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'Parasite' director Bong Joon Ho makes Oscars history with win

A historic best director Oscar goes to 'Parasite' filmmaker Bong Joon Ho, the first Korean winner and only the second time the prize has gone to a film not in English.




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This 'Homeland' director isolates at home in her 'room of stories'

As Showtime's 'Homeland' races toward its finale, prolific director Lesli Linka Glatter isn't done telling her tales.




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Actress JoBeth Williams and director John Pasquin buy Pacific Palisades retreat

After asking $30 million for their Bel-Air abode, actress JoBeth Williams and director John Pasquin have bought a Pacific Palisades home for $9.8 million.




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'Beastie Boys Story' — directed by Spike Jonze — reveals the band at their best and brattiest

Adam Horovitz (Ad-Rock) and Michael Diamond (Mike D) join director Spike Jonze from their separate coronavirus quarantines to talk "Beastie Boys Story," which captures their blazing days with the late Adam Yauch (MCA).




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Peter H. Hunt, Tony winner for '1776' and 'Touched by an Angel' director, dies at 81

Peter H. Hunt followed his success of '1776' with a long film and TV career, plus a decade as artistic director of the Williamstown Theatre Festival.




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Over 50% of people plan not to reinstate direct debits post lockdown – expert gives advice



CORONAVIRUS has forced people to re-evaluate their finances as income takes a hit and budgets are stretched. One of the first port of calls for change has been direct debits and new research reveals that some people may find themselves with more cash available once this all ends.




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The Last Dance director shares crazy story about Michael Jordan and Dennis Rodman



The Last Dance documentary follows Michael Jordan and his final season with the Chicago Bulls.




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Charlie Methven net worth: How much is the former Sunderland director worth?



Charlie Methven features prominently in the new season of Sunderland 'Til I Die - but how much is the club's former executive director worth?




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Director of Engineering and Construction

Ball State University is accepting applications for a professional position as Director of Engineering and Construction available May 8, 2017. The Director of Engineering and Construction directs a staff of engineers and construction managers in the completion of engineering, construction, energy




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Director of Facilities Operations

Ball State University is accepting applications for a professional position as Director of Facilities Operations available May 8, 2017. The Facilities Planning and Management department oversees the maintenance of all academic and administrative buildings and infrastructure on the campus of Ball




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Program Director - Asset Management

Woolpert, Inc. is a cutting-edge national architecture, engineering and geospatial (AEG) firm that delivers value to clients by blending engineering excellence with innovative technology and geospatial applications. Woolpert was recently certified as an Employer of Choice by Great Place To Work




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Program Director - Energy

Woolpert, Inc. is a cutting-edge national architecture, engineering and geospatial (AEG) firm that delivers value to clients by blending engineering excellence with innovative technology and geospatial applications. Woolpert was recently certified as an Employer of Choice by Great Place To Work




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Director of Engineering

Director of Engineering Company Description A-Gas is the global expert in the supply and full lifecycle management of specialty chemicals and gases, providing refrigerants, blowing agents, fire protection agents and carbon credit offsets to our customers around the world. With industry leading




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Health-care workers' union says Ontario wants to change N95 directive in long-term care

A union representing health-care workers in long-term care homes says the province wants to change a directive that gives all workers access N95 masks.




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They tried every dirty trick in the book to overturn a public vote, says ARRON BANKS



AROUND 18 months ago I found myself interviewed by two officers from the National Crime Agency in Bridewell police station in Bristol.




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DSU offers new certificate, chooses new Atwood Innovation Plaza director

Dixie State University recently announced both a new educational certificate and a new director for its Atwood Innovation Plaza.

       




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Director of 'Sound of Music,' 'West Side Story' never forgot his Hoosier roots

The prolific and multi-Oscar-winning director Robert Wise always credited his Indiana roots for his strong work ethic in Hollywood.

      




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Indy Film Fest: Bad decisions fuel road-trip comedy directed by IU grad Hannah Fidell

Indiana University grad Hannah Fidell directed 'The Long Dumb Road,' closing-night movie at this year's Indy Film Fest.

       




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Funeral director on how families are honoring their loved ones during coronavirus pandemic

Eric Bell, a funeral director in Pittsboro, Ind., says the longest he's waited to hold a memorial service is two months for a deceased person. He explains why.

