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LLM Bar Exam, LLC v. Barbri, Inc.

(United States Second Circuit) - Held that a company offering bar exam review courses did not plausibly plead that a competitor conspired with certain law schools to enable it to obtain a monopoly. Affirmed the dismissal of this antitrust lawsuit.



  • Antitrust & Trade Regulation

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Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice

Facioscapulohumeral muscular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein is rare and difficult to detect in human muscle biopsies, and pathological mechanisms are obscure. FSHD is also a chronic disease that progresses slowly over decades. We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4pA-HSA mouse to develop a chronic long-term muscle disease model. After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy. We investigated the transcriptional profile of whole muscle as well as endothelial cells and fibroadiopogenic progenitors (FAPs). Strikingly, differential gene expression profiles of both whole muscle and, to a lesser extent, FAPs, showed significant overlap with transcriptional profiles of MRI-guided human FSHD muscle biopsies. These results demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.




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Mayo Clinic’s clinical trial matching project sees higher enrollment in breast cancer trials through use of artificial intelligence

Mayo Clinic and IBM Watson Health today unveiled results from early use of the Watson for Clinical Trial Matching, an IBM cognitive computing system. Use of this system in the Mayo Clinic oncology practice has been associated with more patients enrolled in Mayo’s breast cancer clinical trials.





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NYC lawmakers push to expand specialized high school exam to combat low black, Latino enrollment

The proposal comes as city officials announced that only 11% of students admitted to specialized schools this year were black or Latino, compared to 70% of all city students, a figure virtually unchanged from years past.




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Clippers owner Steve Ballmer in negotiations to buy the Forum

Clippers owner Steve Ballmer is in negotiations with the owner of the Forum to purchase the Inglewood arena, according to a person familiar with the talks.




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Steve Ballmer could buy his way out of his Clippers arena problems

By effectively buying out MSG's opposition Ballmer would clear a significant obstacle in the path of starting construction on a new arena for the Clippers.




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Clippers owner Steve Ballmer helps donate $25 million to fight the coronavirus

A philanthropic group founded by Clippers owner Steve Ballmer and his wife says it has pledged more than $25 million toward the coronavirus outbreak.




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Lara Hollmann

Research Assistant, Global Health Programme

Biography

Lara works on health security issues with a focus on threats that arise at the human-animal-environment interface (One Health). Her research explores governance and accountability challenges in health security and preparedness and response to health emergencies of international concern.

Prior to joining Chatham House, Lara gained work experience at the Directorate General for European Civil Protection and Humanitarian Aid Operations (DG ECHO) at the European Commission where she worked on humanitarian and global health policy.

She holds an MSc in Global Health from the University of Copenhagen, with time spent at Kilimanjaro Christian Medical College in Moshi, and a BSc in Development Studies with a major in Human Geography from Lund University.

Areas of expertise

  • Global health governance
  • One/Planetary Health
  • Social determinants of health
  • Pandemic preparedness and response
  • Health security




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Christophe Bellmann

Associate Fellow, Hoffmann Centre for Sustainable Resource Economy

Biography

Christophe is a senior resident research associate at ICTSD with decades of experience working on international trade negotiations and policymaking from a sustainable development perspective.

He joined ICTSD in 1998 as programme officer for outreach and partnership, then became director of policy dialogues. Since 2002, he has been  programmes director.

He previously worked for the Swiss Coalition of Development Organisations (SCDO) where he was responsible for activities on multilateral trade and sustainable development issues, and has also worked as a research associate at the Economic Commission for Latin America and the Caribbean (ECLAC) in Santiago, Chile on the relationship between trade and the environment.

Christophe has edited and published a wide range of books, articles and opinion pieces in English, French and Spanish on trade and sustainable development. His work focuses on international trade negotiations, development policies and environmental governance in areas such as agriculture and food security, fisheries, tariffs and non-tariff barriers, rules, regional trade, services and intellectual property rights.

He holds an MA in international relations from the Graduate Institute for International Studies in Geneva.




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Lara Hollmann

Research Assistant, Global Health Programme

Biography

Lara works on health security issues with a focus on threats that arise at the human-animal-environment interface (One Health). Her research explores governance and accountability challenges in health security and preparedness and response to health emergencies of international concern.

Prior to joining Chatham House, Lara gained work experience at the Directorate General for European Civil Protection and Humanitarian Aid Operations (DG ECHO) at the European Commission where she worked on humanitarian and global health policy.

She holds an MSc in Global Health from the University of Copenhagen, with time spent at Kilimanjaro Christian Medical College in Moshi, and a BSc in Development Studies with a major in Human Geography from Lund University.

