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Barrick: What You Don't Know Can Hurt You More




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Covid 19 coronavirus: What you need to know about Saturday's big developments

More revelations have been uncovered from the Government's coronavirus document dump, while new cases remain low as Cabinet prepares to decide when to move to alert level 2. Get all the important news and read the full stories in...




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UAE-India repatriation Day 3 Blog: Flight to Lucknow ready to take off from Sharjah

(MENAFN - Khaleej Times) As part of the Vande Bharat Mission, an Air India flight with around 200 Indians from Sharjah will take off for Lucknow today... ......




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Little Known Characters in America: John L. O'Sullivan

Learn about yet another Little Known Character in America with this week's column from Cal Campbell! ......




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16 astonishing UNESCO sites you probably didn’t know were in Turkey

Turkey has been the host to many ancient civilizations and empires for ages. Its heritage can be seen in its preserved sites, inscribed on the UNESCO World Heritage List. Some of them remain largely undiscovered, though. Click through for our list, prepared by İnci Hazal Özcan, including the 16 UNESCO sites in Turkey that you should --but probably did not-- see. (Photos: Alamy)




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Cyber Security: What Managers Need to Know

There is no cyber-security threat looming on the horizon, the truth is that the storm is already here. An arms race, unseen, digital and all too little understood, is raging. The UK’s Head of Armed Forces, General Sir Nick Carter, recently sta...





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‘I don’t mind if she doesn’t know me,’ says 70-year-old Hong Kong man caring for wife with dementia

After taking care of his wife the whole day, Lam Man-hing, 70, finally has a little time to himself before bedtime.He browses the news, checks messages from friends on his smartphone and watches some television, with his wife Tang Siu-man, 74, asleep by his side.He checks on her from time to time, and keeps the TV volume low to avoid disturbing her.In the morning, like every day, she might not remember him.Tang has Alzheimer’s disease, a progressive form of dementia that begins with…




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What doctors on the front lines in New York wish they’d known a month ago

Ironclad emergency medical practices — about when to use ventilators, for example — have dissolved almost overnight.




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Knowledge is everywhere. Here are four ways to make it easier to share. -- by Sonia Chand Sandhu

A wealth of knowledge – knowhow and wisdom – rests with the officials, professionals, practitioners and communities. The challenge is to unleash the untapped power of this information.




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Q&A: How a New Port is Building Skills and Knowledge in Nauru

Nimitz Adam, 39, from Boe District, is a mechanic at Nauru’s Aiwo Boat Harbor. Since construction began on Nauru's new port in October 2019, the father of 6 says the people of Nauru are beginning to realize their dream of having an efficient, reliable, and climate-resilient international port. “The new port will be like a lifeline for the people of Nauru.” Nimitz Adam, mechanic at Nauru’s Aiwo Boat Harbor




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The universe tends towards disorder. But how come nobody knows why?

Entropy is the physicist’s magic word, invoked to answer to some of the biggest questions in cosmology. Yet a quantum rethink may be needed to tell us what it actually is




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We now know what causes wine ‘legs’ to drip down inside a glass

Wine tears – the drops that form inside a glass after wine is swirled in a glass – are caused by the formation of an unstable shock wave




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We’ve found more than 2500 new viruses and some are unlike any we know

The genomes of 2514 new viruses have been identified in DNA recovered from human and animal cells, many of them belonging to wholly new families




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Earliest known cave-dwelling animal is a 99-million-year-old cockroach

The earliest cave-dwelling animal identified from the dinosaur era is a ghostly white cockroach with tiny eyes and wings that was preserved in amber




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Weird worm is earliest known animal to evolve away body parts

A worm-like creature from 518 million years ago evolved to lose its back legs, the earliest known example of an animal losing body parts it no longer needed




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World's only known pink manta ray spotted in the Great Barrier Reef

This pink manta ray, nicknamed Clouseau, has resurfaced off Australia’s coast. No one knows why it has a bubble-gum pink underside or if there are others out there




