The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

Provided herein are methods of treatment to regenerate, restore or rejuvenate a tissue. Methods include making adult somatic and germ cells pluripotent for administration to a patient. Alternatively, created pluripotent cells may be differentiated to the desired tissue type and administered to a patient to repair or enhance the target tissue.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

The present invention is directed to a Modular Liquid Infusing, Flavoring and Dispensing Device that provides a means to infuse flavor into liquids for variable periods of time prior to dispensing, and after the brewing process, wherein the system provides a means to control the rate at which the liquid is dispensed, reduces the trauma to the dispensed liquid, and reduces the amount of foaming in the dispensed liquid. The present invention further provides a method for using the Modular Liquid Infusing, Flavoring, and Dispensing Device.

A punching device including a punching die (5a) that can be connected to the needle bar and a punching matrix (5b) that can be fastened to a needle plate (7) of a sewing machine. The punching matrix (5b) is embodied as a lid of a clippings container (9). The planar object (23) to be processed is displaced via the tambour frame in a punching plane L2, with this punching plane L2 being arranged parallel above the sewing plane L1.

A thin film forming apparatus and a thin film forming method using the same are disclosed. In one aspect, the thin film forming apparatus comprises a mask that includes a blocking portion and an opening. It also includes an etching source that jets an etching gas through the opening of the mask to etch a thin film according to a pattern. The mask includes a gas blower for blowing a gas around the opening so that the etching gas does not penetrate into a thin film area corresponding to the block portion. When the thin film forming apparatus is used, a normal residual area of a thin film may be safely preserved and patterning may be accurately performed. Thus, the quality of a product manufactured by using the thin film forming apparatus may be improved.

The present invention provides a method for bonding two substrates using a UV radiation curing-redox curing adhesive system having a shadow area and a transparent area, comprising: bonding the shadow area of the substrates using a redox curing adhesive system, and bonding the transparent area of the substrates using a liquid optically clear adhesive containing UV initiators.

The invention relates to a method for connecting a first tube to a second tube, the tubes being interconnected in an overlapping region by means of an adhesive that fills a gap in the overlapping region between the tubes. Said method is characterized in that: a) adhesive is applied to the overlapping region of at least one of the tubes and the adhesive is selected in such a way that it is solid at temperatures of below 30° C. after application to the overlapping region and prior to the connection of the tubes, and cannot be cured without thermal activation; b) the tube having the adhesive in the overlapping region is pushed onto or inside the other tube; c) the tubes are fixed in relation to one another in the overlapping region by a heatable clamp, said clamp being designed in such a way that it can heat the tubes in said region; d) the adhesive is thermally activated by heating the overlapping region with the aid of the heatable clamp, whereby the adhesive cures and connects the two tubes in the overlapping region; and e) the heatable clamp is removed once the adhesive has cured. The invention also relates to a method for producing a refrigerator and to a refrigerator comprising correspondingly joined tube sections.

A pressure-sensitive adhesive optical film of the invention comprises an optical film and a pressure-sensitive adhesive layer provided on the optical film, wherein the pressure-sensitive adhesive layer has a thickness (μm) standard deviation of 0.12 μm or less. The pressure-sensitive adhesive optical film makes it possible to reduce the problem of visible unevenness caused by a pressure-sensitive adhesive layer.

The invention relates to the use of a hot-melt adhesive having high hardness for adhesive bonding of metal films or foils, paper films or foils, and/or plastic films or foils. The invention further relates to a method for adhesively bonding a metal film or foil, paper film or foil, and/or plastic film or foil onto a substrate.

A composition comprising at least one nutrient element, wherein the at least one nutrient element possesses a relative energy-state value greater than the relative energy-state value of the at least one nutrient element in a preexisting state, the composition being effective, perhaps because of the greater energy-state value, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Also a composition comprising at least one nutrient element, wherein the composition possesses an energy spectrum more positive than the energy spectrum of the composition in a preexisting state, the composition being effective, perhaps because of the more positive energy spectrum, to improve the ability of a soil, when combined with the composition, to support plant growth better than the soil, when not combined with the composition. Methods of making and using the same for improving soil, plants, plant growth, seeds, and/or plant products, including quality of plant products, are also disclosed, as well as improved soil, seeds, including quality of seeds, plants, and/or plant products, including quality of plant product.

The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.

The steps of the irrigation method include: flowing a stream of water having input and output and intermediate location; interposing a feeding device into the stream of water at the intermediate location, the feeding device having input and output ends; inserting a quantity of nutrient fertilizer into the feeding device; converting the nutrient fertilizer from the viscous state to the less viscous state through the flow of water through the feeding device; and intermixing the viscous nutrient fertilizer with the water entering the feeding device whereby the water leaving the device to plants and soil will include a fertilizer.

A water-insoluble phosphate fertilizer, methods of producing, and methods of using the same are provided. The fertilizer may comprise at least one alkaline earth metal selected from calcium and magnesium and optionally at least one nutrient ion selected from the group consisting of potassium, ammonium, zinc, iron, manganese, copper, boron, chlorine, iodine, molybdenum or selenium. The fertilizer compounds are preferably water-insoluble, dilute acid-soluble, and free-flowing powders.

A composition includes a first chelating agent, a second chelating agent, and a plurality of metal ions. In one embodiment, the second chelating agent includes citric acid and is different than the first chelating agent. A method for forming a composition includes mixing a first chelating agent, a second chelating agent, and a metal salt together to form a mixture and processing the mixture to form at least one of a granulated composition and a powdered composition. In some embodiments, the second chelating agent includes citric acid and is different than the first chelating agent.

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

Aspects of the present disclosure include a navigation system and computer-implemented methods for proactively re-routing vehicles based on an analysis of input component data obtained from the navigation-enabled devices. The navigation system scores the input component data to obtain a measure of frustration (e.g., a feeling of being upset or annoyed) of the user of the navigation-enabled device. The navigation system may provide a detour suggestion for display on the navigation-enabled device to persuade the user of the device to direct their vehicle to depart from its current location or route in an effort to remove the vehicle from traffic, and thereby reduce the frustration level of the user. The detour suggestion may include an alternative route to the original destination, or an alternative destination.

Aspects of the present disclosure include a navigation system and computer-implemented methods for detecting traffic disruption events based on an analysis of input component data obtained from navigation-enabled devices of vehicles near a particular location. Traffic disruption events are events such as accidents, construction road closures, police and speed traps, or road hazards that cause a decrease in the flow of traffic along a particular route and thus, added time delays for occupants of vehicles traveling along those routes. The navigation system scores the input component data associated with each vehicle and aggregates the scored input component data to obtain a frustration score associated with the vehicle. The navigation system may detect traffic disruption events based on a number of vehicles near a particular area having associated frustration scores above a certain threshold.

A motor mounted on a structural support with a pivot at its center line which comprises a cylindrical vessel for holding a fluid in a closed system and in which a buoyant cylinder containing a lighter fluid is allowed to free float so that a cable attached to either end of the buoyant cylinder may be used to transfer energy to a energy storage unit, a crank or a generator. Two moment arms having a weight attached at the exterior end and inside attachably connected to the surface of two drive pistons that operate in pressure tanks which force a compressed gas against the pistons through pre-sequenced automatic activated valves to extend or retract the moment arms at the end of a cycle. The motor then becomes top heavy and rotates 180 degrees by gravity and relocks in place to repeat the cycle.

A device for generating rotational movement which includes an output shaft supported for rotational movement and at least two one-way clutch mechanisms attached to the output shaft. An inflatable piston (“infton”) assembly is associated with each one-way clutch mechanism and includes a weighted member, an inflatable bladder associated with the weighted member, at least one inlet valve associated with an interior of the inflatable bladder, at least one outlet valve associated with the interior of the inflatable bladder, and a chain associated with the weighted member and extending over and drivingly engaging the respective one-way clutch mechanism. A source of filling fluid supplies each inlet valve. The filling fluid has a density less than that of a buoyancy fluid surrounding the infton assembly. A control system is configured to control the inlet and outlet valves to facilitate filling and discharging of the inflatable bladders.

The present invention provides a new and useful apparatus for charging battery powered electronic devices using a rolling means. The rolling means transfers mechanical energy from a plurality of wheels to a generator by way of a gear ratio. The generator in turn yields electrical energy that is later transformed via integrated circuitry into viable power for the purposes of charging an optional internal batter or that of an attached device. This apparatus does not limit the user's mobility and can be used in everyday settings. The apparatus can be an integral part of a piece of luggage or added to an existing hand cart. Additionally, the apparatus can have a connection for a DC input to charge the internal battery when the apparatus is not in motion.

A testing method using a guided wave generates a guided wave to propagate through a subject as a testing target in a longitudinal direction of the subject, detects a reflected wave of the guided wave and examines the subject on the basis of the reflected wave. The testing method includes the steps of (A) obtaining data for defect amount estimation beforehand indicating a relationship between a defect amount of the subject and a magnitude of a reflected wave, (B) generating a guided wave so as to propagate through the subject, and detecting a reflected wave of the guided wave, and (C) estimating a defect amount of the subject on the basis of the data for defect amount estimation obtained at (A) and the magnitude of the guided wave detected at (B).

A system comprising a surface vessel floating on a body of water; an oil leak located in the body of water; a remotely operated vehicle located near the oil leak; a connection between the surface vessel and the remotely operated vehicle; wherein the remotely operated vehicle comprises a mixer and a dispersant injector.

Nail gel curing devices emitting ultraviolet light, as well as methods of their making and use are disclosed. The devices are useful for curing, inter alia, acrylic compositions, more particularly, acrylic nail gel compositions, and typically employ ultraviolet and/or visible light emitting diodes (“LED”) to cure such ultraviolet and/or visible light curable nail gel resins.

A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.

Apparatus and associated method for sharpening a cutting edge of a tool. In accordance with some embodiments, a side of the tool is placed in contacting engagement against a reverse sharpening guide surface to orient the tool at an acute angle with respect to an abrasive surface, with the abrasive surface extending in a lateral direction from a first end to a second end and the reverse sharpening guide surface located proximate the first end. The tool is moved away from the reverse sharpening guide surface and along the abrasive surface in the lateral direction toward the second end while nominally maintaining the tool at the acute angle so that a cutting edge of the tool is sharpened against the abrasive surface in a trailing cutting edge orientation with a top surface of the tool opposite the cutting edge maintained closer to the second end than the cutting edge.

A method of manufacture of foamed celluloid molded products, involving three steps for the manufacture of higher density (0.7 to 1.25 gm/cc) foamed celluloid products or simple geometry lower density (0.2 to 0.7 gm/cc) foamed celluloid products, and four steps for the manufacture of lower density foamed celluloid products of any geometry. The three step process involving: (1) providing small, uniform, pieces of celluloid; (2) presoaking the pieces in a physical blowing agent (PBA) under pressure; and (3) foaming at raised temperature a controlled quantity of the presoaked pieces in a mold—to obtain the desired shape and density. For a lower density foamed celluloid product, of any moldable geometry, the steps are to: (1) small pieces of celluloid, that (2) have been presoaked in a PBA, are (3) pre-expanded to an intermediate density, and then (4) foam the desired lower density foamed product in a mold at raised temperature.

Bimetallic alloys prepared in a ball milling process, such as iron nickel (FeNi), iron palladium (FePd), and magnesium palladium (MgPd) provide in situ catalyst system for remediating and degrading nitro explosive compounds. Specifically, munitions, such as, 2,4,6-trinitrotoluene (TNT), cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX), nitrocellulose and nitroglycerine that have become contaminants in groundwater, soil, and other structures are treated on site to remediate explosive contamination.

A system and method for using color to indicate a state of a home appliance, such as an iron. The iron has a sole plate and a water tank in fluid communication with the sole plate, a heater for heating the sole plate, a sensor for sensing a temperature of the sole plate, a user interface for setting a desired temperature for the sole plate, and a controller in communication with user interface and the sensor for controlling the heater. An illumination device under the control of the controller is provided to illuminate the water tank, particularly the interior thereof, in a color that is representative of a state of the iron, such as a power condition of the iron and/or a temperature of the sole plate.

The current invention provides a tube-grasping body for grasping an insert tube in a heat exchanger, and heat exchanger production methods and apparatuses utilizing the tube-grasping body, wherein the tube-grasping body enables to enlarge and connect an insert tube to a heat radiating fin for producing a heat exchanger, still keeping the total length of insert tubes at an almost same level even after the enlargement; and the tube-grasping body is connected at its exterior to the guide-pipe.

Provided herein are compositions comprising at least one estolide compound of formula: in which n is an integer equal to or greater than 0; m is an integer equal to or greater than 1; R1, independently for each occurrence, is selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R3 and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched. Also provided are uses of the compositions described herein.

A housing member for a friction clutch and a method for making it. The housing member is made for use with two differently sized fan members. Two annular raised mounting pilot surfaces are provided, one of which is machine finished for mounting one of the two fan members. Two sets of fan member mounting holes are also provided, one set of which is used to mount one of the two fan members thereon.

A hydroforming method for metal produces hardware having a throat in only one side and having approximately right-angled corners without causing thinning and breakage. The method includes using a working fluid to exert a liquid pressure on a metal embryo and cooperating with a push rod of a hydroforming mold to supply material from the lower edge, forcing the side sheet metals to bulge. Furthermore, by using the hydroforming mold to provide a downwardly pressing active force on the metal embryo, under feeding of the downwardly pressing active force cooperating with continuous liquid pressure, the metal embryo deforms and bulges such that each corner of the metal embryo and the wall corners of the die cavity of the hydroforming mold have approximately the same angles. Hardware, every angle of which approximates a right angle, can be obtained after removing the hydroforming mold. This method can also be used to obtain a metal box.

In order to provide a steel sheet for hot pressing from which a hot-pressed part excellent in perforation corrosion resistance is obtainable and a method of manufacturing a hot-pressed part using the steel sheet for hot pressing, provided is a steel sheet for hot pressing having, sequentially on a surface of a base steel sheet: a plating layer I containing 60% by mass or more of Ni and the remainder consisting of Zn and inevitable impurities, a coating mass thereof being 0.01 to 5 g/m2; and a plating layer II containing 10 to 25% by mass of Ni and the remainder consisting of Zn and inevitable impurities, a coating mass thereof being 10 to 90 g/m2.

A steel cord for reinforcement of rubber articles, whose cord strength is enhanced by preventing occurrence of preceding break of the outermost layer filaments in the steel cord having a multi-twisted structure, and a pneumatic tire using it as a reinforcing material are provided. In a steel cord for reinforcement of rubber articles having a multi-twisted structure in which a plurality of strands are twisted together, which strands have a layered twisted structure in which a plurality of steel filaments are twisted together, dc/ds, which represents the ratio between dc, the diameter of outermost layer sheath filaments constituting the outermost layer sheath of a core strand, and ds, the diameter of outermost layer sheath filaments constituting the outermost layer sheath of sheath strands, is 1.05 to 1.25.

A fid apparatus includes a first channel formed along one side of the fid and a second channel formed along an opposite side of the fid. The fid further includes an aperture that passes completely through both the first channel and the second channel. This arrangement enables the fid to be able to grasp or clutch a segment of rope during a splicing process. The splicing process involves a method of using the fid apparatus in such a way that the segment of rope is arranged within the first channel, second channel, and aperture of the fid prior to commencing splicing processes. The segment of rope used is determined by the particular form of splicing that is implemented.

A pouch with multiple tear areas is provided. In one embodiment instructions are provided for resealing with heat. In one embodiment a zip-lock type reseal can be used in place of one of the multiple tear areas.

A display panel driving apparatus includes a data processor configured to receive N-th line data of image data. N is a natural number not less than 2. The data processor is further configured to perform a first line delay on the N-th line data to output (N−1)-th line data, to output (N−1)-th line substitution data which is obtained by N-th line substitution data, which is based on the N-th line data and the (N−1)-th line data, and to compensate the N-th line data based on the N-th line data and the (N−1)-th line substitution data to output compensation image data. The display panel driving apparatus further includes a data driver and a gate driver.

An OLED touch display panel capable of detecting and reacting to touches on the display includes a signal sending element emitting ultrasonic signals, a driving layer configured to provide display driving signals, a light-emitting element configured to receive the display driving signals and emit light, and a signal receiving element configured for receiving reflected ultrasonic signals. The light-emitting element includes a plurality of light-emitting units and a plurality of black matrixes. Every two adjacent light-emitting units are separated from each other by one of the black matrixes. The signal receiving element includes a plurality of thin film transistor units arranged in a matrix. Each thin film transistor unit is formed on one of the black matrixes.

A method for inputting a text and a display apparatus using the same are provided, the text input method including: transferring a message for requesting execution of a text input mode to an external device; receiving the text from the external device; and displaying the received text if it is determined that a situation in which a text is to be input occurs. Therefore, if a situation in which a text is to be input occurs, an external device automatically operates in a text input mode, and thus a user more conveniently inputs the text.