Areas of expertise

  • Global health governance
  • One/Planetary Health
  • Social determinants of health
  • Pandemic preparedness and response
  • Health security




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Christophe Bellmann

Associate Fellow, Hoffmann Centre for Sustainable Resource Economy

Biography

Christophe is a senior resident research associate at ICTSD with decades of experience working on international trade negotiations and policymaking from a sustainable development perspective.

He joined ICTSD in 1998 as programme officer for outreach and partnership, then became director of policy dialogues. Since 2002, he has been  programmes director.

He previously worked for the Swiss Coalition of Development Organisations (SCDO) where he was responsible for activities on multilateral trade and sustainable development issues, and has also worked as a research associate at the Economic Commission for Latin America and the Caribbean (ECLAC) in Santiago, Chile on the relationship between trade and the environment.

Christophe has edited and published a wide range of books, articles and opinion pieces in English, French and Spanish on trade and sustainable development. His work focuses on international trade negotiations, development policies and environmental governance in areas such as agriculture and food security, fisheries, tariffs and non-tariff barriers, rules, regional trade, services and intellectual property rights.

He holds an MA in international relations from the Graduate Institute for International Studies in Geneva.




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Murwillmbah Asparagus with a Blood Orange Hollandaise sauce

Spring has definitely in the air well and truly. Loving the produce, country aromas, and appearance as I cycle through the country side. I love asparagus... this local stuff growing by a great friend and awesome farmer. Side dishes are often overlooked but are a very important part to a great meal.




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Special Education Enrollment Increases in Texas in Wake of Newspaper Investigation

About 14,000 more students in the state are enrolled in special education, after the state lifted what it called a "benchmark" enrollment figure of 8.5 percent.




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Ed. Dept. Seeks to Halt Texas' Special Education Enrollment Benchmark

The U.S. Department of Education said Texas must stop using a guideline for special education enrollment that may have led to thousands of children being denied services they were qualified to receive.




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Ed. Dept. to Host Listening Tour On Texas Special Education Enrollment

Officials want to hear from parents, students and educators in the wake of a newspaper series that said Texas is suppressing special education enrollment.




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Last Day to Submit Comments on Texas Special Education Enrollment

Jan. 6 is the last day to submit comments to the U.S. Department of Education about their experiences with Texas' special education identification processes.




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Texas Illegally Suppressed Special Education Enrollment, Ed. Dept. Finds

The federal office of special education programs said the state failed to ensure that students were properly evaluated for special education, as required by the Individuals with Disabilities Education Act.




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Open Enrollment Has Drained One District. It's Looking to Dissolve

Wisconsin’s Palmyra-Eagle district has lost more than half its students in the last decade, sparking a fiscal crisis. A special board is deciding whether the district should be allowed to dissolve.




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The inflamed mind : a radical new approach to depression / Edward Bullmore.

Depression, Mental -- Etiology.




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Kansas City Data-Sharing Effort Showcases Ballmer Group's Strategy

A $59 million investment in software developer Social Solutions aims to ease the flow of data among schools and social service providers.




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Roman Catholic Students Sue Vermont Over Dual-Enrollment Lockout

A group of Vermont high school students backed by a powerful conservative Christian legal organization is accusing the state of religious discrimination.




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Top three Satou Sabally moments: Sharpshooter's 33-point game in Pullman was unforgettable

Since the day she stepped on campus, Satou Sabally's game has turned heads — and for good reason. She's had many memorable moments in a Duck uniform, including a standout performance against the USA Women in Nov. 2019, a monster game against Cal in Jan. 2020 and a career performance in Pullman in Jan. 2019.




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Kansas City Data-Sharing Effort Showcases Ballmer Group's Strategy

A $59 million investment in software developer Social Solutions aims to ease the flow of data among schools and social service providers.




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Allowing people to be who and what they are, without fear of prejudice, is the hallmark of a civilised society

If you have never given your gender much thought, count yourself lucky. If that tick in the box on almost every form requires no more effort than a flick of the wrist, be aware that for many people gender is not so straightforward.




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Enrollment of Extremely Low Birth Weight Infants in a Clinical Research Study May Not Be Representative

The demographics of trials that use antenatal consent may not be representative of the populations that they are intended to study.

This study analyzes the difference in clinical outcomes between the enrolled and eligible but not enrolled populations of a trial that required antenatal consent. (Read the full article)




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Enrollment in Early Intervention Programs Among Infants Born Late Preterm, Early Term, and Term

Infants born late preterm and early term are at increased risk for short-term morbidities compared with term infants. Longer-term morbidity and disability in this group of infants is not well established.

