The positions are for a non-renewable term of six years.

A meeting in Hong Kong’s legislature descended into shouting matches and scuffles as 11 opposition lawmakers were thrown out by a pro-establishment leader who took control of a key committee to begin clearing a backlog of bills for review.The pan-democrats walked out of talks on Friday after losing their hold over the House Committee, threatening court action against Legislative Council staff, including legal advisers and security guards, whom they accused of abandoning political neutrality and…

Lawmakers on both sides of the political divide are considering whether to report their rivals to police after a row in Hong Kong’s legislature over control of a key committee descended into chaos in the chamber.Two opposition legislators revealed on Saturday they planned to make formal allegations of assault, while the pro-establishment camp was mulling filing complaints of its own to the force.It follows a turbulent meeting of the Legislative Council’s House Committee on Friday, when a pro…

ROME: Italy's economic capital Milan is a virus time "bomb" at risk of erupting with residents now free to move around -- some gathering for canal-side cocktails -- after twomonths under a pandemic lockdown.The city in the northern Lombardy region is the epicentre of Italy´s outbreak, one of...

ROME: Italy’s economic capital Milan is a virus time “bomb” at risk of erupting with residents now free to move around – some gathering for canal-side cocktails – after two months under a pandemic lockdown.The city in the northern Lombardy region is the epicentre of...

Microchip PCN Registration Process

13 lawyers from our Singapore office have volunteered and been appointed to serve as assessors under temporary COVID-19 legislation. 

Registration Now Open for Microchip’s 22nd Annual Worldwide MASTERs Conference

Registration Now Open for Microchip’s 23rd Annual Worldwide MASTERs Conference

An analysis of the topics that cause arguments between newly-wed heterosexual couples puts a lack of affection at the top of the list, with little concern about who sleeps on which side of the bed

It's not every day that the face of a chief epidemiologist is inked as a tattoo. But then it's not every country that has tackled the coronavirus pandemic like Sweden.

Rival lawmakers scuffled in Hong Kong's legislature on Friday in a row over electing the chairman of a key committee, a fresh sign of rising political tension as the coronavirus pandemic tapers off in the Chinese-ruled city. Francesca Lynagh reports.

From vintage satellites to lunar rovers, space archaeologist Alice Gorman is teasing out a unique history of humanity from the objects we've dispatched from Earth

Title: Urologists' Group Issues Updated Guidelines on PSA Test
Category: Health News
Created: 5/3/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM

Title: Many Cardiologists Ill-Equipped to Treat Heart Disease in Cancer Survivors
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: Health Tip: What to Expect From a Gynecologist Visit
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Three physicians describe their impressions of video-based evaluations and things to watch out for.

Title: An Allergist Offers His Expert Advice for a Sneeze-Free Spring
Category: Health News
Created: 3/7/2020 12:00:00 AM
Last Editorial Review: 3/9/2020 12:00:00 AM

To better the health of all North Carolinians, policymakers must come together to improve access to care, expand broadband, and close the coverage gap.

Collaboration within a complicated organization is inherently challenging and can be fraught with discord. Recent emphasis on interdisciplinary and collaborative teamwork in neurology has brought this issue to the forefront of daily practice. The health care system can be complex and opaque, and the stakes—human life—are high. Medical team conflict has been associated with decreased subjective effectiveness, less job satisfaction, and increase in errors. As specialists, neurologists are necessarily embedded within a network of providers and must be adept in the understanding and management of conflictual situations. For the practicing neurologist, it is important to understand team conflict dynamics. Here, management strategies are provided that illustrate how individual neurologists can serve as effective leaders who mitigate harmful effects and capitalize on benefits of team conflict on performance.

Objective

To explore practice differences in the diagnosis and management of autoimmune encephalitis (AE), which is complicated by issues with sensitivity/specificity of antibody testing, nonspecific MRI/EEG/CSF findings, and competing differential diagnoses.

Objective

To specifically report on ataxic-hypotonic cerebral palsy (CP) using registry data and to directly compare its features with other CP subtypes.

As the novel coronavirus spreads, communities across the United States are struggling to offer public testing. The need is urgent. Testing got off to a delayed start in the United States as a result of technical missteps and a slow response from government officials. Now cities across the country are...

