Global health is of increasing interest and relevance to North American pediatric trainees. Opportunities for resident global health training and exposure are most often limited to electives or trainees in dedicated global health tracks.

A series of short, structured, participatory global child health modules improved knowledge and were well received and integrated within academic programs. Such modules enable global health learning for all residents, including those who never intend to practice overseas. (Read the full article)

Predicting high-risk populations in congenital diaphragmatic hernia (CDH) can help target care strategies. Prediction rules for infants with CDH often lack validation, are aimed at a prenatal population, and are of limited generalizability. We cannot currently discriminate the highest risk neonates during the crucial period shortly after birth.

This clinical prediction rule was developed and validated on an international database. It discriminates patients and high, intermediate, and low risk of mortality; is easy to apply; and is generalizable to most infants with CDH. (Read the full article)

Pediatric Brain Injury Research Network investigators recently derived a highly sensitive clinical prediction rule for pediatric abusive head trauma (AHT).

The performance of this AHT screening tool has been validated. Four clinical variables, readily available at the time of admission, detect pediatric AHT with high sensitivity in intensive care settings. (Read the full article)

Some parents choose to "spread out" the recommended vaccine schedule for their child by decreasing the number of simultaneous vaccines or delaying certain vaccines until an older age. Epidemiologic studies demonstrate increasing numbers of parents are choosing to delay vaccines.

We demonstrate that almost all providers encounter requests to spread out vaccines in a typical month and, despite concerns, increasing numbers are agreeing to do so. Providers report many strategies in response to requests but think few are effective. (Read the full article)

Central apnea sometimes complicates bronchiolitis. Because apnea tends to occur early in the course of bronchiolitis, there is a danger that infants may be discharged from the emergency department only to subsequently develop apnea at home.

This study prospectively derived clinical decision rules to help emergency physicians admit infants at risk for apnea while discharging those not at risk. (Read the full article)

The rule requires states to use a standard method in determining if districts are biased in how they identify minority students, discipline them, or place them in restrictive settings.

Source: www.businessinsider.com - Saturday, May 09, 2020
Dating apps like Tinder, Bumble, and Hinge have reported increased use amid the coronavirus pandemic, while touting virtual dating alternatives for users instead of meeting up in person. Swaths of users are still encouraging matches to break quarantine to have sex and go on dates, despite social distancing guidelines and fines to comply with them. An illustrator on Instagram has been collecting screenshots of these situations, and told Business Insider that users will brand themselves as "badasses," dispute the effectiveness of isolating, and lash out in anger and hurl abusive language when they're rejected. Spokespeople for Grindr, Tinder and Bumble told Business Insider they've informed users to adhere to social-distancing guidelines, but did not respond to inquiries about actions they're taking against users in places where violating lockdown orders can be against the law. Visit Business Insider's homepage for more stories . As millions remain confined to their homes to prevent the spread of coronavirus, the desire for human contact and connection has risen dramatically and led some to search for ways to break those social distancing rules. Popular dating apps — including Tinder , Bumble , and Hinge — have reported significant increases during the outbreak of swiping activity, matches between users, and messages exchanged. It's also led to the introduction of a breed of users who are interested in shirking lockdown orders, an

Source: www.businessinsider.com - Saturday, May 09, 2020
Many superyacht crew members have been stuck on their vessels after lockdowns and travel bans were instated due to the coronavirus pandemic. We spoke to crew members who felt 'lucky' to be quarantined in such luxury digs — and grateful to still have jobs and secure wages. There is still plenty of work to be done, but workers also described trivia games, sundeck BBQs, and hot tub nights they're using to pass the time and bond with colleagues. Strict new hygiene and sanitation rules have also been put into place. Visit Business Insider's homepage for more stories . In late March, billionaire businessman David Geffen posted a shot on Instagram taken from his 452-foot superyacht Rising Sun. It was hastily deleted — but not before it had raised more than a few eyebrows and stirred discourse around the 1% and their self-isolation privilege. But it's not just the rare billionaire who is bunkering down on their yacht during the COVID-19 pandemic. Here is another group of people for whom this is a new reality: the yacht's crews.  Before this crisis, there were around 80,000 people employed on pleasure craft around the globe, according to Laurence Lewis, CEO of YPI Crew, a yacht recruitment agency. As countries rushed to close their borders, ports were closed — and overnight, many found themselves unable to travel to get to or leave their yachts.  For many, a superyacht sounds like the dream scenario to see out lockdown. But is it?  "Ther

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Our guide to how foul play is dealt with in futsal.

