The National Institute for Health and Care Excellence (NICE) has recommended that all women with suspected endometriosis be offered an early transvaginal ultrasound scan, even if the pelvic or abdominal examination is normal.In its updated guideline1 on the diagnosis and management of endometriosis, NICE recommends specialist ultrasound as an alternative to magnetic resonance imaging for investigating suspected cases of the condition in secondary care.The updated guideline follows recent reports from both the National Confidential Enquiry into Patient Outcome and Death2 and Endometriosis UK which highlighted problems with delayed diagnoses, partly owing to a lack of awareness among healthcare professionals of the condition and how it presents. Such delays can result in prolonged suffering, ill health, and risks to fertility, the reports warned.Other new and updated recommendations include asking women with suspected endometriosis if any first degree relatives have a history of the condition, and considering neurodiversity when taking into account...

At a recent clinical meeting, I heard that GPs local to me are about to lose the ability to request magnetic resonance imaging (MRI) scans for patients presenting with musculoskeletal symptoms. We’re instead advised to refer our patients to a musculoskeletal clinical assessment and triage service (CATS)—staffed largely by musculoskeletal advanced practitioners, who will assess our patients and determine whether imaging is warranted.The hope is that fewer patients will have unnecessary imaging and that this will reduce the potential harms of overdiagnosis. Radiologists rarely report musculoskeletal MRI scans as entirely normal, and it can be hard to know what to do with abnormal findings on an MRI. More often than not, patients with abnormal scans are referred to orthopaedic teams, even though there may not necessarily be a surgical target.At a population level, this is problematic on two fronts. Firstly, MRI scans are expensive and need to be used judiciously....

This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

Archbishop of Canterbury Justin Welby has opted to quit as head of the Church of England after a critical report over his handling of an abuse scandal, it was announced.

In between trips to archaeology digs around the world, scientist Bruno Frohlich uses 3-D imaging to uncover what makes a great stringed instrument. Read more at: https://www.smithsonianmag.com/smithsonian-institution/scanning-a-stradivarius-13807009/

A night at the museum with the Smithsonian's "Laser Cowboys" http://j.mp/17Vclt8 Using laser scanners and high-tech computer software, Vince Rossi and Adam Metallo are recreating a digital Dinosaur Hall before it's dismantled

This unmanned aerial vehicle can be launched from, and land on, a moving ship thanks to new technology Narrated by T.A. Frail Script by Brendan McCabe Video courtesy of Insitu

A short movie explores 3D scans of some of the mid-Cretaceous lizards found trapped in amber. (courtesy of Daza et al., Science Advances)

More on 3D scanning: http://j.mp/JM43KD Specialists are using new technology to unravel a mystery in the Smithsonian collections.

Created from more than 25,000 high-resolution images, the digital model shows artifacts from the ill-fated expedition, including a boot, dishes and a flare gun

The archbishop of Canterbury, Justin Welby, resigned over an abuse cover-up scandal on Tuesday, marking an unprecedented moment for the Church of England.

A Very Royal Scandal, featuring Ruth Wilson and Michael Sheen, brings viewers into the world of the British royal family’s explosive 2019 interview that revealed new truths about Prince Andrew. Now available in India on SonyLIV, the series dives deep into royal drama. Directed by Julian Jarrold and produced by Amazon MGM Studios, it revisits key events and figures surrounding one of the monarchy’s most notable scandals.

Can anyone tell me how i can supress few strings or integers while reading with $sscanf.

I read a line from a file into a string. there are few strings and integers seperated by white spaces in the line. I am interested in one string which comes at postion 5 in the line. how can i suppress all other strings and integers with $scanf.

i tried the following syntax but it dint work.

 $sscanf(line,"* * * * %s",string_arg);

i am tring to supress first 4 integers/strings in the line.

