THE UK's chief Brexit negotiator has hit back after his EU counterpart Michel Barnier said progress in trade talks had been "disappointing" and accused Britain of refusing to commit "seriously" on a number of key points.

Michigan coach Jim Harbaugh's proposal on rules for college players thinking NFL could help reduce talent base at programs like Ohio State, Alabama.

IndyStar high school sports Insider Kyle Neddenriep caught up with outgoing IHSAA commissioner Bobby Cox.

2020-03-26 -

Watford become the third team to publicly oppose the use of neutral venues when Premier League football returns.

If you don’t know what capital gains indexing to inflation means, you probably wouldn’t benefit from it.

velocityconf: Who's up for a 5 minute lightning talk. Last day to get your #Ignite proposal in for #velocityconf CA. http://t.co/pzL0WJtQH5

The East Kowloon Cultural Centre Public Artwork Commissioning Project is inviting artists, designers and architects to create an art landscape for the centre.

Presented by the Leisure & Cultural Services Department and organised by the Art Promotion Office, the project endeavors to capture and showcase the past, present and future of East Kowloon.

The commissioned artworks will represent five themes - memory, impression, moment, dream and imagination - aiming to display the district’s changing nature, and to manifest the local community’s cultural sustainability, aspirations and dreams.

Interested participants must submit their preliminary proposal with their curriculum vitae, documentation of their previous artwork and the artistic concept of the proposed artwork.

All proposals must be delivered to the centre’s Public Art Project Management Team at G/F, 50-54 Lok Ku Road, Sheung Wan before 7pm on May 4.

Participants shortlisted by the selection panel are required to submit detailed proposals before 7pm on June 30 for the next stage of the selection process.

Up to three proposals shall be chosen by the selection panel for commissioning and installing in the centre.

Lucía Trilla-Fuertes
Apr 1, 2020; 19:690-700
Research

Anal squamous cell carcinoma is a rare tumor. Chemo-radiotherapy yields a 50% 3-year relapse-free survival rate in advanced anal cancer, so improved predictive markers and therapeutic options are needed. High-throughput proteomics and whole-exome sequencing were performed in 46 paraffin samples from anal squamous cell carcinoma patients. Hierarchical clustering was used to establish groups de novo. Then, probabilistic graphical models were used to study the differences between groups of patients at the biological process level. A molecular classification into two groups of patients was established, one group with increased expression of proteins related to adhesion, T lymphocytes and glycolysis; and the other group with increased expression of proteins related to translation and ribosomes. The functional analysis by the probabilistic graphical model showed that these two groups presented differences in metabolism, mitochondria, translation, splicing and adhesion processes. Additionally, these groups showed different frequencies of genetic variants in some genes, such as ATM, SLFN11 and DST. Finally, genetic and proteomic characteristics of these groups suggested the use of some possible targeted therapies, such as PARP inhibitors or immunotherapy.

The White House immigration plan offered as a solution to resolve the fate of DREAMers seeks legal immigration cuts unlike any seen since 1924. In addition to a decrease of up to 40 percent in family-sponsored immigration, the proposal demands vast increases in enforcement and a retrenchment in protections for those seeking humanitarian relief. In exchange, one-sixth of the unauthorized population could gain legal status.

Even as the 1.8 million number swirls in the discussion of how many DREAMers would be placed on a path to citizenship, proposals debated in the Senate in February 2018 would have resulted in the legalization of smaller numbers, as this commentary explains. It offers estimates of potential beneficiaries of several Senate proposals, including one backed by the White House, and analysis of key criteria.

Top Pentagon officials told lawmakers Wednesday that a proposed nationwide network to provide 5G and internet-of-things services was "too risky to be worth it."

The National Institute of Dental and Craniofacial Research is seeking comments on a proposed research initiative on dental fear and anxiety.

The Trump administration’s plan to create a "merit-based" U.S. immigration system, lessening the longstanding focus on family reunification in favor of more economic migrants, has met with a lackluster response from Democrats and Republicans alike. This Policy Beat article explores how the Trump proposal would reshape immigration to the United States, and how it compares to selection systems in other countries and past debates about changing the U.S. system.

Biden's campaign announced March 31 that the 2020 Democratic presidential candidate backs two local attempts to raise more tax revenue for schools.

Democratic Gov. Gina Raimondo proposes to allow traditional public schools to be free of certain regulations, including opening up enrollment outside their neighborhoods.

L. F. South, A. N. Pettitt, C. C. Drovandi.

Source: Bayesian Analysis, Volume 14, Number 3, 773--796.

Abstract:
Sequential Monte Carlo (SMC) methods for sampling from the posterior of static Bayesian models are flexible, parallelisable and capable of handling complex targets. However, it is common practice to adopt a Markov chain Monte Carlo (MCMC) kernel with a multivariate normal random walk (RW) proposal in the move step, which can be both inefficient and detrimental for exploring challenging posterior distributions. We develop new SMC methods with independent proposals which allow recycling of all candidates generated in the SMC process and are embarrassingly parallelisable. A novel evidence estimator that is easily computed from the output of our independent SMC is proposed. Our independent proposals are constructed via flexible copula-type models calibrated with the population of SMC particles. We demonstrate through several examples that more precise estimates of posterior expectations and the marginal likelihood can be obtained using fewer likelihood evaluations than the more standard RW approach.

Mathias Colomb Cree Nation is wondering why the federal government ignored their community's proposal for an emergency COVID-19 response space in favour of a Calgary company's. 

SCOTLAND’S Economy Secretary has penned a letter to the UK Government venting her frustration at being given “insufficient time” to consider workplace safety proposals.

While the Trump administration proposal would not strip student eligibility for Head Start, the federal school lunch program, or the Individual with Disabilities Education Act, it could still affect millions of school-aged children who live with immigrant parents.

Proposed changes to the massive trove of civil rights data the U.S. Department of Education collects from every public school in the country has drawn organized praise from advocates concerned about anti-Semitism in schools.

Many schools treat students with mental-health issues reactively, rather than proactively, write Catherine A. Hogan & Laura F. Main.

Congressional Republicans and Democrats are at work on competing proposals to reauthorize the Elementary and Secondary Education Act. Use our interactive explorer to take a deeper dive into each proposal.

The Center for the Performing Arts at Penn State, through a program funded by The Andrew W. Mellon Foundation, has selected five proposals for the development of inter-domain courses that include the performing arts at their cores.

Members of the Scottish Parliament’s Justice Committee have launched a call for views on the Scottish Government’s plans to update hate crime laws.

A proposal to name a planned new art museum at University Park in honor of the late Barbara and James Palmer was approved today (May 8) by the Penn State Board of Trustees.

Agency: DHR Closing Date: 5/15/2020

Agency: TRE Closing Date: 5/15/2020

DNREC the Delaware Division of Public Health are now accepting project proposals from state, county and municipal governments, and conservation districts, for matching grants for wastewater, surface water, and drinking water project planning.

DNREC, with the Division of Public Health, is now accepting project proposals for matching grants for waste, surface, and drinking water project planning.

he Delaware Division of Public Health’s Drinking Water State Revolving Fund (DWSRF) is currently accepting project proposals from public drinking water systems for Safety Assessments and Feasibility Evaluations (SAFE) grants. Proposals must be received by August 15, 2019.

DNREC’s Division of Watershed Stewardship is now accepting project proposals for matching grants for community water quality improvement projects.

Citing security concerns, the Home Ministry of India puts on hold the proposal sent by Tourism Ministry to provide e-visa facility to the delegates visiting the country for conferences and meetings. According to an  official from Tourism Ministry,…