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Earliest known animal was a half-billion-year-old underwater blob

The weird ‘Ediacaran’ fossils have stumped scientists for decades - now fatty molecules found inside some of them confirm they are the most ancient animals we know




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The Northern Lights make a mysterious noise and now we might know why

For 30 years, one man has been obsessed with the whisperings of the aurora borealis. His search for its origins may finally be over




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We may now know what our common ancestor with Neanderthals looked like

A prehistoric human species that lived in Europe 1.2 million to 800,000 years ago is emerging as a contender to be our last common ancestor with Neanderthals




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The universe tends towards disorder. But how come nobody knows why?

Entropy is the physicist’s magic word, invoked to answer to some of the biggest questions in cosmology. Yet a quantum rethink may be needed to tell us what it actually is




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We know the best spots to look for alien life – can we get to them?

Extraterrestrial oceans are an obvious place to search for alien life, but getting there and having a look won't be easy, says NASA's Kevin Hand in his book Alien Oceans




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We still don't know how effective the NHS contact-tracing app will be

The UK government will begin trials of its coronavirus contact-tracing app this week, but what impact it will have on slowing the spread of covid-19 is unclear




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You can 'see' the closest known black hole to Earth with the naked eye

Astronomers found a star that appeared to be orbiting nothing at all – but it’s actually the closest black hole ever at just 1000 light years away




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Knowledge Is Power for Patients With Heart Failure

Title: Knowledge Is Power for Patients With Heart Failure
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM




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1 in 3 Americans May Have Had Warning Stroke Without Knowing It

Title: 1 in 3 Americans May Have Had Warning Stroke Without Knowing It
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM




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What Drives Millennials to Tan, Knowing the Risks?

Title: What Drives Millennials to Tan, Knowing the Risks?
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/3/2018 12:00:00 AM




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What Couples Considering IVF Need to Know

Title: What Couples Considering IVF Need to Know
Category: Health News
Created: 5/1/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM




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COMMENTARY: The Links Between COVID-19 and Diabetes, Known and Unknown

Dr Harpreet Bajaj summarizes the known and unknown links between diabetes and COVID-19, focusing on three clinical questions.




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Knowledge, Attitudes and Practices of Dental Hygienists Regarding Diabetes Risk Assessments and Screenings

Purpose: Untreated and poorly controlled diabetes causes increased levels of blood glucose associated with poor periodontal disease outcomes. Dental hygienists can play a significant role in screening patients for diabetes mellitus, leading to referral and early diagnosis. The purpose of this study was to determine the knowledge, attitudes, practices, and barriers faced by clinical dental hygienists regarding diabetes risk assessment and screenings.Methods: A mixed method design was used with a convenience sample of dental hygienists in clinical practice (n=316). A 32 item, electronic survey was validated at item-level, and participants were recruited through multiple dental hygiene Facebook groups. Descriptive statistics were used to analyze the data. The survey also included two open-ended attitude questions that were interpreted using thematic analysis to pinpoint common patterns within the data.Results: Dental hygienists had high knowledge scores regarding diabetes and oral health, although many were unaware of their states' specific statutes and regulations for screening practices. Nearly all (95.9%), were likely to educate and refer patients (82%), although fewer than half (40.9%), were likely to perform chairside screening for diabetes. Emergent themes for barriers to screening were time, money, patient acceptance/willingness, lack of education, not having the proper tools, and states' rules and regulations.Conclusion: Despite high knowledge scores regarding diabetes and oral health, there is a gap in regards to dental hygienists' willingness to perform diabetes screenings in a clinical setting. Dental hygienists should be capable of integrating chairside diabetes screening practices into the process of care with proper training.




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Acknowledgment of Invited Editors




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Acknowledgment of Reviewers




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Minnesota association acknowledges states ancestral lands, residents

In a nod to the people who came before them — and those who still live among them — the Minnesota Public Health Association is acknowledging ancestral lands.