The new Trump administration rule regarding immigrants' use of federal benefits could have an indirect but significant impact on schools, education advocates warn.

Some educators and advocates fear the rule will dissuade immigrants from seeking certain government benefits, and that further burdens will fall on schools.

The human diseases caused by the fungal pathogens Cryptococcus neoformans and C. gattii are associated with high indices of mortality, and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anti-cryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far. In this study, we investigated the antifungal potential of fenbendazole, the most effective anti-cryptococcal benzimidazole. Fenbendazole was inhibitory against 17 different isolates of C. neoformans and C. gattii at a low concentration. The mechanism of anti-cryptococcal activity of fenbendazole involved microtubule disorganization, as previously described for human parasites. In combination with fenbendazole, the concentrations of the standard antifungal amphotericin B required to control cryptococcal growth were lower than those required when this antifungal was used alone. Fenbendazole was not toxic to mammalian cells. During macrophage infection, the anti-cryptococcal effects of fenbendazole included inhibition of intracellular proliferation rates and reduced phagocytic escape through vomocytosis. Fenbendazole deeply affected the cryptococcal capsule. In a mice model of cryptococcosis, the efficacy of fenbendazole to control animal mortality was similar to that observed for amphotericin B. These results indicate that fenbendazole is a promising candidate for the future development of an efficient and affordable therapeutic tool to combat cryptococcosis.

Despite the worldwide re-emergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. We here aim to identify the target of a novel class of CHIKV inhibitors i.e. CHVB series. CHVB compounds inhibit the in vitro replication of CHIKV isolates with 50% effective concentrations in the low micromolar range. A CHVB-resistant variant (CHVB^res) was selected that carried two mutations in the gene encoding nsP1 (responsible for viral RNA capping), one mutation in nsP2 and one mutation in nsP3. Reverse genetics studies demonstrated that both nsP1 mutations were necessary and sufficient to achieve ~18-fold resistance, suggesting that CHVB targets viral mRNA capping. Interestingly, CHVB^res was cross-resistant to the previously described CHIKV capping inhibitors from the MADTP series, suggesting they share a similar mechanism of action. In enzymatic assays, CHVB inhibited the methyltransferase and guanylyltransferase activities of alphavirus nsP1 proteins. To conclude, we identified a class of CHIKV inhibitors that targets the viral capping machinery. The potent anti-CHIKV activity makes this chemical scaffold a potential candidate for CHIKV drug development.

BACKGROUND:

Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with a mortality of ~27%. The Congenital Diaphragmatic Hernia Study Group (CDHSG) developed a simple postnatal clinical prediction rule to predict mortality in newborns with CDH. Our aim for this study is to externally validate the CDHSG rule in the European population and to improve its prediction of mortality by adding prenatal variables.

The laws of futsal are similar to those of football but with some important differences: let us talk you through the rolling substitutions, accumulated fouls, double penalties and four-second count.

The Sokolov-Miller Family Financial and Life Skills Center at Penn State has a slate of programming for Financial Literacy Month this April and is offering help to anyone in the University community who is anxious about their financial future.

The provisional schedule for the June 2021 finals has been released, with co-hosts Hungary and Slovenia in action on the opening day.

Too many districts that use a lot of credit recovery to enable students to finish high school don't have sufficient policy safeguards to ensure that those catch-up courses are high quality, according to a new report.

Source: www.worldfootynews.com - Monday, May 04, 2020
The Leeside Lions, one of the AFL Ireland clubs in hiatus due to COVID-19, have shown the world a way out by adroitly combining social-distancing with football skills. The following clip from the Cork-based club showcases a range of talents and proves footy can still move forward despite current challenges to the game. Our thanks to the Leeside Lions for sharing. All clubs are welcome to share their clips and can send to the World Footy Facebook page at https://www.facebook.com/groups/5197533739/ or send to me via email at: wesleyhull22@gmail.com

The provisional schedule has England kicking off the tournament on 7 July 2021, with the final at Wembley on 1 August.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

Section 189 notices commencing a consultation process over proposed retrenchments at SAA were procedurally unfair, the Labour Court found on Friday.