Massachusetts infants born late preterm and early term are at increased risk of early intervention program enrollment than term infants. Boys and children whose mothers were less educated, older, and with public insurance were most affected. (Read the full article)




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A Longitudinal View of Child Enrollment in Medicaid

Cross-sectional estimates suggest that one-third of children are enrolled in Medicaid or other public insurance programs. The percentage of children enrolled in Medicaid at any point during childhood, and which children use Medicaid as a longer-term insurance source, is unknown.

Over a 5-year period, 41% of children were enrolled in Medicaid at some point. Of those children, 51.5% were enrolled during all 5 years. Children with sociodemographic risk factors are more often enrolled for longer periods of childhood. (Read the full article)




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Enrollment in Teacher-Preparation Programs Is Declining Fast. Here's What the Data Show

Nearly every state in the nation has experienced enrollment declines, with some states seeing steep declines of more than 50 percent.




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Open Enrollment Starts Thursday for Delaware’s Health Insurance Marketplace

With shortened enrollment period and fewer assisters, Delawareans urged to sign up early on HealthCare.gov to see if they’re eligible for financial help NEW CASTLE (Oct. 30, 2018) – With the open enrollment period for Delaware’s Health Insurance Marketplace only six weeks long and fewer assisters on the ground this year to help with enrollments, […]




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Nov 1 – Dec 15: Open Enrollment for Delaware’s Health Insurance Marketplace

With the state’s new reinsurance program in place and premiums declining, Delawareans are urged to take another look at marketplace plans during open enrollment for 2020 coverage.



  • Delaware Health and Social Services
  • Governor John Carney
  • Insurance Commissioner
  • News
  • Office of the Governor
  • Affordable Care Act (ACA)
  • Delaware Health Insurance Marketplace
  • Health Insurance
  • Health Insurance Marketplace
  • Westside Family Healthcare

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Enrollment on Delaware’s Health Insurance Marketplace up More Than 6% for Coverage in 2020

Governor John Carney said, “Since the ACA was implemented, we have nearly cut the uninsured population in half in our state. That is another important step in moving us to a stronger and healthier Delaware.”



  • Delaware Health and Social Services
  • Governor John Carney
  • Insurance Commissioner
  • News
  • Office of the Governor
  • ACA
  • Delaware Health Insurance Marketplace
  • Westside Family Healthcare

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Delhi HC allows HDFC Bank to deduct Indiabulls’ loan installment from fixed deposit

Delhi high court, in an interim order on May 1, has allowed HDFC Bank to deduct a Rs 90-crore loan installment from Indiabulls' fixed deposit which it holds as security.




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IBM AIX 6.1 / 7.1 / 7.2 Bellmail Privilege Escalation

IBM AIX versions 6.1, 7.1, and 7.2 suffer from a Bellmail privilege escalation vulnerability.




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Getting it right on railways -- by Naoyuki Yoshino, Grant Stillman

Lining up rights-of-way for megaprojects, such as railways and highways, in crowded places is challenging but it can be done with an imaginative and respectful plan.




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Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-{kappa}B Pathway, Inhibiting Hallmark NF-{kappa}B-Induced Proinflammatory Gene Expression [Virus-Cell Interactions]

The nuclear factor kappa B (NF-B) is a potent transcription factor, activation of which typically results in robust proinflammatory signaling and triggering of fast negative feedback modulators to avoid excessive inflammatory responses. Here, we report that infection of epithelial cells, including primary porcine respiratory epithelial cells, with the porcine alphaherpesvirus pseudorabies virus (PRV) results in the gradual and persistent activation of NF-B, illustrated by proteasome-dependent degradation of the inhibitory NF-B regulator IB and nuclear translocation and phosphorylation of the NF-B subunit p65. PRV-induced persistent activation of NF-B does not result in expression of negative feedback loop genes, like the gene for IBα or A20, and does not trigger expression of prototypical proinflammatory genes, like the gene for tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). In addition, PRV infection inhibits TNF-α-induced canonical NF-B activation. Hence, PRV infection triggers persistent NF-B activation in an unorthodox way and dramatically modulates the NF-B signaling axis, preventing typical proinflammatory gene expression and the responsiveness of cells to canonical NF-B signaling, which may aid the virus in modulating early proinflammatory responses in the infected host.

IMPORTANCE The NF-B transcription factor is activated via different key inflammatory pathways and typically results in the fast expression of several proinflammatory genes as well as negative feedback loop genes to prevent excessive inflammation. In the current report, we describe that infection of cells with the porcine alphaherpesvirus pseudorabies virus (PRV) triggers a gradual and persistent aberrant activation of NF-B, which does not result in expression of hallmark proinflammatory or negative feedback loop genes. In addition, although PRV-induced NF-B activation shares some mechanistic features with canonical NF-B activation, it also shows remarkable differences; e.g., it is largely independent of the canonical IB kinase (IKK) and even renders infected cells resistant to canonical NF-B activation by the inflammatory cytokine TNF-α. Aberrant PRV-induced NF-B activation may therefore paradoxically serve as a viral immune evasion strategy and may represent an important tool to unravel currently unknown mechanisms and consequences of NF-B activation.




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FDA Pushes Enrollment of Older Adults in Trials [News in Brief]

In a draft guidance, the FDA urges researchers to take steps to increase enrollment of adults age 65 and older in clinical trials of investigational of cancer drugs. Noting that a drug's risk–benefit profile can vary significantly across age groups, the FDA recommends including older adults in early-phase studies and modifying trial designs and recruitment strategies to make it easier for them to participate.




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Apartment adjacent to Go Vap, open for sale in the first phase, installment payment on schedule

Get booked 50 million / unitPicity High Park Project District 12Cheap: from 1.6 billion / unitInvestor PKD; 0797988466 See Model House100% full legal - Construction permitPicity High Park - Standard green apartment Singapore-Address: Thanh Xuan 13, Thanh Xuan, D. 12, HCM city.- I...




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Perspectives: Penguin releases powerful essays about the pandemic from top authors including Philip Pullman and Nick Hornby

Malorie Blackman, Lee Child and Philip Pullman are among the first five essayists published




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Aussie John Millman resigned to seeing entire tennis season canned because of coronavirus

Australian Davis Cup star John Millman doubts the ATP and WTA Tours can resume at all in 2020 due to the extent of the coronavirus pandemic.




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Allmpus Labs to focus on increasing R&D in new drug discovery and development




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Federal Prisoner Charged in California for Murder of Cellmate

A federal grand jury returned a two-count indictment today charging Samuel Stone, 32, with first degree murder and murder by a federal prisoner serving a life sentence.



  • OPA Press Releases

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Justice Department Reaches Settlement with School District of Palm Beach County, Fla., to Prevent and Address Discrimination in School Enrollment and Student Discipline

The Justice Department announced that it has reached a comprehensive settlement agreement with the School District of Palm Beach County, Fla., the nation’s eleventh-largest school district, to prevent and address discrimination in school enrollment and student discipline.



  • OPA Press Releases

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New Study with Wellmune Shows Promise for Intestinal Barrier Function Improvements

A study demonstrated Wellmune® may protect intestinal barrier function in adults when faced with stress.




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Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




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How well could tax-based auto-enrollment work?

Auto-enrollment into health insurance coverage is an attractive policy that can drive the U.S. health care system towards universal coverage. It appears in coverage expansion proposals put forward by 2020 presidential candidates, advocates, and scholars. These approaches are motivated by the fact that at any given time half of the uninsured are eligible for existing…

       




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Webinar: Health insurance auto-enrollment

Before the COVID-19 pandemic, 30 million Americans were uninsured, but half of this population is eligible for insurance coverage through Medicaid or for financial assistance to buy coverage on the health insurance marketplace. Auto-enrollment is a method by which individuals are placed automatically into the health insurance coverage they are qualified for, and it has…

       




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How well could tax-based auto-enrollment work?

Auto-enrollment into health insurance coverage is an attractive policy that can drive the U.S. health care system towards universal coverage. It appears in coverage expansion proposals put forward by 2020 presidential candidates, advocates, and scholars. These approaches are motivated by the fact that at any given time half of the uninsured are eligible for existing…

      




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How well could tax-based auto-enrollment work?

Auto-enrollment into health insurance coverage is an attractive policy that can drive the U.S. health care system towards universal coverage. It appears in coverage expansion proposals put forward by 2020 presidential candidates, advocates, and scholars. These approaches are motivated by the fact that at any given time half of the uninsured are eligible for existing…

       




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Webinar: Health insurance auto-enrollment

Before the COVID-19 pandemic, 30 million Americans were uninsured, but half of this population is eligible for insurance coverage through Medicaid or for financial assistance to buy coverage on the health insurance marketplace. Auto-enrollment is a method by which individuals are placed automatically into the health insurance coverage they are qualified for, and it has…