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As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

Seventeen years before the COVID-19 pandemic was declared, another mysterious, virulent respiratory illness suddenly appeared — SARS. On the Enright Files, conversations with public health experts from those unnerving times, as they were assessing what we learned from the SARS and Ebola outbreaks.

This joyous set of Beethoven's sonatas takes its place among the very best.

Every frame of this magical, dreaming movie is detailed and suffused with a moonlight glow.

One of Australia's largest food exporters, SunRice, cuts more than 30 regional staff after producing its second-lowest rice crop.

The Eels make a mess of the Broncos in Parramatta after the Storm ran roughshod over the Knights and the Panthers won a close one against the Rabbitohs.

The South Sydney Rabbitohs hold off Brisbane's late charge in a spiteful clash at Lang Park, while the North Queensland Cowboys comfortably account for Penrith.

The Bulldogs have gone above the Titans at the bottom of the NRL table, after the former upset the Knights in Newcastle and the latter was comfortably beaten by Penrith.

The Broncos get the job done at Lang Park with a four tries to two win over Penrith, after the Eels crush the Titans at Robina.

Penrith brings down competition leaders St George Illawarra to the tune of 28-2, while the Sydney Roosters and Rabbitohs both record convincing wins.

(MN Court of Appeals) - A19-1561

The Music Artist Known As Ivan Enriquez Pons Has Released His Latest Single, “Perdona.”

Oswin enjoying her first supervised enrichment activity. It ended when the nearby construction made a loud upsetting bang. #cat https://ift.tt/2TSjmef

Greed, envy, poor leadership and a poisonous internal culture: New York Times journalist David Enrich has written a book about Deutsche Bank that also sheds light on the financial institution's relationship with U.S. President Donald Trump.

The goal for remote learning during the break “is to maintain the exciting and enriching aspects that Spring Recess provides,” Schools Chancellor Richard Carranza told teachers in a Monday night email.

Henri Richard, who holds the record for most Stanley Cup wins during his 20-year NHL career with the Montreal Canadiens, died Friday at age 84.

The coronavirus emergency has brought uncertain and difficult times. It has changed how we live, separated us from our loved ones and tested our resolve as a nation. But the willingness of people to pull together and help those most in need is a powerful reminder of the strength of our communities.

The coronavirus emergency has brought uncertain and difficult times. It has changed how we live, separated us from our loved ones and tested our resolve as a nation. But the willingness of people to pull together and help those most in need is a powerful reminder of the strength of our communities.

The 2020 high school basketball tournament didn't get to finish. So Kyle Neddenriep built a 64-team bracket of his own.

High school basketball players Sincere McMahon and Connor Hickman, and coach Jeremy Rauch talk with IndyStar's Kyle Neddenriep

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology

Qingbo Shu
Apr 1, 2020; 19:672-689
Research

Karl A. T. Makepeace
Apr 1, 2020; 19:624-639
Research

Large-scale identification of N-linked intact glycopeptides by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in human serum is challenging because of the wide dynamic range of serum protein abundances, the lack of a complete serum N-glycan database and the existence of proteoforms. In this regard, a spectral library search method was presented for the identification of N-linked intact glycopeptides from N-linked glycoproteins in human serum with target-decoy and motif-specific false discovery rate (FDR) control. Serum proteins were firstly separated into low-abundance and high-abundance proteins by acetonitrile (ACN) precipitation. After digestion, the N-linked intact glycopeptides were enriched by hydrophilic interaction liquid chromatography (HILIC) and a portion of the enriched N-linked intact glycopeptides were processed by Peptide-N-Glycosidase F (PNGase F) to generate N-linked deglycopeptides. Both N-linked intact glycopeptides and deglycopeptides were analyzed by LC-MS/MS. From N-linked deglycopeptides data sets, 764 N-linked glycoproteins, 1699 N-linked glycosites and 3328 unique N-linked deglycopeptides were identified. Four types of N-linked glycosylation motifs (NXS/T/C/V, X=P) were used to recognize the N-linked deglycopeptides. The spectra of these N-linked deglycopeptides were utilized for N-linked deglycopeptides library construction and identification of N-linked intact glycopeptides. A database containing 739 N-glycan masses was constructed and utilized during spectral library search for the identification of N-linked intact glycopeptides. In total, 526 N-linked glycoproteins, 1036 N-linked glycosites, 22,677 N-linked intact glycopeptides and 738 N-glycan masses were identified under 1% FDR, representing the most in-depth serum N-glycoproteome identified by LC-MS/MS at N-linked intact glycopeptide level.

An experimental and computational approach for identification of protein-protein interactions by ex vivo chemical crosslinking and mass spectrometry (CLMS) has been developed that takes advantage of the specific characteristics of cyanurbiotindipropionylsuccinimide (CBDPS), an affinity-tagged isotopically coded mass spectrometry (MS)-cleavable crosslinking reagent. Utilizing this reagent in combination with a crosslinker-specific data-dependent acquisition strategy based on MS2 scans, and a software pipeline designed for integrating crosslinker-specific mass spectral information led to demonstrated improvements in the application of the CLMS technique, in terms of the detection, acquisition, and identification of crosslinker-modified peptides. This approach was evaluated on intact yeast mitochondria, and the results showed that hundreds of unique protein-protein interactions could be identified on an organelle proteome-wide scale. Both known and previously unknown protein-protein interactions were identified. These interactions were assessed based on their known sub-compartmental localizations. Additionally, the identified crosslinking distance constraints are in good agreement with existing structural models of protein complexes involved in the mitochondrial electron transport chain.

Jönköping has been at the centre of the healthcare quality improvement movement for years - but how did a forested region of Sweden, situated between it's main cities, come to embrace the philosophy of improvement so fervently? Goran Henriks, chief executive of learning and innovation at Qulturum in Jönköping joins us to explain. He also tells...

by Doug O’Roark Executive Director, Math Circles of Chicago The New York Times recently published an article entitled “The Right Answer? 8,186,699,633,530,061 (An Abacus Makes It Look Almost Easy)”. Its lead photograph features over 100 children seated at desks, facing … Continue reading →

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