tumor

A DNA tetrahedron nanoprobe-based fluorescence resonance energy transfer sensing platform for intracellular tumor-related miRNA detection

By feeds.rsc.org
Published On ::

Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02610J, Paper
Jiaxue Gao, Hua Zhang, Zhenxin Wang
A DNA tetrahedron nanoprobe (DTNP)-based sensing platform for sensitive and selective detection of miRNA via FRET with DNA assisted amplification.
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[ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

By feedproxy.google.com
Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00280


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[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00547


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[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936


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[ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00491


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[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00245


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[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00601


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A DNA logic gate with dual-anchored proximity aptamers for accurate identification of circulating tumor cells

By feeds.rsc.org
Published On ::

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC00564A, Communication
Tianshu Chen, Xin Fu, Qianqian Zhang, Dongsheng Mao, Yuchen Song, Chang Feng, Xiaoli Zhu
We have designed a DNA logic gate that can integrate multiple biomarkers recognition with signal amplification to perform accurate and and sensitive analysis of circulating tumor cells (CTCs). It also...
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A multipedal DNA walker for amplified detection of tumor exosomes

By feeds.rsc.org
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Chem. Commun., 2020, 56,4982-4985
DOI: 10.1039/D0CC01817A, Communication
Peng Miao, Yuguo Tang
A novel electrochemical biosensor for exosomes is proposed based on a multipedal DNA walking strategy. A limit of detection down to 6/μL is obtained with excellent selectivity.
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A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

By feeds.rsc.org
Published On ::

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02943B, Communication
Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim
We report a novel fluorescent molecular conjugate V-M1 enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, well within the near-infrared therapeutic window. Tumor...
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Antitumor effects of novel nickel-hydrazone complexes in lung cancer cells

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Published On ::

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ00921K, Paper
Damir Safin, Burak AY, Onur ŞAHİN, Burcu Saygideğer Demir, Yasemin Saygideger, José Maria López-de-Luzuriaga, Ghodrat Mahmoudi
In this work we have synthesized and characterized two new mononuclear nickel(II) complexes [NiLI]∙CH3CN (1∙CH3CN) and [Ni(H2LII)(NCS)2]∙0.5H2O (2∙0.5H2O), fabricated from a mixture of Ni(NO3)2 and KNCS with N',N'''-(1,2-diphenylethane-1,2-diylidene)di(picolinohydrazide) (H2LI) and...
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Reversibly-regulated drug release using poly(tannic acid) fabricated nanocarriers for reduced secondary side effects in tumor therapy

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Nanoscale Horiz., 2020, Advance Article
DOI: 10.1039/D0NH00032A, Communication
Chao Chen, Tonghao Ma, Wen Tang, Xiaoli Wang, Yibing Wang, Jiafeng Zhuang, Yucheng Zhu, Ping Wang
This article introduced a reversibly pH-responsive and targeting nanocarrier based on mesoporous silica nanoparticles which could be utilized to reduce the “secondary” side effects on normal tissues.
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Defect engineering of 2D BiOCl nanosheets for photonic tumor ablation

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Nanoscale Horiz., 2020, 5,857-868
DOI: 10.1039/C9NH00707E, Communication
Chen Dai, Ruizhi Hu, Chunmei Wang, Zhuang Liu, Shengjian Zhang, Luodan Yu, Yu Chen, Bo Zhang
Photothermal therapy (PTT) is an emerging technology as a noninvasive therapeutic modality for inducing photonic cancer hyperthermia.
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Tumor Markers

By feedproxy.google.com
Published On :: 2019-06-26 12:00:00 -0400

A fact sheet that defines tumor markers and describes how they can be used to aid diagnosis and treatment.


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Diketopyrrolopyrrole-based multifunctional ratiometric fluorescent probe and γ-glutamyltranspeptidase-triggered activatable photosensitizer for tumor therapy

By pubs.rsc.org
Published On ::

J. Mater. Chem. C, 2020, Accepted Manuscript
DOI: 10.1039/D0TC01836H, Paper
Jianli Hua, Zhicheng Yang, Weibo Xu, Jian Wang, Lingyan Liu, Yanmeng Chu, Yu Wang, Yue Hu, Tao Yi
Photosensitizers can generate highly reactive oxygen (ROS) by light exciting, causing cell damage and apoptosis. However, conventional photosensitizers cannot kill cancer cells selectively. In this work, we report a series...
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Influence of nanomedicine mechanical properties on tumor targeting delivery