       




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'Bolsonaro é líder mais isolado do populismo de direita hoje', diz pesquisador do extremismo político

Para Cas Mudde, que há três décadas estuda movimentos de ultradireita, presidente brasileiro pode sair politicamente enfraquecido da pandemia de covid-19.




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Família de Aldir Blanc desmente Regina Duarte e diz que recebeu condolências de assessor

Em entrevista à CNN Brasil, secretária Especial da Cultura diz que optou por mandar mensagens privadas às famílias, em vez de fazer homenagens públicas.




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Diretor da PF foi trocado para garantir mudança de chefia no RJ, diz Moro em depoimento

'Você tem 27 Superintendências, eu quero apenas uma, a do Rio de Janeiro', teria dito Bolsonaro a Moro. Primeira ação do novo diretor-geral da PF foi trocar comando no Rio.




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Real change of direction

Alistair Darling adopted the technique beloved of his predecessor of rattling through the borrowing figures. But the news this year was good - it seems lower than it was expected to be. The bumper tax receipts that the government received...




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Tokyo Kadir'e mesafe koydu

Japonya hükümeti, Uygurlu Türklerin sürgündeki lideri Rabiya Kadir'in Tokyo ziyaretine mesafeli yaklaştı. Çin, Kadir'e vize verilmesinden rahatsızlık duyduğunu ifade etmişti.




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Janelle Monae brings her Dirty Computer Tour to the Murat Theatre

       




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Introducing Domegos: A New Web 2.0 Vacation Rentals Directory

Wandering around the internet, I was searching for 2 different things at the same time: a hotel for a romantic weekend getaway (with our lovely dog!) and a new apartment to rent. I suddenly asked myself: “Why not renting a vacation home instead of booking the usual same type of hotels (those few hotels that [...]




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'Don't go visit your mom' on Mother's Day, San Francisco health director advises

The director of the San Francisco Department of Public Health told residents Wednesday not to visit their mothers on Mother's Day, even if wearing masks and keeping six feet apart.




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An Art Gallery Director’s hectic job

Fun, challenging and creative position at NLC By Steven Benezue | Contributing Writer Being the...




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Coronavirus: Calls to shut down 'dirty fur trade'

Mink have caught Covid-19, adding to the list of infected animals, and prompting calls for trade bans.




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Cathy Yan’s rapid rise from journalist to ‘Birds of Prey’ director: ‘I didn’t think you could do this professionally’

Yan guided Margot Robbie's return to her character Harley Quinn, and is the first woman of Asian descent to direct a major Hollywood superhero movie.




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‘The Incredibles’ director Brad Bird picks what to watch in isolation

Here's how the new Turner Classic Movies "Essentials" guest — the man behind "The Incredibles" and "Ratatouille" — has been influenced by Hitchcock, '50s sci-fi and James Bond.




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Trump’s plan for the economy: Make Drinking Water Dirty Again

Despite administration claims, the president’s deregulatory agenda, so far, hasn’t spurred the economic growth that was promised.




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Direct sales of ebooks in multiple languages

O’Reilly has long been a leader in fostering community and building a direct sales channel. This week we took the next step in enhancing the customer’s direct buying experience by offering German editions for many of our ebook titles. Take …




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AT#458 - Volunteer Travel with Peace Corp Director Carrie Hessler-Radelet

Hear about volunteer travel with the Peace Corps as the Amateur Traveler talks to Peace Corps Director Carrie Hessler-Radelet. Director Hessler-Radelet not only served in the Peace Corps herself in Western Samoa but 4 generations of her family have done so. 




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New White House Press Sec Issues Dire Warning to Americans About the FBI

Newly appointed White House press secretary Kayleigh McEnany continues to impress in her new position working for the White House. Two days after absolutely leveling members of the White House media corps, the 32-year-old former Trump campaign spokeswoman made waves Friday by warning Americans that they, like former National Security Advisor Michael Flynn, could also…

The post New White House Press Sec Issues Dire Warning to Americans About the FBI appeared first on The Western Journal.




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Newsroom: US Direct-to-Consumer Ecommerce Sales Will Rise to Nearly $18 Billion in 2020

Despite strong growth, D2C companies are facing more headwinds   April 2, 2020 (New York, NY) — For the first time, we are breaking out direct-to-consumer (D2C) ecommerce sales. We define […]




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BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO]

The following article, BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO], was first published on 100PercentFedUp.com.

