Hospital colleagues take to the saddle in memory of highly-regarded consultant.

West Midlands Cycle Hire hailed a success with almost 500 rides taken each day.

Birmingham St Mary’s staff on 100 mile bike ride raising funds for hospice.

West Midlands Cycle Hire launched in Wolverhampton and Sutton Coldfield.

Hire bikes now available throughout the city centre.

Latest stage of planned rollout across the West Midlands.

We'll continue to invest in our brand, technology, products, and grow our offline online touchpoints. We are going to open around 350 stores over the next three years and grow our multi-channel competitive strengths. We will also enhance our in-house brands and their distribution through pharmacies and grocery stores. We also plan to invest in manufacturing, international markets and Globalbees, our brand aggregator platform,Supam Maheshwari, cofounder and CEO of FirstCry said.

Steeds meer verkopers houden zich bezig met het delen van content op LinkedIn. Het is de manier om in contact te blijven met je netwerk en nieuwe relaties op te starten. Elke keer nieuwe content bedenken en maken kost veel tijd. Het duurt nog langer als je geen inspiratie hebt. Te weinig tijd en geen […]

The police are urging the motoring public to “drive and ride with caution as the winds are presently very high,” adding that “there is already one report of a woman being blown off of her cycle.” A police spokesperson said, “The motoring public should be advised to please drive and ride with caution as the […]

[Written by Stephen Wright] Aeziah Divine made a solid start to the FAB-Racing Minibike British Championship at the Lydd Kart Circuit in Kent last weekend. The 12-year-old, who competes in the MK50 class, finished fifth in all three races despite missing two days of practice because of mechanical issues. Divine, who qualified in sixth place, said: […]

The Bermuda Motorcycle Racing Club season resumed at the Southside Moto Sports Park. Nevaeh Gaugain won two of the three races in the Ohvale GP 190cc Class, with Jediah Cumbermack winning the other. Daunte Fox won two of the three races in the Kawasaki Ninja 400cc Class, with Jalon Smith claiming victory in the other. […]

A road traffic collision between two motorcycles yesterday [Nov 3] left one man with injuries, while the second driver left the scene before police arrived. A police spokesperson said, “Shortly after 5:15pm on Sunday, November 3, 2024, police attended a road traffic collision involving two motorcycles near the junction of Parson’s Road and Crossland Lane, […]

[Updated] “There has been a serious road traffic collision involving two motorcycles on Blue Hole Hill, Hamilton Parish,” the police said this evening [Nov 7]. “The roadway is currently closed, with traffic being diverted through the Grotto Bay compound. Motorists heading into or out of the east end are encouraged to delay their departure, if possible […]

The police said there has been an increase in the number of motorcycles reported stolen, with 20 motorcycles reported stolen in the last week. A police spokesperson said, “In recent times, the Bermuda Police Service [BPS] has observed an increase in the number of motorcycles reported stolen. Last week, 20 motorcycles were reported stolen from various locations around […]

The Bermuda Police Service recovered stolen motorcycles in a Warwick search. A police spokesperson said, “On Wednesday 11th September, 2024, the Bermuda Police Service continued to progress Operation Athlestan. Members of the Serious Crime Unit assisted by the Gang Targeting Unit and Police Support Unit, executed a search warrant at a property located along South […]

Fun Fact: No-So-Handy Andy was also born on the year of the Dragon.

WARNING: Volume. RIP headphone users.

Cycles
di: fantasynight

Gomi has revolutionized the electronics industry by tackling the persistent problem of proper disposal at the end of a product's life. Unlike many other speaker companies, Gomi adopts a circular approach that enhances product longevity and significantly reduces pre and post-consumer waste.[...]

Complete with a Shiver and 26" wheels.
( Photos: 7, Comments: 159 )

Jan Goedgebeur, Jorik Jooken, On-Hei Solomon Lo, Ben Seamone and Carol T. Zamfirescu
Math. Comp. 93 (), 3059-3082.
Abstract, references and article information

Dr. Stan Wagon of Macalester College discusses the mathematics behind rolling a square smoothly. In 1997, inspired by a square wheel exhibit at The Exploratorium museum in San Francsico, Dr. Stan Wagon enlisted his neighbor Loren Kellen in building a square-wheeled tricycle and accompanying catenary track. For years, you could ride the tricycle at Macalester College in St. Paul, Minnesota. The National Museum of Mathematics in New York now also has square-wheeled tricycles that can be ridden around a circular track. And more recently, the impressive Cody Dock Rolling Bridge was built using rolling square mathematics by Thomas Randall-Page in London.

