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[Place of publication not identified] : [publisher not identified], [18--?]

[Place of publication not identified] : [publisher not identified], [18--?]

[Place of publication not identified] : [publisher not identified], [18--?]

[Place of publication not identified] : [publisher not identified], [18--?]

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Kraus, Peter -- Biography.

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination both in vitro and ex vivo models. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. These in vivo findings corroborate initial in vitro studies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.

SIGNIFICANCE STATEMENT This study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.

This eruption is the longest since 2018 when the volcano caused a deadly tsunami

On March 29, the musical world lost a giant - Polish composer and conductor Krzysztof Penderecki. The Library of Congress Music Division remains connected to Penderecki through primary sources in our collections, and we hope that you can remain connected to him in this way, as well.

The Scene  Akron Beacon Journal

German translation of Press Release about BIS General Manager Agustín Carstens giving a speech on "Money in the digital age: what role for central banks?" (6 February 2018)

German translation of Press Release on the pre-release of two special chapters of the Annual Economic Report of the BIS, 17 June 2018. Trust is the missing link in today's cryptocurrencies - Cryptocurrencies' model of generating trust limits their potential to replace conventional money, the Bank for International Settlements (BIS) writes in its Annual Economic Report (AER), a new title launched this year.

OM Ukraine's sports team equips and trains churches in using non-traditional sports in their summer camps.

A Ukrainian pastor responds to nearly 100 per cent unemployment in his village by starting biofuel and cash crop business enterprises.

Through a new cricket league and sports field approved by the local government, OM Ukraine can minister to hundreds of local families.

Ministering in a country at war is not fun – but a privilege. Ukraine is going through intense emotions and people are open to Kingdom conversations.

A 17 year old high school student shares about how she fled from the war zone and came to stay at OM Odessa's centre.

Through the "Lighthouse" soccer team, Maksim Shlikov is reaching out to young orphanage graduates looking for meaning and hope.

OM Ukraine and experts in crisis management held a seminar for pastors serving on both sides of the conflict line in Eastern Ukraine.

Short Term Mission participants bring inspiration to Ukraine's churches for ministry amongst the aged and internally displaced people.

Churches in Ukraine are busier than ever as Christians gain a vision for mission and reach out to others.

"The door for ministry is wide open to use our gifts," explains OM Ukraine Field Leader Wayne. "In my case, God is using my love for cricket to create relationships and influence people who have never heard the gospel...”

We meet the Oleksandr Kadenko, the gold medal recipient in the 2010 UEFA Grassroots Day Awards for best leader.

Türkiye devleti ile uluslararası alanda terör örgütü olarak kabul edilen PKK arasındaki çözüm sürecinin çökmesi, Temmuz 2015’te çatışmaların yeniden başlaması ve daha sonra derinleşen şiddet sarmalı, yeni bir çözüm sürecinin inşasını hiç olmadığı kadar gerekli kılıyor.