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Acknowledgment of Ad Hoc Reviewers [Editorial]




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Rapid acquisition through fast mapping: stable memory over time and role of prior knowledge [RESEARCH]

In recent years, there have been intensive debates on whether healthy adults acquire new word knowledge through fast mapping (FM) by a different mechanism from explicit encoding (EE). In this study, we focused on this issue and investigated to what extent retention interval, prior knowledge (PK), and lure type modulated memory after FM and EE. Healthy young participants were asked to learn novel word-picture associations through both FM and EE. Half of the pictures were from familiar categories (i.e., high PK) and the other half were from unfamiliar categories (i.e., low PK). After 10 min and 1 wk, the participants were tested by forced-choice (FC) tasks, with lures from different categories (Experiment 1) or from the same categories of the target pictures (Experiment 2). Pseudowords were used to denote names of the novel pictures and baseline performance was controlled for each task. The results showed that in both Experiments 1 and 2, memory performance remained stable after FM, while it declined after EE from 10 min to 1 wk. Moreover, the effect of PK appeared at 10 min after FM while at 1 wk after EE in Experiment 2. PK enhanced memory of word-picture associations when the lures were from the same categories (Experiment 2), rather than from different categories (Experiment 1). These results were largely confirmed in Experiment 3 when encoding condition was manipulated as a between-subjects factor, while lure type as a within-subjects factor. The findings suggest that different from EE, FM facilitates rapid acquisition and consolidation of word-picture knowledge, and highlight that PK plays an important role in this process by enhancing access to detailed information.




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The unknown planktonic foraminiferal pioneer Henry A. Buckley and his collection at The Natural History Museum, London

The Henry Buckley Collection of Planktonic Foraminifera at the Natural History Museum in London (NHMUK) consists of 1665 single-taxon slides housing 23 897 individuals from 203 sites in all the major ocean basins, as well as a vast research library of Scanning Electron Microscope (SEM) photomicrographs. Buckley picked the material from the NHMUK Ocean-Bottom Deposit Collection and also from fresh tow samples. However, his collection remains largely unused as he was discouraged by his managers in the Mineralogy Department from working on or publicizing the collection. Nevertheless, Buckley published pioneering papers on isotopic interpretation of oceanographic and climatic change and was one of the first workers to investigate foraminiferal wall structure using the SEM technique. Details of the collection and images of each slide are available via the NHMUK Data Portal (http://dx.doi.org/10.5519/0035055). The Buckley Collection and its associated Ocean-Bottom Deposit Collection have great potential for taxon-specific studies as well as geochemical work, and both collections are available on request.




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Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil [Susceptibility]

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc1 complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin have been optimized to produce novel quinolones that are active in vitro and in animal models. While these quinolones exhibit potent ex vivo activity against Plasmodium falciparum and Plasmodium vivax, their activity against the zoonotic agent Plasmodium knowlesi is unknown. We screened several of these novel endochin-like quinolones (ELQs) for their activity against P. knowlesi in vitro and compared this with their activity against P. falciparum tested under identical conditions. We demonstrated that ELQs are potent against P. knowlesi (50% effective concentration, <117 nM) and equally effective against P. falciparum. We then screened selected quinolones and partner drugs using a longer exposure (2.5 life cycles) and found that proguanil is 10-fold less potent against P. knowlesi than P. falciparum, while the quinolones demonstrate similar potency. Finally, we used isobologram analysis to compare combinations of the ELQs with either proguanil or atovaquone. We show that all quinolone combinations with proguanil are synergistic against P. falciparum. However, against P. knowlesi, no evidence of synergy between proguanil and the quinolones was found. Importantly, the combination of the novel quinolone ELQ-300 with atovaquone was synergistic against both species. Our data identify potentially important species differences in proguanil susceptibility and in the interaction of proguanil with quinolones and support the ongoing development of novel quinolones as potent antimalarials that target multiple species.