LONDON — The head of the Church of England, spiritual leader of the global Anglican Communion, is under pressure to resign after an investigation found that he failed to inform police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Some members of the General Synod, the church's national assembly, have started a petition calling on Archbishop of Canterbury Justin Welby to step down, saying he had "lost the confidence of his clergy." The petition had garnered more than 1,800 signatures on Change.org by late morning London time on Monday. Compounding the pressure, a senior cleric added her voice to those who believe he should resign. Helen-Ann Hartley, the bishop of Newcastle, told the BBC that Welby's position is "untenable.'' Calls for Welby's resignation have grown since Thursday, when the church released the results of an independent review into John Smyth, who sexually, psychologically and physically abused about 30 boys and young men in the United Kingdom and 85 in Africa over five decades. The 251-page report concluded that Welby failed to report Smyth to authorities when he was informed of the abuse in August 2013, soon after he became Archbishop of Canterbury. Welby last week took responsibility for not ensuring that the allegations were pursued as "energetically" as they should have been after he learned of the abuse but said he had decided not to resign. On Monday, his office issued a statement reiterating Welby's "horror at the scale of John Smyth's egregious abuse." "As he has said, he had no awareness or suspicion of the allegations before he was told in 2013 — and therefore, having reflected, he does not intend to resign," the statement said. "He hopes the Makin Review supports the ongoing work of building a safer church here and around the world." Church officials were first made aware of the abuse in 1982, when they received the results of an internal investigation into Smyth. The recipients of that report "participated in an active cover-up" to prevent its findings from coming to light, the Makin Review found. Between 1984 and 2001, Smyth moved to Zimbabwe and subsequently relocated to South Africa. He continued to abuse boys and young men in Zimbabwe and there is evidence that the abuse continued in South Africa until he died in August 2018. Smyth's abuse wasn't made public until a 2017 investigation by Britain's Channel 4 television, which led Hampshire Police to start an investigation. Police were planning to question Smyth at the time of his death and had been preparing to extradite him. The Makin Review found that if Smyth had been reported to police in 2013, it could have helped to uncover the truth, prevented further abuse and led to a possible criminal conviction. "In effect, three and a half years was lost, a time within which John Smyth could have been brought to justice and any abuse he was committing in South Africa discovered and stopped," the review found. The Archbishop of Canterbury is the head of the Church of England and is seen as the spiritual leader of the Anglican Communion, which has more than 85 million members in 165 countries. He is considered first among equals with respect to the communion's other primates.

London — Archbishop of Canterbury Justin Welby, head of the Church of England and spiritual leader of the global Anglican Communion, resigned Tuesday after an investigation found that he failed to tell police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it.  Pressure on Welby had been building since Thursday, when release of the inquiry's findings kindled anger about a lack of accountability at the highest reaches of the church. Helen-Ann Hartley, the bishop of Newcastle, said Monday that his position was "untenable" after some members of the church's national assembly started a petition calling on Welby to step down because he had "lost the confidence of his clergy."  "I believe that stepping aside is in the best interests of the Church of England, which I dearly love and which I have been honored to serve," Welby said in a statement.  The strongest outcry came from the victims of John Smyth, a prominent attorney who abused teenage boys and young men at Christian summer camps in Britain, Zimbabwe and South Africa over five decades. Andrew Morse, who was repeatedly beaten by Smyth over a period of five years, said that resigning was a chance for Welby to start repairing the damage caused by the church's handling of historical abuse cases more broadly.  "I believe that now is an opportunity for him to resign,'' Morse told the BBC before Welby stepped down. "I say opportunity in the sense that this would be an opportunity for him to stand with the victims of the Smyth abuse and all victims that have not been treated properly by the Church of England in their own abuse cases."  Welby's resignation comes against the backdrop of widespread historical sexual abuse in the Church of England. A 2022 report by the Independent Inquiry Child Sexual Abuse found that deference to the authority of priests, taboos surrounding the discussion of sexuality and a culture that gave more support to alleged perpetrators than their victims helped make the Church of England Church of England "a place where abusers could hide." 

