"‘Wish I Were Here' Is So Engaging, I Can Hardly Believe It's Their Debut"

Limited Edition Of 1500 Numbered Copies On 180 Gram Audiophile Gold Colored Vinyl

Former Oasis star Liam Gallagher has announced that he has delayed the release of his 'MTV Unplugged' live album

Seven Seas Music Will Now Represent The Re-recorded 11-track Album For Placements In Film Trailers, Advertising, Video Games, And More.

The Critically-Acclaimed Group Netted The #4 Most Added Spot On The Billboard Mainstream Indicator Chart & Was The #1 Most Added On The Foundations Chart Week

Montreal Hip-hop Collective Triple-R Has Signed With Squash Comp And Released Their Debut Album “Red Rum Records”

Curren$y, Trademark And Young Roddy Have Set The Stage For Their Long-awaited Full-length Album, "Plan Of Attack", Dropping Worldwide On Oct. 11th.

The Follow-up To JUNO Nominated Myles Goodwyn And Friends Of The Blues Due From Linus Entertainment

Collection Of Folk, Pop, World And Jazz Originals Tells A Tale Of Love In Many Guises;

#62ndGrammyAwards #Blues #GrammyAwards #GrammyNominations

The Album Will Be Released On 11th May Via Cherry Red Records Worldwide Excluding Japan Where The Album Is Available Via King Records.

Rings Around Saturn Debuts At #3 With Halliday Named As #3 “Top Artist”

TOM KEIFER’s Highly Anticipated Album RISE With #keiferband Has Garnered Impressive Debuts On Various Billboard Charts.

District 97 “Screens” Will Be Released In The UK/Europe Oct. 4 And North America Oct. 11, 2019.

Shiny Penny Celebrates Billboard Chart Debut At #50 On Billboard Christian Album Sales Chart (for Week Of September 28, 2019) With New Album Entitled HERE IN THE OPEN

#62ndGrammyAwards #Blues #GrammyAwards #GrammyNominations

Album Produced By Steve Evetts (The Dillinger Escape Plan, Suicide Silence, Poison The Well), And Mixed By Jamie King (Between The Buried And Me, The Contortionist)

Toronto-based Rock Band, Across The Board Will Release Their Second Full-length Album, "Sonic Boom" On May 4, 2018. Produced And Recorded In Toronto By MC2 Music Media, The Album Pays Homage To A Band

Which Names Spring To Mind When You Think Of Folk Rock Music? Jethro Tull, Perhaps?

Canadian Singer Prince Amine Announces New Album And Will Be The Opening Act For Maitre Gims On May 4th

Does Meek Mill have the greatest rap intro of all time?

Cardi B scores the award for Album of the Year.

He says he’ll send the rapper’s mother to an awards show.

He has some huge names on his next project.

Carey’s fans are dedicated to her success.

She already has a “no-brainer” collaborator in mind.

Cardi B scores the award for Album of the Year.

Frank Ocean Blonde and Endless New Orleans-born and L.A.-raised Frank Ocean has been one of the most consistently interesting and mysterious pop stars of the 2010’s. After helping shape the sound of boundary-pushing and controversial L.A. rap collective Odd Future, Ocean released his first mixtape, Nostalgia Ultra in 2011. Frank Ocean was then highly featured … Continue reading "Frank Ocean’s Two Album Splash: Endless and Blonde"

I’m certainly not the first person to say 2016 was full of loss and turmoil, both with losing several music legends and the world experiencing all sorts of violence and tragedy. Some of our picks speak to that turmoil, whether it be speaking to police brutality and racism in our justice system, or the fear … Continue reading "LxL’s 10 Best Albums of 2016"

Below are our favorite albums of 2017. 10. King Gizzard and the Lizard Wizard – Sketches Of Brunswick East 9. The War on Drugs – A Deeper Understanding 8. Hurray for the Riff Raff – The Navigator 7. Kaitlyn Aurelia Smith – The Kid 6. Ibeyi – Ash 5. Alvvays – Antisocialites 4. Vince Staples – … Continue reading "LxL’s Best Albums of 2017"

The L.A. Times have a new interview with Robert, and he gives them an update about the new album:

How far along are you on a new Cure album?
We’re going back in [the studio] three days after we get back from Pasadena for me to try and finish the vocals, which is, as ever, what’s holding up the album. I keep going back over and redoing them, which is silly. At some point, I have to say that’s it.

Has this been in the works for a long time or did you suddenly get to a point where it all came out at once?
I was offered the chance to curate the Meltdown Festival [in London] and I said yes. And then I realized I didn’t really listen to very much new music anymore. So I threw myself headlong into it and started listening to bands again and meeting kids who were in bands, and something clicked inside my head: I want to do this again. It came as a bit of a shock to me, to be honest. No one really believed me until we started recording.

