The invention relates to a method for controlling the divergence of a jet of particles in vacuo with an aerodynamic lens, the aerodynamic lens including at least one chamber; a diaphragm, a so-called inlet diaphragm, intended to form an inlet of the aerodynamic lens for a jet of particles, the inlet diaphragm having a given diameter (d1); and another diaphragm, a so-called outlet diaphragm, intended to form an outlet of the aerodynamic lens for this jet of particles; the method including: a step for generating the jet of particles from the inlet to the outlet, in vacuo, of the aerodynamic lens; and a step for adjusting the diameter (ds) of the outlet diaphragm for controlling the divergence of the jet of particles.

In a lens plate (18) for an optical sensor device in a vehicle, in particular for a rain sensor, with a transmitter-side lens structure (28) and a receiver-side lens structure (32), the transmitter-side lens structure (26) partially is provided with anti-transmission features which In individual regions of the lens plate (18) partially or completely prevent the passage of the light emitted by a light transmitter (14).

A system for harnessing solar energy using heating applications to generate intense heat for steam boilers and all other water heating applications. Electricity is generated using a steam turbine engine that employs a bank of four biconvex octave lenses, with each having specific sizes, radii, arc convexity and distances from one another in mathematical orderliness in compliance with the Geometry of Space and the Law of Octave of Elements of Matter. The focal points of these lenses are positioned onto a boiler tank consisting of a pair of flat steel sheets in which water runs through from one side and comes out as steam on the other side of it. The steam is then fed into a steam turbine engine to generate electricity. A dual axle sun tracker is adjusted beneath the boiler plate to track the sun's movement from both east to west and north to south at all times. A system of highly conductive carbon rods is assembled on top of the Tasoptic lenses to be activated and subsequently produce an intense arc of hot white light to simulate the sun's parallel rays during the night and cloudy days for the continuity of operation at all times.

Total expenses for fiscal year 2019 came in at Rs 514.52 crore, up about 20% compared to the year-ago period when expenses were at Rs 429 crore.

I stopped wearing contacts for a few months and now they make my eyes red and unhappy even if I only wear them for a few hours. What have I done wrong?

I've worn contacts every day for years and years, but I recently stopped bothering on account of being at home all the time anyway. The last two times I tried wearing them, everything felt fine until I took them out and then I had red, irritated eyes and some discharge the next morning. This last time I only left them in for a couple of hours to see if it helped but I've had the same problem. Does anyone know how I can fix this? Thanks!

One reader captured this excellent shot of a stunning wood duck wading across the water, showing that self-isolation sometimes really all it’s quacked up to be.

As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

One reader captured this excellent shot of a stunning wood duck wading across the water, showing that self-isolation sometimes really all it’s quacked up to be.

As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

Every Mother's Day, climbers flock to Mount St. Helens in festive dresses in the continuation of a tradition started by 'the woman in the red dress.' This Mother's Day, a new mini-documentary from OPB tells the story of Kathy Phibbs, a gifted alpinist who paved the way for a more inclusive outdoors community — and pink flamingos on mountain summits.

Every Mother's Day, climbers flock to Mount St. Helens in festive dresses in the continuation of a tradition started by 'the woman in the red dress.' This Mother's Day, a new mini-documentary from OPB tells the story of Kathy Phibbs, a gifted alpinist who paved the way for a more inclusive outdoors community — and pink flamingos on mountain summits.

One reader captured this excellent shot of a stunning wood duck wading across the water, showing that self-isolation sometimes really all it’s quacked up to be.

As always, a big “thank you” to our front-line workers for their selfless, tireless service — and, in this instance, for sharing a hopeful image of the Seattle skyline, shot from West Seattle on a recent morning.

Every Mother's Day, climbers flock to Mount St. Helens in festive dresses in the continuation of a tradition started by 'the woman in the red dress.' This Mother's Day, a new mini-documentary from OPB tells the story of Kathy Phibbs, a gifted alpinist who paved the way for a more inclusive outdoors community — and pink flamingos on mountain summits.

Every Mother's Day, climbers flock to Mount St. Helens in festive dresses in the continuation of a tradition started by 'the woman in the red dress.' This Mother's Day, a new mini-documentary from OPB tells the story of Kathy Phibbs, a gifted alpinist who paved the way for a more inclusive outdoors community — and pink flamingos on mountain summits.

Google Lens now lets you copy/paste text from handwritten notes to your laptop!

Компания Google выпустила новую версию приложения Google Lens с несколькими полезными изменениями.