Sterilization and cleaning of an escalator hand rail are performed. A sterilization and cleaning device including a hand rail; a plasma source for irradiating the hand rails with ions or radicals or UV light; an enclosure for housing the plasma source; a power source for generating plasma; a fan for generating relatively negative pressure in the enclosure; filter units for removing removed bacteria, viruses, and organic matters such as hand marks; and filter plates located backward and forward of a moving direction of the hand rail in the enclosure along the hand rail is provided.

Embodiments of the disclosure may provide a ladder access system. The ladder access system may include a base having a clamp disposed proximal an excavation end thereof. The clamp may be configured to secure the base to an excavation support structure. A first side rail may be disposed on a first side of the base and a second side rail may be disposed on a second side of the base. The ladder access system may also include a gate disposed at a surface end of the base and extending between the first and second side rails. The ladder access system may further include a ladder support disposed proximal the excavation end of the base and extending from the first or second side rail, the ladder support being configured to uphold an upper end of a ladder disposed in an excavation and leaning thereupon.

A memory system may include a memory device including 0th to N-1th memory blocks, wherein N is a positive integer; and a controller having a first list and a second list, wherein the first list includes 0th to N-1th erase count values respectively for the 0th to N-1th memory blocks, wherein the second list includes 0th to N-1th difference values respectively for the 0th to N-1th memory blocks, wherein each of the 0th to N-1th difference values is a difference between an average value of the 0th to N-1th erase count values and each of the 0th to N-1th erase count values, wherein the controller selects a source block and a target block among the 0th to N-1th memory blocks depending on the 0th to N-th erase count values included in the first list and the 0th to N-1th difference values included in the second list to perform a wear leveling between the source block and the target block.

A mechanism that allows the successful decoding of MCS information of cell edge UEs while retaining the performance for the other UEs of the cell is provided. In one aspect, a UE may determine an uplink control coding rate based on an uplink signal quality. The UE may encode uplink control data based on the uplink control coding rate. The UE may apply a pattern of unused resource element locations in uplink control resource elements based on the uplink control coding rate. The UE may transmit the uplink control resource elements with the pattern of unused resource element locations. In another aspect, an eNB may receive uplink control resource elements. The eNB may determine an uplink control coding rate based on a pattern of resource element locations in the uplink control resource elements. The eNB may decode uplink control data based on the uplink control coding rate.

A technique for emulating virtual port control of airtime fairness for wireless stations using per station Enhanced Distributed Channel Access (EDCA) parameters. Specific parameters are received for each of a plurality of stations connected to the access point. An EDCA field of a beacon that stores a general EDCA parameter is set to an empty state. The beacon is broadcast to a plurality stations on the wireless communication network and within range of an access point. The beacon comprises a BSSID (Basic Service Set Identifier) for use by the plurality of stations to connect with the access point for access to the wireless communication network. The beacon also comprises an empty EDCA field. In response to broadcasting the empty EDCA parameter, receiving a direct inquiry from each of the plurality of stations for the general EDCA parameter. Each of the plurality of stations is responded to with a direct communication of a specific parameter corresponding to each station. A transmission is received from at least one of the stations complying with the specific parameter.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a radio resource control (RRC) connection establishment process is problematic; and transmitting a D2D signal using an exception resource, when the RRC connection establishment process is determined to be problematic.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a communication link with a base station is problematic; and transmitting a D2D signal using an exception resource, when the communication link with the base station is determined to be problematic.

XQuery queries that include functions that operate on dynamically typed XML data are rewritten into compilable SQL constructs. XML data that is dynamically typed is XML data for which a specific XML data type cannot be determined at compile time and in fact may vary. In general, XQuery queries are rewritten into SQL queries that use SQL constructs in lieu of XQuery constructs. The SQL constructs include an “SQL polymorphic function” that is defined or recognized by a database system as valid syntax for an SQL query. The rewritten query applies the XML data to the SQL polymorphic function, but the XML data has been typed as XMLType, a data type recognized by SQL standards.

This invention is about a structure for supporting clothes to be decolorized and for aiding in the process of decoloration, to a method of forming the same, and to a method of using the same to decolorize clothes. It includes manufacturing a semi-finished product for supporting clothes and manufacturing the supporting structure as well as a the method of decolorizing clothes using the supporting structure to have various decolorizing textures and styles.