The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to obesity. However, in a commonly used model of T2D, the db/db mouse, β-cells have an inbuilt adaptive flexibility enabling them to effectively adjust insulin production rates relative to the metabolic demand. Pancreatic β-cells from these animals have markedly reduced intracellular insulin stores, yet high rates of (pro)insulin secretion, together with a substantial increase in proinsulin biosynthesis highlighted by expanded rough endoplasmic reticulum and Golgi apparatus. However, when the metabolic overload and/or hyperglycemia is normalized, β-cells from db/db mice quickly restore their insulin stores and normalize secretory function. This demonstrates the β-cell’s adaptive flexibility and indicates that therapeutic approaches applied to encourage β-cell rest are capable of restoring endogenous β-cell function. However, mechanisms that regulate β-cell adaptive flexibility are essentially unknown. To gain deeper mechanistic insight into the molecular events underlying β-cell adaptive flexibility in db/db β-cells, we conducted a combined proteomic and post-translational modification specific proteomic (PTMomics) approach on islets from db/db mice and wild-type controls (WT) with or without prior exposure to normal glucose levels. We identified differential modifications of proteins involved in redox homeostasis, protein refolding, K48-linked deubiquitination, mRNA/protein export, focal adhesion, ERK1/2 signaling, and renin-angiotensin-aldosterone signaling, as well as sialyltransferase activity, associated with β-cell adaptive flexibility. These proteins are all related to proinsulin biosynthesis and processing, maturation of insulin secretory granules, and vesicular trafficking—core pathways involved in the adaptation of insulin production to meet metabolic demand. Collectively, this study outlines a novel and comprehensive global PTMome signaling map that highlights important molecular mechanisms related to the adaptive flexibility of β-cell function, providing improved insight into disease pathogenesis of T2D.

A three-judge panel from the 9th U.S. Circuit Court of Appeals ruled against a proposed plan that would have paid certain student-athletes as much as $5,000 annually in deferred compensation.

DOVER, DE – Delaware Insurance Commissioner Trinidad Navarro is pleased to announce that there will be another decrease in workers’ compensation insurance rates, effective December 1, 2019. “I am delighted to approve a decrease in workers’ compensation rates in Delaware for the third year in a row,” stated Commissioner Navarro. “These continued decreases mean significant […]

Workplace Safety Program saves $7.6 million for participants The Delaware Department of Insurance has analyzed new filings from the state’s top writers of workers’ compensation insurance after announcing the third consecutive year of decreased rates in November. The top writers represent nearly 10,000 companies that hold policies within the state. Policyholders of these companies will […]

Andhra Pradesh Chief Minister YS Jaganmohan Reddy has announced Rs one crore as compensation to the families of those who died because of exposure to a toxic gas that leaked overnight at a chemical...

Banks to pay Rs 1.06 crore to customers for online banking frauds

Ury Estate Limited v BP Exploration Operating Company Limited [2019] CSOH 36 A landowner raised a court action against BP seeking compensation for their inability to develop land due to a presence of an oil pipeline.  The proposed development w...

Summary of the communication from the EU commissionInterpretative Guidelines on EU Regulation 261/2004 on passenger rights in the context of the developing situation with Covid-19 - 18 March 2020 Right to choose between reimbursement and rerouting ...

Intro / Summary The Supreme Court has refused to grant Emirates permission to appeal the Court of Appeal’s decision in the joint case of Gahan v Emirates and Buckley and ors v Emirates meaning the Court of Appeal’s decision to award comp...

A reader would like to know what they are entitled to after being hit by a car while passing through an intersection.