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Chem. Soc. Rev., 2020, 49,2273-2290
DOI: 10.1039/C9CS00575G, Tutorial Review
Zheng Li, Chen Xiao, Tuying Yong, Zifu Li, Lu Gan, Xiangliang Yang
This tutorial review summarizes the influence of nanomedicine mechanical properties on drug delivery efficiency, antitumor efficacy and safety.
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Cancer drug delivery systems based on the tumor microenvironment edited by Yasuhiro Matsumura, David Tarin

By library.mit.edu
Published On :: Sun, 16 Feb 2020 07:32:02 EST

Online Resource


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Glucose-responsive cascaded nanocatalytic reactor with self-modulation of the tumor microenvironment for enhanced chemo-catalytic therapy

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Published On ::

Mater. Horiz., 2020, Advance Article
DOI: 10.1039/D0MH00105H, Communication
Linqiang Mei, Dongqing Ma, Qin Gao, Xiao Zhang, Wenhui Fu, Xinghua Dong, Gengmei Xing, Wenyan Yin, Zhanjun Gu, Yuliang Zhao
Here, a glucose-responsive cascaded nanocatalytic reactor was proposed for enhanced synergetic chemo-catalytic therapy through persistent TME self-modulation.
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[ASAP] Noncovalent Indocyanine Green Conjugate of C-Phycocyanin: Preparation and Tumor-Associated Macrophages-Targeted Photothermal Therapeutics

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00139


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[ASAP] Reprogramming Tumor Microenvironment with Photothermal Therapy

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00135


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[ASAP] An Integrin Alpha 6-Targeted Radiotracer with Improved Receptor Binding Affinity and Tumor Uptake

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00170


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Biofunctional Janus Particles Promote Phagocytosis of Tumor Cells by Macrophages

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Published On ::

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01146K, Edge Article
Open Access
Ya-Ru Zhang, Jia-Qi Luo, Jia-Xian Li, Qiu-Yue Huang, Xiao-Xiao Shi, Yong-Cong Huang, Kam W Leong, Weiling He, Jinzhi Du
Herein, a versatile strategy for the construction of biofunctional Janus particles (JPs) through the combination of Pickering emulsion and copper-free click chemistry is developed for the study of particle-mediated cell-cell interactions. A...
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A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery

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Chem. Sci., 2020, 11,4397-4402
DOI: 10.1039/D0SC00844C, Edge Article
Open Access
Wenjia Duan, Qi Yue, Ying Liu, Yunfei Zhang, Qinghua Guo, Cong Wang, Shujie Yin, Dandan Fan, Wenjing Xu, Jiexian Zhuang, Jiachao Gong, Xinwei Li, Ruimin Huang, Liang Chen, Silvio Aime, Zhongliang Wang, Jianfeng Feng, Ying Mao, Xiao-Yong Zhang, Cong Li
A novel pH ratiometrically responsive surface-enhanced resonance Raman scattering (SERRS) probe was developed for tumor acidic margin delineation and image-guided surgery.
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A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy

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Published On ::

Lab Chip, 2020, 20,1418-1425
DOI: 10.1039/D0LC00149J, Paper
Chun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling Zhang
A system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.
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A microfluidic platform for functional testing of cancer drugs on intact tumor slices

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Lab Chip, 2020, 20,1658-1675
DOI: 10.1039/C9LC00811J, Paper
A. D. Rodriguez, L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, A. Folch
We have developed a digitally-manufacturable microfluidic platform that allows for multiplexed drug testing of intact tumor slices.
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Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

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Published On ::

Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper
Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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In NIH trial, selumetinib shrinks tumors, provides clinical benefit for children with NF1

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Published On :: Wed, 18 Mar 2020 08:00:00 -0400

An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.


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[ASAP] Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

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Published On :: Fri, 01 May 2020 04:00:00 GMT

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05855


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Onc Daily: Nivolumab for Tough Tumor, End-of-Life Wording

By www.medscape.com
Published On :: Fri, 8 May 2020 15:06:53 EDT

These are the most important oncology stories you need to know about today.
Medscape Medical News


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[ASAP] Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

By feedproxy.google.com
Published On :: Mon, 04 May 2020 04:00:00 GMT

Nano Letters
DOI: 10.1021/acs.nanolett.9b05035


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Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00314J, Research Article
Bo-Han Li, Wenlong Yao, Hong Yang, Congying Wu, De-Cai Xiong, Yuxin Yin, Xin-Shan Ye
KH-1 antigen core nonasaccharide was efficiently assembled by photo-induced glycosylation.
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Bacteria producing checkpoint inhibitors shrink tumors in mice

