Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

Alterations in calcium signaling in pancreatic acinar cells can result in pancreatitis. Although pressure changes in the pancreas can elevate cytosolic calcium (Ca2+) levels, it is not known how transient pressure-activated elevations in calcium can cause prolonged calcium changes and consequent pancreatitis. In this issue of the JCI, Swain et al. describe roles for the mechanically activated plasma membrane calcium channels Piezo1 and transient receptor potential vanilloid subfamily 4 (TRPV4) in acinar cells. The authors used genetic deletion models and cell culture systems to investigate calcium signaling. Notably, activation of the Piezo1-dependent TRPV4 pathway was independent of the cholecystokinin (CCK) stimulation pathway. These results elegantly resolve an apparent discrepancy in calcium signaling and the pathogenesis of pancreatitis in pancreatic acinar cells.

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

This week saw a couple of big announcements, led by the launch of an update for the 13-inch MacBook Pro line. Most notably, the update brought the improved Magic Keyboard previously introduced on its 16-inch sibling and the MacBook Air, with high-end models also receiving updated processors.

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The second significant announcement this week was that Apple's first all-digital Worldwide Developers Conference will kick off on June 22. Other news this week included a firmware update for the AirPods Pro, an update on Apple's Mini-LED efforts, and more.

Read on below and check out our video above for recaps of all of this week's most important stories!

New 13-Inch MacBook Pro Announced With Magic Keyboard, 10th-Gen Processors, Up to 32GB RAM and 4TB SSD, and More

Apple this week refreshed its 13-inch MacBook Pro lineup, with key features including the same Magic Keyboard as the 16-inch MacBook Pro, up to 80 percent faster Intel graphics than the previous generation, up to 32GB of RAM, up to 4TB of SSD storage, and 6K display support.


First introduced on the 16-inch MacBook Pro last year, the Magic Keyboard features a far more reliable scissor mechanism with 1mm of key travel. After five years, Apple has finally transitioned its entire notebook lineup away from its issue-prone butterfly keyboard.

10th-generation Intel processor options are only available on higher-end models, with the $1,799 configuration proving to be up to 16.5% faster than the $1,299 base model with an older 8th-generation processor.

Apple's Virtual WWDC Event to Kick Off on June 22

Apple has announced that its first-ever online-only WWDC will begin Monday, June 22 via the Apple Developer app and website. The weeklong event will include a virtual keynote, sessions, and labs, with more details to be shared in June. And it's free!


Apple is expected to introduce iOS 14, iPadOS 14, macOS 10.16, tvOS 14, and watchOS 7 at WWDC 2020, with beta testing to take place over the summer.

Student developers from all over the world can enter Apple's Swift Student Challenge by creating an interactive scene in Swift Playgrounds that can be experienced in three minutes. Winners will receive an exclusive WWDC20 jacket and pin set. Submissions are open through May 17.

Apple Updates AirPods Pro Firmware to Version 2D15

Apple this week released a new firmware version 2D15 for the AirPods Pro, replacing version 2C54.


In recent months, some AirPods Pro owners have been complaining about reduced noise cancellation and crackling or static sounds, so users have listened for any improvements following the update.

Perhaps proving how subjective sound quality can be, feedback has been decidedly mixed, with some users noticing an improvement, some noticing no change, and some noticing further degradation to noise cancellation.

Apple has offered some help in the form of two new support documents for users to troubleshoot noise cancellation or crackling sound issues.

10 Tips and Tricks for the iPad Pro Magic Keyboard

Have you recently picked up a new Magic Keyboard for the iPad Pro? Here's a list of our favorite tips and tricks that you need to know.


The tips and tricks relate to adjusting the backlight brightness, customizing the cursor's behavior, enabling tap-to-click on the trackpad, other trackpad gestures, accessing the Emoji keyboard, and more.

Apple's Mini-LED Product Roadmap May Have Been Pushed Back to 2021

Disappointed that the new 13-inch MacBook Pro was not the rumored 14-inch model? That may be due to a slight delay in Apple's plans to release a range of new products with Mini-LED backlit displays.

Kuo believes Apple's first Mini-LED products might not launch until 2021. The analyst has previously said these products would include a new 14.1-inch MacBook Pro, 16-inch MacBook Pro, 12.9-inch iPad Pro, and more.


Kuo has previously said that Mini-LED displays will allow for thinner and lighter product designs, while offering many of the same benefits of OLED displays used on the latest iPhones, including good wide color gamut performance, high contrast and dynamic range, and local dimming for truer blacks.

NFC-Based Digital Key Specification Released Ahead of Apple's Rumored CarKey Feature on iPhone

Amid rumors that Apple is working on a digital "CarKey" feature for iPhone, the Car Connectivity Consortium has announced that its NFC-based Digital Key Release 2.0 specification has been finalized and made available to its members, which includes Apple.


"CarKey" will allow an iPhone or Apple Watch to unlock, lock, and start an NFC-compatible vehicle. Just like credit cards and boarding passes, users will be able to add a digital car key to the Wallet app, eliminating the need to use a physical car key or key fob.

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This article, "Top Stories: New 13" MacBook Pro, WWDC Starts June 22, AirPods Pro Firmware Update, and More" first appeared on MacRumors.com

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With only 37 days until Britain leaves the EU, its biggest foreign and trade policy shift in more than 40 years, divisions over Brexit are redrawing the political landscape.

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results.

The publisher is adding videos of their creators entertaining themselves while sheltering in place.

The post SHUT IN THEATER: What are Dynamite creators in quarantine up to? appeared first on The Beat.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

Disappointing results for malaria drug hydroxychloroquine which has been favoured by Donald Trump and some in the media as a possible treatment for coronavirus.

IBM scientists have developed a new approach to simulate molecules on a quantum computer that may one day help revolutionize chemistry and materials science. The scientists successfully used a seven-qubit quantum processor to address the molecular structure problem for beryllium hydride (BeH2) – the largest molecule simulated on a quantum computer to date. The results demonstrate a path of exploration for near-term quantum systems to enhance our understanding of complex chemical reactions that could lead to practical applications.

IBM today announced the first clients to tap into its IBM Q™ early-access commercial quantum computing systems to explore practical applications important to business and science. They include: JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, Oxford University and University of Melbourne.

IBM has been recognized as a Leader in the Gartner Magic Quadrant for Solid-State Arrays (SSA) for the fourth year in a row.

IBM has been recognized as a storage software Leader in the 2017 Gartner Magic Quadrant for Data Center Backup and Recovery Solutions1. In its Magic Quadrants’, Gartner analysts evaluate technology and solutions with an ‘Ability to Execute’ and a ‘Completeness of Vision’.

IBM Security today announced it has been positioned by Gartner, Inc. as a Leader for the sixth consecutive year in the Magic Quadrant for Enterprise Mobility Management Suites1 for its ability to execute and completeness of vision.

IBM today announced plans to acquire Promontory Financial Group, a global market-leading risk management and regulatory compliance consulting firm. Upon close, the capabilities of Promontory combined with IBM's deep industry expertise and Watson’s cognitive capabilities will directly address the massive operational effort and manual cost of escalating regulation and risk management requirements.

IBM today announced second-quarter 2015 diluted earnings from continuing operations of $3.58 per share, down 15 percent year-to-year. Operating (non-GAAP) diluted earnings from continuing operations were $3.84 per share, compared with operating diluted earnings of $4.43 per share in the second quarter of 2014, a decrease of 13 percent.

IBM today announced that for the seventh consecutive year, Gartner, Inc. has named IBM as a leader in the April 2017 Gartner Magic Quadrant for Multichannel Campaign Management.

IBM today announced second-quarter earnings results.

IBM today announced that Vancouver-based company Fusion Genomics selected IBM’s cloud capabilities to help advance Fusion’s ability to detect pandemics before they happen. Fusion Genomics has developed disruptive DNA and RNA technology that it believes can positively identify infectious diseases and enhance the surveillance of emerging pathogens like MERS, SARS, avian flu, and swine flu.

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IBM today announced its intention to acquire Vivant Digital business (Vivant), a boutique digital and innovation agency based here. This acquisition extends the strategy and design expertise of IBM iX, one of the world’s largest digital agencies and global business design partners, with Vivant talent and expertise to accelerate clients’ digital transformations.

IBM today announced third-quarter earnings results.

IBM announced today two significant quantum processor upgrades for its IBM Q early-access commercial systems. These upgrades represent rapid advances in quantum hardware as IBM continues to drive progress across the entire quantum computing technology stack, with focus on systems, software, applications and enablement.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable December 9, 2017 to stockholders of record November 10, 2017.

IBM today announced it has completed the acquisition of Vivant Digital business (Vivant), a boutique digital and innovation agency based in Australia, to join IBM iX. Financial details were not disclosed.

IBM today announced fourth-quarter and full-year 2017 earnings results.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable March 10, 2018 to stockholders of record February 9, 2018. IBM has paid consecutive quarterly dividends every year since 1916.

IBM today announced a research collaboratory in Singapore, where researchers from IBM intend to collaborate with scientists and engineers from public agencies in Singapore to improve the quality of its urban services. The focus of this research effort will be to use sensor networks to more effectively model, predict and manage the use of natural and physical infrastructure resources – water, transport and energy.  

IBM, which is celebrating its centennial this Thursday, announced that its Watson computer system was honored this evening as the Person Of The Year at the 15th Annual Webby Awards gala in New York City. Earlier this year, Watson captured the international spotlight when it competed on the renowned quiz show Jeopardy! and defeated the show's two most successful and celebrated contestants, Ken Jennings and Brad Rutter.

• Con vigencia de 10 años, Banorte e IBM firman alianza estratégica que permitirá establecer las bases de un nuevo modelo de banca enfocado al cliente, y mejorar sustancialmente sus índices de eficiencia para alcanzar niveles cercanos al 40%, así como retornos sobre capital superiores al 20%. El acuerdo incluye servicios de consultoría y de tecnología, investigación y desarrollo. • “Estamos plenamente satisfechos con el acuerdo logrado, pues este suma el mejor talento humano, tanto de IBM, como de Banorte Ixe, y está en línea con nuestra búsqueda de herramientas tecnológicas para servir a nuestros clientes de manera individualizada”: Alejandro Valenzuela.

IBM and AT&T* today announced they have entered into a definitive agreement for IBM to acquire Sterling Commerce from AT&T for approximately $1.4 billion in cash. The acquisition of the Dublin, OH-based company will expand IBM's ability to help organizations create more intelligent and dynamic business networks by simplifying and automating the way they connect and communicate with customers, partners and suppliers both on-premise or through cloud computing delivery models.

Científicos de IBM (NYSE: IBM) desarrollaron un nuevo enfoque para simular moléculas en una computadora cuántica, lo que podrá un día ayudar a revolucionar la química y la ciencia de los materiales. Los científicos utilizaron con éxito un procesador cuántico de siete bits para abordar el problema de la estructura molecular del hidruro de berilio (BeH2), la molécula más grande simulada en una computadora cuántica hasta la fecha. Los resultados muestran una ruta de exploración para los sistemas cuánticos a corto plazo para realzar nuestra comprensión de las reacciones químicas complejas que podrían conducir a aplicaciones prácticas.

IBM ha revelado IBM 5 en 5: las 5 innovaciones científicas y tecnológicas que en los próximos 5 años tendrán un gran impacto en la manera que funciona el mundo. Todas ellas suponen una importante evolución en computación como nunca antes se había visto.

Como parte de su compromiso por contribuir con la tecnología más innovadora a la resolución de los desafíos y retos que enfrenta el mundo, IBM dio a conocer que seleccionó a CUCEA (Centro Universitario de Ciencias Económico y Administrativas) de la Universidad de Guadalajara (UdeG); a fin de poner en marcha en México la implementación del Programa IBM Skills Academy, con foco en competencias de tecnología de Nube.

IBM anuncia el lanzamiento de IBM Cloud Private, una plataforma de software creada para los clientes que requieren la flexibilidad y capacidad de una nube pública en un ambiente privado. IBM Cloud Private transforma los sistemas de TI (Tecnologías de la Información) en un ambiente de nube flexible para crear un puente hasta las nubes públicas y acelerar el desarrollo de aplicativos.

IBM y PAPALOTE MUSEO DEL NIÑO, anunciaron hoy su alianza para desarrollar y ofrecer dos cursos de formación para profesores de la Ciudad de México. El taller estará basado en el portal web teacherstryscience.org de IBM y representa el compromiso de ambas instituciones por contribuir a la enseñanza de la ciencia y en particular de la astronomía, a través de dispositivos en línea.

IBM (NYSE: IBM) reinventa hoy el correo electrónico empresarial con una nueva oferta de colaboración social freemium que utiliza la tecnología de analítica integrada para dar a los empleados una nueva forma de conversar, encontrar a las personas y la información correcta rápidamente, y hacer su trabajo de manera eficiente. IBM Verse es el resultado de una inversión de US$100 millones en diseño e innovación, y reúne las plataformas líderes cloud, analytics, social y de seguridad de la compañía para transformar el futuro del trabajo.

IBM has successfully prototyped a new software architecture for automating data management, potentially making it easier for researchers to collect usable information from mega-scale data collection projects like the Square Kilometre Array (SKA) global telescope which aims to address unanswered questions about our universe.

La Generación Z, conocida también como la primera generación “digitalmente nativa” (aquellos nacidos entre 1995 y 2010), replanteará los nuevos hábitos de consumo. El estudio ‘Uniquely Generation Z’, publicado por IBM (NYSE: IBM) y la Federación Nacional de Retail -NRF por sus siglas en inglés- encontró que el 98% de los jóvenes de esta generación prefiere comprar en tiendas físicas antes que online.

IBM y Red Hat, líder mundial de software de nube de código abierto, anunciaron un acuerdo en el que IBM adquirirá todas las acciones comunes emitidas y en circulación de Red Hat por USD$190.00 por acción en efectivo, lo que representa un valor total para la empresa de aproximadamente USD$34 mil millones.

La enfermedad de Parkinson es un trastorno neurológico degenerativo crónico que afecta a una de cada 100 personas mayores de 60 años. Se estima que más de 5 millones de personas en el mundo tienen Parkinson y el número está aumentando con la población actual que envejece.

IBM reveló un nuevo estudio acerca de la manera en que los profesionales de marketing y ventas están adoptando soluciones cognitivas o de Inteligencia Artificial (IA). A pesar de que el 64% de los Directores de Marketing -CMOs por sus siglas en inglés- y líderes de ventas encuestados cree que sus industrias estarán listas para adoptar ese tipo de tecnologías en los próximos tres años, sólo 24% de los encuestados cree que tiene una estrategia establecida para hacerlo en la actualidad.