This morning during a nearly one hour interview with Fox & Friends, President Trump addressed the decision by the DOJ to drop the case against the innocent General Michael Flynn. Trump ripped into the “dirty politicians and dirty cops” who went after General Michael Flynn. President Trump called the players involved in the horrible plot […]

Continue reading: BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO] ...




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Chatham House appoints Adam Ward as deputy director

17 January 2017

Chatham House is pleased to announce that Adam Ward will join the institute in a new role as deputy director.

Adam Ward takes up the position of deputy director on 10 April 2017 and will join Chatham House from the International Institute of Strategic Studies (IISS) in London, where he has served as director of studies since 2009.

As deputy director, Adam will oversee and coordinate Chatham House's multiple areas of research, help manage the institute's relationships with key external constituencies, ensure the delivery of high-quality publications and deputize for the institute’s director, Dr Robin Niblett.

This is a new position, created after a period of sustained growth for Chatham House, especially in research and policy outputs. The appointment also coincides with the opening this spring of new working and meeting space for the institute in Ames House, the building adjacent to Chatham House on Duke of York Street in the St James's area of central London.

At IISS, publishers of the renowned annual Military Balance and other high-quality publications and organizers of influential annual security summits, including the Shangri-La Dialogue, Adam was responsible for the oversight of its worldwide research activities, which are also conducted from IISS offices in the Middle East, Asia and the US. Adam led the establishment of the office in Washington and was previously a senior fellow for East Asia.

Dr Robin Niblett, director of Chatham House, said:‘I am delighted that Adam Ward will shortly be joining Chatham House. At a time of great uncertainty and risk in international affairs, his experience in leading research at the prestigious IISS and knowledge of how research institutes can develop and communicate their ideas on public policy will be of enormous value. His wide-ranging expertise on geopolitics and the foreign policies of China and the United States will also help the institute develop integrated projects that reflect the changing balance of world power. I very much look forward to working with him.

Adam Ward said:‘I am excited to take up this opportunity to join Chatham House's executive leadership and to work with Robin Niblett and his senior management team. Chatham House has a well-deserved reputation for rigour and excellence in its research and for providing insights and solutions across a comprehensive range of international challenges. Chatham House's capacity for inter-disciplinary research is one of its distinctive strengths, and I look forward to ensuring its ideas are brought to bear on an ever more complex policy environment.’ 

Editor's notes

About Chatham House

Chatham House, the Royal Institute of International Affairs, is an independent policy institute based in London. Its mission is to help build a sustainably secure, prosperous and just world. Founded in 1920, Chatham House engages governments, the private sector, civil society and its members in open debate and confidential discussion on the most significant developments in international affairs. Each year, the institute runs more than 300 private and public events – conferences, workshops and roundtables – in London and internationally with partners. Its convening power attracts world leaders and the best analysts in their respective fields from across the globe.

About Adam Ward

As director of studies of the IISS, Adam Ward has since 2009 led the execution of the Institute’s worldwide research activities, including setting priorities, raising funds and the management of a research staff distributed across four international offices. Between 2009 and 2014 he organized the annual series of IISS Global Strategic Review conferences. He represents the institute internationally among its audiences in government, the expert community and business.

Adam was previously, from 2006, executive director of the IISS office in Washington DC, where he led the relocation of the office to larger premises, an expansion in its staff, the development of a busy events programme and research activities and acted as the institute’s principal liaison with US government agencies and the Washington-based diplomatic and academic community. Prior to this, he served from 2001 simultaneously as the IISS senior fellow for East Asian security and editor of Strategic Comments, a series of analytical briefing papers on global topics.

He began his career in 1997 as an analyst and editor at the consulting firm Oxford Analytica, focusing on the Asia-Pacific region. He holds a bachelor’s degree in German and Politics and an MA in International Relations, both from the University of Warwick, and also studied for one academic year at the University of Salzburg in Austria.




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Chatham House appoints Tim Benton as Research Director for Energy, Environment and Resources

30 May 2019

Chatham House is pleased to announce that Professor Tim Benton has been appointed as research director of the Energy, Environment and Resources Department.

He brings substantial expertise on food systems and environmental change to the role and will focus on establishing new initiatives at the intersection of research and policymaking.