Highly engineered phytases, which sequentially hydrolyze the hexakisphosphate ester of inositol known as phytic acid, are routinely added to the feeds of monogastric animals to improve phosphate bioavailability. New phytases are sought as starting points to further optimize the rate and extent of dephosphorylation of phytate in the animal digestive tract. Multiple inositol polyphosphate phosphatases (MINPPs) are clade 2 histidine phosphatases (HP2P) able to carry out the stepwise hydrolysis of phytate. MINPPs are not restricted by a strong positional specificity making them attractive targets for development as feed enzymes. Here, we describe the characterization of a MINPP from the Gram-positive bacterium Bifidobacterium longum (BlMINPP). BlMINPP has a typical HP2P-fold but, unusually, possesses a large α-domain polypeptide insertion relative to other MINPPs. This insertion, termed the U-loop, spans the active site and contributes to substrate specificity pockets underpopulated in other HP2Ps. Mutagenesis of U-loop residues reveals its contribution to enzyme kinetics and thermostability. Moreover, four crystal structures of the protein along the catalytic cycle capture, for the first time in an HP2P, a large ligand-driven α-domain motion essential to allow substrate access to the active site. This motion recruits residues both downstream of a molecular hinge and on the U-loop to participate in specificity subsites, and mutagenesis identified a mobile lysine residue as a key determinant of positional specificity of the enzyme. Taken together, these data provide important new insights to the factors determining stability, substrate recognition, and the structural mechanism of hydrolysis in this industrially important group of enzymes.

Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to decreased cell proliferation. Thus, evidence is growing for PYCR1 as a potential cancer therapy target. Inhibitors of cancer targets are useful as chemical probes for studying cancer mechanisms and starting compounds for drug discovery; however, there is a notable lack of validated inhibitors for PYCR1. To fill this gap, we performed a small-scale focused screen of proline analogs using X-ray crystallography. Five inhibitors of human PYCR1 were discovered: l-tetrahydro-2-furoic acid, cyclopentanecarboxylate, l-thiazolidine-4-carboxylate, l-thiazolidine-2-carboxylate, and N-formyl l-proline (NFLP). The most potent inhibitor was NFLP, which had a competitive (with P5C) inhibition constant of 100 μm. The structure of PYCR1 complexed with NFLP shows that inhibitor binding is accompanied by conformational changes in the active site, including the translation of an α-helix by 1 Å. These changes are unique to NFLP and enable additional hydrogen bonds with the enzyme. NFLP was also shown to phenocopy the PYCR1 knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth. In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle.

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

In SAS Life Science Analytics Framework 4.6, group membership removal fails with an exception if a user is set as assignee, a candidate, or a notification recipient in a user task for a Process Flow . The Process

Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration. This photochemical reaction initiates the signal transduction pathway that eventually leads to the transmission of a visual signal to the brain and leaves the opsins insensitive to further light stimulation. For the eye to restore light sensitivity, opsins require recharging with 11-cis-retinal. This trans–cis back conversion is achieved through a series of enzymatic reactions composing the retinoid (visual) cycle. Although it is evident that the classical retinoid cycle is critical for vision, the existence of an adjunct pathway for 11-cis-retinal regeneration has been debated for many years. Retinal pigment epithelium (RPE)–retinal G protein-coupled receptor (RGR) has been identified previously as a mammalian retinaldehyde photoisomerase homologous to retinochrome found in invertebrates. Using pharmacological, genetic, and biochemical approaches, researchers have now established the physiological relevance of the RGR in 11-cis-retinal regeneration. The photoisomerase activity of RGR in the RPE and Müller glia explains how the eye can remain responsive in daylight. In this review, we will focus on retinoid metabolism in the eye and visual chromophore regeneration mediated by RGR.  