A logistic regression model and a bivariate statistical analysis were used in this paper to evaluate the groundwater recharge susceptibility. The approach is based on the assessment of the relationship involving groundwater recharge and parameters that influence this hydrological process. Surface parameters and aquifer-related parameters were evaluated as thematic map layers using ArcGIS. Then, a weighted-rating method was adopted to categorize each parameter's map. To assess the role of each parameter in the aquifer recharge, a logistic regression model and a bivariate statistical analysis were applied to the Guenniche phreatic aquifer (Tunisia). Models are explored to establish a map showing the aquifer recharge susceptibility. The code Modflow was used to simulate the consequence of the recharge. The recharge amount was introduced in the model and was tested to verify the recharge effect on the hydraulic head for the two models. The obtained results reveal that the recharge as mapped in the bivariate statistical model has a minor impact on the hydraulic head. Results of the logistic regression model are more significant as the hydraulic head is widely affected. This model provides good results in mapping the spatial distribution of the aquifer recharge susceptibility.

A multidisciplinary endocrinologist-led shared medical appointment (SMA) model showed statistically significant reductions in A1C from baseline over 3 years that were not significantly different from appointments with endocrinologists or primary care providers alone within a resource-poor population. Similarly, the SMA model achieved clinical outcomes on par with endocrinologist-only visits with the added benefit of improving endocrine provider productivity and specialty access for patients. Greater patient engagement with the SMA model was associated with significantly lower A1C.

OBJECTIVE

The effect of early-life antibiotic treatment on the risk of type 1 diabetes is debated. This study assessed this question, applying a register-based design in children up to age 10 years including a large sibling-control analysis.

Purpose:

Unleashing the immune system by PD-1 and/or CTLA-4 blockade can cause severe immune-related toxicity necessitating immunosuppressive treatment. Whether immunosuppression for toxicity impacts survival is largely unknown.

Purpose:

We hypothesized that the combination of a local stimulus for activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally encoded IL15Rα-IL15 as the T-cell activating stimulus and a prostaglandin synthesis inhibitor as the anti-immunosuppressant were combined with adoptive transfer of tumor-specific T cells.

New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus. Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus. In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.

Infections with nontuberculous mycobacteria (NTM) have a poor prognosis in patients with underlying respiratory diseases. Clofazimine (CFZ) showed both experimental and clinical promising results against clinically relevant NTM. However, there are no data on CFZ in combination with the current recommended treatment; therefore, we aimed to study its in vivo activity in an aerosol mouse model of Mycobacterium avium. In an aerosol infection BALB/c mouse model using M. avium strain Chester, we treated 58 mice with four combinations of rifampin (RIF) at 10 mg/kg, CFZ at 25 mg/kg, and clarithromycin (CLR) and ethambutol (EMB) at 100 mg/kg. Treatment efficacy was assessed on the basis of lung CFU counts after 2 (M2) and 4 (M4) months of treatment. At M2, CLR-RIF-EMB was slightly but significantly more efficient than CFZ-RIF-EMB (3.02 ± 0.12 versus 3.55 ± 0.28, respectively, P < 0.01), whereas CLR-CFZ-EMB and CLR-CFZ-RIF-EMB dramatically decreased lung CFU counts by 4.32 and 4.47 log₁₀, respectively, compared to untreated group. At M4, CLR-RIF-EMB was significantly more efficient than CFZ-RIF-EMB (2 ± 0.53 versus 2.66 ± 0.22, respectively, P = 0.01). The addition of CLZ to CLR dramatically decreased the lung CFU count, with CFU counts 5.41 and 5.79 log₁₀ lower in the CLR-CFZ-EMB and CLR-CFZ-RIF-EMB groups, respectively, than in the untreated group. The addition of CFZ to CLR seems to improve the efficacy of CLR as early as M2 and was confirmed at M4. CFZ, in addition to RIF and EMB, on the other hand, is less effective than CLR-RIF-EMB. These results need to be confirmed by similar studies along with CFZ potential for shortening treatment.

Lactoferrin (LF) is a multifunctional milk protein with antimicrobial activity against a range of pathogens. While numerous studies report that LF is active against fungi, there are considerable differences in the level of antifungal activity and the capacity of LF to interact with other drugs. Here we undertook a comprehensive evaluation of the antifungal spectrum of activity of three defined sources of LF across 22 yeast and 24 mold species and assessed its interactions with six widely used antifungal drugs. LF was broadly and consistently active against all yeast species tested (MICs, 8 to 64 μg/ml), with the extent of activity being strongly affected by iron saturation. LF was synergistic with amphotericin B (AMB) against 19 out of 22 yeast species tested, and synergy was unaffected by iron saturation but was affected by the extent of LF digestion. LF-AMB combination therapy significantly prolonged the survival of Galleria mellonella wax moth larvae infected with Candida albicans or Cryptococcus neoformans and decreased the fungal burden 12- to 25-fold. Evidence that LF directly interacts with the fungal cell surface was seen via scanning electron microscopy, which showed pore formation, hyphal thinning, and major cell collapse in response to LF-AMB synergy. Important virulence mechanisms were disrupted by LF-AMB treatment, which significantly prevented biofilms in C. albicans and C. glabrata, inhibited hyphal development in C. albicans, and reduced cell and capsule size and phenotypic diversity in Cryptococcus. Our results demonstrate the potential of LF-AMB as an antifungal treatment that is broadly synergistic against important yeast pathogens, with the synergy being attributed to the presence of one or more LF peptides.