dsPIC33/PIC24 FRM, High-Speed Analog Comparator with Slope Compensation DAC

Shih-Jung Hsu and Bo Cheng

In the presence of wind or background image motion, flies are able to maintain a constant retinal slip velocity via regulating flight speed to the extent permitted by their locomotor capacity. Here we investigated the retinal slip compensation of tethered blue-bottle flies (Calliphora vomitoria) flying semi-freely along an annular corridor in a magnetically levitated flight mill enclosed by two motorized cylindrical walls. We perturbed the flies’ retinal slip via spinning the cylindrical walls, generating bilaterally averaged retinal slip perturbations from -0.3 to 0.3 m·s^–1 (or -116.4 to 116.4 deg.·s^–1) When the perturbation was less than ~0.1 m·s^–1 (38.4 deg.·s^–1), the flies successfully compensated the perturbations and maintained a retinal slip velocity by adjusting their airspeed up to 20%. However, with greater retinal slip perturbation, the flies’ compensation became saturated, as the flies’ airspeed plateaued, indicating that they were unable to further maintain a constant retinal slip velocity. The compensation gain, i.e., the ratio of airspeed compensation and retinal slip perturbation, depended on the spatial frequency of the grating patterns, being the largest at 12 m^–1 (0.04 deg.^–1).

EXCLUSIVE

The Workers Compensation Commission finds in favour of a former House Rules contestant who claimed she was now unemployable because of the negative way she was portrayed on the Channel Seven show.

“The charges announced today send a strong message that we will not tolerate any fraudulent activity designed to profit from this tragic oil spill,” said Assistant Attorney General Breuer.

Attorney General Eric Holder today announced that he has chosen Sheila L. Birnbaum to head the September 11th Victim Compensation Fund program. Birnbaum, a life-long New Yorker, has decades of experience resolving complicated litigation.

One month after assuming the position, September 11th Victim Compensa­tion Fund (VCF) Special Master Sheila L. Birnbaum today published draft regulations to govern the VCF, and asked the public to give her feedback on the proposals before victims can begin submitting claims to the fund later this year.

With the 10-year anniversary of Sept. 11, 2001, approaching, September 11th Victim Compensa¬tion Fund Special Master Sheila L. Birnbaum today announced the final rule governing the fund.

September 11th Victim Compensa¬tion Fund (VCF) Special Master Sheila L. Birnbaum today announced that the fund is officially open for claimants.

The Justice Department announced today that, as part of its settlement with BAC Home Loans Servicing LP, a subsidiary of Bank of America Corporation, servicemembers whose homes were unlawfully foreclosed upon will each receive a minimum $116,785 plus compensation for any equity lost to compensate them for the bank’s alleged violation of the Servicemember Civil Relief Act.

The government has intervened in a False Claims Act lawsuit against Infirmary Health System Inc. and its related entities: IMC-Diagnostic and Medical Clinic P.C., Diagnostic Physicians Group P.C. and Infirmary Medical Clinics P.C.

The Department of Justice announced the filing of a lawsuit today against Clark County, Nev., alleging that the county discriminated against Therese Scupi, an African-American woman, on the basis of race and sex and retaliated in violation of Title VII of the Civil Rights Act of 1964, as amended.

A Federal judge has ruled that seven Virginia homeowners made legitimate damage claims regarding corrosion of metal items in the home and personal inconvenience caused by use of

Settlement Overview Video. If you lived at Huronia, Rideau, or Southwestern Regional Centres, you may be eligible to make a claim.

Major League Baseball said it will offer financial assistance to minor league players affected by the work stoppage due to the coronavirus pandemic.

Air travelers cannot receive cash compensation if their flight is delayed by a passenger biting others and assaulting crew members, an adviser at the Court of Justice of the European Union said on Thursday.

There's no doubt that the fifth victim of the Ghatkopar plane crash, architect Govind Dubey, 32, was in the place at the wrong time. But his family is not willing to accept mere bad luck as explanation for his death — they want to know whom to blame. After the family embarked on a sit-in at Rajawadi hospital, refusing to take Govind's body, MLA Jitendra Awhad assured them of compensation and investigation in the matter. With these assurances, the Dubeys finally claimed the body last evening.

Govind was merely passing by when the plane came hurtling down on him. He died on the spot with 100 per cent burns. Due to the extent of his injuries, he was identified only yesterday with the help of his half-burnt wallet. The last location update on his phone also confirms that he was at the spot. The architect hailed from Uttar Pradesh, from where his family has come to collect his body. To his brother's surprise, though, not a single government official has contacted them to assure compensation or action against the culprits.

