature checks

The budget carrier will begin conducting temperature checks via touchless thermometers on June 1. Passengers have to start wearing masks Friday.





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Kohl & Frisch: A Prescription for Competition

How can Canadian pharmaceutical wholesaler Kohl & Frisch deploy its new market clout after acquiring a key competitor?




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Competition Policy

Conference

Need for a paradigm shift?

23 May 2019 - 9:30am to 5:30pm

Chatham House, London

Overview

Agenda

Speakers

Pricing and booking information

Sponsors

Media partners and supporting organizations

Venue and accommodation

Press registration

Contact us

Models for antitrust policy and competition regulation have traditionally been guided by principles that have prioritized consumer welfare standards, albeit according to varied interpretations, and antitrust has often been seen as disconnected from mainstream public interest and political debate. But what can lawmakers and regulators do to meet the challenges of the political trend of populism that is prevailing in many developed economies? What should competition regulators do in response to the idea that the consumer welfare standard should be replaced – or supplemented – with another standard, or more broadly interpreted to allow consideration of consumer welfare effects that go beyond price, including the surrender by consumers of their personal data?  

In this context the annual Chatham House Competition Policy conference will assess how a range of public interest considerations — such as unemployment, discrimination or protection of small businesses — and rapidly evolving marketplaces, are reshaping thinking on antitrust policy and the regulation of markets to the extent that changes to the scope and nature of the consumer welfare standard are being advocated.

Discussion themes include:

  • A consumer welfare approach versus market regulation
  • Potential changes to the consumer welfare approach to encompass concerns other than price-related effects
  • Advances in technology and the rise of new and unseen competition concerns 
  • The realities of AI and big data for competition and market regulation
  • What do these potential changes and new market realities mean for the consistency and predictability of antitrust decisions and business certainty
  • To what extent do public interest considerations and wider trade issues impact on international cooperation between antitrust regulators

Continuing Professional Development 
6 CPD hours are available for delegates attending this event, as per the Bar Standards Board’s CPD Provider Accreditation Scheme. For professionals regulated by the Solicitors Regulation Authority, 6 CPD hours are available for delegates that remain opted into the 16 hours annual CPD requirement.

The Chatham House Rule 
To enable as open a debate as possible, this conference will be held under the Chatham House Rule.

Twitter 
@CH_Events
#CHCompetition

Thursday 23 May
0930

Welcome and Chair's opening remarks
Howard Shelanski, Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell   

Session One | Competition Policy and Regulation: Pressures in a Globalised Economy
1000-1110

This opening session will assess the current political and economic dynamics that are shaping the decision-making environment for competition policy and regulation, and how in the context of the ongoing globalisation of the world economy, the pressures and expectations of populist movements along with rising trade tensions may influence the principles of competition policy and regulation across developed and developing countries.

Chair
Howard Shelanski, Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell   

Speakers
Andreas Mundt, President, Bundeskartellamt
Rebecca Slaughter, Commissioner, Federal Trade Commission
Sarah Cardell, General Counsel, Competition and Markets Authority
Liyuan Wang, State Administration for Market Regulation, China

Questions and discussion

1110 – 1130 Refreshments

Session Two | Merger Control in an Environment of Trade Tensions and Populist Challenges
1130–1300

  • How should competition authorities react to growing calls for them to take a tougher stance in relation to mergers and acquisitions in the face of increasing market concentration and the rise of common ownership?
  • Do big businesses cause problems beyond their effects on competition?  If so, are antitrust laws the cure?
  • To what extent should competition authorities have greater ability to intervene to protect smaller companies, or prevent their acquisition, where competition is not (yet) threatened?
  • Where competition authorities do intervene, how should they ensure that they do not stifle investment or discourage innovation?
  • Should competition authorities assess mergers on public interest grounds, including how mergers impact on labour markets or national security?  Should they be asking whether mergers will reduce competition for employees?
  • How should competition authorities respond to calls for the promotion of national champions or other protectionist tendencies?

