With winter’s official start today, the Delaware Department of Agriculture reminds poultry and livestock growers to take proper precautions to shelter and protect their animals.

People snapped grouping together at popular spots in Milan, defying social-distancing rules just days after the city eased its lockdown, have prompted an Italian virologist to compare it to a ticking coronavirus infection ‘bomb.’
Read Full Article at RT.com

The percentage of applicants is in low single digit as a share of the loan book, the bank said, but this could go up as it has not put a deadline or a cut-off for people to apply.

Jeff Carpoff had a lot to celebrate as friends and business associates gathered at his company’s Christmas party last year.

Jeff Carpoff had a lot to celebrate as friends and business associates gathered at his company’s Christmas party last year.

Are you comfortable with latest government guidelines on working in a pandemic? Are you enforcing social distancing? In a sea of ‘fake news’ do you understand how Coronavirus is actually spread and what is safe and unsafe?...

Some people think that skin whitening is just for beautification purposes, but this is not always the case as it is also a great means of maintaining skin health. And... Read more >

(MENAFN - Saudi Press Agency) Riyadh, May 9, 2020, SPA -- An official source at the Ministry of Interior stated that, in light of the health authoriti... ......

New rules, no problem. At least, that’s the case for a Henderson cafe preparing to host customers for the first time in nearly two months. Magnolia Magat already was set on implementing Centers for Disease Control and Prevention-driven changes to her Truffles N’ Bacon Cafe, 8872 S. Eastern Ave., before the governor told her what she must to do open her business on Saturday. If she doesn’t comply with mandated social distancing, face coverings for her employees and limiting occupancy, she is at risk of a verbal warning, citation and business license suspension. But that likely won’t concern Magat, whose measures for her own cafe will be more stringent than those...

The NBA says some players can voluntarily return to their team practice facilities starting Friday, with some very specific conditions and only in places where ...

It’s been almost two months since Kenya announced its first Covid-19 case. It’s also been more than a month since President Uhuru Kenyatta first announced cessation of movement for some counties and the nationwide night curfew.

The United Nations High Commissioner for Human Rights is calling on governments and leaders around the world to ensure that their respective lockdown measurements don’t end up causing harm to people by those enforcing the lockdowns.   “Emergency powers should not be a weapon governments can wield to quash dissent, control the population, and even perpetuate […]

The post Governments Cautioned Not to Use COVID-19 Lockdown to Cause Harm appeared first on Inter Press Service.

ISLAMABAD: Minister for Information and Broadcasting Senator Shibli Faraz on Friday said people's cooperation is vital for the success of lifting the restrictions of lockdown. In a tweet, he said Standard Operating Procedures for various businesses will have to be implemented strictly. He said...

ISLAMABAD: Minister for Information and Broadcasting Senator Shibli Faraz on Friday said people's cooperation is vital for the success of lifting the restrictions of lockdown.In a tweet, he said Standard Operating Procedures for various businesses will have to be implemented strictly.He said that...

ISLAMABAD: Minister for Information and Broadcasting Senator Shibli Faraz on Friday said people's cooperation is vital for the success of lifting the restrictions of lockdown.In a tweet, he said Standard Operating Procedures for various businesses will have to be implemented strictly.He said that...

Title: Take Precautions to Prevent Child Poisonings
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Have Heart Failure? Take Precautions During Pandemic
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer and activator of transcription (STAT)3 was the focus of intense research into understanding the mammalian response to injury, particularly the acute-phase response. Although known to be essential for liver production of acute-phase reactant proteins, many of which augment innate immune responses, molecular cloning of acute-phase response factor or STAT3 and the research this enabled helped establish the central function of Janus kinase (JAK) family members in cytokine signaling and identified a multitude of cytokines and peptide hormones, beyond interleukin-6 and its family members, that activate JAKs and STAT3, as well as numerous new programs that their activation drives. Many, like the acute-phase response, are adaptive, whereas several are maladaptive and lead to chronic inflammation and adverse consequences, such as cachexia, fibrosis, organ dysfunction, and cancer. Molecular cloning of STAT3 also enabled the identification of other noncanonical roles for STAT3 in normal physiology, including its contribution to the function of the electron transport chain and oxidative phosphorylation, its basal and stress-related adaptive functions in mitochondria, its function as a scaffold in inflammation-enhanced platelet activation, and its contributions to endothelial permeability and calcium efflux from endoplasmic reticulum. In this review, we will summarize the molecular and cellular biology of JAK/STAT3 signaling and its functions under basal and stress conditions, which are adaptive, and then review maladaptive JAK/STAT3 signaling in animals and humans that lead to disease, as well as recent attempts to modulate them to treat these diseases. In addition, we will discuss how consideration of the noncanonical and stress-related functions of STAT3 cannot be ignored in efforts to target the canonical functions of STAT3, if the goal is to develop drugs that are not only effective but safe.