Is there anything from your history that you would compare this new album to?
It’s very much on the darker side of the spectrum. I lost my mother and my father and my brother recently, and obviously it had an effect on me. It’s not relentlessly doom and gloom. It has soundscapes on it, like “Disintegration,” I suppose. I was trying to create a big palette, a big wash of sound.

Do you have a title?
The working title was “Live From the Moon,” because I was enthralled by the 50th anniversary of the Apollo landing in the summer. We had a big moon hanging in the studio and lunar-related stuff lying around. I’ve always been a stargazer.

In the past, when the Cure released an album, you’ve said the band was going to retire. How are you feeling this time?
Being the contrarian that I am, I’d be very unhappy if it was the last one. We’ll be onstage tomorrow and I’ll be saying to them, “This is the last time in Paris,” and they’ll look at me and shrug their shoulders. At some point, I will be proved right.

Read the rest at the L.A. Times.

Bob Dylan is done blowing in the wind.

Kardashian is of Armenian heritage, Friday marked the 105th anniversary of the Armenian genocide.

Fiona Apple's fifth album, five years in the making, is a rich text to scour in quarantine.

Pearl Jam didn't intend for their new album, "Gigaton," to be a coronavirus hymnal. Yet it rises to the occasion with glimmers of hope, resilience and even ecstasy.

Check out 2018 albums by Indiana's Richard Edwards, S.M. Wolf, Rob Dixon, Brother O' Brother and Peteyboy.

Long-term hyperglycemia in patients with diabetes leads to human serum albumin (HSA) glycation, which may impair HSA function as a transport protein and affect the therapeutic efficacy of anticoagulants in patients with diabetes. In this study, a novel mass spectrometry approach was developed to reveal the differences in the profiles of HSA glycation sites between patients with diabetes and healthy subjects. K199 was the glycation site most significantly changed in patients with diabetes, contributing to different interactions of glycated HSA and normal HSA with two types of anticoagulant drugs, heparin and warfarin. An in vitro experiment showed that the binding affinity to warfarin became stronger when HSA was glycated, while HSA binding to heparin was not significantly influenced by glycation. A pharmacokinetic study showed a decreased level of free warfarin in the plasma of diabetic rats. A preliminary retrospective clinical study also revealed that there was a statistically significant difference in the anticoagulant efficacy between patients with diabetes and patients without diabetes who had been treated with warfarin. Our work suggests that larger studies are needed to provide additional specific guidance for patients with diabetes when they are administered anticoagulant drugs or drugs for treating other chronic diseases.

Rapper YoungBoy Never Broke Again's "38 Baby 2" is No. 1 on the U.S. album chart.

1897.

A FEW weeks ago, Wendy James was trending on Twitter. It’s been happening quite often over the last few months, a result of BBC Four’s repeats of Top of the Pops reaching 1988 and 1989, the years in which a pink-lipsticked, bra-flaunting James launched herself on the public consciousness as the brash, blonde frontwoman of Transvision Vamp.

THE market for TV historians is crowded and fiercely competitive. Drop your guard for a second and Dan Snow or Bettany Hughes will be in the door and taking your gig faster than you can don a pair of those special white gloves all in the trade must have. Lucy Worsley made her name by combining immense knowledge – she is the chief curator at Historic Royal Palaces – with a steadfast dedication to raiding the dressing up box.

Jaundiced newborns without additional risk factors rarely develop kernicterus if the total serum bilirubin is <25 mg/dL. Measuring the bilirubin/albumin ratio might improve risk assessment, but the relationships of both indicators to advancing stages of neurotoxicity are poorly documented.

Both total serum bilirubin and bilirubin/albumin ratio are strong predictors of advancing stages of acute and post-treatment auditory and neurologic impairment. However, bilirubin/albumin ratio, adjusted to the same sensitivity, does not improve prediction over total serum bilirubin alone. (Read the full article)

Background

Optimal concentrations of unbound antimicrobials are essential for maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare effects of different albumin states on total and unbound concentrations of ertapenem and ceftriaxone using an ovine model.

Methods

Design

Prospective, three phase intervention observational study.

Subjects

Healthy Merino sheep.

Interventions

Eight sheep were subject to three experimental phases; normoalbuminemia, hypoalbuminemia using plasmapheresis and albumin replacement using a 25% albumin solution. In each phase, ceftriaxone 40 mg/kg and ertapenem 15 mg/kg were given intravenously. Blood samples were collected at pre-defined intervals and analyzed using an ultra-high-performance liquid chromatography tandem mass spectrometry method. Pharmacokinetic parameters such as area under the curve (AUC_0-24), plasma clearance (CL) and apparent volume of distribution in the terminal phase (V_d) were estimated and compared between the phases.