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A Previously Unknown Dendritic Cell Type Reduces Antitumor Response [Immunology]

A cluster of dendritic cells (termed mregDCs), observed in humans and mice, restricted antitumor immunity.




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Good to Know: Kidney Disease: Signs and Treatment




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Screen to Save: Results from NCI's Colorectal Cancer Outreach and Screening Initiative to Promote Awareness and Knowledge of Colorectal Cancer in Racial/Ethnic and Rural Populations

Background:

The Center to Reduce Cancer Health Disparities (CRCHD), NCI, implemented Screen to Save, NCI's Colorectal Cancer Outreach and Screening Initiative to promote awareness and knowledge of colorectal cancer in racial/ethnic and rural populations.

Methods:

The initiative was implemented through CRCHD's National Outreach Network (NON). NON is a national network of Community Health Educators (CHE), aligned with NCI-designated Cancer Centers across the nation. In phases I and II, the CHEs focused on the dissemination of cancer-related information and implementation of evidence-based educational outreach.

Results:

In total, 3,183 pre/post surveys were obtained from male and female participants, ages 50 to 74 years, during the 347 educational events held in phase I. Results demonstrated all racial/ethnic groups had an increase in colorectal cancer–related knowledge, and each group strongly agreed that the educational event increased the likelihood that they would engage in colorectal cancer–related healthful behaviors (e.g., obtain colorectal cancer screening and increase physical activity). For phase II, Connections to Care, event participants were linked to screening. Eighty-two percent of the participants who obtained colorectal cancer screening during the 3-month follow-up period obtained their screening results.

Conclusions:

These results suggest that culturally tailored, standardized educational messaging and data collection tools are key change agents that can serve to inform the effectiveness of educational outreach to advance awareness and knowledge of colorectal cancer.

Impact:

Future initiatives should focus on large-scale national efforts to elucidate effective models of connections to care, related to colorectal cancer screening, follow-up, and treatments that are modifiable to meet community needs.




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Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know [EDITORIALS]




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How to know you’re ready to become a home owner?

Most of us will stop renting and become a homeowner one day. But how do you know when it’s a good time to buy your own home? These are four signs that you’re ready to stop renting and become a home owner.




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7 Things You Should Know Before Signing a Lease

Sure, you're just renting the place for a year, or even just a month. But before you sign on the dotted line, make sure you know what you're signing up for.




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9 negative impacts of land fever investors should know

The upsurge of land price leads to a real estate bubble, pushing up production costs, creating a virtual tendency and gradually increasing bad debt.




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We still don't know how effective the NHS contact-tracing app will be

The UK government will begin trials of its coronavirus contact-tracing app this week, but what impact it will have on slowing the spread of covid-19 is unclear




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Google Pixel 4a: Everything We Know So Far

Last year the release of Google's Pixel 3a heralded a shift in the mid-range phone market. Coming in at $649 and packing some flagship specs, it changed what people should expect from a a phone at that price. Other brands followed suit, including Apple with its recently released iPhone SE. Suffice to say, the arrival of Googles new budget device, the Pixel 4a, is cause for some excitedment. Here's what we know about it so far. More »
    




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Tiny meteorite found in Antarctica came from an unknown asteroid

A tiny meteorite found in Antarctica doesn’t match any asteroid or comet we know of. Instead, it must have come from a mystery parent body that’s full of water




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We know the best spots to look for alien life – can we get to them?

Extraterrestrial oceans are an obvious place to search for alien life, but getting there and having a look won't be easy, says NASA's Kevin Hand in his book Alien Oceans




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You can 'see' the closest known black hole to Earth with the naked eye

Astronomers found a star that appeared to be orbiting nothing at all – but it’s actually the closest black hole ever at just 1000 light years away




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6 Things to Know About the Biggest Chip Ever Built

Startup Cerebras has built a wafer-size chip for AI, but it isn’t the only one possible