Imke K. Mandemaker, Di Zhou, Serena T. Bruens, Dick H. Dekkers, Pernette J. Verschure, Raghu R. Edupuganti, Eran Meshorer, Jeroen A. Demmers, and Jurgen A. Marteijn

Many chromatin remodeling and modifying proteins are involved in the DNA damage response by stimulating repair or inducing DNA damage signaling. Interestingly, here we identified that down regulation of the H1-interacting protein SET results in increased resistance to a wide variety of DNA damaging agents. We found that this increased resistance is not the result of an inhibitory effect of SET on DNA repair, but rather the consequence of a suppressed apoptotic response to DNA damage. We further provide evidence that the histone chaperone SET is responsible for the eviction of H1 from chromatin. Knock down of H1 in SET-depleted cells resulted in re-sensitization of cells to DNA damage, suggesting that the increased DNA damage resistance in SET-depleted cells is the result of enhanced retention of H1 on chromatin. Finally, clonogenic survival assays show that SET and p53 are epistatic in attenuating DNA damage-induced cell death. Altogether, our data show a role for SET in the DNA damage response as a regulator of cell survival following genotoxic stress.

A team from the Smithsonian is starting a pilot program to aid people in restoring their damaged family heirlooms. Click photo to learn more….

The post Smithsonian starts program to help people restore storm-damaged heirlooms appeared first on Smithsonian Insider.

How do you diagnose a sick stream? Count its insects, according to Smithsonian biologist Don Weller.

The post Streams damaged by too many hard surfaces in urban areas appeared first on Smithsonian Insider.

The impact of polluted urban soil on trees is highlighted in a recent study from Latvia. The researchers found that high salt levels from de-icing chemicals and nutrient imbalance in soil damaged lime trees growing in the city of Riga.

Selective fishing aims to prevent the overexploitation of target fish species and to protect by-catch species, but recent research has indicated that it could be having the opposite effect by damaging biodiversity and sustainability. An alternative approach called 'balanced exploitation' works at the level of the ecosystem instead of selectively removing specific components from the ecosystem.

Between 10 and 50% of marine species and ecosystems are recovering from population declines and degradation, according to recent research, which identified five strategies for successful recoveries. Recoveries are often driven by a combination of factors, which include restricting exploitation, better protection of vulnerable habitats and greater political support and local involvement with conservation.

Some Marine and Coastal have been altered over long periods of time, resulting in a loss of knowledge of their true healthy state, new research suggests. In this UK study, researchers used historical records, samples of sediment and present-day diving surveys to reconstruct the true history of shellfish beds on the east coast of Scotland.

Bycatch (species caught unintentionally in fisheries) in some commercial marine fisheries is the main cause of death in some populations of seabirds, sea turtles, marine mammals, sharks and fish. New research has revealed that bycatch from tuna fishing can be reduced by using better equipment, without compromising industry profits. However, significant policy efforts are needed to monitor bycatch and enforce more sustainable fishing practices.

The impact of polluted urban soil on trees is highlighted in a recent study from Latvia. The researchers found that high salt levels from de-icing chemicals and nutrient imbalance in soil damaged lime trees growing in the city of Riga.

Damage caused by boats anchoring in seagrass meadows off the coast of Sardinia continues despite restrictions, new research shows. The study's authors provide a number of recommendations to help protect seagrass. These include creating special anchoring areas in seagrass-free locations, and limiting the number of boats that enter a marine protected area.

A new method of assessing human impacts on seafloor habitats suggests that over a third of habitats in the Baltic Sea have an ‘unfavourable’ status. The method is presented in a recent study which concludes that the tool can be effective in helping implement the EU’s Marine Strategy Framework Directive (MSFD).

During the last century, large areas of the seafloor have been damaged by human activities such as fishing, sand and gravel extraction and navigational dredging. This Thematic Issue presents quality research exploring the physical damage to the seafloor, new methods for providing seabed information and pressures on marine ecosystems from activities such as deep-sea mining.

Nearly 85% of residents in central Dublin, Ireland, could be exposed to damaging levels of night-time traffic noise, according to a recent study. The researchers explain how they assessed population exposure to noise and calculate the impacts of several noise reduction measures, providing information that could help EU Member States meet the Environmental Noise Directive’s requirements.

Sustainability in the production of goods and services could be encouraged by replacing value-added tax (VAT) with ‘DaVAT,’ a damage and value-added tax, a new study suggests. This tariff is partly based on a life-cycle assessment (LCA) of goods and services and varies from high (products deemed to seriously harm the environment and human health) to low (those with a lesser impact). The researchers propose a novel way to convert VAT into DaVAT and provide a new policy tool, based on LCA, that can be applied by any country wishing to reform its consumption tax system and move towards a more sustainable future.