Results

The protein and albumin concentrations were significantly different between phases. Hypoalbuminemia resulted in a significantly lower AUC_0-24 and higher CL of total and unbound concentrations of ceftriaxone compared to the other phases. Whereas albumin replacement led to higher AUC_0-24 and lower CL compared to other phases for both drugs. The V_d for total drug concentrations for both drugs were significantly lower with albumin replacement.

Conclusions

For highly protein-bound drugs such as ceftriaxone and ertapenem, both hypoalbuminemia and albumin replacement may affect unbound drug exposure.

'Rough and Rowdy Ways' will be released on June 19, according to a brief announcement on Dylan’s official website

The post Bob Dylan announces first album of new music since 2012 appeared first on Premium Times Nigeria.

Title: Huey Lewis: His New Album, Hearing Loss, and Meniere's Disease
Category: Health News
Created: 2/13/2020 12:00:00 AM
Last Editorial Review: 2/13/2020 12:00:00 AM

ABSTRACT

A large portion of biological iron is found in the form of an iron-protoporphyrin IX complex, or heme. In the human host environment, which is exceptionally poor in free iron, heme iron, particularly from hemoglobin, constitutes a major source of iron for invading microbial pathogens. Several fungi were shown to utilize free heme, and Candida albicans, a major opportunistic pathogen, is able both to capture free heme and to extract heme from hemoglobin using a network of extracellular hemophores. Human serum albumin (HSA) is the most abundant host heme-scavenging protein. Tight binding of heme by HSA restricts its toxic chemical reactivity and could diminish its availability as an iron source for pathogenic microbes. We found, however, that rather than inhibiting heme utilization, HSA greatly increases availability of heme as an iron source for C. albicans and other fungi. In contrast, hemopexin, a low-abundance but high-affinity heme-scavenging serum protein, does inhibit heme utilization by C. albicans. However, inhibition by hemopexin is mitigated in the presence of HSA. Utilization of albumin-bound heme requires the same hemophore cascade as that which mediates hemoglobin-iron utilization. Accordingly, we found that the C. albicans hemophores are able to extract heme bound to HSA in vitro. Since many common drugs are known to bind to HSA, we tested whether they could interfere with heme-iron utilization. We show that utilization of albumin-bound heme by C. albicans can be inhibited by the anti-inflammatory drugs naproxen and salicylic acid.

IMPORTANCE Heme constitutes a major iron source for microorganisms and particularly for pathogenic microbes; to overcome the iron scarcity in the animal host, many pathogenic bacteria and fungi have developed systems to extract and take up heme from host proteins such as hemoglobin. Microbial heme uptake mechanisms are usually studied using growth media containing free heme or hemoglobin as a sole iron source. However, the animal host contains heme-scavenging proteins that could prevent this uptake. In the human host in particular, the most abundant serum heme-binding protein is albumin. Surprisingly, however, we found that in the case of fungi of the Candida species family, albumin promoted rather than prevented heme utilization. Albumin thus constitutes a human-specific factor that can affect heme-iron utilization and could serve as target for preventing heme-iron utilization by fungal pathogens. As a proof of principle, we identify two drugs that can inhibit albumin-stimulated heme utilization.

OBJECTIVE

Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing phenotype in patients with type 2 diabetes. However, it remains unclear whether its prognosis is poorer than that of other DKD phenotypes.

Urinary albumin-to-creatinine ratio (ACR) is a marker of diabetic nephropathy and microvascular damage. Metabolic-related traits are observationally associated with ACR, but their causal role is uncertain. Here, we confirmed ACR as a marker of microvascular damage and tested whether metabolic-related traits have causal relationships with ACR. The association between ACR and microvascular function (responses to acetylcholine [ACH] and sodium nitroprusside) was tested in the SUMMIT study. Two-sample Mendelian randomization (MR) was used to infer the causal effects of 11 metabolic risk factors, including glycemic, lipid, and adiposity traits, on ACR. MR was performed in up to 440,000 UK Biobank and 54,451 CKDGen participants. ACR was robustly associated with microvascular function measures in SUMMIT. Using MR, we inferred that higher triglyceride (TG) and LDL cholesterol (LDL-C) levels caused elevated ACR. A 1 SD higher TG and LDL-C level caused a 0.062 (95% CI 0.040, 0.083) and a 0.026 (95% CI 0.008, 0.044) SD higher ACR, respectively. There was evidence that higher body fat and visceral body fat distribution caused elevated ACR, while a metabolically "favorable adiposity" phenotype lowered ACR. ACR is a valid marker for microvascular function. MR suggested that seven traits have causal effects on ACR, highlighting the role of adiposity-related traits in causing lower microvascular function.