[Image: An example of gravitational lens effects, via Wikipedia.] Over at WIRED, Daniel Oberhaus, author of the recent book Extraterrestrial Languages, takes a look at some proposals from NASA’s Innovative Advanced Concept (NIAC) program. “Among this year’s NIAC grants,” Oberhaus writes, “are proposals to turn a lunar crater into a giant radio dish, to develop … Continue reading "Gravitational Lensing, Interstellar Cinematography, and the Future of Magical Warfare in Space"

By Dan Duddy  Published: May 06th, 2020 

The post Review: Struman Optics Cinematic Lenses for Smartphones appeared first on Digital Photography School. It was authored by Lee Herbet.

The argument of whether smartphones can take good photos or not has been settled – they can! In this article, we are going to have a look at a set of lenses for smartphones from an Australian company, Struman Optics. While there are many lenses for smartphones on the market, I found a manufacturer that […]

The post Review: Struman Optics Cinematic Lenses for Smartphones appeared first on Digital Photography School. It was authored by Lee Herbet.

Recent breakthroughs in scanning, image processing, and machine learning are helping researchers read historic documents once considered lost to time.

A team of researchers at the University of California at San Diego have created a soft robotic lens that responds to eye movements.

Trump is all about the favors. Even when it concerns our livelihood.

Invitation Only Research Event

Invitation Only Research Event

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

23 October 2019

14 February 2020

Invitation Only Research Event

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

23 October 2019

Invitation Only Research Event

The Modi government's push for a Citizenship Amendment Act and National Register of Citizens sparked deadly riots and chilled India's 200 million Muslims, who fear being relegated to second-class citizenship—and for some, even statelessness. This article explores actions by Modi's Bharatiya Janata Party, the significance of Bangladeshi illegal immigration as a driver, and what a register of citizens in Assam might mean for India.

It’s a conviction that was published in the November issue of The Journal of the American Dental Association and the basis for the October 2019 forum that Dr. Francisco Ramos-Gomez fostered, where dentists, physicians, nurses and public health and public policy experts proposed, discussed and recommended solutions for preventing early childhood caries through the lens of social justice, health equity and human rights.

Jena : Fischer, 1904.

Identification of input data points relevant for the classifier (i.e. serve as the support vector) has recently spurred the interest of researchers for both interpretability as well as dataset debugging. This paper presents an in-depth analysis of the methods which attempt to identify the influence of these data points on the resulting classifier. To quantify the quality of the influence, we curated a set of experiments where we debugged and pruned the dataset based on the influence information obtained from different methods. To do so, we provided the classifier with mislabeled examples that hampered the overall performance. Since the classifier is a combination of both the data and the model, therefore, it is essential to also analyze these influences for the interpretability of deep learning models. Analysis of the results shows that some interpretability methods can detect mislabels better than using a random approach, however, contrary to the claim of these methods, the sample selection based on the training loss showed a superior performance.

Marc Tucker's most-read blog posts in 2017.

This bundle normally sells for $1,149.95 but is available right now for just $596.95, and it will arrive before Christmas with Prime.

Methicillin-resistant Staphylococcus aureus (MRSA) has grown to become a major burden on healthcare systems. The cumulation of limited therapeutic options and worsened patient outcomes with persistent MRSA bacteremia has driven research in optimizing its initial management. The guidelines published by the Infectious Disease of America currently recommend combination therapy for refractory MRSA bacteremia, but the utility of combining antibiotics from the start of therapy is under investigation. The alternative strategy of early use of a β-lactam antibiotics in combination with vancomycin upon initial MRSA bacteremia detection has shown promise. While this concept has gained international attention, providers should give this strategy serious consideration prior to implementation. The objective of this review is to examine retrospective and prospective evidence for early combination with vancomycin and β-lactam antibiotics, as well as explore potential consequences of combination therapy.

Does a student have a fixed or a growth mindset? That's the wrong question for us to measure, argues researcher Dave Paunesku.

Indian filmmakers stare at a loss of production year as uncertainty persists over international film festivals

Winds are from the West at 12.7 gusting to 36.8 MPH (11 gusting to 32 KT). The pressure is 1006.9 mb and the humidity is 34%. The wind chill is 31. Last Updated on May 9 2020, 11:53 am EDT.

There has been so much hype about the “Internet of Things” (IoT) that it is refreshing to hear about a cutting-edge development project that can bring concrete benefits to millions of people. That project is the ongoing development of the Google Smart Contact Lens, and it was detailed in a keynote speech June 8 at the Design Automation Conference (DAC 2015).

The keynote speech was given by Brian Otis (right), a director at Google and a research associate professor at the University of Washington. The “smart lens” that the project envisions is essentially a disposable contact lens that fits on an eye and continuously monitors blood glucose levels. This is valuable information for anyone who has, or may someday have, diabetes.

Since he was speaking to an engineering audience, Otis focused on the challenges behind building such a device, and described some of the strategies taken by Google and its partner, Novartis. The project required new approaches to miniaturization, low-power design, and connectivity, as well as a comfortable and reliable silicon-to-human interface. Otis discussed the “why” as well and showed how the device could potentially save or improve millions of lives.