Higher atmospheric carbon dioxide levels and temperatures under climate change are likely to increase the rate of corrosive damage in reinforced concrete structures, according to a recent study. This could result in costly repairs in the future, unless structures are suitably adapted.

Over 75 000 regulatory inspection reports for over 32 000 oil and gas production wells drilled in Pennsylvania, US between 2000 and 2012, have been analysed in a recent study. In these reports, the inspectors logged six times as many incidents of damage to the walls of shale gas and oil wells than in wells for conventional oil and gas.

Ocean acidification could damage the organs of Atlantic herring, as well as slow their growth and development, recent experiments show. It adds to the list of pressures currently threatening this commercially important species, including over-fishing and marine pollution.

Marine litter not only causes environmental damage, but has significant economic costs for industry. A recent study has now estimated that marine litter in the Asia-Pacific region is likely to cost over US$1.26billion per year in damage to marine industries. Policy options for reducing this cost are explored.

Human activities are threatening river ecosystems in the Mediterranean. Recent research in south-east Spain has highlighted the need to assess biodiversity and the ecological condition of river ecosystems at both basin-wide and local scales. The researchers say this will provide a better assessment of river ecosystems, aiding management decisions.

Climate change is likely to increase the frequency and severity of flooding. This study reviewed damage mitigating measures at local, regional and national scales, and suggests that approaches including both spatial planning and private precautionary measures (such as building adaptations) are important for integrated risk management.

Researchers have developed a new tool for assessing and predicting the damage caused by droughts to crop yields and hydroelectric energy production. The tool could provide useful information to policymakers, helping them develop drought management practices to improve food and energy security and adapt to climate change.

New research from the Mediterranean suggests that marine ecosystems are disturbed by the organic food and faeces waste from fish farms, even when the pollutants themselves can no longer be detected. The study recommends calculating an individual pollution 'carrying capacity' for each type of marine habitat, and provides the first published estimate for a ma??rl habitat.

Milder winters under climate change could increase the extent of alder tree (Alnus glutinosa) decline in Europe due to the increased spread of the pathogen Phytophthora alni, a recent study has found. However, this may be offset by hotter summers, which reduce the severity of the disease.

Adapted habitat equivalency analysis (HEA) may help decision makers select projects to restore damaged ecosystems under a limited budget. HEA, used to assess damages to natural resources, can help to clarify objectives and compare trade-offs between projects to choose the most cost-effective among them, according to this study’s authors.

Insect-eating bats are estimated to be worth US$ 1 billion (€0.91 billion) a year to maize farmers around the world, a new study has revealed. Not only do bats reduce crop damage by eating adult corn earworm crop pests, they also suppress fungal infections in maize ears. Bats and their habitats need to be better protected for their ecological and economic contributions, say the study’s authors.

Moss helps prevent soil erosion on fire-damaged land, a Portuguese study suggests. The researchers analysed water that ran off from post-fire hillsides. They found less sediment and organic matter in run-off from patches of land with high levels of moss than from those with low levels of moss. Moss quickly establishes itself on land after fires, so the study suggests that land managers could take advantage of its restorative effects by deliberately encouraging its growth.

Combinations of antibiotics have been found in high enough concentrations to pose a serious threat to aquatic ecosystems, in a recent Spanish study. Antibiotics can have toxic effects on the bacteria and algae that form the basis of aquatic ecosystems.

Thousands of tonnes of chemical warfare agents were dumped into the Baltic Sea after the Second World War. A recent study has shown that fish caught near the dumping grounds show high levels of genetic and cell damage, revealing the long legacy of these toxic substances.

Tiny polyester fibres, which are washed into rivers, lakes and seas every time we do our laundry could cause more harm to animals than plastic microbeads, finds a new study. The researchers looked at the effect of microbeads and fibres on a small crustacean called Ceriodaphnia dubia, which lives in freshwater lakes. They found that although both types of plastic were toxic, microfibres caused more harm. Both microplastics stunted the growth of the animals, and reduced their ability to have offspring; microfibres, however, did this to a greater degree, and also caused noticeable deformities in the crustacean’s body and antennae.

Nano-sized particles of plastic can be more damaging to marine species than larger sized microplastics, a new study shows. Lab tests revealed that nanoplastics can damage cell membranes in tiny marine creatures called rotifers (Rotifera), disrupting their natural defences against toxicants. The researchers found that rotifers that had been exposed to nanoparticles of polystyrene were significantly more susceptible to the lethal effects of persistent organic pollutants (POPs).

