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By enabling formal trade, Nigeria can unleash its vast potential

3 December 2015

Nigeria’s booming informal trade is costly for society, business and government, yet a critical opportunity exists to formalize such trade and drive more sustainable and less volatile growth, argues a new report from Chatham House.

According to one estimate, informal activity accounts for up to 64 per cent of Nigeria’s GDP. Nigeria's Booming Borders: The Drivers and Consequences of Unrecorded Trade finds that this is a result of obstacles that impede trading through formal channels. These drivers include bureaucratic burdens and other factors, such as:

  • The need for Nigerian businesses to produce at least nine documents in order to send an export shipment and at least 13 in order to bring in an import consignment.
  • Rigid and dysfunctional foreign-exchange regulations that push most smaller traders into the incompletely regulated parallel exchange market.
  • Corruption and unofficial ‘taxation’, especially on major border highways, which delegitimize formal channels and encourage the use of smuggling routes.

As a result, the state loses direct tax revenues that would be generated by formal cross-border trade. This is not just siphoned into the informal economy; some is lost entirely. For example, many shippers opt to dock in neighbouring countries rather than deal with the expense and difficulty of using Nigeria’s ports.

Informal trade also undermines the social contract between the private sector and government. The state lacks tax revenues to pay its officials, improve infrastructure or implement reforms, while traders feel the government provides no services in return for any taxes they might pay.

‘Every day tens of thousands of unofficial payments are made, none destined for the government. Policy-makers need to create an environment that encourages trade to flow through formal channels and capture lost revenue’, says co-author Leena Koni Hoffmann.

‘Formalization would assist Nigeria to pursue more high-quality, high-tech economic activity at a time when rising labour costs in Asia are creating scope for Nigerian manufacturers to compete’, she adds.

The report makes a number of recommendations for how Nigeria could encourage more formal trade, including:

  • Strengthening the resources and capacity of the Federal Ministry of Industry, Trade and Investment to coordinate action across key government ministries, departments and agencies, as well as public and private stakeholders.
  • Prioritizing engagement in the development of Economic Community of West African States (ECOWAS) trade policies and fully implementing the ECOWAS Protocol on Free Movement of Persons to reduce harassment at borders.
  • Allowing banks to operate simple services for small and medium-sized businesses to make trade payments directly from Nigerian naira to CFA francs and vice versa.
  • Improving basic facilities that support traders, including improving the efficiency of border posts, installing truck parks and all-weather surfacing on market access roads, and introducing online booking for trucks to enter ports.
  • Separating responsibilities for assessing duty and tariff liabilities from revenue collection in order to reduce opportunities for corruption, an approach already tested with success by the Lagos State Internal Revenue Service.
  • Increasing funding and technical support for the National Bureau of Statistics, which has a significant role to play in measuring and capturing more of Nigeria’s external trade.

Interviews conducted for the report reveal that business people would welcome the opportunity to pay taxes, but only if they received assurance that these payments would represent a contract with government guaranteeing that conditions for business would be improved.

‘As Africa’s largest economy, formalizing external trade would allow Nigeria to fulfil its potential as the trading engine of the West and Central African economy and shape the business landscape across the region,’ says co-author Paul Melly.

Editor's notes

  • Read Nigeria's Booming Borders: the Drivers and Consequences of Unrecorded Trade (embargoed until 17:00 GMT on Monday 7 December).
  • To request an interview with the authors, contact the press office.
  • Nigeria’s recorded external trade for 2014 was $135.8 billion.
  • Estimate of informal activity as a percentage of GDP from Jonathan Emenike Ogbuabor and Victor A. Malaolu, ‘Size and Causes of the Informal Sector of the Nigerian Economy: Evidence from Error Correction Mimic Model’, Journal of Economics and Sustainable Development, Vol. 4, No. 1, 2013.

Contacts

Press Office

+44 (0)20 7957 5739




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Realizing TTIP’s Strategic Potential

14 July 2016

The strategic case for TTIP is greater – and the stakes higher – now that the UK has decided to leave the EU. But TTIP will create new risks for the West whether it succeeds or fails.

Gregor Irwin

Chief economist, Global Counsel

2016-07-14-ttip.jpg

The container ship Osaka Express, operated by Hapag-Lloyd AG, leaves the container terminal at the port in Southampton, UK, on 2 October 2015. Photo: Getty Images.