Significance Statement

Key biological functions of Janus kinase (JAK)/signal transducer and activator of transcription (STAT)3 signaling can be delineated into two broad categories: those essential for normal cell and organ development and those activated in response to stress that are adaptive. Persistent or dysregulated JAK/STAT3 signaling, however, is maladaptive and contributes to many diseases, including diseases characterized by chronic inflammation and fibrosis, and cancer. A comprehensive understanding of JAK/STAT3 signaling in normal development, and in adaptive and maladaptive responses to stress, is essential for the continued development of safe and effective therapies that target this signaling pathway.

You've probably never heard of LockBit, but that's likely to change.

Boris Johnson has insisted he will act with “maximum caution” in any measures aimed at easing the lockdown

Chelsea forward Willian has urged caution when it comes to the resumption of the Premier League season.

We just shouldn’t be commenting on Adele’s body at all, activists say.

You might forgive the ARLC chairman his belligerence if the cost of careless statements and premature season recommencement dates could not now literally be measured in human lives, writes Richard Hinds.

The governors of Colorado and New York outlined plans to ease pandemic restrictions but stressed they were moving with caution.

How do Ukrainians assess the performance and prospects of President Volodymyr Zelenskiy, now five months in office, as he tackles the country’s two largest challenges: resolving the war with Russia and implementing economic and anti-corruption reforms? In two words: cautious optimism. Many retain the optimism they felt when Zelenskiy swept into office this spring, elected…

Architects usually keep their proprietary research locked up and closely held. Perkins + Will has done the opposite and made it a public service. Launched at Greenbuild the Precautionary List is a compilation of available data on chemicals and

As government authorities and airlines think about coronavirus health screenings, it isn't clear who's in charge of carrying out new policies.

Buffett praised the Fed for its actions to blunt the effects of the coronavirus but said he worries about the repercussions.

CNBC's Eamon Javers breaks down new survey results from battleground states, and split opinions on the coronavirus pandemic among Democratic and Republican voters.

Posted by Victoria Strauss for Writer Beware®

Founded in 2010, The Sunday Times Audible Short Story Award bills itself as "the richest prize for a single short story in the English language." And indeed, the prize is major: the winner receives a cool £30,000 (no, I did not add extra zeroes.)

With judges yet to be finalized, the selection process will include a 20-story longlist announced in May 2020, a six-story shortlist unveiled in June 2020, and the winner revealed on July 2. The shortlisted stories will be published in an Audible audiobook, with included writers receiving "an extra £1,000 fee, on top of a prize payment of £1,000". To be eligible, writers must previously have had at least one work published in the UK or Ireland by an "established print publisher or an established printed magazine" (the Terms and Conditions include an extensive list of the kinds of publishers and magazines that don't qualify). The contest is open for entries until 6:00 pm on December 13.

You can read more about the award, including the prestigious judges who've participated and the well-known writers who've submitted stories, here.

So what's the catch? -- because you know I wouldn't be writing this post if there weren't one. Well, as so often happens, it's in the Terms and Conditions. Specifically:


To summarize this dense paragraph: simply by entering the competition, you are granting a sweeping, non-expiring license not just to Times Newspapers Limited (The Sunday Times' parent company), but also to Audible and any other licensees of TNL, to use your story or any part of it in any way they want, anywhere in the world, without payment to or permission from you.

This is far from the first time I've written about "merely by entering you grant us rights forever" clauses in the guidelines of literary contests, some of them from major publishers or companies that should know better. Sure, in this case the license is non-exclusive, so you could sell your story elsewhere--but only as a reprint, because by granting non-exclusive rights to one company, you remove your ability to grant first rights to another, at least for as long as the initial rights grant is in force.

It's not uncommon for literary contests that involve publication to bind all entrants to a uniform license or grant of rights--so that, when winners are chosen, the license is already in place. But ideally, the license should immediately expire for entries that are removed from consideration--or, if the contest sponsor wants to retain the right to consider any entered story for publication (as TNL clearly does--see Clause 4.2, below), rights should be released within a reasonable period of time after the contest finishes--say, three or six months. There's simply no good reason to make a perpetual claim on rights just in case, at some unspecified point in the future, you might just possibly want to use them.