Chair
Jorge Padilla, Senior Managing Director and Head, Compass Lexecon Europe

Speakers
Cecilio Madero Villarejo, Deputy Director-General, DG Competition, European Commission
Amelia Fletcher, Professor of Competition Policy, Centre for Competition Policy, University of East Anglia
Aaron Hoag, Chief, Technology and Financial Services Section, Antitrust Division, U.S. Department of Justice
Wolfgang Heckenberger, Chief Counsel Competition, Siemens
Alex Nourry, Partner, Clifford Chance

Questions and discussion

1300 – 1400 Lunch

Session Three | Antitrust Tools and the Challenges of the Digital Economy
1400–1540

  • Does the current antitrust framework need to be supplemented by regulation, inter alia to ensure common standards on transparency and fairness of online platforms?
  • Is there a risk that undue intervention by competition authorities or regulation will hurt innovation and destroy incentives for new entrants to emerge capable of challenging incumbents?
  • Does the possession of so-called Big Data give rise to barriers to entry or more efficient and innovative markets?
  • Whilst the use of pricing algorithms can benefit consumers, how concerned should competition authorities be about the possibility that algorithms might facilitate collusive outcomes and lead to higher prices for consumers?
  • Is there any reason to be concerned about the ability of firms to innovate without fear of undue enforcement, particularly given the special duty ascribed to dominant companies as regards their competitors and consumers?

Chair
Thomas Vinje, Partner, Chairman, Global Antitrust Group, Clifford Chance

Speakers
Jason Furman, Professor of the Practice of Economic Policy, Harvard Kennedy School
Tommaso Valletti, Chief Competition Economist, European Commission
Heike Schweitzer, Professor, Humboldt University
David Sevy, Executive Vice President, Compass Lexecon
Horacio Gutierrez, General Counsel, VP Business & Legal Affairs, Spotify

Questions and discussion

1540 – 1610 Afternoon refreshments

Session Four | International Co-operation Between Competition Authorities: Ensuring Consistent and Effective Enforcement in Interconnected Economy
1600–1730

  • How can the compatibility of procedural and substantive competition rules be maintained, along with legal certainty and predictability, in the face of the growing divergence in trade and industrial policies and conflicting public interest goals?
  • To what extent, if any, could the promotion of best practices and substantive convergence in competition enforcement through multi-lateral organisations such as the OECD and the ICN be enhanced?
  • What other steps could be taken to increase co-operation and coordination in the enforcement of the competition rules such as, for example, the development of international standards for comity, systems of mutual recognition of decisions of other authorities or deference to a lead authority?
  • Is bi-lateral and multi-lateral cooperation sufficient to ensure effective and consistent enforcement or is there a greater need for supra-national authorities, at least, regionally, if not internationally?
  • Can or should WTO rules play a greater role in ensuring a level playing field and thereby removing the incentives for divergence in the scope and enforcement of the competition rules?

Chair
Sean Ennis, Director, Centre for Competition Policy and Professor of Competition Policy, University of East Anglia

Speakers
Isolde Goggin, Chairperson of the Competition and Consumer Protection Commission, Ireland
João Paulo Resende, Commissioner, Administrative Council for Economic Defense, Brazil 
Gabriel Harnier, Head of Law, Patents & Compliance, Bayer
Avaantika Kakkar, Partner, Head of Competition Practice, Cyril Amarchand Mangaldas

Questions and discussion

1730 Close of conference and drinks reception

© The Royal Institute of International Affairs 2019

Speakers

Sarah Cardell

General Counsel, CMA

Sean Ennis

Director, Centre for Competition Policy and Professor of Competition Policy, University of East Anglia

Amelia Fletcher

Professor of Competition Policy at the Centre for Competition Policy, University of East Anglia

Jason Furman

Professor of the Practice of Economic Policy, Harvard Kennedy School

Isolde Goggin

Chairperson, Competition and Consumer Protection Commission, Ireland

Horacio Gutierrez

General Counsel and VP Business & Legal Affairs, Spotify

Gabriel Harnier

General Counsel, Bayer

Wolfgang Heckenberger

Senior Competition Advisor, Siemens

Aaron Hoag

Chief, Technology and Financial Services Section, Antitrust Division, U.S. Department of Justice