Summary

  • The Transatlantic Trade and Investment Partnership (TTIP) – currently being negotiated between the United States and the European Union – represents a bolder and riskier approach to liberalizing trade than traditional trade deals. It is bolder because it aims to cover a wide range of policy issues that are not typically included, and because it aims to be strategic and extraterritorial in its impact. It is riskier because of the difficulty in getting agreement on these issues between the parties concerned, and because the responses of other countries are uncertain.
  • EU and US negotiators have much work to do if a deal is to be reached that realizes TTIP’s full potential. While progress has been made on tariff reduction, considerable ground still needs to be covered on setting standards and regulations affecting trade, which is where TTIP has the most potential to make an impact at a strategic level. Meanwhile, trade scepticism is rising on both sides of the Atlantic, with concerns about the impact of deals like TTIP on jobs and regulatory standards. The negotiation process is also now complicated by the United Kingdom’s decision to leave the EU. Making a clear and credible strategic case for TTIP may be necessary if the negotiations are to continue and be successful.
  • If the United States and the EU are able to agree on the regulations and standards affecting international trade, they will have the scale to define these globally for years to come. International leadership in this area brings commercial advantages and benefits for consumers in the EU and the United States, and it also often is a global public good. However, it sometimes pits EU and US interests against those of other countries, creating scope for conflict over policies in areas such as the rules governing state-owned enterprises.
  • There would be benefits to the United Kingdom, the EU and the United States if the United Kingdom joins TTIP once it is agreed. In the intervening period, it makes sense for the United Kingdom to participate actively in EU decisions regarding TTIP while still a member of the EU, as this could help to smooth an eventual British accession to the partnership.
  • The soft-power benefits from TTIP are potentially substantial, but they would only be maximized if other strategically important countries, such as Turkey, are able to join. Perhaps the clearest sign of TTIP being likely to meet or exceed the highest ambitions for its strategic impact would be if it has an even broader geographical reach, drawing in countries in other regions.
  • The potential security benefits from TTIP are marginal and overhyped. The benefits that unity on trade would bring to transatlantic security are intangible and hard to substantiate. The energy security benefits are likely to be limited, as the volumes of US liquefied natural gas (LNG) exports to the EU are likely to be small. If the EU and the United States are serious about using TTIP to improve security, they should include defence procurement, but this has never been on the agenda.
  • Not only do the differences between the EU and the United States mean that it will be difficult to get a deal, they also constrain how any deal would be implemented and exploited for strategic purposes. If TTIP is to succeed at a strategic level, both sides must be disciplined, consistent and coordinated in using it as the reference point in their negotiations with other countries. 
  • The United States is more capable of acting strategically than the EU, in part because of the difficulties for EU member states in coalescing around a shared set of strategic objectives. Until the EU is able to do this, the United States is likely to have much more influence over the strategic direction of TTIP. If the EU wants to bridge this gap, then the European Council should start by reaching a political agreement on its objectives and priorities for bringing other countries into TTIP.
  • There are also strategic risks from TTIP. One is that by emphasizing the values that are reflected in international rules, the EU and the United States could make it harder for other countries to accept these rules, or make TTIP seem like an attempt to reassert the old world order. Thus, instead of having a magnetic effect, TTIP could create a rift with emerging countries, with some choosing to maintain a distance for political reasons.
  • The bigger risk for TTIP, however, is failure. If negotiations break down or a deal is reached that falls short of the ambition set for it, this would send a damaging signal to the rest of the world about the inability of the EU and the United States to work together. The damage would be all the greater if the process was acrimonious, or if it exposed US indifference to Europe or latent anti-Americanism in the EU. The United Kingdom’s decision to leave the EU raises the stakes, particularly for the latter, as it is a blow to the international credibility of the EU. Agreeing TTIP would help to offset this blow, while failure would amplify it.




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Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

Ludovic C. Gillet
Jun 1, 2012; 11:O111.016717-O111.016717
Research




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Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 [Signal Transduction]

The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity.