Tim was appointed as a distinguished visiting fellow of Chatham House in the Energy, Environment and Resources Department in 2016. He has since contributed to the institute in a number of ways, not least through leading the GCRF-AFRICAP project which aims to enhance policy making in Sub-Saharan Africa, through building climate-smart food systems.

Tim’s research focuses on food security and building food systems that are resilient and sustainable, working within the broader areas of ecology, natural resources and climate change impacts. He has published over 150 academic papers, most tackling the core themes of agriculture’s environmental impact and more generally how systems respond to environmental change. He is a lead author of the upcoming Intergovernmental Panel on Climate Change (IPCC) special report on climate change and land. He is also coordinating lead author on international risks for the UK’s Climate Change Risk Assessment, which draws on his broader interests in sustainable finance, trade and energy. He has advised other governments as well as global companies on related issues.

Tim joins Chatham House in his new capacity from the University of Leeds where he is dean of strategic research initiatives. Prior to this, from 2011 to 2016, Tim was the champion of the UK’s Global Food Security programme, a large multi-agency partnership of the UK’s public bodies involved in addressing challenges around food. He has also been research dean in the Faculty of Biological Sciences, and head of department, at Leeds.

Dr Robin Niblett, director of Chatham House, said: 'Tim’s wealth of experience will be especially valuable as we build up our interdisciplinary Chatham House research theme of promoting sustainable growth. We look forward to welcoming Tim to his new role in early July.'

Tim Benton said: 'I am honoured to be joining Chatham House as Research Director for Energy, Environment and Resources. Chatham House has a global reputation in these areas, on which we can build. Informed analysis, combined with effective action to transition towards sustainable economies, is needed now, more than ever.'

About the Energy, Environment and Resources Department

The Energy, Environment and Resources department at Chatham House seeks to advance the international debate on energy, environment and development policy and to influence and enable decision-makers – governments, NGOs and business – to take well-informed decisions that contribute to achieving sustainable development. Independent of any actor or ideology, we do this by carrying out innovative research on major policy challenges, bringing together diverse perspectives and constituencies and injecting new ideas into the international arena.

Tim Benton takes over the role from Rob Bailey who has joined Marsh & McLennan Insights as Director, Climate Resilience.




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Webinar: Director's Briefing – US Elections: The Road to November 2020

Corporate Members Event Webinar Partners and Major Corporates

16 April 2020 - 1:00pm to 2:00pm

Online

Event participants

Edward Luce, US National Editor and Columnist, Financial Times
Dr Lindsay Newman, Senior Research Fellow, US and the Americas Programme, Chatham House
Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

As the coronavirus crisis deepens globally, the effects have reverberated through the American economy, and in only a few short weeks, the US presidential election race has changed beyond recognition. Unemployment claims have hit unprecedented levels and look set to continue to rise with stark warnings that the worst is still to come. Polling, however, has suggested that over half the country approves of the way President Trump is handling the crisis. No issue is likely to be more important to voters come November than the recovery and rebuilding of America once the pandemic subsides.
 
In this discussion, Ed Luce and Dr Lindsay Newman will examine the new uncertain outlook for the November 2020 election and discuss how it might play out in these challenging circumstances. Where are we versus where we thought we would be at this point in the election cycle? What should we be watching for in the coming months as the US looks to hold elections in these uncharted waters? Will the elections effectively become a referendum on Trump’s handling of the coronavirus pandemic? And what will this mean for potential policy priorities of the president?

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to rsvp@chathamhouse.org.




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Webinar: Director's Briefing – Democracy in the Americas

Corporate Members Event Webinar Partners and Major Corporates

30 April 2020 - 1:00pm to 2:00pm

Online

Event participants

Luis Almagro, Secretary General, Organization of American States (OAS); Foreign Minister, Uruguay (2010-15)
Respondent: Dr Elena Lazarou, Associate Fellow, US and the Americas Programme, Chatham House
Respondent: Dr Christopher Sabatini, Senior Research Fellow for Latin America, US and the Americas Programme, Chatham House
Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

As governments in the Americas grapple with the economic and health emergencies posed by COVID-19, the region continues to face socioeconomic and political challenges reflected in the protests that erupted in many countries in 2019. According to an annual survey by Latinóbarometro, of 18 countries across Latin America, trust in government dropped from 45 per cent in 2009 to 22 per cent in 2018, and those expressing dissatisfaction with democracy has increased from 51 per cent to 71 per cent. 