Avaantika Kakkar

Partner, Head of Competition Practice, Cyril Amarchand Mangaldas

Andreas Mundt

President, Bundeskartellamt

Alex Nourry

Partner, Clifford Chance

Dr Jorge Padilla

Senior Managing Director and Head, Compass Lexecon Europe

João Paulo Resende

Commissioner, Administrative Council for Economic Defense, Brazil

Heike Schweitzer

Professor of Competition, Humboldt University

David Sevy

Executive Vice President, Compass Lexecon

Howard Shelanski

Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell LLP

Rebecca Slaughter

Commissioner, Federal Trade Commission

Tommaso Valletti

Chief Competition Economist, European Commission

Cecilio Madero Villarejo

Deputy Director-General, DG Competition, European Commission

Thomas Vinje

Partner and Chairman, Global Antitrust Group, Clifford Chance

Liyuan Wang

Deputy Director, State Administration for Market Regulation, China

General Counsel of major companies may register at the standard government department rate.

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Quote Chatham House

This conference will be held under the Chatham House Rule. Information for journalists.

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For registration enquiries please call Boudicca Georgii Hellberg on +44 (0)20 7314 2785

For general enquiries please email conferences@chathamhouse.org 

Department/project




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Power Politics Could Impede Progress on Responsible Regulation of Cyberspace

3 December 2019

Harriet Moynihan

Senior Research Fellow, International Law Programme
A new Chatham House paper examines the prospects of countries reaching agreement on issues of sovereignty and non-intervention in cyberspace in the face of persistent, low-level, state-to-state cyber attacks.

2019-11-29-Intl-Law-Cyberattacks.jpg

A computer hacked by a virus known as Petya. The Petya ransomware cyberattack hit computers of Russian and Ukrainian companies on 27 June 2017. Photo: Getty Images.

In discussions to date about how international law applies in cyberspace, commentators have tended to focus their attention on how the rules on the use of force, or the law of armed conflict, apply to cyber activities conducted by states that give rise to physical damage, injury or death.

But in practice, the vast majority of state cyberattacks fall below this threshold. Far more common are persistent, low-level attacks that may leave no physical trace but that are capable of doing significant damage to a state’s ability to control its systems, often at serious economic cost.

Such cyber incursions might include network disruptions in the operation of another government’s websites; tampering with electoral infrastructure to change or undermine the result; or using cyber means to destabilize another state’s financial sector.

For these kinds of cyber operation, the principle of sovereignty, and the principle of non-intervention in another state’s internal affairs, are the starting point.

A UN Group of Government Experts (GGE) agreed in 2013 and 2015 that the principles in the UN Charter, including sovereignty and the prohibition on intervention in another state’s affairs, apply to states’ activities in cyberspace. The 2015 GGE also recommended eleven (non-binding) norms of responsible state behaviour in cyberspace.

However, states have not yet reached agreement on how to apply these principles. Until recently, there has also been very little knowledge of what states actually do in cyberspace, as they usually conduct cyber operations covertly and have been reluctant to put their views on record.

A new Chatham House research paper analyses the application of the principles of sovereignty and non-intervention to state cyberattacks that fall below the principle of use of force. As well as analysing the application of the law in this area, the paper also makes recommendations to governments on how they might best make progress in reaching agreement in this area.

Existing rules or new rules?

As the research paper makes clear, there is currently some debate, principally between countries in the West, about the extent to which sovereignty is a legally binding rule in the context of cyberspace and, if so, how it and the principle of non-intervention might apply in practice.

In the last few years, certain states have put on record how they consider international law to apply to states’ activities in cyberspace, namely the UK, Australia, France and the Netherlands. While there may be some differences in their approaches, which are discussed in the paper, there also remains important common ground: namely, that existing international law already provides a solid framework for regulating states’ cyber activities, as it regulates every other domain of state-to-state activity.

There is also an emerging trend for states to work together when attributing cyberattacks to hostile states, enabling them to call out malign cyber activity when it violates international law. (See, for example, the joint statements made in relation to the NotPetya cyber attack and malicious cyber activity attributed to the Russian government).

However, other countries have questioned whether existing international law as it stands is capable of regulating states’ cyber interactions and have called for ‘new legal instruments’ in this area.