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Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice

RK Tangirala
Nov 1, 1995; 36:2320-2328
Articles




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Use of cyclodextrins for manipulating cellular cholesterol content

AE Christian
Nov 1, 1997; 38:2264-2272
Articles




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Harnessing the Potential of Cities

Corporate Members Event

13 December 2019 - 12:30pm to 2:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Penny Abeywardena, Commissioner for International Affairs, New York City

Chair: Dr Beyza Unal, Senior Research Fellow, International Security Department, Chatham House

Cities are strong engines of growth and job creation accounting for some 85 per cent of global GDP. By 2030, more than 60 per cent of people worldwide will live in cities and they will be on the front lines of managing issues transcending borders such as climate, migration and sustainability. International organizations like the United Nations are striving to meet these challenges but relying on traditional multilateral agreements is growing ever more unpredictable. If cities and local governments are key to global prosperity, how can their power and influence be harnessed to accelerate impact for their citizens?

Drawing on the pioneering work of New York City in the area of foreign policy leadership at a municipal level, Penny Abeywardena will discuss how the influence of subnational leadership and diplomacy is more important than ever as national governments are abdicating their responsibility at the multilateral level. How can the Sustainable Development Goals be localized among cities on policy issues that impact communities? And what can large cities, beyond the capital, do to remain influential and harness job growth?

 This event will be preceded by an informal sandwich reception from 12.30pm-1pm. The roundtable discussion to follow will take place from 1pm-2pm.

This event is corporate members only.  If you'd like to attend, please RSVP to Linda Bedford.

To enable as open a debate as possible, this event will be held under the Chatham House Rule.

Members Events Team




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{alpha}-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are maȷor seed-competent species [Molecular Bases of Disease]

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.




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Undercurrents: Episode 4 – Illegal Hospital Detentions in Africa, and LGBTQ+ Rights in Lebanon




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Citizenship and Discontent in the Middle East




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Britain’s Soft Power Potential: In Conversation with Penny Mordaunt




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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015 [Molecular Biophysics]

Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage mAb that prevents extracellular proteolytic activation of pro- and latent myostatin. Here we used integrated structural and biochemical approaches to elucidate the molecular mechanism of antibody-mediated neutralization of pro-myostatin activation. The crystal structure of pro-myostatin in complex with 29H4-16 Fab, a high-affinity variant of SRK-015, at 2.79 Å resolution revealed that the antibody binds to a conformational epitope in the arm region of the prodomain distant from the proteolytic cleavage sites. This epitope is highly sequence-divergent, having only limited similarity to other closely related members of the transforming growth factor β superfamily. Hydrogen/deuterium exchange MS experiments indicated that antibody binding induces conformational changes in pro- and latent myostatin that span the arm region, the loops contiguous to the protease cleavage sites, and the latency-associated structural elements. Moreover, negative-stain EM with full-length antibodies disclosed a stable, ring-like antigen–antibody structure in which the two Fab arms of a single antibody occupy the two arm regions of the prodomain in the pro- and latent myostatin homodimers, suggesting a 1:1 (antibody:myostatin homodimer) binding stoichiometry. These results suggest that SRK-015 binding stabilizes the latent conformation and limits the accessibility of protease cleavage sites within the prodomain. These findings shed light on approaches that specifically block the extracellular activation of growth factors by targeting their precursor forms.




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COP26 Diplomatic Briefing: Climate Ambition in Europe and its Potential Global Impact

17 February 2020 - 8:30am to 10:00am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Jacob Werksman, Principal Adviser to Directorate General for Climate Action, European Commission
Imke Lübbeke, Head of EU Climate and Energy Policy, WWF European Policy Office 
Simon Petrie, Head of International Climate Strategy - Europe, UK Department for Business, Energy and Industrial Strategy
Jen Austin, Policy Director, We Mean Business Coalition
Chair: Jill Duggan, Associate Fellow, Chatham House

The President of the European Commission, Ursula von der Leyen, has declared that she wants Europe to become ‘the first climate-neutral continent by 2050’, and in December 2019, the Commission presented the European Green Deal in order to achieve this objective. However, even though greenhouse gas emissions from the EU have fallen by more than 20 per cent since 1990, the Union remains the third largest emitter in the world, after the United States and China.

What are the opportunities and challenges for raising climate ambition in Europe?  Will the EU increase its Nationally Determined Contribution and what impact might this have globally? How might Brexit affect climate action in the EU and the UK?  The second event in the Chatham House COP26 Diplomatic Briefing Series will address these critical questions.

