The Genetics Society of America (GSA) is pleased to announce the 2020 recipients of its annual awards for distinguished service in the field of genetics. The awardees were nominated and selected by their colleagues and will be recognized with presentations at The Allied Genetics Conference (TAGC), held April 22-26, 2020, in the metro Washington, DC area.

Today I said goodbye to the most amazing, resilient, loving cat in the world. After fighting a myriad of diseases like a champ, her body finally tired

Our Beloved Denver (Big Guy), Thank you for teaching us the true meaning of what love was always meant to be. You were a beautiful dog with a beautiful

My dear, beloved friend, whom I loved more than life itself, is gone. My darling Reggie, the Plymouth Rock rooster, was snatched from my arms by a sudden

Turner, Our boy always loving, playful. We will miss you but, we know it's time. We have held you, given you a thousand kisses, and told you how much

I've been reading these stories about beloved pets who died at such young ages, so I feel very blessed to have had you for 14 years. Thank you very much

Our beautiful 23 year old long haired tabby Sophie died peacefully in my husband's arms this week on 19 June 2013 - my birthday. The pain is unbearable

You were the perfect companion. We did not share your life on earth for very long, just 6 short years. I feel privileged to have been part of your life

It's so hard to believe it has now been a year since you went to Rainbow Bridge. I miss you just as much now as I did the day you passed. You will

Yesterday I lost my best friend. Nine years ago you saved my life and brought me happiness every day since. Selfishly I wanted to keep you around forever

Dude you were the best dog ever and I feel sad that we didn't tell you this every day. Yes, you drove us nuts by stealing the cats food and sleeping on

Jason: It's been one month now since you have gone to Rainbow Bridge. Jason your love was unconditional. You have left my life, but you will never leave

Pixie, you came to us beaten, starved, scared and lonely. No one wanted to take on a rescue Staffordshire Bull Terrier, but we did as company for our

Saffron, you were the most perfect being that I could ever envision. You were my sunshine. I miss you beyond words, my little Spoopa Roopa. How can we

Hey Jason! Just checking to see how you are doing at Rainbow Bridge? Hope you are making friends and being a good boy! I missed you so much my baby,

Jess came to me in June 1999 as a birthday gift. She was beautiful white with some brown and black. She was the best birthday present that I ever got or

My Sweet Toby. You were only with us for a short time and was just 15 days shy of 5 months. Why the door had to open when it did, why you ran into the

Khan-li my darling boy you were and always will be the Apple of my Eye, The Love Of My Life My Heart and all that is wonderful. The memories I have of

2 days ago I lost my best friend. Nine years ago you saved my life and stole my heart. You brought me happiness at my lowest point and gave me reason to

My darling, all of Mama's love. You have gone leaving a void in my life. I still hear you sigh, and the patter of your feet up the steps, and the sound

To my beautiful little girl Sassy, I hope wherever you are you are happy and well. I look at your photos that are all around the house and wish you were

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results.

DC made a good choice in moving away from Diamond.

The post The Coronavirus Journal: Alternative Distribution Will Help Us Survive appeared first on The Beat.

IBM (NYSE: IBM) anunció hoy que está trabajando con más de 300 universidades y más de 400 instituciones educativas en toda Latinoamérica para respaldar la inminente necesidad de desarrollar habilidades asociadas a los requerimientos de la transformación digital, ya que el 60% de los ejecutivos se esfuerza hoy por mantener las habilidades de la fuerza laboral actualizadas y relevantes frente al rápido avance tecnológico.

La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla

IBM (NYSE:IBM) today announced it has selected Synnex, one of Australia’s largest IT distribution companies, as a new IBM System and Technology Group (STG) distributor. The strategic agreement enables IBM to capture a larger share of the lucrative small and medium business IT marketplace with its IBM Express volume hardware products.

Zaměstnanci Škody Auto od pondělí začnou pracovat na tři směny, a to v závodech v Mladé Boleslavi a Kvasinách. Ve Vrchlabí zatím zůstává dvousměnný provoz, oznámil vedoucí komunikace podniku Tomáš Kotera. Automobilka obnovila výrobu 27. dubna ve všech třech českých závodech, ale jen na dvě směny. Obnovení výroby doprovází více než 80 hygienických opatření.

Ve Spojených státech v dubnu zaniklo rekordních 20,5 milionu pracovních míst. Míra nezaměstnanosti vzrostla na 14,7 procenta z březnových 4,4 procenta. Dostala se tak na nejvyšší úroveň od velké hospodářské krize ve 30. letech minulého století.

Until now Facebook users haven’t had a lot of say or control over what they see in their news feeds. That’s all changed recently as Facebook launched a new subscribe button for its profile pages. This new feature allows Facebook to provide even more publicly available content for its users..................

1. Tributes flow after death of veteran journalist Frank Crook  Sydney Morning Herald
2. Editor, broadcaster, raconteur and writer’s writer Frank Crook dies  Daily Telegraph
3. View Full coverage on Google News

The “Long Earth” is a name given to a possibly infinite series of parallel worlds that are similar to Earth, which can be reached by using an inexpensive device called a “Stepper”. The “close” worlds are almost identical to “our” Earth (referred to as “Datum Earth”), while others differ in greater and greater details. Click...

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Alan Gilmour from Glasgow City Community Health Partnership who participated in the PROP2 programme. This research aimed to gain an understanding of how training and information support contributes to positive outcomes for carers. It provided a range of information to answer specific questions such as: • Do carers feel that their needs are identified appropriately at different stages of their journey? • Does training contribute to the carer’s outcomes? • What are the barriers to carers engaging in training?

These people are not afraid to carry on hilarious protest signs and tell the world what they really think of Donald Trump's Presidency. Via: Sad and useless  

Slick Willy just had to go and crack a dad joke that simultaneously dug on President Trump and kept the pun game strong, didn't he? Naturally, people were highly entertained and vaguely irritated. 

Great leaders are like mirrors. What they want to see in their team they often exhibit in themselves, even if that means facing things they’d prefer not to. Can a handful of leadership attributes define every great leader? Or could you have a combination of many skills and still be a great leader? Could a [...]Read More...

Recent experiences with combustible gas releases in residential buildings have led to a proposal for NFPA Standards Development for locating combustible gas detectors and consensus on installation location requirements. NFPA is considering a proposed

If you are a frequent event attender like myself, you have probably gotten a handful of emails with the subject line “Schlesinger v. Ticketmaster Settlement.” This was a class-action lawsuit where someone actually took ticket monopoly Ticketmaster on and sued them for all their excessive and deceptive “processing” fees. For once, the good guys won … Continue reading "Even in Losing, Ticketmaster Sets the Terrible Rules"

Welcome to the first episode of the Internet Musician Podcast! Show notes for Episode #1: Subscribe to the Internet Musician Podcast with iTunes: The first episode of The Internet Musician Podcast, hosted by indie artist and internet music marketing junkie Brian Hartzog (http://www.brianhartzog.net).  In this introductory episode, Brian introduces himself, his indie music credentials and […]

How long have you been trying to build a team and generate a residual income with Usana Vitamins? Well whether it is 3 days. 3 months or 3 years it really does not matter. You will benefit from the information I am going to share with you today.

As an Advocare Distributor to make a residual income you need to make as much sales as possible and build the biggest down-line possible within your budget, right? Here are two secrets that your up-line kept quiet that will help you achieve just that!

Whether you are trying to build your team or retail the Xango juice, I have some distributor tips that will cover both. What you need to understand is there is a technique to successful article marketing.