This includes a proposal by the Shanghai Cooperation Organization (led by Russia and China) for an International Code of Conduct on Information Security, a draft of which was submitted to the UN in 2011 and 2015, without success. The UN has also formed a new Open-Ended Working Group (OEWG) under a resolution proposed by Russia to consider how international law applies to states’ activities in cyberspace.

The resolution establishing the OEWG, which began work earlier this year, includes the possibility of the group ‘introducing changes to the rules, norms and principles of responsible behaviour of States’ agreed in the 2013 and 2015 GGE reports. In the OEWG discussions at the UN in September, several countries claimed that a new legal instrument was needed to fill the ‘legal vacuum’ (Cuba) or ‘the gap of ungoverned areas’ (Indonesia).

It would be concerning if the hard-won consensus on the application of international law to cyberspace that has been reached at past GGEs started to unravel. In contrast to 2013 and 2015, the 2017 meeting failed to reach an agreement.

On 9 December, a renewed GGE will meet in New York, but the existence of the OEWG exploring the same issues in a separate process reflects the fact that cyber norms have become an area of geopolitical rivalry.

Aside from the application of international law, states are also adopting divergent approaches to the domestic regulation of cyberspace within their own territory. The emerging trend towards a ‘splinternet’ – i.e. between states that believe the internet should be global and open on the hand, and those that favour a ‘sovereignty and control’ model on the other  – is also likely to make discussions at the GGE more challenging.

Distinct from the international law concept of sovereignty is the notion of ‘cybersovereignty’, a term coined by China to describe the wide-ranging powers it assumes under domestic law to regulate its citizens’ access to the internet and personal data within its territory. This approach is catching on (as reflected in Russia’s recently enacted ‘Sovereign Internet Law’), with other authoritarian states likely to follow suit.

The importance of non-state actors

In parallel with regional and UN discussions on how international law applies, a number of initiatives by non-state actors have also sought to establish voluntary principles about responsible state behaviour in cyberspace.

The Global Commission on the Stability of Cyberspace, a multi-stakeholder body that has proposed principles, norms and recommendations to guide responsible behaviour by all parties in cyberspace, recently published its final report. The Cybersecurity Tech Accord  aims to promote collaboration between tech companies on stability and resilience in cyberspace. President Macron’s ‘Paris Call for Trust and Security in Cyberspace’ has to date received the backing of 67 states, 139 international and civil society organizations, and 358 private-sector organizations.

It remains to be seen in the long term whether the parallel processes at the UN will work constructively together or be competitive. But notwithstanding the challenging geopolitical backdrop, the UN GGE meeting next week at the least offers states the opportunity to consolidate and build on the results of past meetings; to increase knowledge and discussion about how international law might apply; and to encourage more states to put their own views of these issues on the record.




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Characterization of signaling pathways associated with pancreatic {beta}-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice

Taewook Kang
Apr 7, 2020; 0:RA119.001882v1-mcp.RA119.001882
Research




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Proteome and phosphoproteome analysis of brown adipocytes reveals that RICTOR loss dampens global insulin/AKT signaling

Samuel W Entwisle
Apr 6, 2020; 0:RA120.001946v2-mcp.RA120.001946
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DHS herding people on to an imperfect system in myGov

Over the past few weeks I have been answering calls for the myGov helpdesk.




mpe

Economic containment as a strategy of Great Power competition

6 November 2019 , Volume 95, Number 6

Dong Jung Kim

Economic containment has garnered repeated attention in the discourse about the United States' response to China. Yet, the attributes of economic containment as a distinct strategy of Great Power competition remain unclear. Moreover, the conditions under which a leading power can employ economic containment against a challenging power remain theoretically unelaborated. This article first suggests that economic containment refers to the use of economic policies to weaken the targeted state's material capacity to start military aggression, rather than to influence the competitor's behaviour over a specific issue. Then, this article suggests that economic containment becomes a viable option when the leading power has the ability to inflict more losses on the challenging power through economic restrictions, and this ability is largely determined by the availability of alternative economic partners. When the leading power cannot effectively inflict more losses on the challenging power due to the presence of alternative economic partners, it is better off avoiding economic containment. The author substantiates these arguments through case-studies of the United States' responses to the Soviet Union during the Cold War. The article concludes by examining the nature of the United States' recent economic restrictions against China.