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




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Visão embaçada e distorcida nem sempre é miopia: fique atento aos sinais do ceratocone

Aos primeiros sinais de visão embaçada, as hipóteses mais frequentes sempre são miopia, astigmatismo, hipermetropia. Mas esses sintomas podem indicar outra doença ocular chamada ceratocone - uma deformidade progressiva da córnea, que assume o formato...

The post Visão embaçada e distorcida nem sempre é miopia: fique atento aos sinais do ceratocone appeared first on Saúde Próspera.



  • Dicas de Saúde

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Improving Stents - Part 2

Stents are expandable tubes that are inserted into blocked or damaged blood vessels. They offer a practical way to treat coronary artery disease, repairing vessels and keeping them open so that blood can flow freely. When stents work, they are a great alternative to radical surgery, but they can deteriorate or become dislodged. Mathematical models of blood vessels and stents are helping to determine better shapes and materials for the tubes. These models are so accurate that the FDA is considering requiring mathematical modeling in the design of stents before any further testing is done, to reduce the need for expensive experimentation. Precise modeling of the entire human vascular system is far beyond the reach of current computational power, so researchers focus their detailed models on small subsections, which are coupled with simpler models of the rest of the system. The Navier-Stokes equations are used to represent the flow of blood and its interaction with vessel walls. A mathematical proof was the central part of recent research that led to the abandonment of one type of stent and the design of better ones. The goal now is to create better computational fluid-vessel models and stent models to improve the treatment and prediction of coronary artery disease the major cause of heart attacks. For More Information: Design of Optimal Endoprostheses Using Mathematical Modeling, Canic, Krajcer, and Lapin, Endovascular Today, May 2006.




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Improving Stents - Part 1

Stents are expandable tubes that are inserted into blocked or damaged blood vessels. They offer a practical way to treat coronary artery disease, repairing vessels and keeping them open so that blood can flow freely. When stents work, they are a great alternative to radical surgery, but they can deteriorate or become dislodged. Mathematical models of blood vessels and stents are helping to determine better shapes and materials for the tubes. These models are so accurate that the FDA is considering requiring mathematical modeling in the design of stents before any further testing is done, to reduce the need for expensive experimentation. Precise modeling of the entire human vascular system is far beyond the reach of current computational power, so researchers focus their detailed models on small subsections, which are coupled with simpler models of the rest of the system. The Navier-Stokes equations are used to represent the flow of blood and its interaction with vessel walls. A mathematical proof was the central part of recent research that led to the abandonment of one type of stent and the design of better ones. The goal now is to create better computational fluid-vessel models and stent models to improve the treatment and prediction of coronary artery disease the major cause of heart attacks. For More Information: Design of Optimal Endoprostheses Using Mathematical Modeling, Canic, Krajcer, and Lapin, Endovascular Today, May 2006.




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Patents vs. the Pandemic

The flu vaccine was developed through open science, without any intellectual-property considerations. Imagine if we could do the same for COVID-19.




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Content as low as 85 cents/100w! - US Writers - Money Back Guarantee - 700+ Samples available




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The Report of the Compliance Committee under the Cartagena Protocol on Biosafety on the Work of Its Tenth Meeting is now available.




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The report of the tenth meeting of the Liaison Group on Capacity-building for Biosafety is now available.




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CBD News: Statement by the Executive Secretary, Ahmed Djoghlaf, on "Climate Change, REDD and Biodiversity" on the occasion of the International Expert Meeting on Potential Impacts of "Reducing Emissions from Deforestation and Forest Degrada




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CBD News: State of Paraná Reports on Carbon-Offset Programme for the Operations of the Secretariat through the Tenth Meeting of the Conference of the Parties




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CBD Communiqué: Executive Secretary discusses Preparations for the Tenth Meeting of the Conference of the Parties with all Japanese Stakeholders.




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CBD News: Message from Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Tenth Anniversary of the Adoption of the Cartagena Protocol on Biosafety.




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CBD UN Press Release: Japanese Singer Misia Appointed Honorary Ambassador for Tenth Conference of Parties to UN Convention on Biodiversity, in Nagoya, 18-29 October.




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CBD Notification: Fair on experiences and best practices in Communication, Education and Public Awareness (CEPA) at the tenth meeting of the Conference of the Parties to the Convention on Biological Diversity.




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CBD News: Minutes of the Tenth Meeting of the Bureau of the Conference of the Parties to the Convention on Biological Diversity.