Insulin receptor substrate 2 (IRS2) is an essential adaptor that mediates signaling downstream of the insulin receptor and other receptor tyrosine kinases. Transduction through IRS2-dependent pathways is important for coordinating metabolic homeostasis, and dysregulation of IRS2 causes systemic insulin signaling defects. Despite the importance of maintaining proper IRS2 abundance, little is known about what factors mediate its protein stability. We conducted an unbiased proteomic screen to uncover novel substrates of the Anaphase Promoting Complex/Cyclosome (APC/C), a ubiquitin ligase that controls the abundance of key cell cycle regulators. We found that IRS2 levels are regulated by APC/C activity and that IRS2 is a direct APC/C target in G₁. Consistent with the APC/C's role in degrading cell cycle regulators, quantitative proteomic analysis of IRS2-null cells revealed a deficiency in proteins involved in cell cycle progression. We further show that cells lacking IRS2 display a weakened spindle assembly checkpoint in cells treated with microtubule inhibitors. Together, these findings reveal a new pathway for IRS2 turnover and indicate that IRS2 is a component of the cell cycle control system in addition to acting as an essential metabolic regulator.

A British daredevil was intentionally dragged behind his motorcycle at a speed of 159.52 mph to break a Guinness World Record.

Google is educating users about the lunar cycle with its latest interactive Doodle released Thursday.

Theater students in Scunthorpe, England, rehearse for their performance celebrating the life of homegrown cyclist Lal White

367.382 mph in a Two-Wheeled Missile

SOLIDWORKS and COSMOS analysis software help legendary Italian manufacturer speed innovations to market

New 'everybike' reclaims the joy of your first two-wheeler

3D CAD models are faster to create and easier to comprehend

Designed in SOLIDWORKS software, this lowriding sport machine becomes nimble highrider on demand

Designed and Tested in SOLIDWORKS and SOLIDWORKS Simulation, Each Reee Chair Made of Plastic From Nine Recycled Game Consoles

Company Renowned for ‘Headset’ Innovation Cuts Time and Cost with SolidWorks Design and Simulation Software

Luxury Bike Shop Eliminates Prototypes Using SOLIDWORKS Simulation Software

Ride 2 Transform takes its third tour of southern Malawi for ministry and support.

Penn State Great Valley has unveiled a mural depicting the Penn State Nittany Lion, created from upcycled plastic bottle caps by mosaic studio artist Judith Hokky.  

One girl’s dream comes true, as she is now able to go to a village primary school, started by OM.

Massive distribution efforts by OM teams in Bangladesh over more than 10 years sowed gospel seeds and made the Bengali New Testament a #1 best seller.

The event was part of a trend of young Chinese travelling on the cheap and spending as little as possible at a time of scarce job prospects, when wages are under pressure.

The Delaware Division of the Arts’ Mezzanine Gallery presents artist Colleen Zufelt’s exhibition, Recycle, Repurpose…RE-IMAGINE, showing March 4 through 25, 2022. Her exhibit will also be part of Art Loop Wilmington — the monthly self-guided tour of art in and around the city.

The Delaware Department of Agriculture (DDA) announced that beginning on April 19, 2023, the Delaware Council on Farm & Food Policy (Council) will accept grant applications for the second cycle of the First State Food System Program. Through this program, funding is available to Delaware farmers and a diverse range of food supply chain entities. Awarded funds will aid local entities to expand capacity, coordinate with partners in their communities, and do their part to build resilience in Delaware’s food system.

The Delaware Council on Farm & Food Policy (Council) is accepting grant applications for Cycle 3 of the First State Food System Program. Through this program, funding is available to Delaware farmers and a diverse range of food supply chain entities. Awarded funds will aid local entities in expanding capacity, coordinating with partners in their communities, and doing their part to build resilience in Delaware’s food system.

Governor John Carney has proclaimed May as Motorcycle Awareness Month and the Delaware Division of Motor Vehicles (DMV), in support of the Delaware Office of Highway Safety’s (OHS) Motorcycle Safety campaign, urges both motorists and motorcyclists to create a safer ride through education and awareness. Motorcyclists of all skill levels, both novice and advanced can […]

Governor John Carney has proclaimed May is Motorcycle Awareness Month and the Delaware Division of Motor Vehicles (DMV) along with the Delaware Office of Highway Safety (OHS) encourages motorcyclists to ride smart and ride safely through education and awareness. Every year from April through November, DMV offers six motorcycle safety courses for various skill levels, […]

SB 86 will require anyone obtaining a new motorcycle endorsement starting September 1, 2023, to wear a helmet and eye protection during the first two years of their endorsement. A civil penalty will be assessed to those found to be in violation.