By feedproxy.google.com
Published On :: 12 Feb 2020 05:00:00 +0000

After being injected into tumors, the bacteria self-destruct to release their therapeutic cargo


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Ecografia in oncologia [electronic resource] : testo-atlante di ultrasonologia diagnostica e interventistica dei tumori / Orlando Catalano, Alfredo Siani

By darius.uleth.ca
Published On ::

Milano : Springer, [2007]


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[ASAP] Surfactin Ameliorated the Internalization and Inhibitory Performances of Bleomycin Family Compounds in Tumor Cells

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00281


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Ergosterol peroxide from Pleurotus ferulae inhibits gastrointestinal tumor cell growth through induction of apoptosis via reactive oxygen species and endoplasmic reticulum stress

By feeds.rsc.org
Published On ::

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02454A, Paper
Yi Yang, Xiaoyu Luo, Mayila Yasheng, Jun Zhao, Jinyu Li, Jinyao Li
Ergosterol peroxide was purified from Pleurotus ferulae by silica gel chromatography, Sephadex LH-20 chromatography and recrystallization and named as PFEP, which was identified by ESI-MS and NMR.
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Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster

By dx.doi.org
Published On :: Tue, 05 Mar 2013 20:59:00 +0000

Interview with Kevin L Winthrop, MD, MPH, author of Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster


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Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

By dx.doi.org
Published On :: Tue, 17 Jun 2014 20:00:00 +0000

Interview with Nynne Nyboe Andersen, MD, author of Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease


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[ASAP] Enhanced Upconversion Luminescence-Guided Synergistic Antitumor Therapy Based on Photodynamic Therapy and Immune Checkpoint Blockade

By feedproxy.google.com
Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Chemistry of Materials
DOI: 10.1021/acs.chemmater.0c01031


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A biodegradable CO2-based polymeric antitumor nanodrug via a one-pot surfactant- and solvent-free miniemulsion preparation

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2234-2244
DOI: 10.1039/C9BM01931F, Paper
Qiaojie Luo, Xiaojun Li, Ying Wang, Jianfang He, Qiao Zhang, Pengfei Ge, Xia Cai, Qiang Sun, Weipu Zhu, Zhiquan Shen, Xiaodong Li
A biodegradable CO2-based polymeric nanodrug is obtained via a surfactant- and solvent-free miniemulsion preparation, which can be concentrated at tumor site by EPR and releases the encapsulated drug through pH responsiveness.
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A polymeric nanocarrier with a tumor acidity-activatable arginine-rich (R9) peptide for enhanced drug delivery

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2255-2263
DOI: 10.1039/D0BM00069H, Paper
Liting Zhang, Chengtao Jiang, Fanjun Zeng, Haiyu Zhou, Dongdong Li, Xinyu He, Song Shen, Xianzhu Yang, Jun Wang
The cell-penetrating function of R9 peptide of DA@R9-NPDOX was masked in the blood circulation, while reactivated in tumor tissue for enhanced tumor cellular uptake.
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Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2274-2282
DOI: 10.1039/C9BM02036E, Paper
Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun
PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.
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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper
Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
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An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2202-2211
DOI: 10.1039/C9BM01794A, Paper
Li Zhang, Shiyu Zhang, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, Jinheng Li, Junqiao Zhu, Chao Peng, Yaru Zhang, Zhe Hong, Ying Wang, Yingjia Li
Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.
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MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, 8,2308-2317
DOI: 10.1039/C9BM02007A, Paper
Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He, Lu Sun
A novel MT1-MMP activatable fluorogenic probe for tumor detection with enhanced specificity was developed via high-affinity and specific peptide conjugation.
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Correction: An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM90037K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhilin Liu, Na Shen, Zhaohui Tang, Dawei Zhang, Lili Ma, Chenguang Yang, Xuesi Chen
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Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00466A, Paper
Peng Zhang, Yu Zhang, Xiaoya Ding, Chunsheng Xiao, Xuesi Chen
An efficient strategy to selectively promote nanoparticle accumulation in solid tumors was developed by encapsulating sildenafil in cisplatin-incorporated polymeric micelles.
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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy

By pubs.rsc.org
Published On ::

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00062K, Paper
Chaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin Yang
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...
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