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CBD News: Tenth meeting of the Coordination Mechanism for the Global Taxonomy Initiative, 24 October 2010, Nagoya, Japan




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CBD Communiqué: Tenth Meeting of the Joint Liaison Group of the Rio Conventions.




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CBD Communiqué: The Ministers of Foreign Affairs of the Group of 77 and China support the adoption of the Multi-Year Plan of Action on South-South Cooperation on Biodiversity for Development at the tenth meeting of the Conference of the Parties to th




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CBD News: Statement by Ahmed Djoghlaf, CBD Executive Secretary, at the Opening Session of the Tenth Meeting of the Conference of the Parties to the Convention on Biological Diversity, Nagoya, 18 October 2010.




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CBD Press Release: The Group of 77 and China propose a Multi-Year Plan of Action for South-South Cooperation on Biodiversity for Development for adoption at the tenth meeting of the Conference of the Parties.




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CBD News: Summary of the Second Global Private Donor Forum, which took place this past October 26th, 2010 at the margins of the tenth Conference of Parties (COP10) in Nagoya, Japan.




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CBD News: In conjunction with the 61st meeting of the Standing Committee of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), the Government of Switzerland, in partnership with the Japanese presidency of the tent




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CBD Press Release: At United Nations Biodiversity Conference, countries agree to double resources for biodiversity protection by 2015 - Special attention for biodiversity-rich marine areas among other key outcomes.




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CBD News: Under the theme, 10 Years of Promoting Safety in the Use of Biotechnology, the international community is marking the tenth anniversary of the entry into force of the international agreement governing the movement of living modified organisms (L




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CBD News: To focus attention on the global extinction crises and advance implementation of the Aichi Biodiversity Targets, the LifeWeb initiative of the Convention on Biological Diversity (CBD) is launching the Zero Extinction Campaign.




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CBD News: The Secretariat of the Convention on Biological Diversity (CBD) has welcomed the Warsaw Framework for REDD+ for its potential to contribute both to climate change mitigation and biodiversity conservation.




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CBD News: Wetlands are among our most valuable ecosystems. The values of benefits provided by wetlands, per unit area, have been consistently shown to be orders of magnitude higher than for other ecosystems, with the major benefit delivered through improv




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CBD News: A new report from the Secretariat of the Convention on Biological Diversity discusses the potential for synthetic biology to have both positive and negative impacts on biodiversity and looks at the role and adequacy of existing risk assessment a




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CBD News: On 10 June, HSH Prince Albert II of Monaco closed a historic meeting of biodiversity and Antarctic experts. The purpose of the meeting was to examine the extent to which conservation of the biodiversity of Antarctica and the Southern Ocean is re




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CBD News: Articles are presently being sought from members of civil society and indigenous peoples and local communities for the tenth edition of the CBD newsletter for civil society, [square brackets], being prepared to coincide with the nineteenth meeti




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CBD News: The first meeting of the Subsidiary Body on Implementation (SBI 1) of the Convention on Biological Diversity (CBD) came to a close on 6 May 2016 in Montreal, Canada. Delegates from around the world advanced attention on national action by recom




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CBD News: In today's global celebrations of the International Day for Biological Diversity, under the theme of 'Biodiversity and Sustainable Tourism', people are examining the positive but also potentially negative impacts that tourism can ha




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CBD News: The ten-year anniversary of the United Nations Declaration on the Rights of Indigenous Peoples presents a fitting opportunity to draw attention to the significant contribution of indigenous peoples to the conservation and sustainable use of the




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CBD News: Following traditional blessings by Elders of the local Mohawk Community of Kahnawake, delegates to the tenth meeting of the Ad Hoc Open-ended Working Group on Article 8(j) and Related Provisions of the Convention on Biological Diversity will beg




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CBD News: Statement by the Executive Secretary of the Convention on Biological Diversity, Dr. Cristiana Pasca Palmer, at the Tenth meeting of the ad hoc open-ended Working Group on Article 8(j) and related provisions of the Convention on Biological Divers




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CBD News: Delegates to the tenth meeting of the Ad Hoc Open-ended Working Group on Article 8(j) and Related Provisions of the Convention on Biological Diversity agreed on a set of recommendations related to the contributions of indigenous peoples and loca




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CBD News: The film highlights the importance of nature in tackling climate change, calling for the need to protect, restore and fund nature and mobilizing attention to scale nature-based solutions.