BACKGROUND AND PURPOSE:

Flow diversion for the posterior circulation remains a promising treatment option for selected posterior circulation aneurysms. The Flow-Redirection Intraluminal Device (FRED) system has not been previously assessed in a large cohort of patients with posterior circulation aneurysms. The purpose of the present study was to assess safety and efficacy of FRED in this location.

BACKGROUND AND PURPOSE:

NeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis.

The official Twitter account for the hugely popular free-to-play battle royale game, Fortnite, announced the game now has over 350 million registered players. In April, players spent over 3.2 billion hours in game. 

Epic Games plans to "the party going with our Party Royale Premiere LIVE on May 8 at 9pm ET." It will feature Deadmau5, Steve Aoki and Dillon Francis. The Party Royale will last an hour and take place on the big screen at the Main Stage. 

If you miss the Party Royale it will be rebroadcasted on May 9 at 2pm ET. 

Read an overview of the Party Royale below:

Let’s get ready to party! The Party Royale Premiere arrives on Friday, May 8, at 9 PM ET.

Dillon Francis, Steve Aoki, and deadmau5 are coming to Party Royale with back-to-back-to-back sets LIVE on the big screen at the Main Stage. Hit the dance floor, chill with friends, or jump into activities in Party Royale.

No RSVP Necessary

If you can’t make it right at 9 PM ET, you can still catch the rest of the live show as long as you join before it ends at 10 PM ET.

Bring on the Encore

If you're still busy, don’t worry — the Party Royale Premiere will return for a rebroadcast. On May 9 from 2 PM to 3 PM ET, you can catch the full show once again at the Main Stage.

And just like the first airing, you can still jump in during the show. 

Party Favors

The Party Royale Premiere also has a party favor. Anyone who logs into Fortnite from Friday, May 8 at 6 PM ET to Monday, May 11 at 10 AM ET will get the new, music-reactive Neon Wings Back Bling for free! Perfect for wearing at the show.

Beyond the Main Stage

Shows at the Main Stage are just some of the many attractions at Party Royale. In this new experimental and evolving space, there are many things to do and places to explore. For example: take on aerial obstacle courses at Skydive Rift, participate in boat races at Fishsticks’ Boat Race, and grab items at The Plaza such as the new Paint Launcher.

There are no weapons or mats in Party Royale — it’s all about just hanging out and having fun. No Sweat. All Chill. Let’s Party!

Fortnite is available on the Nintendo Switch, PlayStation 4, Xbox One, Windows PC, iOS, and Android.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443407/fortnite-tops-350-million-registered-players/

From vintage satellites to lunar rovers, space archaeologist Alice Gorman is teasing out a unique history of humanity from the objects we've dispatched from Earth

An analysis of the fossilized teeth of Deinonychus antirrhopus, a species of wolf-sized dromaeosaurid dinosaur that lived between 115 and 108 million years ago (Cretaceous period) in what is now the United States, adds to the growing evidence that this and other raptors were not complex social hunters by modern mammalian standards. The image of [...]

The top Republican in the U.S. House of Representatives called for a pause in coronavirus legislation on Thursday, saying Congress should first assess the impact of earlier relief bills and then take a slower path forward through committee hearings.

Fed up with invasive species and sterile landscapes, Douglas Tallamy urges Americans to go native and go natural

Read our live coronavirus blog HERE

A Zoom blunder from Wales's health minister left fellow politicians with their heads in their hands as he was heard swearing about a colleague with his microphone still on.

Labour has proposed legislation to deliver a dedicated fast-tracked fund for domestic abuse services affected by the coronavirus crisis.

Cumbria Police have apologised for an "ill-judged" tweet that suggested people should not buy plants or compost during the coronavirus lockdown.

A former senior North Korean diplomat has apologised after saying Kim Jong-un was probably so ill he could not stand, days before he was seen at an event attended by hundreds of officials.

New car sales were almost wiped out last month as the the number of registrations collapsed to their lowest level for 74 years.

Follow our live coronavirus updates HERE Coronavirus: the symptoms

Modern dating techniques are providing new time frames for indigenous settlements in Northeast North America, free from the Eurocentric bias that previously led to incorrect assumptions.