The Nebula Capsule II by Anker is an unusual entertainment projector: It runs the Android TV operating system, and can double as a Bluetooth speaker.

A new rule proposed by the Federal Aviation Administration would make it possible for the United States government to track almost all drones in the country.

MPs have been told that some tax changes proposed by Finance Minister Pravin Gordhan in his February budget will hit small firms hard.

Local exporters have to cope with change at breakneck speed. What are their new realities?

A new concession means there's a more flexible way of transferring a residence from your company, trust and CC.

Check the fixtures and results for all ten matchdays of the European Qualifiers here.

Experts have condemned new taxation proposals on interest income.

The Delaware Department of Justice has filed suit against the developer of The Villages of Noble’s Pond, an 879-lot “55-plus” community in Kent County, for numerous violations of the Consumer Fraud Act, the Deceptive Trade Practices Act, and other Delaware laws protecting consumers against unlawful and predatory behavior. Attorney General Kathy Jennings announced the filing […]

Attorney General Kathy Jennings today announced that she is joining a lawsuit opposing the Trump Administration’s new rule circumventing the Flores Settlement Agreement, which has governed the treatment of children in immigration custody since 1997. In the complaint before the U.S. District Court for the Central District of California, the coalition argues that the rule eliminates several critical protections […]

Dover, DE   August 8, 2019 — A Wilmington woman was indicted by the New Castle County Grand Jury for insurance fraud and other felony charges. Theresa T. Milton, 44, of the 900 block of Clayton Street, was indicted on seven felony counts of insurance fraud, one felony count of theft by false pretense, and one […]

The Delaware Public Archives will host students from across the state Saturday for the culmination of the 16th Annual Delaware Day Fourth Grade Competition. (This program was postponed in December due to inclement weather)

Enjoy the season and learn about the First State’s many contributions to the history and culture of the United States.

Program explores Washington’s 110 Rules of Civility and Decent Behavior and discusses how they were practiced by subsequent American presidents together with their relevance to contemporary American politics.

In her 20-year-long stint with the organisation, she headed Sony Max, and played a pivotal role in Sony Entertainment Television’s content revamp.

Alejandro Dominguez, president of the South American football body, CONMEBOL said that he was surprised by FIFA's decision to allow five substitutes when the sport resumes after coronavirus pandemic.

The US Department of Commerce is close to signing off on a new rule that would allow US companies to work with China's Huawei Technologies on setting standards for next generation 5G networks, people...

<strong>New Delhi:</strong> Delhi Government's Odd-Even scheme has come into effect from today and will continue till November 15. In a bid to control the deteriorating air quality in the national capital, this is the third Odd-Even car rationing scheme that has kicked off from Monday. A flagship scheme of the

An Indian-origin man in Singapore was on Wednesday sentenced to seven months in prison for verbally abusing police and safe-distancing enforcement officers who were urging compliance with the COVID-19...

The Delaware Office of Management and Budget will be holding three public hearings to gather public comment on regulations under Governor Markell’s Executive Order 36, a statewide review by all agencies to identify and remove regulatory hurdles.

The Office of Management and Budget (OMB) is currently accepting comments and will hold a series of public hearings on three OMB regulations in accordance with the regulatory review provisions of HB 147 of the 148th General Assembly. Comments will be accepted through November 1 for the following regulations: • 4102 Regulations for the Annual […]

A Beekeeping 101 workshop will be held Jan. 18 for anyone interested in the art and science of beekeeping. The event will take place 8 a.m. to 3 p.m. at the Delaware State University Research & Outreach Center, 844 Smyrna-Leipsic Road, Smyrna.

DOVER, Del. – The Delaware Department of Agriculture (DDA) Food Products Inspection was granted statutory authority on June 11, 2019 to enforce compliance with the Produce Safety Rule in the Food Safety Modernization Act (FSMA). The Food Safety Modernization Act is a proactive approach to prevent foodborne illnesses by strengthening the food supply. These regulations, […]