Recently re-elected to a new term, Luis Almagro, secretary general of the Organization of American States, will reflect on the state of democracy in the Americas. What are the greatest threats and opportunities to democratic governance and political participation in the region? How can multilateral organizations and states defend democratic institutions and human rights in a changing global environment? To what extent might the ongoing COVID-19 pandemic provide leaders with an opportunity to undemocratically consolidate power? Or, conversely, might the crisis spark a new understanding of the social contract between states and governed and greater consensus around national policies and leadership?  

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to lbedford@chathamhouse.org.




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Webinar: Director's Briefing – National Leadership in Times of Crisis

Corporate Members Event Webinar Partners and Major Corporates

14 May 2020 - 6:00pm to 7:00pm
Add to Calendar

Online

Janet Napolitano, President, University of California; US Secretary of Homeland Security (2009-13)

Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

Across the globe, leaders on the local, national and international levels are grappling with the impacts of COVID-19 on their communities and the economy. But the coronavirus pandemic is just one of several existential crises the world is currently facing. Climate change, political instability and growing tensions with China and Russia, along with a lack of strong global leadership, has made it more difficult for individual nations to respond and coalesce in times of crisis.

This discussion will explore how leaders at all levels can best negotiate both the practical issues and the larger questions associated with these ‘grand challenges’. How is current US foreign policy affecting our collective ability to respond to issues such as pandemics or climate change? Has the COVID-19 crisis cemented the US retreat from global leadership and if so, who might step into the breach? How do we maintain momentum on other issues in the midst of a public health disaster of this magnitude? And what is the role of the business community, higher education institutions and other sectors in responding to these crises and shaping future public policy?

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to lbedford@chathamhouse.org.




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Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

S Xu
Jul 1, 1997; 38:1289-1298
Articles




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Direct transesterification of all classes of lipids in a one-step reaction

G Lepage
Jan 1, 1986; 27:114-120
Articles




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Webinar: Director's Briefing – China's Economic Outlook

Corporate Members Event Webinar Partners and Major Corporates

8 April 2020 - 1:00pm to 2:00pm

Online

Event participants

Dr Yu Jie, Senior Research Fellow on China, Asia-Pacific Programme, Chatham House
James Kynge, Global China Editor, Financial Times; Editor, Tech Scroll Asia
Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

Only a few months into 2020, the coronavirus pandemic has presented a huge challenge for China’s ruling party against an already tumultuous 12 months of economic slowdown coupled with an increasingly hostile international environment. The crisis looks set to worsen a deteriorating relationship between the US and China as the two countries battle to avoid further economic ramifications. It has also undermined President Xi Jinping and the Chinese Communist Party’s domestic political legitimacy and economic growth.

The panellists will examine the wider geopolitical fallout of the coronavirus pandemic and discuss China’s future economic planning. How will the COVID-19 outbreak further strain the US-China relationship? What effect will this have on global trade and vulnerable supply chains at a time when cooperation is needed more than ever? And to what extent is the ruling party addressing growing concerns over job losses, wealth inequality and a lack of social mobility?

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to Linda Bedford.




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Webinar: Director's Briefing – US Elections: The Road to November 2020

Corporate Members Event Webinar Partners and Major Corporates

16 April 2020 - 1:00pm to 2:00pm

Online

Event participants

Edward Luce, US National Editor and Columnist, Financial Times
Dr Lindsay Newman, Senior Research Fellow, US and the Americas Programme, Chatham House
Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

As the coronavirus crisis deepens globally, the effects have reverberated through the American economy, and in only a few short weeks, the US presidential election race has changed beyond recognition. Unemployment claims have hit unprecedented levels and look set to continue to rise with stark warnings that the worst is still to come. Polling, however, has suggested that over half the country approves of the way President Trump is handling the crisis. No issue is likely to be more important to voters come November than the recovery and rebuilding of America once the pandemic subsides.
 
In this discussion, Ed Luce and Dr Lindsay Newman will examine the new uncertain outlook for the November 2020 election and discuss how it might play out in these challenging circumstances. Where are we versus where we thought we would be at this point in the election cycle? What should we be watching for in the coming months as the US looks to hold elections in these uncharted waters? Will the elections effectively become a referendum on Trump’s handling of the coronavirus pandemic? And what will this mean for potential policy priorities of the president?

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to rsvp@chathamhouse.org.




dir

Webinar: Director's Briefing – Democracy in the Americas

Corporate Members Event Webinar Partners and Major Corporates

30 April 2020 - 1:00pm to 2:00pm

Online

Event participants

Luis Almagro, Secretary General, Organization of American States (OAS); Foreign Minister, Uruguay (2010-15)
Respondent: Dr Elena Lazarou, Associate Fellow, US and the Americas Programme, Chatham House
Respondent: Dr Christopher Sabatini, Senior Research Fellow for Latin America, US and the Americas Programme, Chatham House
Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

As governments in the Americas grapple with the economic and health emergencies posed by COVID-19, the region continues to face socioeconomic and political challenges reflected in the protests that erupted in many countries in 2019. According to an annual survey by Latinóbarometro, of 18 countries across Latin America, trust in government dropped from 45 per cent in 2009 to 22 per cent in 2018, and those expressing dissatisfaction with democracy has increased from 51 per cent to 71 per cent. 

Recently re-elected to a new term, Luis Almagro, secretary general of the Organization of American States, will reflect on the state of democracy in the Americas. What are the greatest threats and opportunities to democratic governance and political participation in the region? How can multilateral organizations and states defend democratic institutions and human rights in a changing global environment? To what extent might the ongoing COVID-19 pandemic provide leaders with an opportunity to undemocratically consolidate power? Or, conversely, might the crisis spark a new understanding of the social contract between states and governed and greater consensus around national policies and leadership?  

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to lbedford@chathamhouse.org.




dir

A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice [Neurobiology]

Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two–hybrid screen for interactions between murine RNA-binding proteins (RBPs) and motor proteins, here we identified protein interaction with APP tail-1 (PAT1) as a potential direct adapter between zipcode-binding protein 1 (ZBP1, a β-actin RBP) and the kinesin-I motor complex. The amino acid sequence of mouse PAT1 is similar to that of the kinesin light chain (KLC), and we found that PAT1 binds to KLC directly. Studying PAT1 in mouse primary hippocampal neuronal cultures from both sexes and using structured illumination microscopic imaging of these neurons, we observed that brain-derived neurotrophic factor (BDNF) enhances co-localization of dendritic ZBP1 and PAT1 within granules that also contain kinesin-I. PAT1 is essential for BDNF-stimulated neuronal growth cone development and dendritic protrusion formation, and we noted that ZBP1 and PAT1 co-locate along with β-actin mRNA in actively transported granules in living neurons. Acute disruption of the PAT1–ZBP1 interaction in neurons with PAT1 siRNA or a dominant-negative ZBP1 construct diminished localization of β-actin mRNA but not of Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) mRNA in dendrites. The aberrant β-actin mRNA localization resulted in abnormal dendritic protrusions and growth cone dynamics. These results suggest a critical role for PAT1 in BDNF-induced β-actin mRNA transport during postnatal development and reveal a new molecular mechanism for mRNA localization in vertebrates.




dir

Webinar: Director's Briefing – National Leadership in Times of Crisis

Corporate Members Event Webinar Partners and Major Corporates

14 May 2020 - 6:00pm to 7:00pm
Add to Calendar

Online

Janet Napolitano, President, University of California; US Secretary of Homeland Security (2009-13)

Chair: Dr Robin Niblett, Director and Chief Executive, Chatham House

Across the globe, leaders on the local, national and international levels are grappling with the impacts of COVID-19 on their communities and the economy. But the coronavirus pandemic is just one of several existential crises the world is currently facing. Climate change, political instability and growing tensions with China and Russia, along with a lack of strong global leadership, has made it more difficult for individual nations to respond and coalesce in times of crisis.

This discussion will explore how leaders at all levels can best negotiate both the practical issues and the larger questions associated with these ‘grand challenges’. How is current US foreign policy affecting our collective ability to respond to issues such as pandemics or climate change? Has the COVID-19 crisis cemented the US retreat from global leadership and if so, who might step into the breach? How do we maintain momentum on other issues in the midst of a public health disaster of this magnitude? And what is the role of the business community, higher education institutions and other sectors in responding to these crises and shaping future public policy?

This event is only open to Major Corporate Member and Partner organizations and selected giving circles of Chatham House. If you'd like to attend, please RSVP to lbedford@chathamhouse.org.




dir

Direct Democracy: Participation Without Populism?