Not to mention--why should Audible get to make this same claim?

There's a couple of other things to be aware of. Shortlisted authors enter into a 12-month exclusive contract with Audible, for which they are given a "one-off" lump-sum payment (the £1,000 noted above). But thereafter, Audible retains the right "to record, distribute and market such audio version for at least ten (10) years." Again, this right is non-exclusive--but there's no indication that Audible has to pay these authors for potentially exploiting their work for a decade. (If you don't consent to these terms, you can't be shortlisted.)


Finally, although publication is guaranteed only for the shortlist, TNL reserves the right to publish longlist and non-listed entries as well. Great! Except...there's nothing to suggest these writers would be paid either.


There's no question that this is a prestigious--and, for the winner, rich--award. But sober evaluation is definitely in order here. Enter at your own risk.

A vacation brought nightmare news to a 26-year-old Shillong man's family. The man drowned in the Bhatsa River near Shahapur. He was in the city to spend his summer vacation with his cousins at his aunt's place. He had accompanied his cousins who went to the river to beat the heat. Though he was a good swimmer, he was sucked in by the current and drowned. In fact, the drowned man helped his cousins escape, but could not do so himself.

This report comes just days after the a 24-year-old techie allegedly drowned in a swimming pool in Pune. The deceased hailed from Andhra Pradesh and was a resident of Pune's Hinjewadi. He was taking swimming classes since the past one month.

Reports say the lifeguard realised that the techie had not resurfaced for a while when he jumped in and found the man unconscious. Though he was rushed to hospital, he was declared dead. His post mortem report also mentioned death due to drowning.

Both reports show us that swimmers tend to underestimate the power of water. They tend to overestimate their prowess in the water and end up paying a heavy price for that.

In the former instance, where a Shillong-based man died, people need to desist from jumping into rivers, lakes, ponds to cool off. The waters can be deceptively calm. If you are on a picnic, be content with simply submerging your feet in the water, instead of jumping into it. These lessons must be learnt well. The monsoon will bring with it revellers, who cavort in gushing waterfalls and water bodies at green getaways. Some of these picnics end in tragedies. Take extra caution when you swim, and do not enter a deep pool if you are a beginner or still learning. It must be action caution when it comes to water.

Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates

Amid the rapid spread of COVID-19 across the globe, a new study has stressed that it's time to encourage people to wear face masks as a precautionary

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Downing Street says any changes will be ‘very limited’ to avoid second peak of infections

S&P up 23% from March nadir on back of state coronavirus action — but more falls possible, warn analysts

Thousands attend military parade in Belarus even as virus spreads rapidly in neighbouring Russia, UK airline industry warns of huge blow if travel quarantine is launched and Seoul closes down bars and clubs in wake of new cluster

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After dying her hair platinum blonde for her 21st birthday bash, Kylie Jenner's stylist needed to take proper precautions when creating the star's VMA look to protect her fragile locks.

By and large, I rather admire the film career carved out by Steve Coogan, an actor to whom there's always been more than the admittedly ridiculously funny Alan Partridge.

A man (pictured) wearing a yellow face mask and a sign on his back reading, 'Caution, I have the Coronavirus,' walked into a Walmart store in Illinois (inset) and sprayed Lysol on merchandise.

The ride-hailing firm was stripped of its licence to operate in London yesterday after Transport for London found 14,000 rides had been provided by drivers using bogus identification.

Sebastian Stan was seen walking around the streets of New York City on Saturday, and he made sure to protect himself with some gear as the city continues to grapple with the coronavirus pandemic.

Postboxes on Canvey Island have been taped up as a precaution after the postman lost his set of keys. A councillor said all were cleared of mail using a spare set of keys before being closed.(stock image)

In reaction to Prince Charles, Meghan has upped precautionary measures at their Vancouver Island mansion, as she was already making staffers wear latex gloves.

By and large, I rather admire the film career carved out by Steve Coogan, an actor to whom there's always been more than the admittedly ridiculously funny Alan Partridge.

There has been only one recorded case on the island to date but the squad are taking a proactive approach with all players and backroom staff provided with an 'immunity pack' for the Test tour

After attracting criticism for continuing in the wake of the coronavirus pandemic, DWTS has taken extreme measures to finish out the season safely, including pushing the show's finale forward to this weekend.