Arvind Dubey, Govind's brother

“It has been over 24 hours since I lost my brother in the incident. It was my brother's bad luck that he at the spot when it happened. But isn't it the responsibility of the government to come forward to give us justice?” said Arvind Dubey, Govind's brother. He added, “We have decided to file a police complaint against the aircraft company for the accident. The government must conduct an inquiry and imprison the person at fault.”

MLAspeak
“The victim comes from an economically weaker section. Hence, I have requested Chief Minister Devendra Fadnavis to consider his case for compensation,” MLA Awhad told mid-day.

Also Read: Ghatkopar plane crash: Aircraft was 10 miles away when it went off radar

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The Maharashtra government on Friday announced a compensation of Rs 500,000 to the next of kin of all the migrants who were run over by a goods train near Aurangabad. Expressing deep anguish over the incident which killed 16 migrants, Chief Minister Uddhav Thackeray said that all the expenses for the treatment of all those injured in the mishap will be borne by the state government. "We are in constant touch with the Centre to make arrangements for running as many trains as possible for the migrants to return to their homes. I appeal to them not to give up hopes," Thackeray urged.

The Chief Minister said that the victims were working for a steel company in Jalna and were proceeding along the railway lines, apparently to their homes in neighbouring Madhya Pradesh. At night they slept on the railway tracks but early Friday a goods train ran over them, killing 16 and injuring many others.

Thackeray said in the past 4-5 days around 100,000 migrants have reached home safely and more trains are being organized, including from Mumbai, to send the other stranded workers to their respective states.

Catch up on all the latest Mumbai news, crime news, current affairs, and a complete guide from food to things to do and events across Mumbai. Also download the new mid-day Android and iOS apps to get latest updates.

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Company: Golden Opportunities Private Limited
Experience: 2 to 10
location: Bengaluru / Bangalore
Ref: 24825714
Summary: We Have an amazing job opportunity in one of the Biggest MNCs located in Bangalore for a role in the International HR operations in Compensation and Benefits specialist

Compensation for adjudicators is generally considered as a core issue for judicial independence and for attracting good judges in the institutional design for courts. This paper examines compensation systems for adjudicators and dispute settlement administrators in investor-state dispute settlement. The paper uses in part a comparative perspective based on approaches in domestic courts in advanced economies.

15 September 2017 - A complaint submitted in 2015 by former workers of Heineken’s subsidiary Bralima in the Democratic Republic of Congo was successfully resolved recently. This article by Roel Nieuwenkamp explains the circumstances and why this agreement is being hailed as historic.

I am pursuing a claim for the exposure to asbestos while working

FSCS could compensate some investors in collapsed mini-bond issuer London Capital Finance

Channel Seven has lodged an appeal after the Workers Compensation Commission (WCC) ordered the network to pay a former House Rules contestant's medical bills. 

AHEAD OF THE GAME: Sky Sports and BT Sport will ask the Premier League for the right to broadcast more matches next season as the price for not demanding a huge compensation fee.

Policewoman Katie Miles, 38, could lose her job after being caught out trying to claim over a fake bout of food poisoning on a holiday in Sharm-el-Sheik, Eygpt. Ms Miles is pictured above riding on a camel.

We had a 25 hour delay to Mexico, we applied for compensation and were told it was on its way via BACs, then a few days later Thomas Cook folded. Will I get it?

We were put over the three hour delay time which entitles us to compensation after we landed at Amsterdam, are we still due a payout or is it based on when the plane touches down?

The claim will help to cover the £250m plus loss of revenue after the coronavirus outbreak wiped out the fortnight-long tournament, which was set to start in June.

The Financial Services Compensation Scheme is looking at claims from 12,000 savers who bought so-called mini bonds from LCF and were left high and dry when the company collapsed.

While mini-bonds are not normally protected, B&G used a regulated company to drum up clients and raise money, which means investors who poured money in that way could be entitled to a payout.

Julie Tuck's family arrived at Doncaster Airport on Wednesday 17 July at 1pm, ready to depart to Kos at 4pm. However, at 4pm they were all advised that their flight had been cancelled.

After enduring a 12-hour flight delay returning from his daughter's wedding in Corsica, Bob Feltham was eager to claim the £1,335 his family was owed.