According to new research, emissions of anthropogenic nitrous oxide (N2O) are now causing more damage to the ozone layer than those of any controlled ozone depleting substance and this is projected to remain the case for the rest of this century. The study suggests that limiting N2O emissions could help both the recovery of the ozone layer and tackle climate change.

The policy implications of agricultural losses caused by high concentrations of ground level ozone have been highlighted by a recent study. The study modelled ozone impacts on 14 of the most important crops grown in the Greater Thessaloniki area of Greece. The results provide information about differences in scale of losses and economic impacts across the region which may be useful in designing agricultural subsidy schemes.

A study in the Czech Republic has found a link between exposure to certain air pollutants and an increase in DNA damage for people exposed to high levels of the pollution. They found that breathing small quantities of a polycyclic aromatic hydrocarbon (PAH), called benzo[a]pyrene (B[a]P), caused an increase in the number of certain ‘biomarkers’ in DNA associated with a higher risk of diseases, including cancer.

FREDERICKSBURG, Va. ⸺ Route 3 in Lancaster County has reopened to through traffic between Route 201 and Route 600 in the Lively area. The road...

FREDERICKSBURG, Va. ⸺  Route 202 (Hampton Hall Road) in Northumberland County reopened to through traffic today following an emergency repair...

FREDERICKSBURG, Va. ⸺  Long-term repair work is underway to rebuild state-maintained roads that sustained severe damage during Tropical Storm...

LYNCHBURG —Over a week after the rain and wind of Tropical Storm Michael took aim on the Commonwealth, the Virginia Department of Transportation continues to assess roads and bridges in the Lynchburg District affected by the storm. By the time Michael exited the area, over 220 road and 360 structures were under water and as of today (Friday, October 19) only six short-term closures, in addition to the long-term closures below, remain.

LYNCHBURG, Va. – US 58 over Sandy Creek at the Halifax/Pittsylvania County line has been closed to traffic since Tropical Storm Michael struck the Commonwealth in October and motorists have used a lengthy detour that required travel in North Carolina. Weather permitting the eastbound structure will re-open to one lane of traffic in each direction today, Wednesday, November 7.

000
WTNT64 KNHC 110400
TCUAT4

Tropical Storm Michael Tropical Cyclone Update
NWS National Hurricane Center Miami FL AL142018
1200 AM EDT Thu Oct 11 2018

...12 AM EDT POSITION UPDATE...
...MICHAEL WEAKENS TO A TROPICAL STORM OVER CENTRAL GEORGIA...
...DAMAGING WINDS STILL OCCURRING INLAND...

NOAA Doppler weather radar data indicate that the center of Michael
is now moving into south-central Georgia. Tropical storm-force
winds continue over central and southern Georgia, and are spreading
across the coast of southeastern Georgia.

This will be the last hourly position update issued by the National
Hurricane Center on Michael. The next intermediate advisory will be
issued at 2 AM EDT...0600 UTC.


SUMMARY OF 1200 AM EDT...0400 UTC...INFORMATION
-----------------------------------------------
LOCATION...32.3N 83.6W
ABOUT 30 MI...45 KM SSW OF MACON GEORGIA
MAXIMUM SUSTAINED WINDS...70 MPH...115 KM/H
PRESENT MOVEMENT...NE OR 40 DEGREES AT 17 MPH...28 KM/H
MINIMUM CENTRAL PRESSURE...975 MB...28.79 INCHES

$$
Forecaster Beven

Alaskan journalist Charles Wohlforth, author of 'The Fate of Nature,' tells MSNBC about the oil spill's likely long-term effects and what could exacerbate them.

Time can be rough on a dam: as it ages, repairs are more costly and it risks catastrophic breakage. But removing one can also be a major eco-hazard.

Here are 7 before-and-after images of cities, as seen from space, showing the impact humans have had on the surrounding environment.

Space shuttle Enterprise suffered minor wing damage on June 3 when it collided with the navigation guides for a New York railroad bridge during the first half o

Mold and water go hand-in-hand, so learn how to find mold and prevent it.

Humidity doesn’t just make you uncomfortable. It also causes problems and health hazards at every level of the home. Here is a bottom-to-top summary of some o

If you watched the Great American Eclipse of 2017, here's how you can tell if you hurt your eyesight in the process.

Two decades after approving imidacloprid, the EPA is re-examining how it and similar pesticides affect bees.

Circumflex Grip Technology gives the Grip Guard a custom mouth guard like fit

Killer Cub Mouthguard