Millions of Users

First, a bit of background. Google announced the smart lens project in a blog post in January 2014. Since then it has been featured in news outlets including Forbes, Time, and the Wall Street Journal. In March 2015, Time reported that Google has been granted a patent for a smart contact lens.

The smart lens monitors the level of blood glucose by looking at its concentration in tears. The lens includes a wireless system on chip (SoC) and a miniaturized glucose sensor. A tiny pinhole in the lens allows tear fluid to seep into the sensor, and a wireless antenna handles communications to the wireless devices.

“We figure that if we can solve a huge problem, it is probably worth doing,” Otis said. “Diabetes is one example.” He noted 382 million people worldwide have diabetes today, and that 35% of the U.S. population may be pre-diabetic. Today, diabetics must *** their fingers to test blood glucose levels, a procedure that is invasive, painful, and subject to infrequent monitoring.

According to Otis, the smart contact lens represents a “new category of wearable devices that are comfortable, inexpensive, and empowering.” The lens does sensor data logging and uses a portable instrument to measure glucose levels. It is thin, cheap, and disposable, he said.

Moreover, the lens is not just for people already diagnosed with diabetes—it’s for anyone who is pre-diabetic, or may be at risk due to genetic predisposition. “If we are pro-active rather than re-active,” Otis said, “Instead of waiting until a person has full-fledged diabetes, we could make a huge difference in peoples’ lives and lower the costs of treating them.”

Technical Challenges

No one has built anything quite like the smart lens, so researchers at Google and Novartis are treading new ground. Otis identified three key challenges:

• Miniaturization: Everything must be really small—the SoC, the passive components, the power supply. Components must be flexible and cheap, and support thin-film integration.
• Platform: Google has developed a reusable platform that includes tiny, always-on wireless sensors, ultra low-power components, and standards-based interfaces.
• Data: Researchers are looking for the best ways to get the resulting data into a mobile device and onto the cloud.

Comfort is another concern. “This is not intended to be for the most severe cases,” Otis said. “This is intended to be for all of us as a pro-active way of improving our lifestyles.”

The platform provides a bidirectional encrypted wireless link, integrated power management, on-chip memory, standards-based RFID link, flexible sensor interface, high-resolution potentiostat sensor, and decoupling capacitors. Most of these capabilities are provided by the standard CMOS SoC, which is a couple hundred microns on a side and only “tens of microns” thick.

Otis noted that unpackaged ICs are typically 250 microns thick when they come back from the foundry. Thus, post-processing is needed so the IC will fit into a contact lens.

Furthermore, the design requires precision analog circuitry and additional environmental sensors. “Some of this stuff sounds mundane but it is really hard, especially when you find out you can’t throw large decoupling capacitors and bypass capacitors onto a board, and all that has to be re-integrated into the chip,” Otis said.

Sensor Challenges

Getting information from the human body is challenging. The smart lens sensor does a direct chemical measurement on the surface of the eye. The sensor is designed to work with very low glucose concentrations. This is because the concentration of glucose in tears is an order of magnitude lower than it is in blood.

In brief, the sensor has two parallel plates that are coated with an enzyme that converts glucose into hydrogen peroxide, which flows around the electrodes of the sensor. This is actually a fairly standard way of doing glucose monitoring. However, the smart lens sensor has two electrodes compared to the typical three.

In manufacturing, it is essential to keep costs low. Otis outlined a three-step manufacturing process:

• Start with the bottom layer, and mold a contact lens in the way you typically would.
• Add the electronics package on top of that layer.
• Build a second layer that encapsulates the electronics and provides the curvature needed for comfort and vision correction.

Beyond the technical challenges are the “clinical” challenges of working with human beings. The human body “is messy and very variable,” Otis said. This variability affects sensor performance and calibration, RF/electro-magnetic performance, system reliability, and comfort.

The final step is making use of the data. “We need to get the data from the device into a phone, and then display it so users can visualize the data,” Otis said. This provides “actionable feedback” to the person who needs it. Eventually, the data will need to be stored in the cloud.

As he concluded his talk, Otis noted that the platform his group developed may have many applications beyond glucose monitoring. “There is a lot you can do with a bunch of logic and sensing capability,” he said, “and there are hundreds of biomarkers beyond glucose.” Clearly this will be an interesting technology to watch.

Richard Goering

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RSA BSAFE Micro Edition Suite, Crypto-C Micro Edition, Crypto-J, and SSL-J contain a fix to address Lenstra's attack. RSA BSAFE Micro Edition Suite (MES) 4.1.5, RSA BSAFE Crypto-C Micro Edition (CCME) 4.1.3, RSA BSAFE Crypto-J 6.2.1, and RSA BSAFE SSL-J 6.2.1 are affected.

Title: Could Your Contact Lenses Track, Treat Your Diabetes?
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM