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Method of separating uranium from irradiated nuclear fuel

The invention provides a method of separating uranium from at least fission products in irradiated nuclear fuel, said method comprising reacting said irradiated nuclear fuel with a solution of ammonium fluoride in hydrogen fluoride fluorinating said reacted irradiated nuclear fuel to form a volatile uranium fluoride compound and separating said volatile uranium fluoride compound from involatile fission products. The invention thus provides a reprocessing scheme for irradiated nuclear fuel. The method is also capable of reacting, and breaking down Zircaloy cladding and stainless steel assembly components. Thus, whole fuel elements may be dissolved as one thereby simplifying procedures over conventional Purex processes.




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Method of chemical decontamination and system therefor

In a chemical decontamination method of chemically decontaminating radioactive nuclides from a metallic material, oxalic acid and hydrazine are injected as a reductive decontaminating agent into water that is in contact with the metallic material. Injection of the hydrazine is stopped after a cation resin arranged in a circulation line connected to the metallic material breaks, and at least the oxalic acid and the hydrazine in the reductive decontaminating agent are decomposed using a decomposing catalyst.




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Container and method for transporting a syringe containing radioactive material

A method and apparatus for transporting syringes containing radioactive material. The apparatus includes a radiopharmaceutical pig having an inner chamber in which a sharps container can be secured. The sharps container has a housing and an attachable cap. The method includes assembling the radiopharmaceutical pig so that the chamber of the radiopharmaceutical pig contains the syringe in the sharps container housing. The radiopharmaceutical pig is disassembled, where upon the syringe is removed, discharged, and then replaced in the sharps container housing. The cap of the sharps container is affixed to the housing of the sharps container, thus enclosing the contaminated syringe therein. The radiopharmaceutical pig is assembled so that its chamber contains the sharps container and the syringe. The radiopharmaceutical pig is transported to a disposal area, where it is disassembled and the sharps container containing the syringe is placed in a particular disposal container.




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Container and method for transporting a syringe containing radioactive material

A method and apparatus for transporting syringes containing radioactive material. The apparatus includes a radiopharmaceutical pig having an inner chamber in which a sharps container can be secured. The sharps container has a housing and an attachable cap. The method includes assembling the radiopharmaceutical pig so that the chamber of the radiopharmaceutical pig contains the syringe in the sharps container housing. The radiopharmaceutical pig is disassembled, where upon the syringe is removed, discharged, and then replaced in the sharps container housing. The cap of the sharps container is affixed to the housing of the sharps container, thus enclosing the contaminated syringe therein. The radiopharmaceutical pig is assembled so that its chamber contains the sharps container and the syringe. The radiopharmaceutical pig is transported to a disposal area, where it is disassembled and the sharps container containing the syringe is placed in a particular disposal container.




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System and method for chemical decontamination of radioactive material

A method for chemically decontaminating radioactive material. The method includes reducing-dissolving step for setting surface of radioactive material in contact with reducing decontamination liquid including mono-carboxylic acid and di-carboxylic acid as dissolvent; and oxidizing-dissolving step for setting the surface of the radioactive material in contact with oxidizing decontamination liquid including oxidizer. The method may include repeated pairs of steps, each pair including the reducing-dissolving step and the oxidizing-dissolving step. The mono-carboxylic acid may include formic acid, and the di-carboxylic acid includes oxalic acid. The oxidizer may be ozone, permanganic acid or permanganate.




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Device for inspecting plant parts located under water

A device for inspecting submersed plant parts is particularly suited for ultrasonic inspection of screws in the core baffle of a nuclear reactor pressure vessel. The device includes a remote-controlled underwater vehicle that is provided at its end face with a carrier that can be pivoted about a pivot axis oriented parallel to the longitudinal central axis of the underwater vehicle, and is provided with a holding device for an inspection head that is arranged on the carrier spaced apart from the pivot axis.




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High temperature cooling system and method

A method for cooling a heat source, a method for preventing chemical interaction between a vessel and a cooling composition therein, and a cooling system. The method for cooling employs a containment vessel with an oxidizable interior wall. The interior wall is oxidized to form an oxide barrier layer thereon, the cooling composition is monitored for excess oxidizing agent, and a reducing agent is provided to eliminate excess oxidation. The method for preventing chemical interaction between a vessel and a cooling composition involves introducing a sufficient quantity of a reactant which is reactive with the vessel in order to produce a barrier layer therein that is non-reactive with the cooling composition. The cooling system includes a containment vessel with oxidizing agent and reducing agent delivery conveyances and a monitor of oxidation and reduction states so that proper maintenance of a vessel wall oxidation layer occurs.




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Foam and gel methods for the decontamination of metallic surfaces

Decontamination of nuclear facilities is necessary to reduce the radiation field during normal operations and decommissioning of complex equipment. In this invention, we discuss gel and foam based diphosphonic acid (HEDPA) chemical solutions that are unique in that these solutions can be applied at room temperature; provide protection to the base metal for continued applications of the equipment; and reduce the final waste form production to one step. The HEDPA gels and foams are formulated with benign chemicals, including various solvents, such as ionic liquids and reducing and complexing agents such as hydroxamic acids, and formaldehyde sulfoxylate. Gel and foam based HEDPA processes allow for decontamination of difficult to reach surfaces that are unmanageable with traditional aqueous process methods. Also, the gel and foam components are optimized to maximize the dissolution rate and assist in the chemical transformation of the gel and foam to a stable waste form.




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Power source for re-circulation pump and method of controlling the same

A variable-voltage variable-frequency power source for an electric motor that drives a re-circulation pump for a boiling water nuclear reactor. The power source has a semiconductor electric power converter and a speed controller for controlling the semiconductor electric power converter. When a part of the semiconductor electric power converter comes into an inoperative state, that part is electrically disconnected, and the variable-voltage variable-frequency power source temporarily stops outputting power, thereby idling the re-circulation pump. Thereafter, the power source re-starts outputting power before the re-circulation pump completely stops. Thus, the re-circulation pump keeps operating, without stopping.




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Three-piece frame assembly for window of enclosure

Frames are disclosed for mounting windows within the walls of enclosures for isolating or sealing substances such as radioactive or other hazardous substances from the surrounding environment. In a first embodiment of the present invention, a window assembly includes a two-piece frame that is welded into the wall of an enclosure. In a second embodiment of the present invention, a window assembly includes a three-piece frame that is clamped to the wall of an enclosure. The frame assemblies may also be used to mount structures other than windows to enclosure walls, such as ducts or pipes intended for passing power, gas, vacuum, or other utilities into the interior of an enclosure.




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Apparatus and method for mounting and moving a working apparatus on a structure for the performance of works on the structure

A working apparatus has: a working equipment for doing works on a structure; an operation mechanism adapted to actively move the working equipment relative to the structure; and an adhering/traveling module coupled to the operation mechanism and adapted to adhere to the structure so as to have the weight of the working apparatus borne by the structure and travel/move on the structure for positioning. With this arrangement, the working apparatus can perform accurate positioning operations in a narrow environment and complex scanning operations by means of various pieces of the working equipment such as inspection sensors, and can secure a large working area within a short period of time and reduce the overall working hours.




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Power conversion circuitry

One form of the invention is directed to an apparatus that comprises step-down circuitry to better match impedance between an input and an output that includes a number of stages each electrically coupled to another and each including a charge storage device. The circuitry further includes a number of switching devices operable in a first electrical connectivity state to connect the charge storage device of each of the stages in series to receive electrical charge from the input and in a second electrical connectivity state opposite the first state to connect the charge storage device of each of the stages in parallel to discharge electricity through the output. This circuitry can be used in connection with a radioisotopic conversion cell.




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Vol-oxidizer for spent nuclear fuel

A vol-oxidizer of spent nuclear fuel, the spent nuclear fuel is injected to a reaction portion, the reaction portion is connected to a driving portion and oxidizes the spent nuclear fuel by rotating and back-rotating the spent nuclear fuel. The oxidized powder of the spent nuclear fuel is gathered in a discharge portion located in a lower portion of the reaction portion. By providing minute powder particles for recycling and a post process of the spent nuclear fuel, even though a size of an apparatus is small, processing a large amount is possible. Time required for oxidation can be reduced, and the powder is readily discharged by gravity since the apparatus is vertically configured.




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Separation and receiving device for spent nuclear fuel rods

Disclosed is a separation and receiving apparatus for a spent nuclear fuel rod. The spent nuclear fuel rod is mounted and downwardly transferred by a pin. At this time, a blade peels the hull of the spent nuclear fuel rod. The hull and a pellet positioned therein are separated by a separator. The peeled hull and pellet are each received in respective receiving vessels. Accordingly, since the hull and pellet made of uranium oxide (UO2) may be automatically separated and received in each respective vessel, safety and automation may be guaranteed.




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Hydrogen combustion system

A hydrogen combustion system comprising: an external cylinder 1 constituting the exterior of a double tube construction; an internal cylinder 2 formed by a porous metal plate constituting the interior of said double tube construction; hydrogen combustion catalyst 4 supported with precious metals on spherical ceramic support surface, formed in pellet state, being packed in said internal cylinder 2; an insert pipe 3 formed by porous metal plate inserted in the center of said internal cylinder 2; pre-heating heaters 5 installed between said insert pipe 3 and said internal cylinder 2 to preheat said hydrogen combustion catalyst 4 to ambient atmosphere of over catalytic reaction temperatures; a hydrogen introducing port 8 connecting to said insert pipe 3; an air introducing port 9 provided at the bottom of said external cylinder 1 in the area between said external cylinder 1 and said internal cylinder 2, wherein air for hydrogen combustion is introduced by the drift effect resulting from the differential pressure generated between the packed layer of hydrogen combustion catalyst and the outside, by thermal convection, achieving safe combustion treatment of hydrogen in simple construction, small size and high treatment efficiency.




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Liquid radioactive waste treatment system

The present invention relates to a liquid radioactive waste treatment system. The liquid radioactive waste treatment system includes a plurality of evaporation plates and each of the evaporation plates has an uneven surface, in a housing comprised of a glass. A liquid radioactive waste is dispersed via a liquid waste dispersing unit to the evaporation plate, and the liquid radioactive waste is evaporated using solar heat and airflow in the housing.




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Flexible glove holder used in the opening of a glove box

The flexible glove holder (1) includes a flat structure (13) with three branches (2, 3 and 4) forming an S-shape on which the glove is wound. The holder (1) is then pushed into the opening of the glove box. This rapid action method makes it possible to avoid knotting the gloves when they must be drawn toward the outside for an operation within the box and also allows the implementation of biological protection on the opening of the glove box as well as a protection of the agents against radiation.




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Low sintering temperature glass waste forms for sequestering radioactive iodine

Materials and methods of making low-sintering-temperature glass waste forms that sequester radioactive iodine in a strong and durable structure. First, the iodine is captured by an adsorbant, which forms an iodine-loaded material, e.g., AgI, AgI-zeolite, AgI-mordenite, Ag-silica aerogel, ZnI2, CuI, or Bi5O7I. Next, particles of the iodine-loaded material are mixed with powdered frits of low-sintering-temperature glasses (comprising various oxides of Si, B, Bi, Pb, and Zn), and then sintered at a relatively low temperature, ranging from 425° C. to 550° C. The sintering converts the mixed powders into a solid block of a glassy waste form, having low iodine leaching rates. The vitrified glassy waste form can contain as much as 60 wt % AgI. A preferred glass, having a sintering temperature of 500° C. (below the silver iodide sublimation temperature of 500° C.) was identified that contains oxides of boron, bismuth, and zinc, while containing essentially no lead or silicon.




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Two-piece frame assembly for window of enclosure

Frames for mounting windows within the walls of enclosures for isolating or sealing substances such as radioactive or other hazardous substances from the surrounding environment. In a first embodiment of the present invention, a window assembly includes a two-piece frame that is welded into the wall of an enclosure. In a second embodiment of the present invention, a window assembly includes a three-piece frame that is clamped to the wall of an enclosure. The frame assemblies may also be used to mount structures other than windows to enclosure walls, such as ducts or pipes intended for passing power, gas, vacuum, or other utilities into the interior of an enclosure.




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System and method for a self-charging battery cell

A system and method for a self-charging battery cell are provided in which beta emissions from a Strontium-90 source are obtained by a sensor device and converted into electric energy. In embodiments, a scintillation device is used to intake emissions from a Strontium-90 source, and consequently emit a light or plurality of light flashes. A sensor device, e.g., a photodiode, is utilized to convert the light or plurality of light flashes into electric voltage, current and/or energy.




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Mixed-layered bismuth-oxygen-iodine materials for capture and waste disposal of radioactive iodine

Materials and methods of synthesizing mixed-layered bismuth oxy-iodine materials, which can be synthesized in the presence of aqueous radioactive iodine species found in caustic solutions (e.g. NaOH or KOH). This technology provides a one-step process for both iodine sequestration and storage from nuclear fuel cycles. It results in materials that will be durable for repository conditions much like those found in Waste Isolation Pilot Plant (WIPP) and estimated for Yucca Mountain (YMP). By controlled reactant concentrations, optimized compositions of these mixed-layered bismuth oxy-iodine inorganic materials are produced that have both a high iodine weight percentage and a low solubility in groundwater environments.




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Nuclear fuel cell repair tool

A method of repairing a nuclear fuel cell wall and tools useful for performing that repair are described. A repair tool may be used to align a jack near a region of a bent or distorted structural component of nuclear fuel cell and that jack may be used to apply a force to that structural component. Application of such a force may serve to bend the structural component of a nuclear fuel cell in a way to restore the structural component to its position before damage occurred. The repair tool includes a way of mounting that tool to a fuel cell, positioning elements to align the tool near a structural deformation or bent element and a jack that may be use to apply a force to at least one structural component in a fuel cell.




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Nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Illustrative embodiments provide a nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system.




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Reactor installation and removal tools

A reactor installation tool and method for installing a reactor unit in a reactor tube. A reactor installation tool including a movable assembly and a fixed assembly linked together such that the movable assembly can be adjusted relative to the fixed assembly. The movable assembly including a reactor sleeve attachment means for releasably securing a reactor sleeve loaded with a reactor unit to the tool. The fixed assembly including an expandable clamping unit for releasably securing the tool to a reactor tube. A reactor unit can be installed in the reactor tube by adjusting the movable assembly to extract the reactor unit from the reactor sleeve as the fixed assembly is rigidly secured to the reactor tube. The fixed assembly can be released from the reactor tube and the reactor installation tool can be removed from the reactor tube.




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Method for recovery of residual actinide elements from chloride molten salt

A method for recovery of residual actinide element from chloride molten salts that are formed after electro-refining and/or electro-winning of a spent nuclear fuel and include actinide elements and rare-earth elements is provided. The method comprises conducting electrolysis using a liquid cadmium cathode (LCC) in the chloride molten salt that is formed after electro-refining and/or electro-winning of a spent nuclear fuel and contains rare-earth elements and actinide elements; electro-depositing the actinide elements contained in the chloride molten salt on the LCC in order to reduce a concentration of the actinide elements; and adding a CdCl2 oxidant to the chloride molten salt containing the LCC-metal alloy in order to oxidize the rare-earth elements co-deposited on the LCC, thereby forming the rare-earth chlorides in the chloride molten salt.




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Compositions and methods for treating nuclear fuel

Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided.




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Method for designing a fuel assembly optimized as a function of the stresses in use in light-water nuclear reactors, and resulting fuel assembly

A method for design of a fuel assembly for nuclear reactors, including structural components made from zirconium alloy: the mean uniaxial tensile or compressive stress to which the components are subjected during the assembly life is calculated, the zirconium alloy of which the components are made is selected according to the following criteria: those components subjected to an axial or transverse compressive stress of between −10 et −20 MPa are made from an alloy with a content of Sn between Sn=(=0.025σ−0.25)% and Sn=−0.05σ%: those components subjected to such a stress of between 0 et −10 MPa are made from an alloy the Sn content of which is between Sn=traces and Sn=(0.05σ+1)%: those components subjected to such a stress of between 0 and +10 MPa are made from an alloy the Sn content of which is between Sn=0.05% and Sn=(0.07σ+1)%: and those components subjected to such a stress of between +10 and +20 MPa are made from an alloy the content of SN of which is between 0.05% and 1.70%. A fuel assembly made according to the method.




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System for injecting mortar into a container

A method of injecting mortar into a container fastened to a first tank and to a second tank, the first tank communicating with the container via a first orifice and the second tank communicating with the container by a second orifice, the method comprising the following operations: a continuous circulation of a first stream of mortar is made to flow in a circulation loop; during the continuous circulation, a second stream of mortar is drawn off from the circulation loop, the second stream being smaller than the first stream of mortar; the second stream of mortar is injected into the container, ensuring that there is dynamic confinement of the gaseous effluents; and the appearance of mortar in the second tank is monitored and, when this appearance is detected, the removal of mortar from the circulation loop is brought to an end.




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Compositions and methods for treating nuclear fuel

Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided.




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Storage rack arrangement for the storage of nuclear fuel elements

A storage rack arrangement (10) for the storage of nuclear fuel elements in a storage pool includes at least two storage racks (1.1-1.3) which each contain a plurality of vertical channels (9) arranged next to one another for the reception of the fuel elements, with positioning elements (6) being provided at the storage racks at the bottom. The storage racks are connected to one another at the top and the storage rack arrangement (10) additionally includes one or more base plates (2.1-2.3) which are provided with positioning members (8) which fit with the positioning elements (6) of the storage racks (1.1-1.3) and which, together with the positioning elements, position the storage racks with respect to the base plate or base plates (2.1-2.3) to prevent a displacement of the storage racks on the base plate or plates.




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Apparatus for treating radioactive nitrate waste liquid

An apparatus for treating a radioactive nitrate waste liquid includes: a denitrification tank (12) that accommodates active sludge which adsorbs or takes in a radioactive substance in a nitrate waste liquid (11) containing nitrate and the radioactive substance and in which an anaerobic microorganism that reduces the nitrate to nitrogen gas grows; a reaeration tank (14) that aerates and mixes a denitrification-treated liquid (24) treated in the denitrification tank (12) with the active sludge in which the aerobic microorganism grows; and a sludge dissolution tank (81) that dissolves redundant sludge (26A, 26B) discharged from the denitrification tank (12) and the reaeration tank (14). Acetic peracid (80) is supplied to the sludge dissolution tank (81) to dissolve redundant sludge, a sludge lysate is supplied to the denitrification tank (12) as a carbon source (22), and acetic acid is supplied to the denitrification tank (12).




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Nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Illustrative embodiments provide a nuclear fission reactor, a vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system.




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Method of installing reactor units

A reactor installation tool and method for installing a reactor unit in a reactor tube. A reactor installation tool including a movable assembly and a fixed assembly linked together such that the movable assembly can be adjusted relative to the fixed assembly. The movable assembly including a reactor sleeve attachment means for releasably securing a reactor sleeve loaded with a reactor unit to the tool. The fixed assembly including an expandable clamping unit for releasably securing the tool to a reactor tube. A reactor unit can be installed in the reactor tube by adjusting the movable assembly to extract the reactor unit from the reactor sleeve as the fixed assembly is rigidly secured to the reactor tube. The fixed assembly can be released from the reactor tube and the reactor installation tool can be removed from the reactor tube.




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Method for measuring the neutron flux in the core of a nuclear reactor using a cobalt detector and associated device

A method for measuring the neutron flux in the core of a nuclear reactor, the method including several steps recurrently performed at instants separated by a period, the method comprising at each given instant the following steps: acquiring a total signal by a cobalt neutron detector placed inside the core of the reactor; assessing a calibration factor representative of the delayed component of the total signal due to the presence of cobalt 60 in the neutron detector; assessing a corrected signal representative of the neutron flux at the detector from the total signal and from the calibration factor; assessing a slope representative of the time-dependent change of the calibration factor between the preceding instant and the given instant; the calibration factor at the given instant being assessed as a function of the calibration factor assessed at the preceding instant, of the slope, and of the time period separating the given instant from the preceding instant.




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Method for drying spent filter media

Disclosed is a process of stabilizing spent filter material that comprises mixing the filter media with a city media to produce a composition having a moisture content that is sufficiently low to retard microbial growth. The composition comprises spent filter media and a dry material, and preferably comprises diatomaceous earth. Soil is treated by adding the composition as a top dressing, soil amendment, or the like.




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Insulation cassette for the heat insulation of elongated elements

Length adjustment can be performed in a simple manner and without impairment of the insulating effect in an insulation cassette for the heat insulation of elongated elements. A multilayer insulation includes flat reflection elements (21, 22). Each layer of the insulation has at least two of the flat reflection elements (21, 22), which overlap at least partly at their ends (24) facing each other.




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Fine motion control rod drive mechanism handling apparatus and method of handling fine motion control rod drive mechanism

A fine motion control rod drive mechanism handling apparatus attaches a fine motion control rod drive mechanism having a control rod drive mechanism body, a spool piece, a motor bracket and a motor unit to a reactor pressure vessel, and detaches it from the reactor pressure vessel. The fine motion control rod drive mechanism handling apparatus is provided with a bolt wrench assembly, a motor unit attachment mounted to the bolt wrench assembly, for meshing a first gear of a first gear coupling on a spool piece side with a second gear of a second gear coupling on a motor unit side, and a rotation mechanism mounted to the bolt wrench assembly, for rotating the motor unit attachment.




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Nuclear fission reactor, vented nuclear fission fuel module, methods therefor and a vented nuclear fission fuel module system

Disclosed embodiments include methods of assembling a vented nuclear fission fuel module. Given by way of non-limiting example and not of limitation, an illustrative method of assembling a vented nuclear fission fuel module includes receiving a nuclear fission fuel element capable of generating a gaseous fission product. A valve body is coupled to the nuclear fission fuel element, and the valve body defines a plenum therein for receiving the gaseous fission product. A valve is disposed in communication with the plenum for controllably venting the gaseous fission product from the plenum. A flexible diaphragm is coupled to the valve for moving the valve. A cap is mounted on the valve, and a manipulator extendable to the cap for manipulating the cap is received.




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Polypeptides with permease activity

The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.




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Induction of gene expression using a high concentration sugar mixture

Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.




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Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions

Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.




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Pharmaceutical formulations comprising an insulin derivative

The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase the tendency of the insulin derivative to self-associate into dodecamers. The invention further comprises a process for preparing the soluble pharmaceutical formulation.




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Method of lowering cholesterol and triglycerides by administering exendins

Provided herein are pharmaceutical formulations containing exendins, exendin agonists, or exendin analog agonists that are administered at therapeutic plasma concentration levels over a sustained period of time to lower total cholesterol levels; to lower LDL-cholesterol levels; to lower triglyceride levels; to treat dyslipidemia; to treat and slow the progression of atherosclerosis; and to treat, prevent, and reduce the risk of heart attacks and strokes in patients. In the pharmaceutical formulations and methods of the invention, the exendin may be exendin-4, an exendin-4 agonist, or an exendin-4 analog agonist. The pharmaceutical formulations may be polymer-based pharmaceutical formulations that may be administered once weekly. An exemplary pharmaceutical formulation comprises 5% (w/w) of exenatide, about 2% (w/w) of sucrose, and about 93% (w/w) of a poly(lactide-co-glycolide) polymer, wherein the poly(lactide-co-glycolide) polymer is in the form of microspheres encapsulating the exenatide.




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Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.




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Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof

Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.




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Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids

Acylated insulins wherein an acyl moiety is attached to the parent insulin and wherein the acyl moiety comprises repeating units of alkylene glycol containing amino acids and wherein there is only one lysine residue (K & Lys) in the parent insulin, having satisfactory properties when administered pulmonary.




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Cyclic CRF antagonist peptides

Cyclic CRF antagonist peptides having improved properties of “drugability”. The peptides are 33 residues in length with a lactam bond between the residues in position 22 and 25; however, they may be N-terminally shortened by up to 3 residues.




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Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins

Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.




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Molecularly imprinted surfaces using surface-bound peptides

A method of producing a molecularly-imprinted material comprises synthesizing a peptide, oligosaccharide or oligonucleotide on a disposable surface modified support to produce a support surface-attached peptide, oligosaccharide or oligonucleotide, providing a selected monomer mixture, contacting the monomer mixture with the support surface-attached peptide, oligosaccharide or oligonucleotide, initiating polymerisation or at least one crosslinking reaction, dissolving or degrading the support surface-attached peptide, oligosaccharide or oligonucleotide and support, and obtaining molecularly imprinted material.




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Dual variable domain immunoglobulins and uses thereof

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.