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Church of England head Justin Welby resigns over handling of sex abuse scandal

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The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

The role of somatostatin receptor (SSTR) PET/CT, using ⁶⁸Ga-based tracers or [⁶⁴Cu]Cu-DOTATATE (⁶⁴Cu-DOTATATE), in the management of patients with neuroendocrine neoplasm (NEN) is guided by appropriate use criteria (AUC). In this study, we performed systematic analyses of referral patterns and image findings of routine ⁶⁴Cu-DOTATATE PET/CT scans to support AUC development. Methods: We included all clinical routine ⁶⁴Cu-DOTATATE PET/CT scans performed between April 10, 2018 (start of clinical use), and May 2, 2022, at Copenhagen University Hospital–Rigshospitalet. We reviewed the referral text and image report of each scan and classified the indication according to clinical scenarios as listed in the AUC. Results: In total, 1,290 patients underwent 2,249 ⁶⁴Cu-DOTATATE PET/CT scans. Monitoring of patients with NEN seen both on conventional imaging and on SSTR PET without clinical evidence of progression was the most common indication (defined as "may be appropriate" in the AUC) and accounted for 703 (31.3%) scans. Initial staging after NEN diagnosis ("appropriate" in the AUC) and restaging after curative-intent surgery ("may be appropriate" in the AUC) accounted for 221 (9.8%) and 241 (10.7%) scans, respectively. Selection of patients eligible for peptide receptor radionuclide therapy ("appropriate" in the AUC) and restaging after peptide receptor radionuclide therapy completion ("appropriate" in the AUC) accounted for 95 (4.2%) and 115 (5.1%) scans, respectively. The number of scans performed for indications not defined in the AUC was 371 (16.5%). Image result analysis revealed no disease in 669 scans (29.7%), stable disease in 582 (25.9%), and progression in 461 (20.5%). In 99 of the 461 (21.5%) scans, progression was detected on PET but not on CT. Conclusion: Our study provided real-life data that may contribute to support development of ⁶⁴Cu-DOTATATE/SSTR PET/CT guidelines including AUC. Some scenarios listed as "may be appropriate" in the current AUC were frequent in our data. Monitoring of patients with NEN without clinical evidence of progression was the most frequent indication for ⁶⁴Cu-DOTATATE PET/CT, in which disease progression was detected in more than one third, and a large proportion was visible by PET only. We therefore conclude that this scenario could potentially be classified as appropriate.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

The Canadian women's soccer team was implicated in a drone scandal this past summer. But, an investigation determined drone use against opponents, predated the Paris Olympics.

The Archbishop of Canterbury's position is now untenable, according to the Bishop of Newcastle who joined the growing calls for Justin Welby to resign.

The business secretary Jonathan Reynolds has called for a change of culture at the Post Office, as he gave evidence to the inquiry into the Horizon scandal.

Justin Welby's resignation as the Archbishop of Canterbury came after days of mounting pressure following a damning report into the cover-up of horrific abuse.

1. Church of England head Justin Welby who married Prince Harry and Meghan Markle resigns over pedophile scandal  Hindustan Times
2. Archbishop of Canterbury, Trump critic Justin Welby resigns. What is the sex abuse scandal?  The Times of India
3. Video | UK Church Abuse Scandal: Head Of Church Of England Steps Down  NDTV
4. ‘Church in crisis’: what the papers say about the archbishop of Canterbury’s resignation  The Guardian
5. World News Today Live Updates on November 13, 2024 : Archbishop of Canterbury Justin Welby resigns amid sexual abuse case—Who is he? What's the scandal? All you need to know  Mint

Archbishop of Canterbury Justin Welby has resigned over accusations that he failed to report physical and sexual abuse to the police.

Canada Soccer a définitivement coupé les ponts avec la sélectionneuse de l’équipe féminine Bev Priestman.

His resignation comes after a damning report into a prolific child abuser associated with the Church.

Justin Welby said he had to take responsibility for failures since he was notified about abuse committed by John Smyth.

Mayo Clinic researchers are using AI and a cutting-edge 3D body scanner, originally designed for fashion, to predict medlinkmetabolic syndrome/medlink risk more accurately.

After hearing voices in the head to have a CT scan, a woman has been diagnosed with a brain tumor. A Twitter user has shared the bwoman's unusual

b"The illegal sale of organs is more than just a criminal act; it is a violation of fundamental human rights." - Alex Padilla/b In a shocking revelation,